fluorouracil has been researched along with Hemorrhage in 27 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hemorrhage: Bleeding or escape of blood from a vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine can interact with warfarin, resulting in altered coagulation parameters and bleeding." | 7.73 | Adverse interaction between capecitabine and warfarin resulting in altered coagulation parameters and bleeding: case report and review of the literature. ( Haim, N; Isaacs, K, 2005) |
| "The objectives of this study are to quantify the frequency of concomitant use of capecitabine and warfarin, and to quantify the rate of bleeding events and elevated international normalized ratio (INR) among concomitant users of warfarin and capecitabine." | 7.73 | An observational study examining the impact of capecitabine on warfarin antithrombotic activity and bleeding complications. ( Ackermann Shiff, SP; Alford, SH; Quesenberry, CP; Tsai, AL; Wells, KE; Yood, MU; Yood, SM, 2006) |
| "Our study suggests that in patients receiving concomitant warfarin and a fluoropyrimidine, no significant differences in INR elevation or bleeding events were noted with 5-fluorouracil compared with capecitabine." | 3.76 | Comparison of the 5-fluorouracil-warfarin and capecitabine-warfarin drug interactions. ( Dowell, JE; Martin, R; Shah, SR; Ussery, SM, 2010) |
| "Capecitabine can interact with warfarin, resulting in altered coagulation parameters and bleeding." | 3.73 | Adverse interaction between capecitabine and warfarin resulting in altered coagulation parameters and bleeding: case report and review of the literature. ( Haim, N; Isaacs, K, 2005) |
| "The objectives of this study are to quantify the frequency of concomitant use of capecitabine and warfarin, and to quantify the rate of bleeding events and elevated international normalized ratio (INR) among concomitant users of warfarin and capecitabine." | 3.73 | An observational study examining the impact of capecitabine on warfarin antithrombotic activity and bleeding complications. ( Ackermann Shiff, SP; Alford, SH; Quesenberry, CP; Tsai, AL; Wells, KE; Yood, MU; Yood, SM, 2006) |
| "To report on possible adverse interaction between capecitabine and warfarin in a patient with cancer, who developed subconjunctival and nose bleeding during treatment with these drugs and review of the previously reported five cases in the literature." | 3.73 | Drug interaction between capecitabine and warfarin: a case report and review of the literature. ( Akcali, Z; Basturk, B; Ozyilkan, O; Yildirim, Y, 2006) |
| "The purpose of this study was the evaluation of the effectiveness of intrapericardial administration of tetracycline, 5-fluorouracil and cisplatin in patients with recurrent malignant pericardial effusion." | 3.69 | New approaches to the management and treatment of malignant pericardial effusion. ( Burakowski, J; Fijałkowska, A; Filipecki, S; Szturmowicz, M; Tomkowski, W, 1997) |
| "5 fluorouracil therapy was terminated and the patients were shifted to interferon therapy subsequently." | 1.51 | Severe necrotising inflammatory skin reaction to topical 5-fluorouracil. ( Gokhale, NS, 2019) |
| " The primary objective was to investigate the incidence of adverse drug reactions, particularly those of interest for bevacizumab." | 1.43 | Bevacizumab safety in Japanese patients with colorectal cancer. ( Doi, T; Hatake, K; Ishihara, Y; Shirao, K; Takahashi, Y; Uetake, H, 2016) |
| "The aim of this study was to assess the risk of HCs after CRS combined with HIPEC-Ox versus other drugs, and to determine predictive factors for HCs after HIPEC-Ox." | 1.43 | Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin Increases the Risk of Postoperative Hemorrhagic Complications: Analysis of Predictive Factors. ( Charrier, T; Cotte, E; Elias, D; Eveno, C; Glehen, O; Gocevska, S; Goere, D; Maurice, C; Ortega-Deballon, P; Passot, G; Peron, J; Pocard, M; Quénet, F; Vaudoyer, D, 2016) |
| " The clinical efficacy and bevacizumab-related adverse reactions were observed." | 1.39 | [Efficacy and safety of bevacizumab (BEV) plus chemotherapeutic agents in the treatment of metastatic colorectal cancer, mCRC]. ( Chen, Y; Cui, YH; Guo, X; Liu, TS; Yu, YY; Zhou, YH; Zhuang, RY, 2013) |
