Page last updated: 2024-10-27

fluorouracil and Hyperammonemia

fluorouracil has been researched along with Hyperammonemia in 39 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Hyperammonemia: Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.

Research Excerpts

ExcerptRelevanceReference
"Hyperammonemia is an important adverse event associated with 5-fluorouracil (5FU) from 5FU metabolite accumulation."7.96Successful management of hyperammonemia with hemodialysis on day 2 during 5-fluorouracil treatment in a patient with gastric cancer: a case report with 5-fluorouracil metabolite analyses. ( Funakoshi, T; Horimatsu, T; Ikeda, A; Imamaki, H; Kataoka, S; Matsubara, T; Muto, M; Nakagawa, S; Nishikawa, Y; Oura, M; Ozaki, Y; Watanabe, N; Yanagita, M; Yonezawa, A, 2020)
"A case of hyperammonemia induced by chemotherapy, including high-dose fluorouracil(5-FU), for advanced unresectable large intestinal cancer has been reported."7.91[Case of Hyperammonemia Induced by High-Dose Fluorouracil]. ( Abe, M; Hagiwara, A; Kusakabe, A; Mafune, K; Saito, M, 2019)
"High-dose 5-fluorouracil (5-FU) containing chemotherapy occasionally causes hyperammonemia and can be lethal."7.85Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia. ( Funakoshi, T; Horimatsu, T; Matsubara, K; Matsubara, T; Miyamoto, S; Muto, M; Nakagawa, S; Nishikawa, Y; Yanagita, M; Yonezawa, A, 2017)
"Hyperammonemia or hyperammonemic leukoencephalopathy sometimes occurs as an adverse event after 5-fluorouracil (5-FU) chemotherapy."7.74The aggravating factors of hyperammonemia related to 5-fluorouracil infusion--a report of two cases. ( Asakage, T; Kikuta, S; Kubota, A; Nakao, K; Sugasawa, M, 2008)
"Hyperammonemia is a rare adverse event of 5-FU."6.66[Hyperammonemia with Disturbance of Consciousness during 5-FU plus Nedaplatin Therapy for Esophageal Cancer-A Case Report]. ( Hirakawa, T; Hirata, K; Iwauchi, T; Kurihara, S; Matsutani, S; Miyamoto, H; Morimoto, J; Nagashima, D; Okada, T; Takeuchi, K; Tanaka, H; Tsujio, G; Uchima, Y; Yamagata, S, 2020)
"Although hyperammonemia is a known side effect of 5-FU that can cause serious pathological conditions, only a few cases have been reported."5.42[Four cases of 5-fluorouracil-related hyperammonemia in patients with large intestinal cancer and multiple liver metastases, including a case of hyperammonemia treated using hemodialysis]. ( Iida, T; Isshiki, H; Kaneto, H; Murakami, K; Naganawa, Y; Sasaki, H; Satoh, S; Shimizu, H; Tani, M; Wagatsuma, K, 2015)
" We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia."4.85[A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer]. ( Fujita, J; Hirata, T; Kinjyo, F; Kobashikawa, K; Matayoshi, R; Nakamura, M; Ohshiro, M; Takaki, R; Tamura, J, 2009)
"Hyperammonemia induced by 5-fluorouracil(5-FU)is known as a rare adverse event, but there are few reports of hyperammonemia occurring during FP(5-FU plus CDDP)treatment for esophageal cancer."4.31[A Case of Esophageal Cancer with Consciousness Disorder Due to Hyperammonemia during FP Treatment]. ( Chiba, T; Hayashi, M; Iseki, H; Matsui, T; Miura, T; Noguchi, N; Ryotokuji, T; Tsunemi, A; Yamasaki, Y; Yokosuka, T, 2023)
"Hyperammonemia cases were more likely to be reported with intravenous fluorouracil than orally administered fluoropyrimidines."4.31Fluoropyrimidine usage in cases with hyperammonemia: real-world data study using the Japanese Adverse Drug Event Report (JADER) database. ( Agatsuma, N; Imamaki, H; Nishikawa, Y; Oguro, F; Oura, M, 2023)
"Hyperammonemia is an important adverse event associated with 5-fluorouracil (5FU) from 5FU metabolite accumulation."3.96Successful management of hyperammonemia with hemodialysis on day 2 during 5-fluorouracil treatment in a patient with gastric cancer: a case report with 5-fluorouracil metabolite analyses. ( Funakoshi, T; Horimatsu, T; Ikeda, A; Imamaki, H; Kataoka, S; Matsubara, T; Muto, M; Nakagawa, S; Nishikawa, Y; Oura, M; Ozaki, Y; Watanabe, N; Yanagita, M; Yonezawa, A, 2020)
"A case of hyperammonemia induced by chemotherapy, including high-dose fluorouracil(5-FU), for advanced unresectable large intestinal cancer has been reported."3.91[Case of Hyperammonemia Induced by High-Dose Fluorouracil]. ( Abe, M; Hagiwara, A; Kusakabe, A; Mafune, K; Saito, M, 2019)
