fluorouracil has been researched along with Hearing Loss, Sensorineural in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eight pre/peri-menopausal women with breast cancer had middle ear analysis (tympanometry) and pure tone audiometry conducted prior to and 6 months following Fluorouracil, Epirubicin, Cyclophosphamide (FEC) or FEC plus taxotere chemotherapy treatments." | 3.75 | Hearing sensitivity in women following chemotherapy treatment for breast cancer: results from a pilot study. ( Jenkins, V; Low, R; Mitra, S, 2009) |
| "Systemic immunosuppressives are used to treat sensorineural hearing loss due to inflammation (autoimmune, bacterial, viral), which in animal models causes hearing loss." | 1.31 | Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. ( Harris, JP; Keithley, EM; Song, HT; Yang, GS, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, SH | 1 |
| Ng, WT | 1 |
| Kam, KL | 1 |
| Lee, MC | 1 |
| Choi, CW | 1 |
| Yau, TK | 1 |
| Lee, AW | 1 |
| Chow, SK | 1 |
| Jenkins, V | 1 |
| Low, R | 1 |
| Mitra, S | 1 |
| Yang, GS | 1 |
| Song, HT | 1 |
| Keithley, EM | 1 |
| Harris, JP | 1 |
| Bauer, FP | 1 |
| Westhofen, M | 1 |
| Kehrl, W | 1 |
4 other studies available for fluorouracil and Hearing Loss, Sensorineural
| Article | Year |
|---|---|
Sensorineural hearing loss after treatment of nasopharyngeal carcinoma: a longitudinal analysis.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cochle | 2009 |
Hearing sensitivity in women following chemotherapy treatment for breast cancer: results from a pilot study.
Topics: Acoustic Impedance Tests; Adult; Antineoplastic Combined Chemotherapy Protocols; Audiometry, Pure-To | 2009 |
Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss.
Topics: Animals; Anti-Inflammatory Agents; Cyclosporine; Dexamethasone; Disease Models, Animal; Drug Evaluat | 2000 |
[The ototoxicity of the cytostatic drug carboplatin in patients with head-neck tumors].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Conduction; Carboplatin; Dose-Response Re | 1992 |