Page last updated: 2024-10-27

fluorouracil and Glaucoma

fluorouracil has been researched along with Glaucoma in 324 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

ExcerptRelevanceReference
"To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients."9.24Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma. ( Bell, K; Keicher, A; Lorenz, K; Pfeiffer, N; Renieri, G; Ruckes, C; Thieme, H; Wasielica-Poslednik, J, 2017)
"To compare the efficacy of transconjunctival needling revision with 5-fluorouracil versus medical treatment in glaucomatous eyes with uncontrolled intraocular pressure due to encapsulated bleb after trabeculectomy."9.17Early transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study. ( Susanna, R; Suzuki, R, 2013)
"To compare the effectiveness of trabeculectomy with adjunctive, low-dose, subconjunctival 5-fluorouracil (5-FU) to trabeculectomy alone in patients with uncomplicated glaucoma undergoing their first incisional surgical procedure."9.09Low-dose 5-fluorouracil trabeculectomy as initial surgery in uncomplicated glaucoma: long-term followup. ( Liebmann, JM; Ritch, R; Rothman, RF, 2000)
"In a randomized clinical trial, the authors compared the use of postoperative subconjunctival injections of 5-fluorouracil (5-FU) in 19 eyes with a single intraoperative application of subconjunctival mitomycin (MMC) at the filtering site in 20 eyes at high risk for failure of glaucoma filtering surgery."9.07Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. ( Beeson, CC; Bergstrom, TJ; Falck, FY; Higginbotham, EJ; Klein, TB; Lichter, PR; Musch, DC; Skuta, GL, 1992)
"A study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits in a prospective, randomized, double-masked and placebo-controlled fashion."9.06The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery. ( Eng, CT; Glasgow, BJ; Lee, DA; Leong, KW; Panek, WC, 1988)
" We concluded mitomycin C might be more effective in reducing intraocular pressure and increasing qualified success compared to 5-fluorouracil."8.98Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma? ( Pimentel, E; Schmidt, J, 2018)
"The objective of this review is to assess the effects of post-operative injections of 5-Fluorouracil in eyes of people undergoing surgery for glaucoma."8.81Post-operative 5-Fluorouracil for glaucoma surgery. ( Bunce, C; Wilkins, MR; Wormald, R, 2001)
"The objective of this review is to assess the effects of post-operative injections of 5-Fluorouracil in eyes of people undergoing surgery for glaucoma."8.80Post-operative 5-fluorouracil for glaucoma surgery. ( Bunce, C; Wilkins, MR; Wormald, R, 2000)
"To develop a sustained release 5-fluorouracil (5-FU) implant by three-dimensional (3D) printing to effectively prevent conjunctival fibrosis after glaucoma surgery."8.313D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma. ( Di Luca, M; Ioannou, N; Lamprou, DA; Luo, J; Mathew, E; Qin, M; Tagalakis, AD; Yu-Wai-Man, C, 2023)
"To report the effectiveness and safety of 5-fluorouracil (5-FU)-augmented Xen45 implantation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG)."8.02Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma. ( Başer, EF; Seymenoğlu, RG, 2021)
"To investigate the outcomes of trabeculectomy with 5-fluorouracil (5-FU) with or without subconjunctival bevacizumab in the surgical management of pseudoexfoliation glaucoma (PXG)."7.91Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma. ( Çolak, S; Elgin, U; Sen, E; Yılmazbas, P, 2019)
"To report our experience on treatment of primary congenital glaucoma with trabeculectomy in combination with biological amniotic membranes soaked with 5-fluorouracil."7.88Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil. ( Gao, H; Guo, B; Liu, C; Liu, W; Wang, J; Wang, X; Wu, M; Zhang, C, 2018)
"To examine the effect of mitomycin c and 5-flurouracil on treatment outcomes following Ahmed glaucoma valve implantation."7.85Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation. ( Cui, QN; Han, Y; Hsia, YC; Lin, SC; Mehta, N; Naseri, A; Porco, TC; Rose-Nussbaumer, J; Stamper, RL, 2017)
"This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes."7.81Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes. ( Bi, XZ; Li, CH; Nan, KH; Pan, WH; Ren, ZJ; Song, ZM; Sun, M; Yu, XP, 2015)
"To evaluate the antimitotic and toxic effects of 5-chlorouracil (5-CU) and 5-fluorouracil (5-FU) and study their potential to delay filtering bleb closure in the rabbit eye when released by poly(ortho esters) (POE)."7.74Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma. ( Behar-Cohen, F; BenEzra, D; Bourges, JL; Felt, O; Gurny, R; Jeanny, JC; Polak, MB; Rat, P; Thomas-Doyle, A; Torriglia, A; Valamanesh, F, 2008)
"Although adjunctive postoperative 5-fluorouracil (5-FU) injections are known to improve the success rate of glaucoma surgery, it is still unknown what dose, timing and frequency of application will give the best results with respect to the inhibition of postoperative scarring and intraocular pressure regulation."7.74Dose, timing and frequency of subconjunctival 5-fluorouracil injections after glaucoma filtering surgery. ( Bartz-Schmidt, KU; Besch, D; Denk, PO; Grüb, M; Reinthal, EK, 2007)
"This study was designed to evaluate the long-term effect of phacoemulsification, lens implantation combined with trabeculectomy augmented with 5-Fluorouracil (phaco-trab-5-Fu) in Asian glaucoma patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG)."7.73[The long-term effect of phacoemulsification combined with trabeculectomy and intraoperative 5-fluorouracil in glaucoma patients]. ( Cai, Y; Li, MY; Lim, BA; Lim, Z; Oen, F; Seah, S; Yan, XM, 2005)
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."7.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"To investigate the changes of tear film functions due to the use of postoperative 5-fluourouracil (5-Fu) and intraoperative mitomycin C (MMC) in glaucoma filtration surgery."7.71[Influence on tear film of postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery]. ( Li, J; Pang, L, 2001)
"The authors evaluate the results of preoperative 5-minute administration of 5-fluorouracil (5-FU), 50 mg/ml, during trabeculectomy on 11 high risk eyes of children with primary and secondary glaucoma."7.70[Peroperative administration of 5-fluorouracil during trabeculectomy in complicated glaucoma in children]. ( Burdová, M; Filous, A, 1998)
"To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma."7.70Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma. ( Lightman, S; McCluskey, P; Shaer, B; Towler, HM, 2000)
"Patients with both cataract and glaucoma underwent combined mitomycin C trabeculectomy, extracapsular cataract extraction, and intraocular lens implantation."7.69One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction. ( Bueche, MJ; Feuer, WJ; Grajewski, AL; Joos, KM; Palmberg, PF, 1995)
"Between 2/1991 and 1/1993 twenty-nine eyes of 11 female and 16 male patients with high-risk glaucoma (unsuccessful previous filtering surgery and a high risk of scarring) were treated with subconjunctival injections of 5-Fluorouracil after filtering surgery in the University Eye Hospital Düsseldorf."7.68[5-fluorouracil injection treatment after fistulating glaucoma operations]. ( Klüppel, M; Reinhard, T; Sundmacher, R, 1993)
"We studied 105 patients (105 eyes) operated on for glaucoma with adjunctive fluorouracil, who were followed up for 12 to 48 months (mean, 34."7.68Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil. ( Ophir, A; Ticho, U, 1993)
"Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU)."7.68Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease. ( Lowder, CY; Meisler, DM; Patitsas, CJ; Rockwood, EJ, 1992)
"The authors give an account of the results of trabeculectomy with the use of 5-fluorouracil in a group of 8 patients with complicated glaucoma."7.68[Use of 5-fluorouracil in complicated cases of glaucoma--personal experience]. ( Liehneová, I; Rozsíval, P, 1992)
"Trabeculectomy and subsequent subconjunctival injections of 5-fluorouracil (5-FU) were performed in four eyes (two children) with congenital glaucoma."7.68Subconjunctival injection of 5-fluorouracil following trabeculectomy for congenital and infantile glaucoma. ( Leiba, H; Oliver, M; Zalish, M, 1992)
"The effectiveness of trabeculectomy with adjunctive low-dose 5-fluorouracil (5-FU) as the initial surgical procedure in uncomplicated glaucoma was evaluated retrospectively in a consecutive series of 52 patients (mean follow-up, 18."7.68Initial 5-fluorouracil trabeculectomy in uncomplicated glaucoma. ( Liebmann, JM; Marmor, M; Nunez, J; Ritch, R; Wolner, B, 1991)
"The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy."7.68Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. ( Liebmann, JM; Marmor, M; Ritch, R; Sassani, JW; Speaker, M; Wolner, B, 1991)
"Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53."7.685-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome. ( Cristol, SM; Grajewski, AL; Parrish, RK; Wright, MM, 1991)
"We reviewed the records of 12 eyes of ten adult patients with inflammatory glaucoma who underwent trabeculectomy with the adjuvant use of 5-fluorouracil between January 1986 and January 1989."7.68Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma. ( Jabs, DA; Jampel, HD; Quigley, HA, 1990)
"5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses."7.675-fluorouracil and glaucoma filtering surgery. II. A pilot study. ( Anderson, DR; Gressel, MG; Heuer, DK; Hodapp, E; Palmberg, PF; Parrish, RK, 1984)
"We show that a 40-mg total dose of subconjunctival 5-fluorouracil after glaucoma filtering surgery can provide a success rate comparable to that demonstrated in prior studies employing a higher dose."7.67Low-dose 5-fluorouracil and glaucoma filtration surgery. ( Rabowsky, JH; Ruderman, JM, 1989)
"A prospective, randomized, double-masked, and placebo-controlled study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits."7.67Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil. ( Anderson, PJ; de Kater, AW; Flores, RA; Hertzmark, E; Lee, DA; Leong, KW; Teekhasaenee, C, 1987)
