fluorouracil has been researched along with Herpes Zoster in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Herpes Zoster: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 66-year-old woman with metastatic mammary carcinoma, who was being treated with capecitabine, contracted a herpes zoster infection that was treated with the antiviral drug brivudin." | 8.86 | Interaction between capecitabine and brivudin in a patient with breast cancer. ( Baena-Cañada, JM; García-Olmedo, O; Jiménez-Bárcenas, R; Martínez, MJ; Muriel-Cueto, P, 2010) |
| "A 66-year-old woman with metastatic mammary carcinoma, who was being treated with capecitabine, contracted a herpes zoster infection that was treated with the antiviral drug brivudin." | 4.86 | Interaction between capecitabine and brivudin in a patient with breast cancer. ( Baena-Cañada, JM; García-Olmedo, O; Jiménez-Bárcenas, R; Martínez, MJ; Muriel-Cueto, P, 2010) |
| "A toxicokinetic study was performed using rats to investigate the possible mechanism of 18 acute deaths in Japanese patients with cancer and herpes zoster by interactions of the new oral antiviral drug, sorivudine (SRV), with one of the oral 5-fluorouracil (5-FU) prodrugs within 40 days after approval of the use of SRV." | 3.70 | A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. ( Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T, 1998) |
| "The alphaherpesvirus varicella-zoster virus (VZV) causes chickenpox and shingles." | 1.40 | β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism. ( Arnold, RD; Chavre, S; Chu, CK; De, C; Hagen, FK; Liu, D; Moffat, JF; Singh, US; White, C; Zheng, B, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| García Herrera, AN | 1 |
| Moncayola Vicén, JC | 1 |
| De, C | 1 |
| Liu, D | 1 |
| Zheng, B | 1 |
| Singh, US | 1 |
| Chavre, S | 1 |
| White, C | 1 |
| Arnold, RD | 1 |
| Hagen, FK | 1 |
| Chu, CK | 1 |
| Moffat, JF | 1 |
| Rätz Bravo, AE | 1 |
| Hofer, S | 1 |
| Krähenbühl, S | 1 |
| Ludwig, C | 1 |
| Baena-Cañada, JM | 1 |
| Martínez, MJ | 1 |
| García-Olmedo, O | 1 |
| Jiménez-Bárcenas, R | 1 |
| Muriel-Cueto, P | 1 |
| De Clercq, E | 1 |
| Carter, DM | 1 |
| Balin, AK | 1 |
| Watabe, T | 2 |
| Okuda, H | 1 |
| Ogura, K | 1 |
| Kato, A | 1 |
| Takubo, H | 1 |
3 reviews available for fluorouracil and Herpes Zoster
| Article | Year |
|---|---|
Interaction between capecitabine and brivudin in a patient with breast cancer.
Topics: Aged; Anemia, Aplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc | 2010 |
Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster.
Topics: Antimetabolites; Antiviral Agents; Bromodeoxyuridine; Drug Interactions; Europe; Fluorouracil; Herpe | 2004 |
Dermatological aspects of aging.
Topics: Adult; Aged; Aging; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Female; Fl | 1983 |
5 other studies available for fluorouracil and Herpes Zoster
| Article | Year |
|---|---|
[Lethal interaction between 5-fluorouracil and brivudine].
Topics: Aged; Antimetabolites, Antineoplastic; Antiviral Agents; Bromodeoxyuridine; Diagnostic Errors; Drug | 2018 |
β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chickenpox; Dioxolanes; Drug The | 2014 |
Fatal drug-drug interaction of brivudine and capecitabine.
Topics: Adverse Drug Reaction Reporting Systems; Aged, 80 and over; Antimetabolites, Antineoplastic; Antivir | 2009 |
Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Drug Design; Drug Interactions; Drug Therapy, Com | 1996 |
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cau | 1998 |