"High-dose 5-fluorouracil (5-FU) containing chemotherapy occasionally causes hyperammonemia and can be lethal."3.85Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia. ( Funakoshi, T; Horimatsu, T; Matsubara, K; Matsubara, T; Miyamoto, S; Muto, M; Nakagawa, S; Nishikawa, Y; Yanagita, M; Yonezawa, A, 2017)
"Hyperammonemia or hyperammonemic leukoencephalopathy sometimes occurs as an adverse event after 5-fluorouracil (5-FU) chemotherapy."3.74The aggravating factors of hyperammonemia related to 5-fluorouracil infusion--a report of two cases. ( Asakage, T; Kikuta, S; Kubota, A; Nakao, K; Sugasawa, M, 2008)
"Hyperammonemia is a rare adverse event of 5-FU."2.66[Hyperammonemia with Disturbance of Consciousness during 5-FU plus Nedaplatin Therapy for Esophageal Cancer-A Case Report]. ( Hirakawa, T; Hirata, K; Iwauchi, T; Kurihara, S; Matsutani, S; Miyamoto, H; Morimoto, J; Nagashima, D; Okada, T; Takeuchi, K; Tanaka, H; Tsujio, G; Uchima, Y; Yamagata, S, 2020)
" Hyperammonemia induced by 5-FU is relatively rare, with a reported incidence of 5-9%; however, caution is required with high dosage regimens of 5-FU that are currently recommended for colorectal cancer therapy because hyperammonemia is an important side effect."2.58[A Case of Recurrent Hyperammonemic Encephalopathy during Adjuvant Chemotherapy(Modified FOLFOX6)for Colorectal Cancer]. ( Funahashi, K; Kagami, S; Tamura, A; Yoshino, Y, 2018)
"Because recurrent gastric cancer is often a progressive condition, post-treatment might be promptly transferred to the other posterior regimen without 5-FU as required."1.72[Hyperammonemic encephalopathy after treatment with modified FOLFOX6 regimen for recurrent gastric cancer:a case report]. ( Hirano, S; Ichinokawa, M; Kumagai, K; Kuwabara, S; Matsumoto, J; Murakawa, K; Ono, K; Takeuchi, Y; Wada, H, 2022)
"Idiopathic hyperammonemic encephalopathy is a rare complication of chemotherapy, which has previously mainly been associated with L-asparaginase, cytarabine and 5-FU."1.72Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment. ( Huitema, ADR; Otten, HM; Verkerk, K, 2022)
"5-FU-induced hyperammonaemic encephalopathy started 2 [1-4] days after 5-FU infusion onset."1.565-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey. ( Boige, V; Boilève, A; Chouchana, L; Ducreux, M; Gaboriau, L; Hillaire-Buys, D; Hollebecque, A; Jozwiak, M; Lillo-Le Louët, A; Malka, D; Thomas, L, 2020)
"Although hyperammonemia is a known side effect of 5-FU that can cause serious pathological conditions, only a few cases have been reported."1.42[Four cases of 5-fluorouracil-related hyperammonemia in patients with large intestinal cancer and multiple liver metastases, including a case of hyperammonemia treated using hemodialysis]. ( Iida, T; Isshiki, H; Kaneto, H; Murakami, K; Naganawa, Y; Sasaki, H; Satoh, S; Shimizu, H; Tani, M; Wagatsuma, K, 2015)
"Although hyperammonemia is known as one of the adverse side effects of 5-FU, a disturbance of consciousness caused by hyperammonemia is not a usual finding."1.42[A Case of Consciousness Disturbance Caused by Hyperammonemia during a mFOLFOX6 Regimen for Metastatic Colon Cancer]. ( Egawa, C; Kagawa, Y; Kato, T; Katsura, Y; Murakami, K; Naito, A; Ohmura, Y; Okishiro, M; Takeda, Y; Takeno, A; Tamura, S, 2015)
"Here, we report a case of a male with anal cancer who was treated with 5-FU 1000 mg/m(2), continuous infusion for 5 days q4 weeks."1.33Intermediate dose 5-fluorouracil-induced encephalopathy. ( Choi, HJ; Chung, HC; Jeung, HC; Kim, YA; Rha, SY; Seong, JS, 2006)
"We report here the case of a coma with a favorable outcome following 5FU chemotherapy."1.33[Coma following chemotherapy: is 5FU implicated? Discussion about on case-report]. ( Heluwaert, F; Hilleret, MN; Martin, C; Martin, D; Santre, C, 2006)
"Acute hyperammonemia is a medical emergency for which immediate steps must be taken to minimize permanent brain damage."1.32Unusual causes of hyperammonemia in the ED. ( Chen, WJ; Shih, FF; Weng, TI, 2004)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (20.51)29.6817
2010's18 (46.15)24.3611
2020's13 (33.33)2.80

