fluorouracil and Hemolysis
fluorouracil has been researched along with Hemolysis in 40 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" Herein, highly uniform and stable selenium nanoparticles with epidermal growth factor receptor (EGFR) targeting and tumor microenvironment-responsive ability (Se-5Fu-Gd-P(Cet/YI-12)) were designed and synthesized by using EGFR as the targeting molecule, gadolinium chelate as the magnetic resonance imaging contrast agent, 5-fluorouracil (5Fu) and cetuximab as drug payloads, polyamidoamine (PAMAM) and 3,3'-dithiobis (sulfosuccinimidyl propionate) as the response agents of intratumoral glutathione, and pH for the treatment and diagnosis of nasopharyngeal carcinoma (NPC)." | 7.91 | Highly Uniform Synthesis of Selenium Nanoparticles with EGFR Targeting and Tumor Microenvironment-Responsive Ability for Simultaneous Diagnosis and Therapy of Nasopharyngeal Carcinoma. ( Chen, T; Huang, J; Huang, W; Lin, H; Lin, X; Peng, L; Zhang, Z, 2019) |
"5-FU/Megestrol acetate loaded fibrinogen-graft-PNIPAAm Nanogels (5-FU/Meg-fib-graft-PNIPAAm NGs) were prepared for thermo responsive drug delivery toward α5β1-integrins expressing breast cancer cells in vitro (MCF-7 cells)." | 7.80 | Dual drug encapsulated thermo-sensitive fibrinogen-graft-poly (N-isopropyl acrylamide) nanogels for breast cancer therapy. ( Baby, T; Chennazhi, KP; Jayakumar, R; Rejinold, NS, 2014) |
" Herein, highly uniform and stable selenium nanoparticles with epidermal growth factor receptor (EGFR) targeting and tumor microenvironment-responsive ability (Se-5Fu-Gd-P(Cet/YI-12)) were designed and synthesized by using EGFR as the targeting molecule, gadolinium chelate as the magnetic resonance imaging contrast agent, 5-fluorouracil (5Fu) and cetuximab as drug payloads, polyamidoamine (PAMAM) and 3,3'-dithiobis (sulfosuccinimidyl propionate) as the response agents of intratumoral glutathione, and pH for the treatment and diagnosis of nasopharyngeal carcinoma (NPC)." | 3.91 | Highly Uniform Synthesis of Selenium Nanoparticles with EGFR Targeting and Tumor Microenvironment-Responsive Ability for Simultaneous Diagnosis and Therapy of Nasopharyngeal Carcinoma. ( Chen, T; Huang, J; Huang, W; Lin, H; Lin, X; Peng, L; Zhang, Z, 2019) |
"5-FU/Megestrol acetate loaded fibrinogen-graft-PNIPAAm Nanogels (5-FU/Meg-fib-graft-PNIPAAm NGs) were prepared for thermo responsive drug delivery toward α5β1-integrins expressing breast cancer cells in vitro (MCF-7 cells)." | 3.80 | Dual drug encapsulated thermo-sensitive fibrinogen-graft-poly (N-isopropyl acrylamide) nanogels for breast cancer therapy. ( Baby, T; Chennazhi, KP; Jayakumar, R; Rejinold, NS, 2014) |