| "She underwent curative resection for sigmoid colon cancer( T4a, N2, M0, Stage IIIC)." | 1.39 | [Resection for the treatment of bleeding caused by ovarian metastasis after hepatectomy for metachronous liver metastasis from sigmoid colon cancer]. ( Baba, H; Iida, S; Ishiguro, M; Ishikawa, T; Iwata, N; Kikuchi, A; Kobayashi, H; Okazaki, S; Sugihara, K; Takahashi, H; Uetake, H, 2013) |
| "A 59-years-old woman with metastatic rectal cancer treated with bevacizumab, who developed low back pain after 11 cycles of chemotherapy." | 1.38 | Perirenal hematoma associated with bevacizumab treatment. ( Hayashi, H; Nakagawa, K; Okamoto, I, 2012) |
| "Oral mucositis is a frequent side-effect of cancer therapy." | 1.33 | Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. ( Augusto, RF; Brito, GA; Cunha, FQ; Falcão, BA; Leitão, BT; Lima, V; Rebouças, CG; Ribeiro, RA; Souza, ML, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 12 (44.44) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, NH | 1 |
| Park, JH | 1 |
| Koo, DH | 1 |
| Jung, YS | 1 |
| Yang, JY | 1 |
| Lee, HY | 1 |
| Gokhale, NS | 1 |
| Ng, SY | 1 |
| Colborn, KL | 1 |
| Cambridge, L | 1 |
| Cercek, A | 1 |
| Reidy-Lagunes, DL | 1 |
| Segal, N | 1 |
| Stadler, Z | 1 |
| Saltz, LB | 1 |
| Paty, PB | 1 |
| Guillem, J | 1 |
| Weiser, MR | 1 |
| Nash, G | 1 |
| Garcia-Aguilar, J | 1 |
| Goodman, KA | 1 |
| Al-Tonbary, Y | 1 |
| Darwish, A | 1 |
| El-Hussein, A | 1 |
| Fouda, A | 1 |
| Guo, X | 1 |
| Liu, TS | 1 |
| Yu, YY | 1 |
| Zhou, YH | 1 |
| Chen, Y | 1 |
| Zhuang, RY | 1 |
| Cui, YH | 1 |
| Kobayashi, H | 1 |
| Uetake, H | 2 |
| Iida, S | 1 |
| Ishikawa, T | 1 |
| Ishiguro, M | 1 |
| Okazaki, S | 1 |
| Kikuchi, A | 1 |
| Baba, H | 1 |
| Takahashi, H | 1 |
| Iwata, N | 1 |
| Sugihara, K | 1 |
| Schwameis, M | 1 |
| Thaler, J | 1 |
| Schober, A | 1 |
| Schörgenhofer, C | 1 |
| Kulinna-Cosentini, C | 1 |
| Laggner, A | 1 |
| Röggla, M | 1 |
| Jilma, B | 1 |
| Hatake, K | 1 |
| Doi, T | 1 |
| Takahashi, Y | 1 |
| Ishihara, Y | 1 |
| Shirao, K | 1 |
| Charrier, T | 1 |
| Passot, G | 1 |
| Peron, J | 1 |
| Maurice, C | 1 |
| Gocevska, S | 1 |
| Quénet, F | 1 |
| Eveno, C | 1 |
| Pocard, M | 1 |
| Goere, D | 1 |
| Elias, D | 1 |
| Ortega-Deballon, P | 1 |
| Vaudoyer, D | 1 |
| Cotte, E | 1 |
| Glehen, O | 1 |
| Bercovitz, RS | 1 |
| Greffe, BS | 1 |
| Hunger, SP | 1 |
| Hayashi, H | 1 |
| Okamoto, I | 1 |
| Nakagawa, K | 1 |
| Shah, SR | 1 |
| Martin, R | 1 |
| Dowell, JE | 1 |
| Ussery, SM | 1 |
| Umemoto, S | 1 |
| Kawamoto, S | 1 |
| Yoshida, N | 1 |
| Copur, MS | 1 |
| Ledakis, P | 1 |
| Bolton, M | 1 |
| Morse, AK | 1 |
| Werner, T | 1 |
| Norvell, M | 1 |
| Muhvic, J | 1 |
| Chu, E | 1 |
| Kilickap, S | 1 |
| Abali, H | 1 |
| Celik, I | 1 |
| Lima, V | 1 |
| Brito, GA | 1 |
| Cunha, FQ | 1 |
| Rebouças, CG | 1 |
| Falcão, BA | 1 |
| Augusto, RF | 1 |
| Souza, ML | 1 |
| Leitão, BT | 1 |
| Ribeiro, RA | 1 |
| Isaacs, K | 1 |
| Haim, N | 1 |
| Gordon, MS | 1 |
| Cunningham, D | 1 |
| Yood, MU | 1 |
| Quesenberry, CP | 1 |
| Alford, SH | 1 |
| Tsai, AL | 1 |
| Wells, KE | 1 |
| Yood, SM | 1 |
| Ackermann Shiff, SP | 1 |
| Yildirim, Y | 1 |
| Ozyilkan, O | 1 |
| Akcali, Z | 1 |
| Basturk, B | 1 |
| Vénat-Bouvet, L | 1 |
| Saint-Marcoux, F | 1 |
| Lagarde, C | 1 |
| Peyronnet, P | 1 |
| Lebrun-Ly, V | 1 |
| Tubiana-Mathieu, N | 1 |
| Lamar, RE | 1 |
| Greco, FA | 1 |
| Johnson, DH | 1 |
| Murphy, PB | 1 |
| Hainsworth, JD | 1 |
| Tomkowski, W | 1 |
| Szturmowicz, M | 1 |
| Fijałkowska, A | 1 |
| Burakowski, J | 1 |
| Filipecki, S | 1 |
| Raĭkevich, NP | 1 |
| Spirin, VA | 1 |
| Ponukalin, AN | 1 |
| Merlano, M | 1 |
| Grimaldi, A | 1 |
| Brunetti, I | 1 |
| Modenesi, M | 1 |
| Scala, M | 1 |
| Margarino, G | 1 |
| Scasso, F | 1 |
| Santelli, A | 1 |
| Castiglia, G | 1 |
| Pallestrini, E | 1 |
| Gressel, MG | 1 |
| Parrish, RK | 1 |
3 reviews available for fluorouracil and Hemorrhage
| Article | Year |
|---|---|
Adenocarcinoma of the colon in children: case series and mini-review of the literature.