Authors

AuthorsStudies
Kuwabara, S1
Murakawa, K1
Kumagai, K1
Takeuchi, Y1
Wada, H1
Ichinokawa, M1
Matsumoto, J1
Ono, K1
Hirano, S1
Furuyama, T1
Enjoji, M1
Yamato, M1
Kondo, I1
Hinokida, M1
Tatsutomi, Y1
Nakazawa, K1
Nagayama, K1
Ushirokoji, Y1
Verkerk, K1
Otten, HM1
Huitema, ADR1
Chiu, YW1
Tsui, YK1
Shen, HN1
Yamasaki, Y1
Ryotokuji, T1
Matsui, T1
Miura, T1
Chiba, T1
Hayashi, M1
Yokosuka, T1
Noguchi, N1
Tsunemi, A1
Iseki, H1
Oura, M2
Oguro, F1
Agatsuma, N1
Imamaki, H2
Nishikawa, Y3
Sawazaki, S1
Numata, M1
Ju, M1
Morita, J1
Komori, K1
Maezawa, Y1
Amano, S1
Aoyama, T1
Tamagawa, H1
Sato, T1
Oshima, T1
Mushiake, H1
Yukawa, N1
Masuda, M1
Rino, Y1
Boilève, A3
Thomas, L1
Lillo-Le Louët, A1
Gaboriau, L1
Chouchana, L1
Ducreux, M2
Malka, D2
Boige, V1
Hollebecque, A2
Hillaire-Buys, D1
Jozwiak, M3
Fukuda, M1
Nabeta, M1
Muta, T1
Cho, T1
Shimamatsu, Y1
Shimotsuura, Y1
Fukami, K1
Takasu, O1
Nakamura, T1
Shibata, S1
Miyatani, Y1
Matsubara, H1
Ozaki, Y1
Ikeda, A1
Nakagawa, S2
Funakoshi, T2
Kataoka, S1
Horimatsu, T2
Yonezawa, A2
Matsubara, T2
Yanagita, M2
Muto, M2
Watanabe, N1
Kaizaki, R1
Inoue, T1
Eguchi, S1
Nishiyama, T1
Nobori, C1
Kunimoto, T1
Okazaki, Y1
Takatsuka, S1
Tsukamoto, T2
Nishiguchi, Y1
Okada, T1
Hirakawa, T1
Morimoto, J1
Tanaka, H1
Miyamoto, H1
Tsujio, G1
Kurihara, S1
Matsutani, S1
Nagashima, D1
Hirata, K1
Iwauchi, T1
Yamagata, S1
Uchima, Y1
Takeuchi, K1
Kurokawa, T1
Kanemoto, Y1
Azuma, Y1
Iimura, Y1
Kuroda, S1
Yazawa, K1
Tsurita, G1
Tokuyama, S1
Fukunaga, M1
Konishi, K1
Honda, S1
Yukimoto, R1
Okamoto, A1
Saito, A1
Okada, K1
Ota, H1
Yokoyama, S1
Miki, H1
Kobayashi, K1
Osman, D1
Marthey, L1
Carbonnel, F1
Yoshino, Y1
Tamura, A1
Kagami, S1
Funahashi, K1
Wicker, C1
Verret, B1
Leroy, F1
Pontoizeau, C1
Ottolenghi, C1
De Lonlay, P1
Hagiwara, A1
Abe, M1
Mafune, K1
Saito, M1
Kusakabe, A1
Misumi, N1
Goto, T1
Miyoshi, T1
Hiraike, M1
Shirasawa, H1
Saito, O1
Nishino, T1
Oudo, M1
Okamura, T1
Kawachi, Y1
Nikkuni, K1