"In Kit(Y567F/Y567F) mice, steady-state erythropoiesis was unperturbed while recovery from anemia due to 5-fluorouracil or phenylhydrazine was markedly impaired." | 3.75 | A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. ( Agosti, V; Besmer, P; Karur, V; Sathyanarayana, P; Wojchowski, DM, 2009) |
"In most cases, hyperbilirubinemia was associated with concomitant alterations in other hemolytic parameters." | 2.71 | Fluoropyrimidine therapy: hyperbilirubinemia as a consequence of hemolysis. ( Cassidy, J; Filipovic-Ljeskovic, I; Jelic, S; Nikolic-Tomasevic, Z; Tomasevic, Z, 2005) |
" In addition, the in vivo pharmacokinetic data in mouse model revealed the improved plasma concentrations of 5-FU and CUR which prolonged up to 72 h unlike the bare drugs." | 1.40 | In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies. ( Anitha, A; Chennazhi, KP; Jayakumar, R; Lakshmanan, VK; Sreeranganathan, M, 2014) |
"We report two cases of colorectal cancer whose serum iron level demonstrated recurrent elevation after chemotherapy." | 1.36 | [Two cases of colorectal cancer presenting with periodic, transient elevation of serum iron due to hemolysis after chemotherapy including 5-FU]. ( Furuse, J; Hosokawa, Y; Itabashi, M; Iwamoto, N; Kase, Y; Kitagawa, N; Miyazawa, T; Motoori, S; Saisho, H, 2010) |
Research
Studies (40)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (5.00) | 18.7374 |
1990's | 3 (7.50) | 18.2507 |
2000's | 5 (12.50) | 29.6817 |
2010's | 25 (62.50) | 24.3611 |
2020's | 5 (12.50) | 2.80 |
Authors
Authors | Studies |
---|---|
Ayyad, SE | 1 |
Makki, MS | 1 |
Al-Kayal, NS | 1 |
Basaif, SA | 1 |
El-Foty, KO | 1 |
Asiri, AM | 1 |
Alarif, WM | 1 |
Badria, FA | 2 |
Abdel-Wahab, BF | 1 |
Awad, GE | 1 |
Deng, X | 1 |
Qiu, Q | 1 |
Yang, B | 1 |
Wang, X | 1 |
Huang, W | 3 |
Qian, H | 1 |
Ahmed, MM | 1 |
Ameen, MSM | 1 |
Abazari, M | 1 |
Badeleh, SM | 1 |
Rostamizadeh, K | 1 |
Mohammed, SS | 1 |
Wang, F | 1 |
Zhang, Q | 1 |
Huang, K | 1 |
Li, J | 1 |
Wang, K | 1 |
Zhang, K | 1 |
Tang, X | 1 |
Kumar, B | 2 |
Priyadarshi, R | 1 |
Deeba, F | 2 |
Kulshreshtha, A | 2 |
Kumar, A | 1 |
Agrawal, G | 1 |
Gopinath, P | 2 |
Negi, YS | 2 |
Zhou, S | 1 |
Ding, C | 1 |
Wang, C | 1 |
Fu, J | 1 |
Cao, J | 1 |
Huang, J | 2 |
Gui, S | 1 |
Chu, X | 1 |
Sahu, P | 1 |
Kashaw, SK | 1 |
Jain, S | 2 |
Sau, S | 1 |
Iyer, AK | 1 |
Reneeta, NP | 1 |
Thiyonila, B | 1 |
Aathmanathan, VS | 1 |
Ramya, T | 1 |
Chandrasekar, P | 1 |
Subramanian, N | 1 |
Prajapati, VK | 1 |
Krishnan, M | 1 |
Moghimipour, E | 1 |
Rezaei, M | 1 |
Kouchak, M | 1 |
Ramezani, Z | 1 |
Amini, M | 1 |
Ahmadi Angali, K | 1 |
Saremy, S | 1 |
Abedin Dorkoosh, F | 1 |
Handali, S | 1 |
Kumar, V | 1 |
Bano, S | 1 |
Ashjaran, M | 1 |
Babazadeh, M | 1 |
Akbarzadeh, A | 1 |
Davaran, S | 1 |
Salehi, R | 1 |
Ning, Q | 2 |
Liu, YF | 1 |
Ye, PJ | 2 |
Gao, P | 2 |
Li, ZP | 2 |