"The antimetabolite 5-fluorouracil (5-FU) has been used to inhibit fibroblastic growth to increase the success rate in glaucoma filtration surgery."7.67Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. ( Hersh, P; Kersten, D; Lee, DA; Melamed, S, 1987)
"The effect of 5-fluorouracil (5-FU) subconjunctival injection on the bleb formation and intraocular pressure (IOP) following trabeculectomy was studied in 18 glaucoma patients (20 eyes) with poor surgical prognosis."7.675-Fluorouracil for trabeculectomy in glaucoma. ( Kitazawa, Y; Nakano, Y; Shirato, S; Taniguchi, T; Yamamoto, T, 1987)
"A life-table analysis of surgical outcomes was performed on the first eye of 155 patients who were enrolled in a pilot study of glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU) injections."7.67Glaucoma filtering surgery with 5-fluorouracil. ( Feuer, W; Gressel, MG; Heuer, DK; Hodapp, E; Palmberg, PF; Parrish, RK; Rockwood, EJ; Skuta, GL, 1987)
"We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications."7.67Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. ( Driebe, WT; Heuer, DK; Knapp, A; Stern, GA, 1987)
"Last controlled intraocular pressure is lower in C group patients (13."6.68[Intra- and postoperative use of 5-fluorouracil in the surgical treatment of refractory glaucoma]. ( Apatachioaie, I; Brănişteanu, D; Chiseliţă, D; Poiata, I; Rusu, V; Tătăruş, C, 1997)
"Late postoperative complications are similar with the exception of an increased incidence of Tenon cyst formation in the MMC-treated eyes."6.68Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up. ( Bergstrom, TJ; Higginbotham, EJ; Johnson, AT; Katz, GJ; Lichter, PR; Musch, DC; Skuta, GL, 1995)
"These include young patients, those with pigmentary glaucoma, secondary glaucoma, angle recession glaucoma, aphakic or pseudophakic glaucoma, and patients requiring reoperation."6.67Intraoperative mitomycin C in complicated glaucomas. ( Dogra, A; Kaur, J; Singh, G, 1993)
"Intraocular pressure was 20 mm Hg or lower in 24 eyes (96%) in the treatment group after mean follow-up of 17."6.67A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas. ( Ophir, A; Ticho, U, 1992)
"Raised intraocular pressure is a risk factor for glaucoma."6.52Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery. ( Cabourne, E; Clarke, JC; Evans, JR; Schlottmann, PG, 2015)
"Mitomycin C seems to be a better treatment than 5 fluorouracil."6.38[Mitomycin C in glaucoma surgery]. ( Collignon-Brach, J, 1993)
"5-Fluorouracil (5-FU) has been well described for a failing trabeculectomy bleb, but not for aqueous shunts."5.46Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant. ( Kaplowitz, K; Khodadadeh, S; Lee, D; Tsai, JC; Wang, S, 2017)
" In this study, 5-Fluorouracil (5-FU), a halogenated pyrimidine analogue and a potent anti-mitotic agent, was applied for seven days after trabeculectomy in eighteen complicated and unsuccessful filtering glaucomas, at a daily dosage of 5 mg in the form of 0."5.29The role of 5-fluorouracil in complicated glaucomas. ( Das, S; Jilani, FA; Khan, AM, 1993)
" Whether dose reduction will lead to reduced corneal toxicity in glaucoma filtration surgery following topical or subconjunctival dosing is an interesting therapeutic opportunity that remains to be determined."5.28Corneal penetration of 5-fluorouracil and its improvement by prodrug derivatization in the albino rabbit: implication in glaucoma filtration surgery. ( Bundgaard, H; Buur, A; Lee, VH; Wang, W, 1991)
"The objective of this article was to study longitudinal changes in bleb morphology (presence of microcysts and bleb height and vascularity) in subjects enrolled in the Singapore 5-Fluorouracil (5-FU) trabeculectomy study."5.27Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy. ( Aung, T; Htoon, HM; Husain, R; Kumaran, A, 2018)
"5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation."5.275-fluorouracil and glaucoma filtering surgery: I. An animal model. ( Folberg, R; Gressel, MG; Parrish, RK, 1984)
"To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients."5.24Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma. ( Bell, K; Keicher, A; Lorenz, K; Pfeiffer, N; Renieri, G; Ruckes, C; Thieme, H; Wasielica-Poslednik, J, 2017)
"To compare the efficacy of transconjunctival needling revision with 5-fluorouracil versus medical treatment in glaucomatous eyes with uncontrolled intraocular pressure due to encapsulated bleb after trabeculectomy."5.17Early transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study. ( Susanna, R; Suzuki, R, 2013)
"Primary outcome was bleb vascularity with secondary endpoints including visual acuity, intraocular pressure, bleb morphology, complications and total numbers of 5-fluorouracil injections were recorded at baseline, week 12 and 18 months."5.16Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study. ( Chua, BE; Coote, MA; Crowston, JG; Gupta, V; Nguyen, DQ; Niyadurupola, N; Qin, Q; Ruddle, JB; Wells, AP; Wong, TT, 2012)
"Patients aged ≥ 30 years newly diagnosed with glaucoma were randomized to trabeculectomy with 5-fluorouracil or medical therapy."5.16A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study. ( Congdon, NG; Friedman, DS; Gilbert, D; Goggins, W; Kader, MA; Krishnadas, R; Quigley, HA; Ramakrishnan, R; Tielsch, J, 2012)
"The perioperative use of oral prednisone did not alter the surgical outcome of filtering procedures associated with antifibrosis agents in this population of glaucoma patients."5.09Oral prednisone in guarded filtration procedures supplemented with antimetabolites. ( Augsburger, JJ; Azuara-Blanco, A; Spaeth, GL, 1999)
"To compare the effectiveness of trabeculectomy with adjunctive, low-dose, subconjunctival 5-fluorouracil (5-FU) to trabeculectomy alone in patients with uncomplicated glaucoma undergoing their first incisional surgical procedure."5.09Low-dose 5-fluorouracil trabeculectomy as initial surgery in uncomplicated glaucoma: long-term followup. ( Liebmann, JM; Ritch, R; Rothman, RF, 2000)
"Mean (+/-SD) preoperative and 1-year postoperative intraocular pressures in the 5-fluorouracil group were 26."5.09Randomized, controlled study of low-dose 5-fluorouracil in primary trabeculectomy. ( Caprioli, J; Chaudhry, IA; O'Connor, DJ; Pasha, MA; Weitzman, ML, 2000)
"Trabeculectomy is the procedure of choice for the surgical control of glaucoma, and is often augmented by intraoperative 5-fluorouracil application to reduce scarring."5.09Single intraoperative application of 5-Fluorouracil versus placebo in low-risk trabeculectomy surgery: a randomized trial. ( Bloom, P; Leyland, M; McAlister, J; Migdal, C; Rassam, S; Zinicola, E, 2001)
"To determine the efficacy and safety of subconjunctival 5- fluorouracil injections after trabeculectomy in patients with poor prognoses, to determine risk factors for surgical failure and to examine the relationship of intraocular pressure and visual function."5.08Five-year follow-up of the Fluorouracil Filtering Surgery Study. The Fluorouracil Filtering Surgery Study Group. ( , 1996)
"To study the effect of 5-Fluorouracil (5-FU) in glaucoma filtration surgery, 13 eyes of 12 patients with glaucoma were subjected to trabeculectomy with intraoperative one minute exposure of 50 mg/ml 5-FU."5.08Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy--pilot trial. ( Garg, D; Rao, BS; Revathi, B; Shelat, B; Vijaya, L, 1996)
"The effects of postoperative subconjunctival 5-fluorouracil (5-FU) injections on the surgical outcomes of trabeculectomy were studied after a 5-year follow-up in 263 eyes of glaucoma patients by the life table analysis."5.07[A five-year follow-up of the effect of postoperative 5-fluorouracil subconjunctival injections on the surgical outcome of trabeculectomy]. ( Araie, M; Nakano, Y; Shirato, S; Shoji, N, 1993)
"Eighteen eyes of 15 patients with uncontrolled glaucoma (neovascular, intracapsular aphakia, uveitic, previous filtration failure) at high risk for failure of standard filtration underwent trabeculectomy with implantation of a purified collagen sponge containing 100 micrograms of antimetabolite (5-fluorouracil or bleomycin)."5.07Long-term results of trabeculectomy with collagen sponge implant containing low-dose antimetabolite. ( Herschler, J, 1992)
"In a randomized clinical trial, the authors compared the use of postoperative subconjunctival injections of 5-fluorouracil (5-FU) in 19 eyes with a single intraoperative application of subconjunctival mitomycin (MMC) at the filtering site in 20 eyes at high risk for failure of glaucoma filtering surgery."5.07Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. ( Beeson, CC; Bergstrom, TJ; Falck, FY; Higginbotham, EJ; Klein, TB; Lichter, PR; Musch, DC; Skuta, GL, 1992)
"We conducted a prospective, randomized study to compare mitomycin with fluorouracil for efficacy and safety as an adjunct to trabeculectomy in eyes with glaucoma with poor surgical prognosis."5.07Trabeculectomy with mitomycin. A comparative study with fluorouracil. ( Kawase, K; Kitazawa, Y; Matsushita, H; Minobe, M, 1991)
"A study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits in a prospective, randomized, double-masked and placebo-controlled fashion."5.06The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery. ( Eng, CT; Glasgow, BJ; Lee, DA; Leong, KW; Panek, WC, 1988)
" We concluded mitomycin C might be more effective in reducing intraocular pressure and increasing qualified success compared to 5-fluorouracil."4.98Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma? ( Pimentel, E; Schmidt, J, 2018)
"With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections."4.82Glaucoma-filtering bleb infections. ( Mac, I; Soltau, JB, 2003)
"The use of antifibrotic agents, namely, 5-fluorouracil and mitomycin C, in conjunction with glaucoma surgery has resulted in lower postoperative intraocular pressures after trabeculectomy or combined cataract and glaucoma surgery."4.82Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery. ( Singh, K; Yoon, PS, 2004)
"Agents such as the antimetabolites 5-fluorouracil (5FU) and mitomycin-C (MMC) have revolutionised glaucoma surgery in patients with a high risk of surgical failure."4.82Wound healing after glaucoma surgery: how to manage it? ( Collignon, NJ, 2005)