Nishimura, A1
Makino, S1
Kawahara, M1
Kitami, C1
Hashimoto, Y1
Nakano, E1
Kuroki, M2
Kanno, N1
Matsumura, Y2
Miura, A2
Kikuchi, Y2
Hirakawa, H2
Barrueco, N1
Such Díaz, A1
Sáez de la Fuente, J1
Escobar, I1
Iida, T1
Wagatsuma, K1
Tani, M1
Sasaki, H1
Naganawa, Y1
Isshiki, H1
Murakami, K2
Satoh, S1
Shimizu, H1
Kaneto, H1
Thomas, SA1
Tomeh, N1
Theard, S1
Kagawa, Y1
Kato, T1
Naito, A1
Katsura, Y1
Ohmura, Y1
Okishiro, M1
Takeno, A1
Egawa, C1
Takeda, Y1
Tamura, S1
Miyamoto, S1
Matsubara, K1
Teraishi, F1
Suzuki, T1
Nakamoto, M1
Chikuba, A1
Nezu, M1
Shimamura, H1
Watanabe, T1
Matsuda, T1
Takiue, T1
Chikuba, H1
Toyokawa, A1
Nakajima, T1
Inui, K1
Yamashita, H1
Gon, H1
Kanemitsu, K1
Tanaka, K1
Hamabe, Y1
Ishida, T1
Nakamura, M1
Kobashikawa, K1
Tamura, J1
Takaki, R1
Ohshiro, M1
Matayoshi, R1
Hirata, T1
Kinjyo, F1
Fujita, J1
Shoji, H1
Hiramoto, K1
Advani, PP1
Fakih, MG1
Chang, YY1
Lin, JK1
Jiang, JK1
Martinez-Lapiscina, EH1
Erro, ME1
Cabada, T1
Tuñón, T1
Weng, TI1
Shih, FF1
Chen, WJ1
Lukaschek, J1
Nufer, M1
Maurer, D1
Asanger, M1
Honegger, H1
Widmer, L1
Malet-Martino, M1
Legay, R1
Martino, R1
Kim, YA1
Chung, HC1
Choi, HJ1
Rha, SY1
Seong, JS1
Jeung, HC1
Heluwaert, F1
Santre, C1
Martin, C1
Hilleret, MN1
Martin, D1
Kikuta, S1
Asakage, T1
Nakao, K1
Sugasawa, M1
Kubota, A1

Reviews

4 reviews available for fluorouracil and Hyperammonemia

ArticleYear
[Hyperammonemia with Disturbance of Consciousness during 5-FU plus Nedaplatin Therapy for Esophageal Cancer-A Case Report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2020, Volume: 47, Issue:13

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Consciousness; Esophageal Neoplasms; Fluoroura

2020
[A Case of Hyperammonemia Induced by Chemotherapy with 5-Fluorouracil for Metastatic Colon Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2018, Volume: 45, Issue:4

    Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Colonic Neoplasms; Fluorouracil; Humans; Hyperam

