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fluorouracil and Hepatic Insufficiency

fluorouracil has been researched along with Hepatic Insufficiency in 1 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Hepatic Insufficiency: Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.

Research Excerpts

ExcerptRelevanceReference
"42%; P = ."1.36Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases. ( Abdalla, EK; Capussotti, L; Contreras, CM; Curley, SA; Kishi, Y; Kopetz, S; Maru, DM; Motta, M; Ravarino, N; Ribero, D; Risio, M; Vauthey, JN; Zorzi, D, 2010)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kishi, Y1
Zorzi, D1
Contreras, CM1
Maru, DM1
Kopetz, S1
Ribero, D1
Motta, M1
Ravarino, N1
Risio, M1
Curley, SA1
Abdalla, EK1
Capussotti, L1
Vauthey, JN1

Other Studies

1 other study available for fluorouracil and Hepatic Insufficiency

ArticleYear
Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases.
    Annals of surgical oncology, 2010, Volume: 17, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopl

2010