"The preponderance of evidence from the literature suggests a small (2-4 mmHg) benefit from the use of mitomycin-C (MMC), but not 5-fluorouracil (5-FU), in combined cataract and glaucoma surgery (evidence grade B)."4.81Effect of technique on intraocular pressure after combined cataract and glaucoma surgery: An evidence-based review. ( Bass, EB; Congdon, N; Friedman, DS; Jampel, HD; Kempen, JH; Levkovitch-Verbin, H; Lubomski, LH; Quigley, H; Robinson, KA, 2002)
"To examine why most ophthalmologists routinely use mitomycin C or 5-fluorouracil (antimetabolites) in association with filtering surgery for glaucoma."4.81The use of antimetabolites with trabeculectomy: a critical appraisal. ( Mutlukan, E; Spaeth, GL, 2001)
"The objective of this review is to assess the effects of post-operative injections of 5-Fluorouracil in eyes of people undergoing surgery for glaucoma."4.81Post-operative 5-Fluorouracil for glaucoma surgery. ( Bunce, C; Wilkins, MR; Wormald, R, 2001)
" Cyclosporine A devices were prepared for the treatment of uveitis."4.79Review: implants. ( Ashton, P; Blandford, DL; Jaffe, GJ; Martin, DF; Nussenblatt, RB; Pearson, PA, 1994)
"Intraoperative Mitomycin C may be a helpful adjunct in achieving low final intraocular pressure after trabeculectomy in high-risk glaucoma filtering surgery, and Mitomycin C may be a viable alternative to postoperative 5-Fluorouracil."4.79[Trabeculectomy with mitomycin C. Study apropos of 30 cases]. ( Ballion, JC; Bazin, S; Ducousso, F; Poirier, L; Verin, P; Williamson, W, 1995)
"To develop a sustained release 5-fluorouracil (5-FU) implant by three-dimensional (3D) printing to effectively prevent conjunctival fibrosis after glaucoma surgery."4.313D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma. ( Di Luca, M; Ioannou, N; Lamprou, DA; Luo, J; Mathew, E; Qin, M; Tagalakis, AD; Yu-Wai-Man, C, 2023)
"To report the effectiveness and safety of 5-fluorouracil (5-FU)-augmented Xen45 implantation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG)."4.02Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma. ( Başer, EF; Seymenoğlu, RG, 2021)
"To investigate the outcomes of trabeculectomy with 5-fluorouracil (5-FU) with or without subconjunctival bevacizumab in the surgical management of pseudoexfoliation glaucoma (PXG)."3.91Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma. ( Çolak, S; Elgin, U; Sen, E; Yılmazbas, P, 2019)
"Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU)."3.91Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. ( Ayyala, RS; Blake, D; Fullerton, M; Greenberg, E; John, V; Le, C; Mancera, N; Margo, C; Muddasani, N; Satija, C; Singh, S; Swann, FB; Wall, J; Zhang, Z; Zurakowski, D, 2019)
"To report our experience on treatment of primary congenital glaucoma with trabeculectomy in combination with biological amniotic membranes soaked with 5-fluorouracil."3.88Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil. ( Gao, H; Guo, B; Liu, C; Liu, W; Wang, J; Wang, X; Wu, M; Zhang, C, 2018)
"To evaluate the long-term outcome of trabeculectomy with intra- and postoperative 5-fluorouracil (5-FU) application in glaucoma."3.85Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil. ( Koutsonas, A; Kuerten, D; Lindemann, F; Plange, N; Schimitzek, H, 2017)
"To examine the effect of mitomycin c and 5-flurouracil on treatment outcomes following Ahmed glaucoma valve implantation."3.85Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation. ( Cui, QN; Han, Y; Hsia, YC; Lin, SC; Mehta, N; Naseri, A; Porco, TC; Rose-Nussbaumer, J; Stamper, RL, 2017)
" Antimetabolites, such as mitomycin C and 5-fluorouracil, have been used for many years to increase survival time of filtration surgeries by preventing bleb fibrosis and scarring."3.83A role for antimetabolites in glaucoma tube surgery: current evidence and future directions. ( Amoozgar, B; Han, Y; Kuo, J; Lin, SC, 2016)
"To compare the complication rate and effectiveness of mitomycin C (MMC), Ologen alone, and Ologen with 5-fluorouracil (5-FU) as adjunctives with Ex-PRESS mini shunt for medically uncontrolled glaucoma."3.81Ex-PRESS outcomes using mitomycin-C, Ologen alone, Ologen with 5-fluorouracil. ( Han, Y; Lowry, EA; Menda, SA; Porco, TC; Rubin, MR; Stamper, RL, 2015)
"This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes."3.81Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes. ( Bi, XZ; Li, CH; Nan, KH; Pan, WH; Ren, ZJ; Song, ZM; Sun, M; Yu, XP, 2015)
"To investigate the safety and efficacy of Nd:YAG laser goniopuncture (LGP) in lowering intraocular pressure (IOP) in eyes having late bleb failure following trabeculectomy with mitomycin C administration."3.80Nd:YAG laser goniopuncture for late bleb failure after trabeculectomy with adjunctive mitomycin C. ( Alencar, LM; De Moraes, CG; Ritch, R; Susanna, R, 2014)
"To determine whether primary trabeculectomies performed in a UK district general hospital, specifically without making use of mitomycin-C augmentation but with selective use of the low potency anti-metabolite 5-fluorouracil, produce an acceptable long-term intraocular pressure (IOP)-lowering effect for an unselected patient group."3.79Enhanced trabeculectomy in a UK district general hospital setting: is selective use of 5-fluorouracil all that is required? ( Chaudhry, N; de Klerk, TA; Moriarty, AP, 2013)
"to investigate the ability of drug-loaded N,O-carboxymethyl chitosan (CMCS) hydrogels to modulate wound healing after glaucoma filtration surgery."3.76Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: synthesis, in vitro and in vivo evaluation. ( CAI, X; CHEN, RF; CHENG, LZ; FAN, JZ; GUO, H; LAN, YQ; YANG, LQ; ZHANG, LM; ZHOU, HS, 2010)
" Intraocular pressure, visual acuity, complications and numbers of injections of 5-fluorouracil, suture removal, needling procedures and visits to ophthalmologists were recorded for 2 years."3.75Trabeculectomy with an active postoperative regimen: results and resource utilization. ( Alm, A; Niemelä, P; Taube, AB, 2009)
"To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU)."3.74Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes. ( Alvarado, JA; Hollander, DA; Juster, RP; Lee, LC, 2008)
"To evaluate the antimitotic and toxic effects of 5-chlorouracil (5-CU) and 5-fluorouracil (5-FU) and study their potential to delay filtering bleb closure in the rabbit eye when released by poly(ortho esters) (POE)."3.74Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma. ( Behar-Cohen, F; BenEzra, D; Bourges, JL; Felt, O; Gurny, R; Jeanny, JC; Polak, MB; Rat, P; Thomas-Doyle, A; Torriglia, A; Valamanesh, F, 2008)
"Although adjunctive postoperative 5-fluorouracil (5-FU) injections are known to improve the success rate of glaucoma surgery, it is still unknown what dose, timing and frequency of application will give the best results with respect to the inhibition of postoperative scarring and intraocular pressure regulation."3.74Dose, timing and frequency of subconjunctival 5-fluorouracil injections after glaucoma filtering surgery. ( Bartz-Schmidt, KU; Besch, D; Denk, PO; Grüb, M; Reinthal, EK, 2007)
"To report the experience with trabeculectomy augmented with mitomycin C and 5-fluorouracil for the treatment of paediatric glaucoma."3.73Augmented trabeculectomy in paediatric glaucoma. ( Ehrlich, R; Friling, R; Gaton, DD; Lusky, M; Snir, M; Weinberger, D, 2005)
"To determine the preference of members of the American Glaucoma Society for the use of antifibrotic agents (mitomycin C or 5-fluorouracil or both) and glaucoma drainage devices in ten clinical settings."3.732002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use. ( Feuer, WF; Joshi, AB; Parrish, RK, 2005)
"This study was designed to evaluate the long-term effect of phacoemulsification, lens implantation combined with trabeculectomy augmented with 5-Fluorouracil (phaco-trab-5-Fu) in Asian glaucoma patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG)."3.73[The long-term effect of phacoemulsification combined with trabeculectomy and intraoperative 5-fluorouracil in glaucoma patients]. ( Cai, Y; Li, MY; Lim, BA; Lim, Z; Oen, F; Seah, S; Yan, XM, 2005)
"In this study we compared the two groups of glaucoma patients who had underwent trabeculectomy, with or without intraoperative application of antimetabolite 5-Fluorouracile (5 FU)."3.73[Visual acuty after trabeculectomy]. ( Buzarovska, KB; Dzajkovska, E; Jordanova, VD; Vukosavljević, M, 2005)
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."3.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"To investigate the effect on intraocular pressure (IOP) of intraoperative 5-fluorouracil (5-FU) application during primary trabeculectomy in a West African population."3.72Intraoperative 5-fluorouracil application during primary trabeculectomy in Nigeria: a comparative study. ( Anand, N; Dawda, VK; Mielke, C, 2003)
"A retrospective chart review of 44 eyes of 44 patients with uveitic glaucoma who underwent trabeculectomy with mitomycin C or 5-fluorouracil."3.71Trabeculectomy with antiproliferative agents in uveitic glaucoma. ( Beck, AD; Ceballos, EM; Lynn, MJ, 2002)
"To investigate the changes of tear film functions due to the use of postoperative 5-fluourouracil (5-Fu) and intraoperative mitomycin C (MMC) in glaucoma filtration surgery."3.71[Influence on tear film of postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery]. ( Li, J; Pang, L, 2001)
"To assess the outcome of trabeculectomy supplemented with intraoperative 5-Fluorouracil (5 FU) application in glaucoma patients."3.70Modification of trabeculectomy with single-dose intraoperative 5-Fluorouracil application. ( Anand, N; Menage, MJ; Sahni, K, 1998)
"Bleb leakage occurred in 14 eyes following trabeculectomy (mitomycin C treatment, 10 eyes; 5-fluorouracil treatment, 3 eyes; no antifibrosis agent, 1 eye) and in 1 eye following combined cataract and glaucoma surgery with adjunctive mitomycin C therapy."3.70Late-onset bleb leaks after glaucoma filtering surgery. ( Greenfield, DS; Jee, J; Liebmann, JM; Ritch, R, 1998)
"The authors evaluate the results of preoperative 5-minute administration of 5-fluorouracil (5-FU), 50 mg/ml, during trabeculectomy on 11 high risk eyes of children with primary and secondary glaucoma."3.70[Peroperative administration of 5-fluorouracil during trabeculectomy in complicated glaucoma in children]. ( Burdová, M; Filous, A, 1998)
