Page last updated: 2024-10-27

fluorouracil and HIV

fluorouracil has been researched along with HIV in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"Anal cancer is an increasing issue in HIV-positive men who have sex with men (MSM)."6.78Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial. ( de Vries, HJ; Dijkgraaf, MG; Prins, JM; Richel, O; van Noesel, CJ, 2013)
"Anal cancer is an increasing issue in HIV-positive men who have sex with men (MSM)."2.78Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial. ( de Vries, HJ; Dijkgraaf, MG; Prins, JM; Richel, O; van Noesel, CJ, 2013)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Raić-Malić, S1
Svedruzić, D1
Gazivoda, T1
Marunović, A1
Hergold-Brundić, A1
Nagl, A1
Balzarini, J2
De Clercq, E2
Mintas, M1
Cavaliere, A1
Probst, KC1
Westwell, AD1
Slusarczyk, M1
Richel, O1
de Vries, HJ1
van Noesel, CJ1
Dijkgraaf, MG1
Prins, JM1
Griffon, JF1
Mathé, C1
Faraj, A1
Aubertin, AM1
Sommadossi, JP1
Gosselin, G1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study of Pomalidomide in Anal Cancer Precursors (SPACE): a Phase 2 Study of Immunomodulation in People With Persistent HPV-associated High Grade Squamous Intraepithelial Lesions[NCT03113942]Phase 226 participants (Actual)Interventional2017-06-14Active, not recruiting
Efficacy and Safety of Topical Trichloroacetic Acid vs. Electrocautery for the Treatment of Anal Intraepithelial Neoplasia in HIV-positive Patients (TECAIN) - a Randomized Controlled Trial[NCT02615860]560 participants (Actual)Interventional2015-11-30Completed
A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons[NCT02437851]Phase 216 participants (Actual)Interventional2015-04-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and HIV

ArticleYear
Fluorinated nucleosides as an important class of anticancer and antiviral agents.
    Future medicinal chemistry, 2017, Volume: 9, Issue:15

    Topics: Antineoplastic Agents; Antiviral Agents; Deoxycytidine; Fluorine; Fluorouracil; Gemcitabine; HIV; Ne

2017

Trials

1 trial available for fluorouracil and HIV

ArticleYear
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013
Comparison of imiquimod, topical fluorouracil, and electrocautery for the treatment of anal intraepithelial neoplasia in HIV-positive men who have sex with men: an open-label, randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:4

    Topics: Aminoquinolines; Anus Neoplasms; Carcinoma in Situ; Electrocoagulation; Fluorouracil; HIV; HIV Infec

2013

Other Studies

2 other studies available for fluorouracil and HIV

ArticleYear
Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6- dideoxy-L-ascorbic acid.
    Journal of medicinal chemistry, 2000, Dec-14, Volume: 43, Issue:25

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line; Crystallography, X-Ray;

2000
Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine.
    European journal of medicinal chemistry, 2001, Volume: 36, Issue:5

    Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Cell Division; Drug Design; Flucytosine; Fluorourac

2001