fluorouracil has been researched along with Heart Valve Diseases in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Increasing ascites requiring repeated paracentesis had not responded to chemotherapy including infusion of 5-fluorouracil and vincristine into the coeliac artery." | 3.65 | Carcinoid heart disease: successful tricuspid valve replacement. ( Honey, M; Paneth, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boekel, NB | 1 |
| Schaapveld, M | 1 |
| Gietema, JA | 1 |
| Russell, NS | 1 |
| Poortmans, P | 1 |
| Theuws, JC | 1 |
| Schinagl, DA | 1 |
| Rietveld, DH | 1 |
| Versteegh, MI | 1 |
| Visser, O | 1 |
| Rutgers, EJ | 1 |
| Aleman, BM | 1 |
| van Leeuwen, FE | 1 |
| Honey, M | 1 |
| Paneth, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients Who Receiving Radical Concurrent Chemoradiotherapy and Immunotherapy: a Prospective, Randomized Controlled, Multicenter P[NCT04980716] | Phase 3 | 524 participants (Anticipated) | Interventional | 2021-06-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for fluorouracil and Heart Valve Diseases
| Article | Year |
|---|---|
Cardiovascular Disease Risk in a Large, Population-Based Cohort of Breast Cancer Survivors.
Topics: Age Factors; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, | 2016 |
Carcinoid heart disease: successful tricuspid valve replacement.
Topics: Adult; Ascites; Carcinoid Heart Disease; Carcinoid Tumor; Cardiac Catheterization; Edema; Female; Fl | 1975 |