"This retrospective study was undertaken to evaluate if a "low dose" intraoperative sponge 5-fluorouracil application may improve the quality of the postoperative IOP control without increasing the incidence of postoperative complications following a first trabeculectomy in low-risk and/or severe field defects glaucomatous patients comparatively with a control group."3.70[Use of "low dose" 5-fluorouracil during trabeculectomy]. ( Detry-Morel, M; Kolanowski, C, 1999)
"The use of adjunctive antimetabolites such as 5-fluorouracil (5-FU) and mitomycin C (MMC) in trabeculectomy has caused an increased concern as to the risk of bleb-associated endophthalmitis."3.70Late-onset, bleb-associated endophthalmitis following glaucoma filtering surgery with or without antifibrotic agents. ( Frucht-Pery, J; Solomon, A; Ticho, U, 1999)
"To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma."3.70Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma. ( Lightman, S; McCluskey, P; Shaer, B; Towler, HM, 2000)
"To study the association between after-cataract and secondary glaucoma after lensectomy and 5-fluorouracil treatment in an experimental infant rabbit model."3.70After-cataract and secondary glaucoma in the aphakic infant rabbit. ( Holmén, JB; Kugelberg, U; Lundgren, B; Lundvall, A; Zetterström, C, 2000)
"A concurrent series (from January 1, 1987, to October 1, 1997) of one surgeon's consecutive 585 (456 patients) combined cataract extraction, intraocular lens implantation, and trabeculectomy surgeries, some with intraoperative mitomycin C and/or postoperative subconjunctival 5-fluorouracil."3.70Outcomes of combined cataract extraction, lens implantation, and trabeculectomy surgeries. ( Hahn, J; Larive, B; Rockwood, EJ, 2000)
"The cytostatic 5-fluorouracil (5-FU) is used at present in the postoperative treatment of glaucoma."3.70[Use of 5-fluorouracil in trabeculectomy]. ( Hovorková, M; Kvasnicka, J; Lochman, J; Novák, J; Rozsíval, P, 2000)
"To determine whether there is increased risk to the corneal endothelium when mitomycin C is used in trabeculectomy surgery instead of fluorouracil, and whether these agents play a role in accelerating cataract formation."3.69Effect of mitomycin C and fluorouracil-supplemented trabeculectomies on the anterior segment. ( Chaturvedi, N; Dreyer, EB; Zurakowski, D, 1995)
"Patients with both cataract and glaucoma underwent combined mitomycin C trabeculectomy, extracapsular cataract extraction, and intraocular lens implantation."3.69One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction. ( Bueche, MJ; Feuer, WJ; Grajewski, AL; Joos, KM; Palmberg, PF, 1995)
"To evaluate intraocular pressure (IOP) control and surgical complications following trabeculectomy with 5-fluorouracil (5-FU) or mitomycin at the inferior limbus."3.69Trabeculectomy at the inferior limbus. ( Caronia, RM; Cohen, H; Friedman, R; Liebmann, JM; Ritch, R, 1996)
"Implantable monolithic and reservoir-like water-swellable drainage devices were developed for the subconjunctival sustained release of 5-fluorouracil (5-FU) in glaucoma-filtering surgery."3.695-FU loaded pHEMA drainage implants for glaucoma-filtering surgery: device design and in vitro release kinetics. ( Akata, RF; Gökce, M; Kiremitçi-Gümüşderelioğlu, M, 1996)
"5-Fluorouracil (5-FU) is useful as an adjunct treatment for glaucoma filtering surgery."3.69[Biodegradable controlled-release 5-FU implant in the surgery for glaucoma. Experimental study]. ( Hostyn, P; Kühne, F; Malek-Chehire, N; Parel, JM; Parrish RK, II; Takesue, Y; Villain, F, 1996)
"Administration of subconjunctival 5-fluorouracil (5-FU) and topical mitomycin-C (MMC) has been shown to improve the success rate of glaucoma-filtering surgery."3.69A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies. ( Akata, RF; Gökçe, M; Kiremitçi-Gümüşderelioglu, M, 1996)
"A 2-month-old female infant with intractable congenital glaucoma and diffuse corneal opacification underwent trabeculectomy with 5-fluorouracil (5-FU) injection in both eyes followed by penetrating keratoplasty (PKP) combined with partial cyclocryotherapy in the right eye."3.69Ultrasonographic findings of the optic disc in congenital glaucoma. ( Barash, D; Kremer, I; Lusky, M; Snir, M; Yassur, Y, 1996)
" Preferences for either no antifibrosis agent (up to 39%) or 5-fluorouracil (up to 29%) were highest in primary trabeculectomy."3.69Use of antifibrosis agents and glaucoma drainage devices in the American and Japanese Glaucoma Societies. ( Chen, PP; Kitazawa, Y; Parrish, RK; Sawada, A; Yamamoto, T, 1997)
" Forty patients (controls; TRAB group) who had trabeculectomy alone were matched to the cases for length of follow-up, age, IOP, number of anti-glaucoma medications, number of 5-fluorouracil (5-FU) injections, race, sex and diagnosis."3.69Temporal corneal phacoemulsification in filtered glaucoma patients. ( Caprioli, J; Kwon, YH; Park, HJ; Weitzman, M, 1997)
"To investigate the incidence of complications reportedly caused by the use of 5-fluorouracil (5-FU) in glaucoma filtering surgery, we performed trabeculectomy with 5-FU on 57 eyes of 56 patients with advanced glaucoma."3.68Incidence of complications following 5-fluorouracil with trabeculectomies. ( Gieser, SC; Jacob, A; Raju, R; Sen, S; Thomas, R, 1993)
"Between 2/1991 and 1/1993 twenty-nine eyes of 11 female and 16 male patients with high-risk glaucoma (unsuccessful previous filtering surgery and a high risk of scarring) were treated with subconjunctival injections of 5-Fluorouracil after filtering surgery in the University Eye Hospital Düsseldorf."3.68[5-fluorouracil injection treatment after fistulating glaucoma operations]. ( Klüppel, M; Reinhard, T; Sundmacher, R, 1993)
"54 patients (66 eyes) of late primary glaucoma were divided into 5-Fluorouracil and control groups before trabeculectomy surgery."3.68[The anti-cicatrization effect of low dosage 5-Fu after trabeculectomy in late glaucoma]. ( Xiong, XL, 1993)
"Rabbits undergoing full-thickness glaucoma filtering surgery were exposed for 5 minutes to one of three intraoperative treatments: (1) distilled water; (2) fluorouracil, 50 mg/mL; or (3) mitomycin C, 0."3.68Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C. ( Doyle, JW; Grierson, I; Khaw, PT; McGorray, S; Schultz, G; Sherwood, MB, 1993)
"We measured aqueous flare in 16 glaucomatous eyes after trabeculectomy in which 5-fluorouracil (5-FU) or mitomycin C (MMC) had been used as an adjunctive therapy."3.68Anterior chamber reaction after mitomycin and 5-fluorouracil trabeculectomy: a comparative study. ( Jikihara, S; Kawase, K; Kitazawa, Y; Nishimura, K; Yamamoto, T, 1993)
"We studied 105 patients (105 eyes) operated on for glaucoma with adjunctive fluorouracil, who were followed up for 12 to 48 months (mean, 34."3.68Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil. ( Ophir, A; Ticho, U, 1993)
" These observations have lead to the widespread clinical use in humans of 5-fluorouracil and more recently mitomycin-C in glaucoma filtering surgery."3.68Antimetabolites in the surgical treatment of glaucomas. ( Van Caelenberghe, E; Van Oye, R, 1992)
"Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU)."3.68Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease. ( Lowder, CY; Meisler, DM; Patitsas, CJ; Rockwood, EJ, 1992)
"Trabeculectomy and subsequent subconjunctival injections of 5-fluorouracil (5-FU) were performed in four eyes (two children) with congenital glaucoma."3.68Subconjunctival injection of 5-fluorouracil following trabeculectomy for congenital and infantile glaucoma. ( Leiba, H; Oliver, M; Zalish, M, 1992)
"Repeated doses of 5mg of 5-fluorouracil (5-FU) were injected subconjunctivally in 25 poor-prognosis glaucomatous eyes after filtering surgery to prevent filtering bleb scarring."3.68Regulating the dose of 5-fluorouracil to prevent filtering bleb scarring. ( Ophir, A; Ticho, U, 1991)
"The effectiveness of trabeculectomy with adjunctive low-dose 5-fluorouracil (5-FU) as the initial surgical procedure in uncomplicated glaucoma was evaluated retrospectively in a consecutive series of 52 patients (mean follow-up, 18."3.68Initial 5-fluorouracil trabeculectomy in uncomplicated glaucoma. ( Liebmann, JM; Marmor, M; Nunez, J; Ritch, R; Wolner, B, 1991)
"The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy."3.68Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. ( Liebmann, JM; Marmor, M; Ritch, R; Sassani, JW; Speaker, M; Wolner, B, 1991)
"Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53."3.685-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome. ( Cristol, SM; Grajewski, AL; Parrish, RK; Wright, MM, 1991)
"In five glaucoma patients, a previous filtering surgery that was followed by sub-conjunctival injections of 5-Fluorouracil (5-FU) failed, due to filtering bleb scarring."3.68Filtering surgery with 5-fluorouracil: a second course. ( Ophir, A; Ticho, U, 1990)
"We reviewed the records of 12 eyes of ten adult patients with inflammatory glaucoma who underwent trabeculectomy with the adjuvant use of 5-fluorouracil between January 1986 and January 1989."3.68Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma. ( Jabs, DA; Jampel, HD; Quigley, HA, 1990)
"5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses."3.675-fluorouracil and glaucoma filtering surgery. II. A pilot study. ( Anderson, DR; Gressel, MG; Heuer, DK; Hodapp, E; Palmberg, PF; Parrish, RK, 1984)
"The antimetabolite 5-fluorouracil (5-FU) was used as adjunctive treatment in glaucomatous eyes with poor prognoses undergoing filtering surgery."3.67Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects. ( Weinreb, RN, 1987)
"We show that a 40-mg total dose of subconjunctival 5-fluorouracil after glaucoma filtering surgery can provide a success rate comparable to that demonstrated in prior studies employing a higher dose."3.67Low-dose 5-fluorouracil and glaucoma filtration surgery. ( Rabowsky, JH; Ruderman, JM, 1989)
"5-fluorouracil is a useful new treatment modality in the difficult glaucoma filtering patient."3.67Polyvinyl alcohol membrane permeability characteristics of 5-fluorouracil. ( Hussain, AA; Maurin, MB; Milosovich, SM; Smith, TJ, 1988)
