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fluorouracil and Hearing Loss, Sensorineural

fluorouracil has been researched along with Hearing Loss, Sensorineural in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.

Research Excerpts

ExcerptRelevanceReference
"Eight pre/peri-menopausal women with breast cancer had middle ear analysis (tympanometry) and pure tone audiometry conducted prior to and 6 months following Fluorouracil, Epirubicin, Cyclophosphamide (FEC) or FEC plus taxotere chemotherapy treatments."3.75Hearing sensitivity in women following chemotherapy treatment for breast cancer: results from a pilot study. ( Jenkins, V; Low, R; Mitra, S, 2009)
"Systemic immunosuppressives are used to treat sensorineural hearing loss due to inflammation (autoimmune, bacterial, viral), which in animal models causes hearing loss."1.31Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. ( Harris, JP; Keithley, EM; Song, HT; Yang, GS, 2000)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chan, SH1
Ng, WT1
Kam, KL1
Lee, MC1
Choi, CW1
Yau, TK1
Lee, AW1
Chow, SK1
Jenkins, V1
Low, R1
Mitra, S1
Yang, GS1
Song, HT1
Keithley, EM1
Harris, JP1
Bauer, FP1
Westhofen, M1
Kehrl, W1

Other Studies

4 other studies available for fluorouracil and Hearing Loss, Sensorineural

ArticleYear
Sensorineural hearing loss after treatment of nasopharyngeal carcinoma: a longitudinal analysis.
    International journal of radiation oncology, biology, physics, 2009, Apr-01, Volume: 73, Issue:5

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cochle

2009
Hearing sensitivity in women following chemotherapy treatment for breast cancer: results from a pilot study.
    Breast (Edinburgh, Scotland), 2009, Volume: 18, Issue:5

    Topics: Acoustic Impedance Tests; Adult; Antineoplastic Combined Chemotherapy Protocols; Audiometry, Pure-To

2009
Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss.
    The American journal of otology, 2000, Volume: 21, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Cyclosporine; Dexamethasone; Disease Models, Animal; Drug Evaluat

2000
[The ototoxicity of the cytostatic drug carboplatin in patients with head-neck tumors].
    Laryngo- rhino- otologie, 1992, Volume: 71, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Conduction; Carboplatin; Dose-Response Re

1992