Topics: Abdomen; Adenocarcinoma; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Barium Sulfate; | 2013 |
An adverse interaction between warfarin and capecitabine: a case report and review of the literature.
Topics: Aged; Aged, 80 and over; Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidin | 2001 |
Managing patients treated with bevacizumab combination therapy.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C | 2005 |
24 other studies available for fluorouracil and Hemorrhage
| Article | Year |
|---|---|
A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Hemorrhage; Humans; Pilot Projects; St | 2022 |
Severe necrotising inflammatory skin reaction to topical 5-fluorouracil.
Topics: Administration, Ophthalmic; Antimetabolites, Antineoplastic; Conjunctival Neoplasms; Drug Eruptions; | 2019 |
Induction Chemotherapy Reduces Patient-reported Toxicities During Neoadjuvant Chemoradiation with Intensity Modulated Radiotherapy for Rectal Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, A | 2019 |
[Efficacy and safety of bevacizumab (BEV) plus chemotherapeutic agents in the treatment of metastatic colorectal cancer, mCRC].
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Che | 2013 |
[Resection for the treatment of bleeding caused by ovarian metastasis after hepatectomy for metachronous liver metastasis from sigmoid colon cancer].
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Disease | 2013 |
Tranexamic acid and fibrinogen restore clotting in vitro and in vivo in cardiac thrombus associated hyperfibrinolysis with overt bleedings.
Topics: Adenocarcinoma; Aged; Anemia; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocol | 2014 |
Bevacizumab safety in Japanese patients with colorectal cancer.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; C | 2016 |
Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin Increases the Risk of Postoperative Hemorrhagic Complications: Analysis of Predictive Factors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Region | 2016 |
Acute tumor lysis syndrome in a 7-month-old with hepatoblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disseminated Intravascular Coagulation; F | 2010 |
Perirenal hematoma associated with bevacizumab treatment.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Pro | 2012 |
Comparison of the 5-fluorouracil-warfarin and capecitabine-warfarin drug interactions.
Topics: Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Drug Interactions; Fem | 2010 |
[A case of no recurrence over 10 years in advanced rectal cancer with bleeding treated by urgent arterial embolization followed by synchronous liver resection and extended lymph node dissection].
Topics: Aged; Antimetabolites, Antineoplastic; Chemoembolization, Therapeutic; Combined Modality Therapy; Fe | 2011 |
Bevacizumab, bleeding, thrombosis, and warfarin.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticoagulants; Antineoplastic Combined C | 2003 |
Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters.
Topics: Abscess; Animals; Antimetabolites, Antineoplastic; Cricetinae; Disease Models, Animal; Edema; Erythe | 2005 |
Adverse interaction between capecitabine and warfarin resulting in altered coagulation parameters and bleeding: case report and review of the literature.
Topics: Aged; Anticoagulants; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine | 2005 |
An observational study examining the impact of capecitabine on warfarin antithrombotic activity and bleeding complications.
Topics: Aged; Aged, 80 and over; Anticoagulants; Capecitabine; Cohort Studies; Contraindications; Deoxycytid | 2006 |
Drug interaction between capecitabine and warfarin: a case report and review of the literature.
Topics: Aged; Anticoagulants; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine | 2006 |
Irinotecan-based chemotherapy in a metastatic colorectal cancer patient under haemodialysis for chronic renal dysfunction: two cases considered.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Ch | 2007 |
High-dose, brief duration, multiagent chemotherapy for metastatic breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Neoplasms; Brain Neoplasms; | 1994 |
New approaches to the management and treatment of malignant pericardial effusion.
Topics: Adult; Aged; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineop | 1997 |
Xeloda. Warning: drug interaction increase bleeding risks.
Topics: Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Drug Interactions; Flu | 2002 |
[Endovascular therapy in locally disseminated bladder cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Female; Fl | 1989 |
Simultaneous cisplatin and 5-fluorouracil as second-line treatment of head and neck cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Fe | 1987 |
Fluorouracil and suprachoroidal hemorrhage.
Topics: Choroid; Fluorouracil; Hemorrhage; Humans; Uveal Diseases | 1987 |