fluorouracil has been researched along with Granulomatosis with Polyangiitis in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Granulomatosis with Polyangiitis: A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two fatal cases of interstitial pneumonitis rapidly evolving to pulmonary fibrosis are reported here." | 1.35 | Fatal pneumonitis induced by oxaliplatin. ( Arévalo Lobera, S; Azkue Gabilondo, M; Basterretxea Badiola, L; Egaña Otaño, L; Elejoste Echeberría, I; La Casta Muñoa, A; Melé Olivé, M; Sagastibeltza Mariñelarena, N, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arévalo Lobera, S | 1 |
| Sagastibeltza Mariñelarena, N | 1 |
| Elejoste Echeberría, I | 1 |
| Melé Olivé, M | 1 |
| Egaña Otaño, L | 1 |
| Basterretxea Badiola, L | 1 |
| La Casta Muñoa, A | 1 |
| Azkue Gabilondo, M | 1 |
| Vénat-Bouvet, L | 1 |
| Saint-Marcoux, F | 1 |
| Lagarde, C | 1 |
| Peyronnet, P | 1 |
| Lebrun-Ly, V | 1 |
| Tubiana-Mathieu, N | 1 |
2 other studies available for fluorouracil and Granulomatosis with Polyangiitis
| Article | Year |
|---|---|
Fatal pneumonitis induced by oxaliplatin.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protoc | 2008 |
Irinotecan-based chemotherapy in a metastatic colorectal cancer patient under haemodialysis for chronic renal dysfunction: two cases considered.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Ch | 2007 |