2018
[A Case of Recurrent Hyperammonemic Encephalopathy during Adjuvant Chemotherapy(Modified FOLFOX6)for Colorectal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2018, Volume: 45, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Chemotherapy, Adjuvant; Colon, Ascen

2018
[A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2009, Volume: 106, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neopl

2009

Other Studies

35 other studies available for fluorouracil and Hyperammonemia

ArticleYear
[Hyperammonemic encephalopathy after treatment with modified FOLFOX6 regimen for recurrent gastric cancer:a case report].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2022, Volume: 119, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Female; Fluorouracil; Humans; Hypera

2022
[A Case of Severe Hyperammonemic Encephalopathy in a Dialysis Patient Following mFOLFOX6 Therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2021, Volume: 48, Issue:13

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Fluorouracil; Humans; Hyperamm

2021
Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment.
    Cancer chemotherapy and pharmacology, 2022, Volume: 90, Issue:5

    Topics: Antineoplastic Agents; Asparaginase; Brain Diseases; Cisplatin; Cytarabine; Deoxycytidine; Fluoroura

2022
Reversible cerebral edema and herniation caused by 5-fluorouracil-induced hyperammonemic encephalopathy.
    The American journal of the medical sciences, 2023, Volume: 365, Issue:4

    Topics: Brain Edema; Fluorouracil; Humans; Hyperammonemia; Neurotoxicity Syndromes

2023
[A Case of Esophageal Cancer with Consciousness Disorder Due to Hyperammonemia during FP Treatment].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2023, Volume: 50, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Consciousness Disorders; Esophageal Neoplasms; Fluor

2023
Fluoropyrimidine usage in cases with hyperammonemia: real-world data study using the Japanese Adverse Drug Event Report (JADER) database.
    Cancer chemotherapy and pharmacology, 2023, Volume: 92, Issue:1

    Topics: Antimetabolites; Antineoplastic Agents; Capecitabine; Drug-Related Side Effects and Adverse Reaction

2023
[A Case Altered Consciousness Due to 5-Fluorouracil-Induced Hyperammonemia in a Patient with Recurrent Colorectal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2019, Volume: 46, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Consciousn

2019
5-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey.
    European journal of cancer (Oxford, England : 1990), 2020, Volume: 129

    Topics: Aged; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Citric Acid Cycle; Dose-Response Rel

2020
Disturbance of consciousness due to hyperammonemia and lactic acidosis during mFOLFOX6 regimen: Case report.
    Medicine, 2020, Aug-14, Volume: 99, Issue:33

    Topics: Acidosis, Lactic; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc

2020
Hyperammonemia with impaired consciousness caused by continuous 5-fluorouracil infusion for colorectal cancer: A case report.
    International journal of clinical pharmacology and therapeutics, 2020, Volume: 58, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Consciousness; Female; F

2020
Successful management of hyperammonemia with hemodialysis on day 2 during 5-fluorouracil treatment in a patient with gastric cancer: a case report with 5-fluorouracil metabolite analyses.
    Cancer chemotherapy and pharmacology, 2020, Volume: 86, Issue:5

    Topics: Aged, 80 and over; Ammonia; Antimetabolites, Antineoplastic; beta-Alanine; Drug Administration Sched

2020
[A Case of Disturbance of Consciousness Due to Hyperammonemia during Chemotherapy for Metastasis of Sigmoid Colon Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2020, Volume: 47, Issue:13

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Consciousness; Female; Fluorouracil; Humans; H

2020
Hyperammonemia-induced impaired consciousness following mFOLFOX6 therapy in a patient with recurrent rectal cancer.
    International journal of clinical pharmacology and therapeutics, 2021, Volume: 59, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Consciousness; Female; Fluorouracil; Humans; Hyperam

2021
Drug-induced coma after chemotherapy in intensive care unit: How to make the right diagnosis?
    Journal of the neurological sciences, 2018, 09-15, Volume: 392

    Topics: Adenosine Triphosphate; Adult; Antineoplastic Combined Chemotherapy Protocols; Coma; Esophageal Neop

2018
5-Fluorouracil rechallenge after 5-fluorouracil-induced hyperammonemic encephalopathy.
    Anti-cancer drugs, 2019, Volume: 30, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Diseases; Female; Fluorour