Tang, SY | 1 |
He, DX | 2 |
Tang, SS | 1 |
Wei, H | 1 |
Yu, CY | 2 |
Zhang, Z | 1 |
Lin, X | 1 |
Lin, H | 1 |
Peng, L | 1 |
Chen, T | 1 |
Nejadshafiee, V | 1 |
Naeimi, H | 1 |
Goliaei, B | 1 |
Bigdeli, B | 1 |
Sadighi, A | 1 |
Dehghani, S | 1 |
Lotfabadi, A | 1 |
Hosseini, M | 1 |
Nezamtaheri, MS | 1 |
Amanlou, M | 1 |
Sharifzadeh, M | 1 |
Khoobi, M | 1 |
Tabata, A | 1 |
Ohkubo, Y | 1 |
Tamura, M | 1 |
Tomoyasu, T | 1 |
Ohkura, K | 1 |
Nagamune, H | 1 |
Rejinold, NS | 1 |
Baby, T | 1 |
Chennazhi, KP | 3 |
Jayakumar, R | 3 |
Tavano, L | 1 |
Aiello, R | 1 |
Ioele, G | 1 |
Picci, N | 1 |
Muzzalupo, R | 1 |
Anitha, A | 2 |
Sreeranganathan, M | 1 |
Lakshmanan, VK | 1 |
Salama, A | 1 |
Mayer, B | 1 |
Jain, T | 1 |
Kumar, S | 1 |
Dutta, PK | 1 |
Garg, A | 1 |
Rai, G | 1 |
Lodhi, S | 1 |
Jain, AP | 1 |
Yadav, AK | 1 |
Alupei, L | 1 |
Peptu, CA | 1 |
Lungan, AM | 1 |
Desbrieres, J | 1 |
Chiscan, O | 1 |
Radji, S | 1 |
Popa, M | 1 |
Huang, C | 1 |
Li, NM | 1 |
Yang, S | 1 |
Xiang, L | 1 |
Tan, XW | 1 |
Singh, P | 1 |
Gupta, U | 1 |
Asthana, A | 1 |
Jain, NK | 2 |
Agosti, V | 1 |
Karur, V | 1 |
Sathyanarayana, P | 1 |
Besmer, P | 1 |
Wojchowski, DM | 1 |
Ulusakarya, A | 1 |
Misra, S | 1 |
Haydar, M | 1 |
Habert, H | 1 |
Castagne, V | 1 |
Gumus, Y | 1 |
Delmas-Marsalet, B | 1 |
Machover, D | 1 |
Magalhães, HI | 1 |
Bezerra, DP | 1 |
Cavalcanti, BC | 1 |
Wilke, DV | 1 |
Rotta, R | 1 |
de Lima, DP | 1 |
Beatriz, A | 1 |
Alves, AP | 1 |
Bitencourt, Fda S | 1 |
de Figueiredo, IS | 1 |
Alencar, NM | 1 |
Costa-Lotufo, LV | 1 |
Moraes, MO | 1 |
Pessoa, C | 1 |
Hosokawa, Y | 1 |
Motoori, S | 1 |
Miyazawa, T | 1 |
Iwamoto, N | 1 |
Kase, Y | 1 |
Kitagawa, N | 1 |
Saisho, H | 1 |
Furuse, J | 1 |
Itabashi, M | 1 |
Nair, SV | 1 |
Banerjee, S | 1 |
Sen, K | 1 |
Pal, TK | 1 |
Guha, SK | 1 |
Bhadra, D | 1 |
Bhadra, S | 1 |
INGRAHAM, JS | 1 |
BUSSARD, A | 1 |
Nikolic-Tomasevic, Z | 1 |
Jelic, S | 1 |
Cassidy, J | 1 |
Filipovic-Ljeskovic, I | 1 |
Tomasevic, Z | 1 |
Canti, G | 1 |
Franco, P | 1 |
Marelli, O | 1 |
Ricci, L | 1 |
Nicolin, A | 1 |
Itoh, H | 1 |
Ito, H | 1 |
Amano, H | 1 |
Noda, H | 1 |
Nandurkar, HH | 1 |
Robb, L | 1 |
Tarlinton, D | 1 |
Barnett, L | 1 |
Köntgen, F | 1 |
Begley, CG | 1 |
Blot, E | 1 |
Marie, I | 1 |
Delastre, O | 1 |
Cailleux, N | 1 |
Pouillart, P | 1 |
Lévesque, H | 1 |
Courtois, H | 1 |
Sørbye, H | 1 |
Bruserud, Y | 1 |
Dahl, O | 1 |
Trials
1 trial available for fluorouracil and Hemolysis
Article | Year |
---|---|
Fluoropyrimidine therapy: hyperbilirubinemia as a consequence of hemolysis.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy P | 2005 |
Other Studies
39 other studies available for fluorouracil and Hemolysis
Article | Year |
---|---|
Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma.
