fluorouracil has been researched along with Heart Arrest in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During a regular MR control, the patient developed anaphylactic reaction to Gadolinium, and after that a rectosigmoid ischemia with total necrosis of the posterior rectal wall was diagnosed and surgically treated with Hartmann procedure." | 3.91 | Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication. ( Calvisi, G; Carlei, F; Di Sibio, A; Di Staso, M; Giuliani, A; Lombardi, L; Marchese, M; Romano, L; Romanzi, F; Schietroma, M, 2019) |
| "5-Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems." | 1.29 | Clinical cardiotoxicity of 5-fluorouracil. ( Keefe, DL; Pierri, MK; Roistacher, N, 1993) |
| "We report a case of cardiac arrest occurring during an infusion of 5-fluorouracil where electrocardiograms suggested coronary artery spasm as the underlying event." | 1.27 | Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity. ( Buck, M; Ganju, V; Millward, MJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giuliani, A | 1 |
| Romanzi, F | 1 |
| Di Sibio, A | 1 |
| Calvisi, G | 1 |
| Lombardi, L | 1 |
| Marchese, M | 1 |
| Di Staso, M | 1 |
| Schietroma, M | 1 |
| Carlei, F | 1 |
| Romano, L | 1 |
| Saridaki, Z | 1 |
| Lambrodimou, G | 1 |
| Kachris, S | 1 |
| Makrantonakis, P | 1 |
| Boukovinas, I | 1 |
| Polyzos, A | 1 |
| Anagnostopoulos, A | 1 |
| Athanasiadis, A | 1 |
| Stoltidis, D | 1 |
| Georgoulias, V | 1 |
| Souglakos, J | 1 |
| Fradley, MG | 1 |
| Barrett, CD | 1 |
| Clark, JR | 1 |
| Francis, SA | 1 |
| Lai, S | 1 |
| Marshall, JL | 1 |
| Morrissey, RL | 1 |
| Ray, JC | 1 |
| Cho, P | 1 |
| Dragon, M | 1 |
| Graham, CG | 1 |
| Desai, AA | 1 |
| Vogelzang, NJ | 1 |
| Rini, BI | 1 |
| Ansari, R | 1 |
| Krauss, S | 1 |
| Stadler, WM | 1 |
| Neale, G | 1 |
| Qureshi, F | 1 |
| Wijesinghe, N | 1 |
| Unverdorben, M | 1 |
| Birkenhake, S | 1 |
| Kunkel, B | 1 |
| Dunst, J | 1 |
| Keefe, DL | 1 |
| Roistacher, N | 1 |
| Pierri, MK | 1 |
| Kuntz, BM | 1 |
| Schöttler, B | 1 |
| Brüster, HT | 1 |
| Millward, MJ | 1 |
| Ganju, V | 1 |
| Buck, M | 1 |
1 trial available for fluorouracil and Heart Arrest
| Article | Year |
|---|---|
A high rate of venous thromboembolism in a multi-institutional phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal | 2002 |
12 other studies available for fluorouracil and Heart Arrest
| Article | Year |
|---|---|
Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication.
Topics: Aged; Anaphylaxis; Anus Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Chemoradiotherapy; Colon, Si | 2019 |
Postoperative treatment with docetaxel, cisplatin, and capecitabine (DCX) and chemoradiotherapy (CRT) with capecitabine for resected gastric adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; C | 2015 |
Ventricular fibrillation cardiac arrest due to 5-fluorouracil cardiotoxicity.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Coronary Angiography; Coronary Vasospasm; Defibrill | 2013 |
Rechallenging 5-Fluorouracil in a Patient With Capecitabine-Induced Ventricular Fibrillation.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Defibrillators, Implantable; Fluorouracil; Heart Arre | 2015 |
A Case of 5-Fluorouracil-Induced Cardiac Arrest.
Topics: Antimetabolites, Antineoplastic; Chest Pain; Female; Fluorouracil; Heart Arrest; Humans; Middle Aged | 2016 |
Not in the BNF.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Emergency Service, Hospital; Fat | 2006 |
A case of late-onset severe cardiotoxicity from 5-fluorouracil therapy resulting in death.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; | 2007 |
Fluorouracil and cardiotoxicity.
Topics: Adult; Fatal Outcome; Female; Fluorouracil; Heart Arrest; Humans | 1994 |
[Extended reversible global left ventricular contraction dysfunction with symptomless coronary system as effect of cytostatic therapy with 5-fluorouracil].
Topics: Anus Neoplasms; Combined Modality Therapy; Coronary Angiography; Coronary Vasospasm; Diagnosis, Diff | 1994 |
Clinical cardiotoxicity of 5-fluorouracil.
Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart Arr | 1993 |
[Resuscitation necessitated by a transfusion reaction after HLA mismatched platelets substitution].
Topics: Anaphylaxis; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Cyt | 1994 |
Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity.
Topics: Carcinoma, Squamous Cell; Electrocardiography; Fluorouracil; Heart; Heart Arrest; Humans; Male; Midd | 1988 |