fluorouracil has been researched along with Hepatic Insufficiency in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hepatic Insufficiency: Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "42%; P = ." | 1.36 | Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases. ( Abdalla, EK; Capussotti, L; Contreras, CM; Curley, SA; Kishi, Y; Kopetz, S; Maru, DM; Motta, M; Ravarino, N; Ribero, D; Risio, M; Vauthey, JN; Zorzi, D, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kishi, Y | 1 |
| Zorzi, D | 1 |
| Contreras, CM | 1 |
| Maru, DM | 1 |
| Kopetz, S | 1 |
| Ribero, D | 1 |
| Motta, M | 1 |
| Ravarino, N | 1 |
| Risio, M | 1 |
| Curley, SA | 1 |
| Abdalla, EK | 1 |
| Capussotti, L | 1 |
| Vauthey, JN | 1 |
1 other study available for fluorouracil and Hepatic Insufficiency
| Article | Year |
|---|---|
Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopl | 2010 |