fluorouracil has been researched along with Heart Failure, Systolic in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Heart Failure, Systolic: Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients are now surviving long enough for the adverse cardiovascular effects of some cancer therapies to become apparent." | 2.44 | Chemotherapy and cardiotoxicity. ( Broder, H; Gottlieb, RA; Lepor, NE, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Broder, H | 1 |
| Gottlieb, RA | 1 |
| Lepor, NE | 1 |
1 review available for fluorouracil and Heart Failure, Systolic
| Article | Year |
|---|---|
Chemotherapy and cardiotoxicity.
Topics: Age of Onset; Anthracyclines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplas | 2008 |