Topics: Animals; Antineoplastic Agents; Antioxidants; Benzothiazoles; Cell Line, Tumor; Cell Survival; Chlor | 2011 |
Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Antioxidants; Bacteria; Cell Proliferation; D | 2011 |
Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities.
Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; | 2015 |
Chitosan-decorated and tripolyphosphate-crosslinked pH-sensitive niosomal nanogels for Controlled release of fluoropyrimidine 5-fluorouracil.
Topics: Animals; Antimetabolites; Chitosan; Delayed-Action Preparations; Drug Carriers; Fluorouracil; Hemoly | 2023 |
Preparation and characterization of carboxymethyl cellulose containing quaternized chitosan for potential drug carrier.
Topics: Anti-Bacterial Agents; Apoptosis; Bandages; Carboxymethylcellulose Sodium; Chitosan; Drug Carriers; | 2020 |
Redox responsive xylan-SS-curcumin prodrug nanoparticles for dual drug delivery in cancer therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Curcumin; Disulfides; Drug Delivery Systems; Drug Li | 2020 |
UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer grafted mesoporous silica nanoparticles for drug and gene co-delivery in vitro.
Topics: Animals; Biocompatible Materials; Cations; Chlorocebus aethiops; COS Cells; Coumarins; Cross-Linking | 2020 |
Preparation, Synergism, and Biocompatibility of in situ Liquid Crystals Loaded with Sinomenine and 5-Fluorouracil for Treatment of Liver Cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Death; Drug Carriers; Drug Liberatio | 2021 |
Assessment of penetration potential of pH responsive double walled biodegradable nanogels coated with eucalyptus oil for the controlled delivery of 5-fluorouracil: In vitro and ex vivo studies.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line; Cell Survival; Chitosan; Delayed-Act | 2017 |
Encapsulation and Systemic Delivery of 5-Fluorouracil Conjugated with Silkworm Pupa Derived Protein Nanoparticles for Experimental Lymphoma Cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; Bombyx; Cell Line, Tumor; Cell Pr | 2018 |
A mechanistic study of the effect of transferrin conjugation on cytotoxicity of targeted liposomes.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Cytochromes c; | 2018 |
Lipophilic 5-fluorouracil prodrug encapsulated xylan-stearic acid conjugates nanoparticles for colon cancer therapy.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Colonic Neoplasms; Disease Models, Ani | 2019 |
Stimuli-responsive polyvinylpyrrolidone-NIPPAm-lysine graphene oxide nano-hybrid as an anticancer drug delivery on MCF7 cell line.
Topics: Acrylamides; bcl-2-Associated X Protein; Drug Carriers; Drug Liberation; Fluorouracil; Gene Expressi | 2019 |
Delivery of Liver-Specific miRNA-122 Using a Targeted Macromolecular Prodrug toward Synergistic Therapy for Hepatocellular Carcinoma.
Topics: ADAM17 Protein; Animals; Apoptosis; Biocompatible Materials; Carcinoma, Hepatocellular; Cell Line; C | 2019 |
Highly Uniform Synthesis of Selenium Nanoparticles with EGFR Targeting and Tumor Microenvironment-Responsive Ability for Simultaneous Diagnosis and Therapy of Nasopharyngeal Carcinoma.
Topics: Cell Line, Tumor; Cell Movement; Cetuximab; Contrast Media; Drug Carriers; ErbB Receptors; Fluoroura | 2019 |
Magnetic bio-metal-organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment.
Topics: Animals; Biocompatible Materials; Cell Death; Cell Line, Tumor; Cell Survival; Chitosan; Curcumin; D | 2019 |
Construction of an improved drug delivery system tool with enhanced versatility in cell-targeting.
Topics: Carcinoembryonic Antigen; Cell Membrane; Cells, Cultured; Cholesterol; Drug Delivery Systems; Fibrob | 2013 |
Dual drug encapsulated thermo-sensitive fibrinogen-graft-poly (N-isopropyl acrylamide) nanogels for breast cancer therapy.