"A prospective, randomized, double-masked, and placebo-controlled study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits."3.67Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil. ( Anderson, PJ; de Kater, AW; Flores, RA; Hertzmark, E; Lee, DA; Leong, KW; Teekhasaenee, C, 1987)
"The antimetabolite 5-fluorouracil (5-FU) has been used to inhibit fibroblastic growth to increase the success rate in glaucoma filtration surgery."3.67Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. ( Hersh, P; Kersten, D; Lee, DA; Melamed, S, 1987)
"The effect of 5-fluorouracil (5-FU) subconjunctival injection on the bleb formation and intraocular pressure (IOP) following trabeculectomy was studied in 18 glaucoma patients (20 eyes) with poor surgical prognosis."3.675-Fluorouracil for trabeculectomy in glaucoma. ( Kitazawa, Y; Nakano, Y; Shirato, S; Taniguchi, T; Yamamoto, T, 1987)
"We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications."3.67Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. ( Driebe, WT; Heuer, DK; Knapp, A; Stern, GA, 1987)
"4), use of antiglaucoma medication, dosage of topical steroid postoperatively, and being operated on by a trainee surgeon (odds ratio, 2."2.72Effect of trabeculectomy on lens opacities in an East Asian population. ( Aung, T; Chew, PT; Devereux, JG; Foster, PJ; Gazzard, G; Husain, R; Khaw, PT; Oen, FT; Seah, SK, 2006)
"5-Fluorouracil and MMC were found to be equally safe and effective adjuncts to primary trabeculectomy in the short- and medium-term postoperative periods."2.69Trabeculectomy with intraoperative mitomycin C versus 5-fluorouracil. Prospective randomized clinical trial. ( Baerveldt, GS; Budenz, DL; Chen, PP; Cohen, JS; Greenfield, DS; Mehta, K; Moster, MR; Shaikh, NM; Shaikh, S; Singh, K; Tsai, JC, 2000)
"Last controlled intraocular pressure is lower in C group patients (13."2.68[Intra- and postoperative use of 5-fluorouracil in the surgical treatment of refractory glaucoma]. ( Apatachioaie, I; Brănişteanu, D; Chiseliţă, D; Poiata, I; Rusu, V; Tătăruş, C, 1997)
"Late postoperative complications are similar with the exception of an increased incidence of Tenon cyst formation in the MMC-treated eyes."2.68Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up. ( Bergstrom, TJ; Higginbotham, EJ; Johnson, AT; Katz, GJ; Lichter, PR; Musch, DC; Skuta, GL, 1995)
"These include young patients, those with pigmentary glaucoma, secondary glaucoma, angle recession glaucoma, aphakic or pseudophakic glaucoma, and patients requiring reoperation."2.67Intraoperative mitomycin C in complicated glaucomas. ( Dogra, A; Kaur, J; Singh, G, 1993)
"Intraocular pressure was 20 mm Hg or lower in 24 eyes (96%) in the treatment group after mean follow-up of 17."2.67A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas. ( Ophir, A; Ticho, U, 1992)
"The risk of suprachoroidal hemorrhage was strongly associated with the level of the preoperative intraocular pressure."2.67Risk factors for suprachoroidal hemorrhage after filtering surgery. The Fluorouracil Filtering Surgery Study Group. ( , 1992)
"Raised intraocular pressure is a risk factor for glaucoma."2.52Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery. ( Cabourne, E; Clarke, JC; Evans, JR; Schlottmann, PG, 2015)
"In cases where such treatment fails, glaucoma-filtering surgery is considered, most commonly trabeculectomy surgery with variations in technique, for example, the type of conjunctival flap (fornix- or limbal-based)."2.52Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma. ( Abdulaal, M; Al-Haddad, C; Al-Moujahed, A; Ervin, AM, 2015)
"The mean follow-up time after treatment for endophthalmitis was 6."2.41Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes. ( Budenz, DL; Flynn, HW; Scott, IU; Song, A, 2002)
"The use of antiscarring agents, particularly the antimetabolites 5-fluorouracil and mitomycin C, have revolutionized glaucoma surgery over the past decade."2.39Current techniques in wound healing modulation in glaucoma surgery. ( Khaw, PT; Migdal, CS, 1996)
"Mitomycin C seems to be a better treatment than 5 fluorouracil."2.38[Mitomycin C in glaucoma surgery]. ( Collignon-Brach, J, 1993)
"Filtering bleb encapsulation may, in some cases, be a severe complication following filtering surgery."2.38Encapsulated filtering bleb. A selective review--new deductions. ( Ophir, A, 1992)
" There was no significant adverse event for either group and no significant IOP difference in any of the observational periods between them (P=0."1.51Comparison of Efficacy and Safety of Bleb Needle Revision With and Without 5-Fluorouracil for Failing Trabeculectomy Bleb. ( Jeoung, JW; Kim, HJ; Kim, JS; Kim, YK; Na, KI; Park, KH, 2019)
"5-Fluorouracil (5-FU) has been well described for a failing trabeculectomy bleb, but not for aqueous shunts."1.46Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant. ( Kaplowitz, K; Khodadadeh, S; Lee, D; Tsai, JC; Wang, S, 2017)
"Intraocular pressure was 16 mmHg in the right and 36 mmHg in the left eye."1.40Iridocorneal endothelial syndrome. ( Akhtar, F; Ali, M; Saleem, AA, 2014)
"Mitomycin C was used in 12% and 0."1.35Australia and New Zealand survey of antimetabolite and steroid use in trabeculectomy surgery. ( Khaw, PT; Liu, L; Siriwardena, D, 2008)
"The area and the height of the bleb in the conjunctivae with radial incision (Ain and Hin, respectively) were compared with the area and the height of the bleb in the conjunctivae without radial incision (Ano and Hno, respectively)."1.35Restricted post-trabeculectomy bleb formation by conjunctival scarring. ( Inatani, M; Iwao, K; Ogata-Iwao, M; Takihara, Y; Tanihara, H, 2009)
"Others were encapsulated bleb 7."1.35Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up. ( Ashaye, AO; Komolafe, OO, 2009)
"Twenty-four glaucoma filtering blebs in 24 eyes of 17 patients."1.33Comparison of two clinical Bleb grading systems. ( Ashraff, NN; Hall, RC; Purdie, G; Wells, AP, 2006)
" The consultants were asked to estimate the number of trabeculectomies they performed per year, how often they used 5-fluorouracil (5-FU) in primary and redo surgery, their usual method of administration of 5-FU, how often they used mitomycin (MMC) in primary and redo surgery, and their usual dosage regimen of MMC."1.32National survey of antimetabolite use in glaucoma surgery in the United Kingdom. ( Edmunds, B; Khaw, PT; Siriwardena, D; Wormald, RP, 2004)
"5-Fluorouracil was safe and improved trabeculectomy survival."1.31The efficacy and safety of intraoperative and/or postoperative 5-fluorouracil in trabeculectomy and phacotrabeculectomy. ( Goldberg, I; Mohsin, M; Singh, RP, 2001)
"Mitomycin C was administered intraoperatively in the dose of 0."1.31[Antimetabolites in glaucoma surgery--long-term results]. ( Ferková, S; Jakabovicová, E; Michalíková, L; Strmen, P, 2002)
"Intraocular pressures were lower in the group that received MMC compared to the 5-FU group, but not in the group that did not receive antimetabolites, at all time intervals measured (P < ."1.30Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents. ( Budenz, DL; Gordon, J; Keates, EU; Piltz-Seymour, J; Pyfer, M; Singh, K, 1999)
"To study the effect of tissue plasminogen activator (t-PA) in combination with 5-fluorouracil (5-Fu) polyphase liposome on the prevention of scar formation in filtration surgery."1.30[The inhibitory effect of tissue plasminogen activator combined with 5-fluorouracil polyphase liposome on the scar formation in experimental filtration surgery]. ( Chen, R; Jing, M; Xi, S, 1997)
" The dose-response to 5-fluorouracil (5FU) and mitomycin C (MMC) was determined."1.30Collagen type I and III synthesis by Tenon's capsule fibroblasts in culture: individual patient characteristics and response to mitomycin C, 5-fluorouracil, and ascorbic acid. ( Gross, RL, 1999)
"14 eyes of 14 patients with medically untreatable glaucoma and extremely bad surgical prognosis because of young age, secondary glaucomas or following previous surgery were treated by means of goniotrephination with a scleral flap and a fornix-based conjunctival flap."1.29[5-fluorouracil in goniotrepanation with poor prognosis. Results of 1-year follow-up]. ( Grehn, F; Pfeiffer, N, 1993)
" In this study, 5-Fluorouracil (5-FU), a halogenated pyrimidine analogue and a potent anti-mitotic agent, was applied for seven days after trabeculectomy in eighteen complicated and unsuccessful filtering glaucomas, at a daily dosage of 5 mg in the form of 0."1.29The role of 5-fluorouracil in complicated glaucomas. ( Das, S; Jilani, FA; Khan, AM, 1993)
"Complications included suprachoroidal hemorrhage in 7 (14%) of 49 eyes and intraoperative vitreous hemorrhage in 2."1.29Holmium laser sclerectomy. Success and complications. ( Bellows, AR; Hutchinson, BT; Lytle, R; Puliafito, CA; Schuman, JS; Stinson, WG, 1993)
"5-Fluorouracil (5-FU) has been used to improve the outcome of trabeculectomy in high-risk cases, employing a postoperative regimen of subconjunctival injections."1.29Low-dose perioperative 5-fluorouracil in trabeculectomy. ( Hugkulstone, CE; Vernon, SA, 1996)
" In addition, toxic effects of 5-FU on existing fibroblasts, in rabbits and in vitro, were demonstrated."1.28Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy. ( Ophir, A; Ticho, U, 1992)
" Whether dose reduction will lead to reduced corneal toxicity in glaucoma filtration surgery following topical or subconjunctival dosing is an interesting therapeutic opportunity that remains to be determined."1.28Corneal penetration of 5-fluorouracil and its improvement by prodrug derivatization in the albino rabbit: implication in glaucoma filtration surgery. ( Bundgaard, H; Buur, A; Lee, VH; Wang, W, 1991)
"5-fluorouracil was injected subconjunctivally as an antiproliferative agent to prevent or decrease cell proliferation and scar formation."1.28External limbal sclerostomy with contact Nd:YAG laser versus surgical knife. ( Khoobehi, B; Oncel, M; Peyman, GA; Tawakol, ME, 1989)
"5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation."1.275-fluorouracil and glaucoma filtering surgery: I. An animal model. ( Folberg, R; Gressel, MG; Parrish, RK, 1984)