2019
[Case of Hyperammonemia Induced by High-Dose Fluorouracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2019, Volume: 46, Issue:Suppl 1

    Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Consciousness Disorders; Female;

2019
[Risk factors for hyperammonemia during mFOLFOX6 treatment].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:4

    Topics: Aged; Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Flu

2013
[A case of hyperammonemic encephalopathy related to 5-FU in an aged patient with recurrent colon cancer treated with FOLFIRI therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:5

    Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Brain Dise

2013
[A case of metastatic colorectal cancer with hyperammonemic encephalopathy induced by 5-FU in a patient continuously treated with XELOX therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:13

    Topics: Amino Acids, Branched-Chain; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases, Metabol

2013
[Hyperammonemic encephalopathy in a patient treated with 5-fluorouracil].
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2014, Jan-01, Volume: 38, Issue:1

    Topics: Adenocarcinoma; Antimetabolites; Fluorouracil; Humans; Hyperammonemia; Lung Neoplasms; Male; Middle

2014
[Four cases of 5-fluorouracil-related hyperammonemia in patients with large intestinal cancer and multiple liver metastases, including a case of hyperammonemia treated using hemodialysis].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2015, Volume: 112, Issue:2

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Hyperammonemia; Inte

2015
Fluorouracil-induced Hyperammonemia in a Patient with Colorectal Cancer.
    Anticancer research, 2015, Volume: 35, Issue:12

    Topics: Adult; Colorectal Neoplasms; Fluorouracil; Humans; Hyperammonemia; Male

2015
[A Case of Consciousness Disturbance Caused by Hyperammonemia during a mFOLFOX6 Regimen for Metastatic Colon Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2015, Volume: 42, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Colectomy; Consciousness; Fem

2015
Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia.
    Cancer chemotherapy and pharmacology, 2017, Volume: 79, Issue:3

    Topics: Aged; Ammonia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta

2017
[A case of hyperammonemic encephalopathy in a patient with recurrent colon cancer treated with modified FOLFOX6].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases, Metabolic; Colonic Neoplasms;

2009
[A case of hyperammonemia with encephalopathy related to FOLFIRI chemotherapy for advanced colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Che

2009
[A case of metastatic colorectal cancer suffering from hyperammonemic encephalopathy induced by 5-FU, continuously treated with FOLFOX therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:8

    Topics: Amino Acids, Branched-Chain; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Comb

2010
5-FU-induced hyperammonemic encephalopathy in a case of metastatic rectal adenocarcinoid successfully rechallenged with the fluoropyrimidine analog, capecitabine.
    Anticancer research, 2011, Volume: 31, Issue:1

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Brain Diseases; Capecitabine; Deoxycytidine;

2011
Oxaliplatin-related hyperammonaemic encephalopathy in a patient with colon cancer.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2012, Volume: 14, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neopl

2012
5-Fluorouracil induced hyperammonemic encephalophathy: etiopathologic correlation.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2012, Volume: 39, Issue:4

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Brain Neoplasms; Diffusion Magnetic Resonance Imagi

2012
Unusual causes of hyperammonemia in the ED.
    The American journal of emergency medicine, 2004, Volume: 22, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Antimetabolites, Antineoplastic; Emergency Service, Hospital; Female;

2004
Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Dec-15, Volume: 22, Issue:24

    Topics: Acetaldehyde; Aged; Antimetabolites, Antineoplastic; Brain Diseases; Carcinoma; Chemistry, Pharmaceu

2004
Intermediate dose 5-fluorouracil-induced encephalopathy.
    Japanese journal of clinical oncology, 2006, Volume: 36, Issue:1

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasm

2006
[Coma following chemotherapy: is 5FU implicated? Discussion about on case-report].
    Gastroenterologie clinique et biologique, 2006, Volume: 30, Issue:2

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cecal Neoplasms; Cecum; Coma; Fluorouracil; Humans;

2006
The aggravating factors of hyperammonemia related to 5-fluorouracil infusion--a report of two cases.
    Auris, nasus, larynx, 2008, Volume: 35, Issue:2

    Topics: Brain Diseases; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Fluorouracil; Humans; Hypera

2008