Page last updated: 2024-10-27

fluorouracil and Heart Arrest

fluorouracil has been researched along with Heart Arrest in 13 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.

Research Excerpts

ExcerptRelevanceReference
"During a regular MR control, the patient developed anaphylactic reaction to Gadolinium, and after that a rectosigmoid ischemia with total necrosis of the posterior rectal wall was diagnosed and surgically treated with Hartmann procedure."3.91Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication. ( Calvisi, G; Carlei, F; Di Sibio, A; Di Staso, M; Giuliani, A; Lombardi, L; Marchese, M; Romano, L; Romanzi, F; Schietroma, M, 2019)
"5-Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems."1.29Clinical cardiotoxicity of 5-fluorouracil. ( Keefe, DL; Pierri, MK; Roistacher, N, 1993)
"We report a case of cardiac arrest occurring during an infusion of 5-fluorouracil where electrocardiograms suggested coronary artery spasm as the underlying event."1.27Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity. ( Buck, M; Ganju, V; Millward, MJ, 1988)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's4 (30.77)18.2507
2000's3 (23.08)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giuliani, A1
Romanzi, F1
Di Sibio, A1
Calvisi, G1
Lombardi, L1
Marchese, M1
Di Staso, M1
Schietroma, M1
Carlei, F1
Romano, L1
Saridaki, Z1
Lambrodimou, G1
Kachris, S1
Makrantonakis, P1
Boukovinas, I1
Polyzos, A1
Anagnostopoulos, A1
Athanasiadis, A1
Stoltidis, D1
Georgoulias, V1
Souglakos, J1
Fradley, MG1
Barrett, CD1
Clark, JR1
Francis, SA1
Lai, S1
Marshall, JL1
Morrissey, RL1
Ray, JC1
Cho, P1
Dragon, M1
Graham, CG1
Desai, AA1
Vogelzang, NJ1
Rini, BI1
Ansari, R1
Krauss, S1
Stadler, WM1
Neale, G1
Qureshi, F1
Wijesinghe, N1
Unverdorben, M1
Birkenhake, S1
Kunkel, B1
Dunst, J1
Keefe, DL1
Roistacher, N1
Pierri, MK1
Kuntz, BM1
Schöttler, B1
Brüster, HT1
Millward, MJ1
Ganju, V1
Buck, M1

Trials

1 trial available for fluorouracil and Heart Arrest

ArticleYear
A high rate of venous thromboembolism in a multi-institutional phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma.
    Cancer, 2002, Oct-15, Volume: 95, Issue:8

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal

2002

Other Studies

12 other studies available for fluorouracil and Heart Arrest

ArticleYear
Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication.
    Annali italiani di chirurgia, 2019, Jun-26, Volume: 8

    Topics: Aged; Anaphylaxis; Anus Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Chemoradiotherapy; Colon, Si

2019
Postoperative treatment with docetaxel, cisplatin, and capecitabine (DCX) and chemoradiotherapy (CRT) with capecitabine for resected gastric adenocarcinoma.
    American journal of clinical oncology, 2015, Volume: 38, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; C

2015
Ventricular fibrillation cardiac arrest due to 5-fluorouracil cardiotoxicity.
    Texas Heart Institute journal, 2013, Volume: 40, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Coronary Angiography; Coronary Vasospasm; Defibrill

2013
Rechallenging 5-Fluorouracil in a Patient With Capecitabine-Induced Ventricular Fibrillation.
    Clinical colorectal cancer, 2015, Volume: 14, Issue:3

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Defibrillators, Implantable; Fluorouracil; Heart Arre

2015
A Case of 5-Fluorouracil-Induced Cardiac Arrest.
    The Journal of emergency medicine, 2016, Volume: 50, Issue:1

    Topics: Antimetabolites, Antineoplastic; Chest Pain; Female; Fluorouracil; Heart Arrest; Humans; Middle Aged

2016
Not in the BNF.
    British journal of hospital medicine (London, England : 2005), 2006, Volume: 67, Issue:5

    Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Emergency Service, Hospital; Fat

2006
A case of late-onset severe cardiotoxicity from 5-fluorouracil therapy resulting in death.
    The New Zealand medical journal, 2007, Nov-30, Volume: 120, Issue:1266

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin;

2007
Fluorouracil and cardiotoxicity.
    The Medical journal of Australia, 1994, Apr-04, Volume: 160, Issue:7

    Topics: Adult; Fatal Outcome; Female; Fluorouracil; Heart Arrest; Humans

1994
[Extended reversible global left ventricular contraction dysfunction with symptomless coronary system as effect of cytostatic therapy with 5-fluorouracil].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1994, Volume: 170, Issue:8

    Topics: Anus Neoplasms; Combined Modality Therapy; Coronary Angiography; Coronary Vasospasm; Diagnosis, Diff

1994
Clinical cardiotoxicity of 5-fluorouracil.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:11

    Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart Arr

1993
[Resuscitation necessitated by a transfusion reaction after HLA mismatched platelets substitution].
    Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1994, Volume: 32

    Topics: Anaphylaxis; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Cyt

1994
Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity.
    Australian and New Zealand journal of medicine, 1988, Volume: 18, Issue:5

    Topics: Carcinoma, Squamous Cell; Electrocardiography; Fluorouracil; Heart; Heart Arrest; Humans; Male; Midd

1988