Research

Studies (324)

TimeframeStudies, this research(%)All Research%
pre-199029 (8.95)18.7374
1990's151 (46.60)18.2507
2000's88 (27.16)29.6817
2010's48 (14.81)24.3611
2020's8 (2.47)2.80

Authors

AuthorsStudies
Al-Mugheiry, TS1
Clark, A1
Broadway, DC1
Lee, JY1
Wu, J1
Liu, Y1
Saraswathy, S1
Zhou, L1
Bu, Q1
Su, Y1
Choi, D1
Park, E1
Strohmaier, CA1
Weinreb, RN3
Hong, YK1
Pan, X1
Huang, AS1
Ioannou, N1
Luo, J1
Qin, M1
Di Luca, M1
Mathew, E1
Tagalakis, AD1
Lamprou, DA1
Yu-Wai-Man, C1
Halili, A1
Kessel, L1
Subhi, Y1
Bach-Holm, D1
Başer, EF1
Seymenoğlu, RG1
Inobhas, A1
Chansangpetch, S1
Manassakorn, A1
Tantisevi, V1
Rojanapongpun, P1
Zhao, X1
Liu, S1
Han, Y4
Wang, Y2
Lin, Q1
Kaplowitz, K2
Khodadadeh, S1
Wang, S1
Lee, D1
Tsai, JC3
Lindemann, F1
Plange, N2
Kuerten, D1
Schimitzek, H1
Koutsonas, A2
Quaranta, L1
Katsanos, A1
Legramandi, L1
Riva, I1
Zhang, C2
Wang, J2
Gao, H1
Wang, X1
Wu, M1
Guo, B2
Liu, C1
Liu, W2
Mercieca, K1
Drury, B1
Bhargava, A1
Fenerty, C1
Bhullar, GK1
Skalicky, SE1
Lew, HR1
Pimentel, E1
Schmidt, J1
Elgin, U2
Sen, E1
Çolak, S1
Yılmazbas, P1
Koike, KJ1
Chang, PT1
Kumaran, A1
Husain, R2
Htoon, HM1
Aung, T3
Arnljots, TS1
Kasina, R1
Bykov, VJN1
Economou, MA1
Rabiolo, A1
Marchese, A1
Bettin, P1
Monteduro, D1
Galasso, M1
Dolci, MP1
Di Matteo, F1
Fiori, M1
Ciampi, C1
Bandello, F1
Swann, FB1
Singh, S1
Blake, D1
John, V1
Le, C1
Fullerton, M1
Margo, C1
Zhang, Z1
Muddasani, N1
Wall, J1
Satija, C1
Greenberg, E1
Mancera, N1
Zurakowski, D2
Ayyala, RS1
Kim, JS1
Kim, HJ1
Na, KI1
Kim, YK1
Park, KH1
Jeoung, JW1
Lin, M1
Alizadeh, R1
Law, SK2
Tatham, A1
Sarodia, U1
Karwatowski, W1
Suh, W1
Kee, C1
Wu, X1
Sun, Y1
Zhang, Y1
Zhang, H1
Zhao, J1
Suzuki, R2
Susanna, R2
Ozgonul, C1
Mumcuoglu, T1
Gunal, A1
De Fendi, LI1
Arruda, GV1
Scott, IU2
Paula, JS1
Remky, A1
De Moraes, CG1
Alencar, LM1
Ritch, R6
Green, E1
Wilkins, M1
Bunce, C5
Wormald, R4
Saleem, AA1
Ali, M1
Akhtar, F1
Menda, SA1
Lowry, EA1
Porco, TC2
Stamper, RL5
Rubin, MR1
Zheng, L1
Arvind, H1
Wechsler, D1
Cabourne, E1
Clarke, JC1
Schlottmann, PG1
Evans, JR1
Bi, XZ1
Pan, WH1
Yu, XP1
Song, ZM1
Ren, ZJ1
Sun, M1
Li, CH1
Nan, KH1
Al-Haddad, C1
Abdulaal, M1
Al-Moujahed, A1
Ervin, AM1
Amoozgar, B1
Lin, SC3
Kuo, J1
Panarelli, JF1
Vinod, K1
Huang, G1
Sidoti, PA2
Cui, QN1
Hsia, YC1
Rose-Nussbaumer, J1
Mehta, N1
Naseri, A1
Lorenz, K1
Wasielica-Poslednik, J1
Bell, K1
Renieri, G1
Keicher, A1
Ruckes, C1
Pfeiffer, N2
Thieme, H1
Minckler, DS3
Francis, BA2
Hodapp, EA1
Jampel, HD4
Samples, JR1
Smith, SD1
Singh, K5
Alvarado, JA1
Hollander, DA1
Juster, RP2
Lee, LC1
Polak, MB1
Valamanesh, F1
Felt, O1
Torriglia, A1
Jeanny, JC1
Bourges, JL1
Rat, P1
Thomas-Doyle, A1
BenEzra, D1
Gurny, R2
Behar-Cohen, F1
Taube, AB1
Niemelä, P1
Alm, A2
Liu, L1
Siriwardena, D2
Khaw, PT15
Palanca-Capistrano, AM2
Hall, J1
Cantor, LB2
Morgan, L1
Hoop, J2
WuDunn, D2
Zarkovic, A1
Chow, K1
Mora, JS2
Memarzadeh, F1
Varma, R1
Lin, LT1
Parikh, JG1
Dustin, L1
Alcaraz, A1
Eliott, D1
Iwao, K1
Inatani, M1
Ogata-Iwao, M1
Takihara, Y1
Tanihara, H1
Anand, N4
Khan, A1
Kapasi, MS1
Birt, CM1
Hau, S1
Barton, K2
Kotecha, A1
Spratt, A1
Garway-Heath, DF1
Viswanathan, A1
Tay, E1
Cree, IA1
Hungerford, J1
Franks, W1
YANG, LQ1
LAN, YQ1
GUO, H1
CHENG, LZ1
FAN, JZ1
CAI, X1
ZHANG, LM1
CHEN, RF1
ZHOU, HS1
Knape, RM1
Smith, MF7
Shafi, F1
Agrawal, P1
Holder, R1
Sung, V1
Narayanaswamy, AK1
Lee, K1
Zhen, M1
Chua, J1
Chai, SM1
Boey, PY1
Zheng, C1
Venkatraman, S1
Wong, TT2
Salim, S1
Chua, BE1
Nguyen, DQ1
Qin, Q1
Ruddle, JB1
Wells, AP2
Niyadurupola, N1
Gupta, V1
Coote, MA1
Crowston, JG1
Roy, S1
Mermoud, A2
Congdon, NG1
Krishnadas, R1
Friedman, DS2
Goggins, W1
Ramakrishnan, R1
Kader, MA1
Gilbert, D1
Tielsch, J1
Quigley, HA3
Simsek, T1
Cankaya, AB1
Hirji, N1
Griffiths, M1
Landers, J1
de Klerk, TA1
Chaudhry, N1
Moriarty, AP1
Ceballos, EM1
Beck, AD1
Lynn, MJ1
Dickens, CJ4
Iwach, AG5
Hoskins, HD5
Hetherington, J2
Wong, PC2
Klufas, MT1
Leong, CJ1
Nguyen, N2
Alvi, NP1
Finley, C1
Lakhani, V1
Burnstein, A1
Knotts, SL1
Lubomski, LH1
Kempen, JH1
Quigley, H1
Congdon, N1
Levkovitch-Verbin, H1
Robinson, KA1
Bass, EB1
Zhang, X1
Peng, D2
Zeng, S1
Zheng, J1
Durak, I1
Ozbek, Z1
Yaman, A1
Soylev, M1
Cingil, G1
Jordan, JF1
Mac, I1
Soltau, JB1
Akarsu, C1
Onol, M1
Hasanreisoglu, B1
Mielke, C1
Dawda, VK1
Ung, CT1
Von Lany, H1
Claridge, KG1
Fagerli, M1
Løfors, KT1
Elsås, T1
Marquardt, D1
Lieb, WE1
Grehn, F4
Higginbotham, EJ3
Yoon, PS1
Hooi, ST1
Hooi, SH1
Fraser, S1
Edmunds, B1
Wormald, RP1
Chiseliţă, D1
Rusu, V1
Brănişteanu, D1
Apatachioaie, I1
Poiata, I1
Tătăruş, C1
Szaflik, J1
Zaleska-Zmijewska, A1
Pasternack, JJ1
Wand, M1
Shields, MB2
Abraham, D1
Ehrlich, R1
Snir, M2
Lusky, M2
Weinberger, D1
Friling, R1
Gaton, DD1
Du, LT1
Najafi, K1
Murthy, R1
Kurumety, U1
Rao, N1
Joshi, AB1
Parrish, RK11
Feuer, WF1
Cai, Y1
Lim, Z1
Lim, BA1
Oen, F1
Yan, XM1
Li, MY1
Seah, S1
Collignon, NJ1
Kirwan, C1
O'Keefe, M1
Lanigan, B1
Mahmood, U1
Detry-Morel, M2
Pourjavan, S1
Wojtulewicz, M1
Rekas, M1
Wierzbowska, J1
Kabiru, J1
Bowman, R1
Wood, M1
Mafwiri, M1
Polikoff, LA1
Taglienti, A1
Chanis, RA1
Ramos-Esteban, JC1
Donas, N1
Tsong, J1
Gagliuso, DJ1
Danias, J1
Serle, JB1
Buzarovska, KB1
Jordanova, VD1
Vukosavljević, M2
Dzajkovska, E1
Ashraff, NN1
Hall, RC1
Purdie, G1
Ren, ZQ1
Qiao, RH1
Arora, S1
Clowes, M1
Shingleton, BJ2
Price, RS1
O'Donoghue, MW1
Goyal, S1
Gazzard, G1
Foster, PJ1
Devereux, JG1
Chew, PT2
Oen, FT1
Seah, SK1
Li, G1
Kasner, O1
Klink, T1
Guthoff, R1
Schlunck, G1
Perucho-Martínez, S1
Gutiérrez-Díaz, E1
Montero-Rodríguez, M1
Mencía-Gutiérrez, E1
Lago-Llinás, MD1
Reinthal, EK1
Denk, PO1
Grüb, M1
Besch, D1
Bartz-Schmidt, KU1
Mehta, JS1
Maurino, V2
Patel, H1
Kirwin, J1
Murdoch, IE1
Chang, L1
Thiagarajan, M1
Moseley, M1
Woodruff, S1
Bentley, C1
Bloom, P2
Cabarga del Nozal, C1
Chakraborty, D1
Dutta Choudhury, B1
Müller, M1
Pape, S1
Kusserow, C1
Hoerauf, H1
Laqua, H1
Labbé, A1
Khammari, C1
Baudouin, C1
Milivojević, M1
Aleksić, P1
Stojković, R1
Dimitrijević, J1
Latković, Z1
Avramović, S1
Ashaye, AO1
Komolafe, OO1
Rotchford, AP1
King, AJ1
Slezak, H1
Heuer, DK7
Gressel, MG5
Hodapp, E3
Palmberg, PF5
Anderson, DR1
Folberg, R2
Ashton, P1
Blandford, DL1
Pearson, PA1
Jaffe, GJ1
Martin, DF1
Nussenblatt, RB1
Dreyer, EB1
Chaturvedi, N1
Bazin, S1
Williamson, W1
Poirier, L1
Ducousso, F1
Ballion, JC1
Verin, P1
Gray, TB1
Joos, KM1
Bueche, MJ1
Feuer, WJ2
Grajewski, AL2
Trope, GE1
Cheng, YL1
Sheardown, H1
Liu, GS1
Menon, IA1
Heathcote, JG1
Rootman, DS1
Chiu, WJ1
Gould, L1
Yu, K1
Liu, X1
Lee, DA5
Thomas, R1
Jacob, A1
Raju, R1
Gieser, SC1
Sen, S1
Nuyts, RM1
Felten, PC1
Pels, E1
Langerhorst, CT1
Geijssen, HC1
Grossniklaus, HE1
Greve, EL1
Lanigan, L1
Stürmer, J1
Baez, KA2
Hitchings, RA3
Reinhard, T1
Klüppel, M1
Sundmacher, R1
Drake, MV3
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Spaeth, GL5
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Cunliffe, IA1
Longstaff, S1
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Yassur, Y1
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Musch, DC2
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Kim, PH1
Eliassi-Rad, B1
Khatana, AK1
Keole, NS1
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Rassam, S1
Migdal, C1
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Pang, L1
Hawkins, AS1
Flanagan, JK1
Brown, SV1
Chang, SH1
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Song, A1
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Ferková, S1
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Dietze, PJ1
Feldman, RM1
Levin, ML1
Beeson, CC1
Klein, TB1
Falck, FY1
Zalish, M1
Leiba, H1
Oliver, M1
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Gillies, WE2
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Hatchell, DL1
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Koya, P1
Leong, K1
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Park, MH1
Baek, NH1
Zhang, HC1
Matsushita, H1
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Hennings, DR1
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Cristol, SM1
Wang, W1
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Nevárez, JA1
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Jones, MA1
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Hayashida, T1
Yamamoto, A1
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Nakamura, A1
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Vallaud, C1
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Rabowsky, JH1
Ruderman, JM3
Tawakol, ME1
Peyman, GA1
Oncel, M1
Khoobehi, B1
Leong, KW2
Panek, WC1
Eng, CT1
Glasgow, BJ1
Smith, TJ1
Maurin, MB1
Milosovich, SM1
Hussain, AA1
Furberg, CD1
Flores, RA1
Anderson, PJ1
Teekhasaenee, C1
de Kater, AW1
Hertzmark, E1
Kopel, J1
Welch, DB2
Shoch, DE2
Wilensky, JT1
Hersh, P1
Kersten, D1
Melamed, S1
Taniguchi, T1
Feuer, W1
Knapp, A1
Stern, GA1
Driebe, WT1
Dillberger, JE1
Altman, NH1
Diem, E1
Fritsch, P1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Macular Thickness in Patients With Glaucoma in Use of Topical Prostaglandin Analogue Undergoing Trabeculectomy With Mitomycin C[NCT06000280]37 participants (Actual)Interventional2021-01-04Completed
Early Transconjunctival Needling Revision With 5-fluorouracil Versus Medical Treatment in Encapsulated Blebs: a 12-month Prospective Study[NCT01887223]Phase 240 participants (Actual)Interventional2010-05-31Completed
Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Chinese Primary Angle Closure Glaucoma[NCT02964676]246 participants (Anticipated)Interventional2017-01-31Not yet recruiting
Efficacy and Safety of Trabeculectomy With Subconjunctival Bevacizumab Versus Trabeculectomy With Mitomycin C.[NCT01310764]36 participants (Actual)Interventional2009-04-30Completed
Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489]Phase 470 participants Interventional2004-09-30Completed
Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Primary Open Angle Glaucoma: a Three-year Comparative Study[NCT01633775]100 participants (Actual)Observational2007-12-31Completed
Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy[NCT00695747]95 participants (Actual)Interventional1998-01-31Completed
[NCT00000122]Phase 30 participants Interventional1985-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

