fluorouracil has been researched along with Granulocytic Leukemia, Chronic in 16 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 62-year-old male patient who developed Philadelphia chromosome-positive chronic myeloid leukemia (CML) after cisplatin and 5-fluorouracil treatment for colon adenocarcinoma is reported." | 3.71 | Chronic myeloid leukemia in a patient with colon adenocarcinoma. ( Gokel, Y; Paydas, S, 2002) |
| "We report here a very rare case of chronic myeloid leukemia (CML) with a minor bcr-abl transcript, which developed following long-term chemotherapy with fluorouracil for esophageal carcinoma." | 2.41 | A case of chronic myeloid leukemia with minor bcr-abl transcript following fluorouracil therapy for esophageal carcinoma. ( Dan, K; Hanawa, H; Inokuchi, K; Nakamura, H; Tajika, K; Tamura, H; Yamaguchi, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Höpner, SS | 1 |
| Raykova, A | 1 |
| Radpour, R | 1 |
| Amrein, MA | 1 |
| Koller, D | 1 |
| Baerlocher, GM | 1 |
| Riether, C | 1 |
| Ochsenbein, AF | 1 |
| Kassar, O | 1 |
| Mseddi, S | 1 |
| Mdhaffer, M | 1 |
| Bellaaj, H | 1 |
| Mnif, S | 1 |
| Ghorbel, M | 1 |
| Sennena, H | 1 |
| Elloumi, M | 1 |
| Wu, ZJ | 1 |
| Zhao, X | 1 |
| Banaszak, LG | 1 |
| Gutierrez-Rodrigues, F | 1 |
| Keyvanfar, K | 1 |
| Gao, SG | 1 |
| Quinones Raffo, D | 1 |
| Kajigaya, S | 1 |
| Young, NS | 1 |
| Schmid-Wendtner, MH | 1 |
| Wendtner, CM | 1 |
| Peng, C | 1 |
| Chen, Y | 1 |
| Shan, Y | 1 |
| Zhang, H | 1 |
| Guo, Z | 1 |
| Li, D | 1 |
| Li, S | 1 |
| Gokel, Y | 1 |
| Paydas, S | 1 |
| Kadikoylu, G | 1 |
| Yavasoglu, I | 1 |
| Barutca, S | 1 |
| Meydan, N | 1 |
| Bolaman, Z | 1 |
| Kelliher, MA | 1 |
| Weckstein, DJ | 1 |
| Knott, AG | 1 |
| Wortis, HH | 1 |
| Rosenberg, N | 1 |
| Jazwiec, B | 1 |
| Mahon, FX | 2 |
| Pigneux, A | 1 |
| Pigeonnier, V | 1 |
| Reiffers, J | 2 |
| Grosse, PY | 1 |
| Bressolle, F | 1 |
| Pinguet, F | 1 |
| Pigeonnier-Lagarde, V | 1 |
| Chahine, H | 1 |
| Maguer-Satta, V | 1 |
| Ripoche, J | 1 |
| Guyotat, D | 1 |
| Wahbi, K | 1 |
| Viallet, A | 1 |
| Piselli, S | 1 |
| Campos, L | 1 |
| Hao, SX | 1 |
| Ren, R | 1 |
| Nakamura, H | 1 |
| Inokuchi, K | 1 |
| Hanawa, H | 1 |
| Yamaguchi, H | 1 |
| Tamura, H | 1 |
| Tajika, K | 1 |
| Dan, K | 1 |
| Chen, H | 1 |
| Pierce, A | 1 |
| Whetton, T | 1 |
| Reiter, Z | 1 |
| Ozes, ON | 1 |
| Tomson, S | 1 |
| Blatt, LM | 1 |
| Taylor, MW | 1 |
1 review available for fluorouracil and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
A case of chronic myeloid leukemia with minor bcr-abl transcript following fluorouracil therapy for esophageal carcinoma.
Topics: Esophageal Neoplasms; Fluorouracil; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic | 2000 |
15 other studies available for fluorouracil and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Topics: Animals; Antigens, CD34; Cell Cycle; Cell Differentiation; Cell Proliferation; Cell Self Renewal; DN | 2021 |
Chronic myeloid leukemia following the treatment of nasopharyngeal carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Female; | 2017 |
CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation.
Topics: Cell Cycle; Cell Differentiation; Cell Proliferation; CRISPR-Cas Systems; Fluorouracil; Humans; Leuk | 2018 |
Intensified inflammatory reaction of actinic keratoses after single application of topical 5-fluorouracil in a patient treated with nilotinib for chronic myeloid leukemia.
Topics: Administration, Cutaneous; Aged; Antineoplastic Agents; Dermatologic Agents; Drug Therapy, Combinati | 2009 |
LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells.
Topics: Animals; Antigens, CD; Antigens, Ly; Apoptosis; Arachidonate 5-Lipoxygenase; Benzamides; Cell Lineag | 2012 |
Chronic myeloid leukemia in a patient with colon adenocarcinoma.
Topics: Adenocarcinoma; Cisplatin; Colonic Neoplasms; Fluorouracil; Humans; Leukemia, Myelogenous, Chronic, | 2002 |
Chronic myeloid leukemia following the treatment of rectal adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; De | 2008 |
ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.
Topics: Animals; Base Sequence; Bone Marrow; Cell Transformation, Neoplastic; Fluorouracil; Fusion Proteins, | 1993 |
5-Fluorouracil-resistant CD34+ cell population from peripheral blood of CML patients contains BCR-ABL-negative progenitor cells.
Topics: Antigens, CD34; Base Sequence; Cytapheresis; Drug Resistance; Fluorouracil; Fusion Proteins, bcr-abl | 1995 |
In vitro modulation of doxorubicin and docetaxel antitumoral activity by methyl-beta-cyclodextrin.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; beta-Cyclodex | 1998 |
Ex vivo cytokine expansion of peripheral blood Ph-negative cells in chronic myeloid leukaemia.
Topics: Antigens, CD34; Cell Culture Techniques; Colony-Forming Units Assay; Cytokines; Flow Cytometry; Fluo | 1998 |
Selection of BCR/ABL-negative stem cells from marrow or blood of patients with chronic myeloid leukemia.
Topics: Animals; Cell Culture Techniques; Cell Separation; Fluorouracil; Fusion Proteins, bcr-abl; Hematopoi | 1999 |
Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder.
Topics: Animals; Antimetabolites, Antineoplastic; B-Lymphocytes; Base Sequence; Bone Marrow Transplantation; | 2000 |
[Influence of chemotherapeutants and cytokines on growth and transgene expression of bone marrow cells from MT/p210(bcr-abl) transgenic mice].
Topics: Animals; Antigens, Polyomavirus Transforming; Antineoplastic Combined Chemotherapy Protocols; Bone M | 1999 |
A dual anti-tumor effect of a combination of interferon-alpha and 5-flurouracil or 2-chlorodeoxyadenosine on natural killer (NK) cell mediated cytotoxicity.
Topics: 2-Chloroadenosine; Acquired Immunodeficiency Syndrome; Antimetabolites, Antineoplastic; Cell Divisio | 1991 |