Topics: Acrylic Resins; Animals; Apoptosis; Breast Neoplasms; Cattle; Drug Delivery Systems; Female; Fibrino | 2014 |
Niosomes from glucuronic acid-based surfactant as new carriers for cancer therapy: preparation, characterization and biological properties.
Topics: Antineoplastic Agents; Doxorubicin; Drug Carriers; Fluorouracil; Glucuronic Acid; Hemolysis; Humans; | 2014 |
In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Blood Coagulation; Cell Cycle; Cell Line; Cell Lin | 2014 |
Diagnostic pitfalls of drug-induced immune hemolytic anemia.
Topics: Aged; Anemia, Hemolytic, Autoimmune; Antigen-Antibody Complex; Antihypertensive Agents; Antimetaboli | 2014 |
Dibutyrylchitin nanoparticles as novel drug carrier.
Topics: Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Cells, Cult | 2016 |
Hyaluronic acid embedded cellulose acetate phthlate core/shell nanoparticulate carrier of 5-fluorouracil.
Topics: Adipates; Animals; Cell Line, Tumor; Cellulose; Drug Carriers; Drug Liberation; Fluorouracil; Hemoly | 2016 |
New hybrid magnetic nanoparticles based on chitosan-maltose derivative for antitumor drug delivery.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Survival; Chitosan; Drug Delivery Systems; Fluorour | 2016 |
In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy.
Topics: A549 Cells; Absorption, Physiological; Animals; Antimetabolites, Antineoplastic; Carcinoma, Hepatoce | 2017 |
Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice.
Topics: Animals; Antineoplastic Agents; Dendrimers; Drug Carriers; Female; Fluorouracil; Folic Acid; Hemolys | 2008 |
A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis.
Topics: Amino Acid Substitution; Anemia; Animals; Antimetabolites, Antineoplastic; Erythroid Precursor Cells | 2009 |
Acute renal failure related to oxaliplatin-induced intravascular hemolysis.
Topics: Acute Kidney Injury; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combi | 2010 |
In vitro and in vivo antitumor effects of (4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone.
Topics: Animals; Antimetabolites, Antineoplastic; Antimitotic Agents; Antineoplastic Agents; Benzophenones; | 2011 |
[Two cases of colorectal cancer presenting with periodic, transient elevation of serum iron due to hemolysis after chemotherapy including 5-FU].
Topics: Aged; Bilirubin; Colonic Neoplasms; Female; Fluorouracil; Hemolysis; Humans; Iron; Male; Middle Aged | 2010 |
5-flourouracil loaded N,O-carboxymethyl chitosan nanoparticles as an anticancer nanomedicine for breast cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blood Coagulation Tests; Breast Neoplasms; Casp | 2012 |
Poly(styrene-co-maleic acid)-based pH-sensitive liposomes mediate cytosolic delivery of drugs for enhanced cancer chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cult | 2012 |
A PEGylated dendritic nanoparticulate carrier of fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Drug Carriers; Drug Stability; | 2003 |
APPLICATION OF A LOCALIZED HEMOLYSIN REACTION FOR SPECIFIC DETECTION OF INDIVIDUAL ANTIBODY-FORMING CELLS.
Topics: Alcohols; Animals; Antibodies; Antibody Formation; Antigen-Antibody Reactions; Antimetabolites; Comp | 1964 |
Hematoporphyrin derivative rescue from toxicity caused by chemotherapy or radiation in a murine leukemia model (L1210).
Topics: Animals; Antibody Formation; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Hemagglutination | 1984 |
Inhibitory action of a (1-->6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Meth A fibrosarcoma-bearing mice and its antitumor mechanism.
Topics: Agaricus; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Synergism; Erythrocytes; Fema | 1994 |
Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Fluorouracil; | 1997 |
[Thrombotic microangiopathy associated with cancer is an oncologic emergency: a case report].
Topics: Adenocarcinoma; Adult; Anticoagulants; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Ch | 1999 |
Oxaliplatin-induced haematological emergency with an immediate severe thrombocytopenia and haemolysis.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Colonic Ne | 2001 |