42 reviews available for fluorouracil and Glaucoma

ArticleYear
Needling after trabeculectomy - does augmentation by anti-metabolites provide better outcomes and is Mitomycin C better than 5-Fluoruracil? A systematic review with network meta-analyses.
    Acta ophthalmologica, 2020, Volume: 98, Issue:7

    Topics: Fluorouracil; Glaucoma; Humans; Immunosuppressive Agents; Intraocular Pressure; Mitomycin; Network M

2020
Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma?
    Medwave, 2018, Jan-18, Volume: 18, Issue:1

    Topics: Antimetabolites; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mitomycin; Randomiz

2018
Trabeculectomy: A Brief History and Review of Current Trends.
    International ophthalmology clinics, 2018,Summer, Volume: 58, Issue:3

    Topics: Angiogenesis Inhibitors; Fluorouracil; Glaucoma; History, 20th Century; History, 21st Century; Human

2018
Mitomycin C versus 5-fluorouracil as an adjunctive treatment for trabeculectomy: a meta-analysis of randomized clinical trials.
    Clinical & experimental ophthalmology, 2013, Volume: 41, Issue:8

    Topics: Alkylating Agents; Antimetabolites; Chemotherapy, Adjuvant; Epithelium, Corneal; Fluorouracil; Glauc

2013
5-Fluorouracil for glaucoma surgery.
    The Cochrane database of systematic reviews, 2014, Feb-19, Issue:2

    Topics: Antimetabolites; Cicatrix; Fluorouracil; Glaucoma; Humans; Randomized Controlled Trials as Topic; Tr

2014
Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery.
    The Cochrane database of systematic reviews, 2015, Nov-06, Issue:11

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Press

2015
Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma.
    The Cochrane database of systematic reviews, 2015, Nov-25, Issue:11

    Topics: Antihypertensive Agents; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Limbus Corneae; Mitom

2015
Corneal complications of glaucoma surgery.
    Current opinion in ophthalmology, 2009, Volume: 20, Issue:2

    Topics: Corneal Diseases; Corneal Transplantation; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Graft

2009
Current variations of glaucoma filtration surgery.
    Current opinion in ophthalmology, 2012, Volume: 23, Issue:2

    Topics: Alkylating Agents; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mitomycin; Surgical Flaps;

2012
Deep sclerectomy.
    Developments in ophthalmology, 2012, Volume: 50

    Topics: Conjunctiva; Fibrosis; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Immunosuppressive Agents;

2012
Effect of technique on intraocular pressure after combined cataract and glaucoma surgery: An evidence-based review.
    Ophthalmology, 2002, Volume: 109, Issue:12

    Topics: Antimetabolites, Antineoplastic; Cataract; Cataract Extraction; Evidence-Based Medicine; Fluorouraci

2002
[Modulation of wound healing in filtration surgery for glaucoma].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2003, Volume: 100, Issue:4

    Topics: Adolescent; Adult; Age Factors; Alkylating Agents; Animals; Antimetabolites; Child; Filtering Surger

2003
Glaucoma-filtering bleb infections.
    Current opinion in ophthalmology, 2003, Volume: 14, Issue:2

    Topics: Anti-Bacterial Agents; Drug Administration Schedule; Endophthalmitis; Fibrosis; Filtering Surgery; F

2003
Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery.
    Current opinion in ophthalmology, 2004, Volume: 15, Issue:2

    Topics: Antimetabolites, Antineoplastic; Cataract Extraction; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Dra

2004
[Pharmacological methods improving the effectiveness of filtering procedures].
    Klinika oczna, 2004, Volume: 106, Issue:1-2 Suppl

    Topics: Antibiotics, Antineoplastic; Antibodies; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Cy

2004
Wound healing after glaucoma surgery: how to manage it?
    Bulletin de la Societe belge d'ophtalmologie, 2005, Issue:295

    Topics: Adult; Aged; Antimetabolites; Filtering Surgery; Fluorouracil; Glaucoma; Guidelines as Topic; Humans

2005
[Postoperative care after glaucoma filtration surgery].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2006, Volume: 103, Issue:9

    Topics: Administration, Topical; Cicatrix; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Immunosuppress

2006
[Wound healing modulation in glaucoma surgery].
    Journal francais d'ophtalmologie, 2007, Volume: 30, Issue:6

    Topics: Adult; Animals; Cataract Extraction; Child; Cicatrix; Eye Diseases; Filtering Surgery; Fluorouracil;

2007
Review: implants.
    Journal of ocular pharmacology, 1994,Winter, Volume: 10, Issue:4

    Topics: Animals; Cyclosporine; Cytomegalovirus Retinitis; Delayed-Action Preparations; Drug Implants; Filter

1994
[Trabeculectomy with mitomycin C. Study apropos of 30 cases].
    Journal francais d'ophtalmologie, 1995, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Fluorouracil; Follow-Up

1995
Antifibrosis agents and glaucoma surgery.
    Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:11

    Topics: Animals; Conjunctiva; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomycin

1994
[Mitomycin C in glaucoma surgery].
    Bulletin de la Societe belge d'ophtalmologie, 1993, Volume: 247, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Midd

1993
Antifibrotic agents in glaucoma filtering surgery.
    International ophthalmology clinics, 1993,Fall, Volume: 33, Issue:4

    Topics: Animals; Cataract Extraction; Fluorouracil; Glaucoma; Humans; Mitomycin; Rabbits; Sclerostomy; Wound

1993
Wound healing modulation in glaucoma filtration surgery.
    Ophthalmic surgery, 1993, Volume: 24, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Fluorouracil; Glaucoma; Humans; Intraocular

1993
Trabeculectomy with intraoperative sponge 5-fluorouracil.
    Ophthalmology, 1996, Volume: 103, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Child; Child, P

1996
[Filtering glaucoma operations. Can growth factor blockers replace antimetabolites?].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1997, Volume: 94, Issue:3

    Topics: Antimetabolites, Antineoplastic; Cell Division; Combined Modality Therapy; Filtering Surgery; Fluoro

1997
Basic science and clinical aspects of wound healing in glaucoma filtering surgery.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1998, Volume: 14, Issue:1

    Topics: Culture Techniques; Fibroblasts; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomy

1998
Combined glaucoma filtration surgery and phacoemulsification.
    Seminars in ophthalmology, 1992, Volume: 7, Issue:4

    Topics: Cataract Extraction; Filtration; Fluorouracil; Glaucoma; Humans; Lens, Crystalline; Lenses, Intraocu

1992
Management of coincident glaucoma and cataract.
    Current opinion in ophthalmology, 1995, Volume: 6, Issue:1

    Topics: Cataract; Cataract Extraction; Exfoliation Syndrome; Fluorouracil; Glaucoma; Humans; Lenses, Intraoc

1995
Surgical consequences in coexisting cataract and glaucoma.
    Current opinion in ophthalmology, 1995, Volume: 6, Issue:2

    Topics: Cataract; Cataract Extraction; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Lenses, Intraoc

1995
Current techniques in wound healing modulation in glaucoma surgery.
    Current opinion in ophthalmology, 1996, Volume: 7, Issue:2

    Topics: Animals; Antimetabolites; Cataract Extraction; Cicatrix; Filtering Surgery; Fluorouracil; Glaucoma;

1996
A major review of antimetabolites in glaucoma therapy.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1999, Volume: 213, Issue:4

    Topics: Antimetabolites; Cytarabine; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomycin; Ophthalmi

1999
Glaucoma surgery: are there new perspectives in perioperative pharmacology?
    Current opinion in ophthalmology, 1999, Volume: 10, Issue:2

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Fibrinolytic Agents; Filtering Surgery; Fluorouracil; Glauc

1999
[The use of antimetabolites in the treatment of glaucoma].
    Oftalmologia (Bucharest, Romania : 1990), 1999, Volume: 48, Issue:3

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Fluorouracil; Glaucoma; Humans; Intraoperative Care; Mitomy

1999
Post-operative 5-fluorouracil for glaucoma surgery.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Antimetabolites; Fluorouracil; Glaucoma; Humans; Trabeculectomy

2000
The use of antimetabolites with trabeculectomy: a critical appraisal.
    Journal of glaucoma, 2001, Volume: 10, Issue:3

    Topics: Antimetabolites; Combined Modality Therapy; Delivery of Health Care; Fluorouracil; Glaucoma; Humans;

2001
Post-operative 5-Fluorouracil for glaucoma surgery.
    The Cochrane database of systematic reviews, 2001, Issue:3

    Topics: Antimetabolites; Cicatrix; Fluorouracil; Glaucoma; Humans; Trabeculectomy; Wound Healing

2001
Advances in glaucoma surgery: evolution of antimetabolite adjunctive therapy.
    Journal of glaucoma, 2001, Volume: 10, Issue:5 Suppl 1

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Fluorouracil; Glaucoma; Humans; Intraoperative Period; Mito

2001
Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes.
    Ophthalmology, 2002, Volume: 109, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Bacteria; Endophthalmitis; Eye Infections, Bacteri

2002
Encapsulated filtering bleb. A selective review--new deductions.
    Eye (London, England), 1992, Volume: 6 ( Pt 4)

    Topics: Animals; Blister; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Post

1992
Surgical management of the secondary glaucomas: Part I.
    Ophthalmic surgery, 1987, Volume: 18, Issue:11

    Topics: Ciliary Body; Cryosurgery; Filtration; Fluorouracil; Glaucoma; Humans; Laser Therapy; Light Coagulat

1987
[Prevention of eye scarring by 5-fluorouracil].
    Harefuah, 1987, Nov-15, Volume: 113, Issue:10

    Topics: Animals; Cicatrix; Disease Models, Animal; Eye; Fluorouracil; Glaucoma; Humans; Postoperative Compli

1987

Trials

46 trials available for fluorouracil and Glaucoma

ArticleYear
Fluorouracil Filtering Surgery Study One-Year Follow-up.
    American journal of ophthalmology, 2018, Volume: 186

    Topics: Aged; Conjunctiva; Dose-Response Relationship, Drug; Female; Filtering Surgery; Fluorouracil; Follow

2018
Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy.
    Journal of glaucoma, 2018, Volume: 27, Issue:7

    Topics: Aged; Blister; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; Cysts; Female; Fluorou

2018
The effect of bevacizumab on the outcome of trabeculectomy with 5-Fluorouracil.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2013, Volume: 29, Issue:7

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Bevaciz

2013
Early transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study.
    Clinics (Sao Paulo, Brazil), 2013, Volume: 68, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Blister; Conjunctiva; Female; Fluorouracil; Glaucom

2013
Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Acetazolamide; Aged; Antihypertensive Agents; Dexamethasone; Drug Combinations; Female; Fluorouracil

2017
Long-term outcomes of intraoperative 5-fluorouracil versus intraoperative mitomycin C in primary trabeculectomy surgery.
    Ophthalmology, 2009, Volume: 116, Issue:2

    Topics: Administration, Topical; Alkylating Agents; Antihypertensive Agents; Antimetabolites; Combined Modal

2009
Optic disc and visual field changes after trabeculectomy.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Disease Progression; Dou

2009
Randomized, controlled trial of a sustained delivery formulation of 5-fluorouracil for the treatment of failing blebs.
    Ophthalmology, 2012, Volume: 119, Issue:2

    Topics: Aged; Aqueous Humor; Conjunctiva; Delayed-Action Preparations; Female; Fluorouracil; Glaucoma; Human

2012
Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study.
    Clinical & experimental ophthalmology, 2012, Volume: 40, Issue:8

    Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antimetabolites; Bevacizumab; Conj

2012
A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study.
    Ophthalmic epidemiology, 2012, Volume: 19, Issue:3

    Topics: Aged; Antihypertensive Agents; Antimetabolites, Antineoplastic; Brimonidine Tartrate; Drug Combinati

2012
Comparison of needle revision with subconjunctival bevacizumab and 5-fluorouracil injection of failed trabeculectomy blebs.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Bevacizumab; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans;

2012
A prospective randomized trial comparing intraoperative 5-fluorouracil vs mitomycin C in primary trabeculectomy.
    American journal of ophthalmology, 2002, Volume: 134, Issue:4

    Topics: Antimetabolites; Double-Blind Method; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Intraope

2002
[Intra- and postoperative use of 5-fluorouracil in the surgical treatment of refractory glaucoma].
    Oftalmologia (Bucharest, Romania : 1990), 1997, Volume: 41, Issue:2

    Topics: Antimetabolites; Conjunctiva; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraoc

1997
Comparison of 1-site versus 2-site phacotrabeculectomy.
    Journal of cataract and refractive surgery, 2006, Volume: 32, Issue:5

    Topics: Antihypertensive Agents; Case-Control Studies; Cataract; Fluorouracil; Follow-Up Studies; Glaucoma;

2006
Effect of trabeculectomy on lens opacities in an East Asian population.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2006, Volume: 124, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Cataract; Combined Modality Therapy; Disease Progre

2006
[A comparative study of homoharringtonine with 5-fluorouracil in filtering surgery].
    Yan ke xue bao = Eye science, 1994, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Double-Blind Method; Female; Fluorouracil; Glaucoma; Harringtonines; Homoharringt

1994
Update of the subconjunctival THC:YAG (holmium) laser sclerostomy ab externo clinical trial: 30-month report.
    Ophthalmic surgery, 1994, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Fluorouracil; Follow-Up Studies; Glaucoma

1994
Risk factors for the development of encapsulated filtering blebs. The role of surgical glove powder and 5-fluorouracil.
    Ophthalmology, 1994, Volume: 101, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Gloves, Surgical;

1994
Intraoperative mitomycin C in complicated glaucomas.
    Indian journal of ophthalmology, 1993, Volume: 41, Issue:2

    Topics: Adult; Age Factors; Aged; Aphakia; Drug Evaluation; Female; Fluorouracil; Glaucoma; Glaucoma, Open-A

1993
Three-year follow-up of the Fluorouracil Filtering Surgery Study.
    American journal of ophthalmology, 1993, Volume: 115, Issue:1

    Topics: Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Postoperative Care; Surviva

1993
[A five-year follow-up of the effect of postoperative 5-fluorouracil subconjunctival injections on the surgical outcome of trabeculectomy].
    Nippon Ganka Gakkai zasshi, 1993, Volume: 97, Issue:2

    Topics: Adult; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraocul

1993
Five-year follow-up of the Fluorouracil Filtering Surgery Study. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1996, Volume: 121, Issue:4

    Topics: Cataract Extraction; Chemotherapy, Adjuvant; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Immu

1996
Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy--pilot trial.
    Indian journal of ophthalmology, 1996, Volume: 44, Issue:2

    Topics: Adolescent; Adult; Aged; Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Female; Fluorouracil;

1996
Temporal corneal phacoemulsification combined with superior trabeculectomy: a controlled study.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Aged; Aged, 80 and over; Case-Control Studies; Cataract; Cornea; Female; Fluorouracil; Glaucoma; Hum

1996
Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up.
    Ophthalmology, 1995, Volume: 102, Issue:9

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Filter

1995
Trabeculectomy with intraoperative 5-fluorouracil vs mitomycin C.
    American journal of ophthalmology, 1997, Volume: 123, Issue:1

    Topics: Antimetabolites; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Intraoperative Care;

1997
Oral prednisone in guarded filtration procedures supplemented with antimetabolites.
    Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:2

    Topics: Administration, Oral; Aged; Chemotherapy, Adjuvant; Double-Blind Method; Female; Filtering Surgery;

1999
A randomized phase II trial of interferon-alpha2b versus 5-fluorouracil after trabeculectomy.
    Australian and New Zealand journal of ophthalmology, 1999, Volume: 27, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cataract; Cataract Extraction; Connective Tissue; Double-Blind Metho

1999
Combined cataract and glaucoma surgery: trabeculectomy versus endoscopic laser cycloablation.
    Journal of cataract and refractive surgery, 1999, Volume: 25, Issue:9

    Topics: Cataract; Ciliary Body; Endoscopy; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intrao

1999
Low-dose 5-fluorouracil trabeculectomy as initial surgery in uncomplicated glaucoma: long-term followup.
    Ophthalmology, 2000, Volume: 107, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Female; Fluorouracil; Follow-Up

2000
Trabeculectomy with intraoperative mitomycin C versus 5-fluorouracil. Prospective randomized clinical trial.
    Ophthalmology, 2000, Volume: 107, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Evaluation; Female; Fluorouracil

2000
Randomized, controlled study of low-dose 5-fluorouracil in primary trabeculectomy.
    American journal of ophthalmology, 2000, Volume: 130, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Drug Evaluatio

2000
Prognosis and risk factors for early postoperative wound leaks after trabeculectomy with and without 5-fluorouracil.
    American journal of ophthalmology, 2001, Volume: 132, Issue:5

    Topics: Antimetabolites; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections;

2001
Single intraoperative application of 5-Fluorouracil versus placebo in low-risk trabeculectomy surgery: a randomized trial.
    Journal of glaucoma, 2001, Volume: 10, Issue:6

    Topics: Aged; Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Double-Blind Method; Female; Fluorouraci

2001
Long-term results of trabeculectomy with collagen sponge implant containing low-dose antimetabolite.
    Ophthalmology, 1992, Volume: 99, Issue:5

    Topics: Adult; Aged; Biological Dressings; Bleomycin; Collagen; Drug Implants; Female; Fluorouracil; Glaucom

1992
A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:8

    Topics: Aged; Aged, 80 and over; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans; Injections; Intraocula

1992
Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery.
    Ophthalmology, 1992, Volume: 99, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Corneal Diseases; Epithelium; Female; Fluorouracil; Glaucoma; Humans

1992
Risk factors for suprachoroidal hemorrhage after filtering surgery. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1992, May-15, Volume: 113, Issue:5

    Topics: Aged; Cataract Extraction; Choroid Hemorrhage; Fluorouracil; Glaucoma; Humans; Incidence; Intraocula

1992
Trabeculectomy with mitomycin. A comparative study with fluorouracil.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:12

    Topics: Adult; Aged; Cicatrix; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Intraocula

1991
The use of 5-fluorouracil in patients following combined trabeculectomy and cataract extraction.
    Ophthalmic surgery, 1991, Volume: 22, Issue:8

    Topics: Aged; Aged, 80 and over; Cataract Extraction; Combined Modality Therapy; Female; Fluorouracil; Glauc

1991
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Effect of postoperative subconjunctival 5-fluorouracil injections on the surgical outcome of trabeculectomy in the Japanese.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1989, Volume: 227, Issue:6

    Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Conjunctiva; Fluorouracil; Follow-Up Studi

1989
The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery.
    Investigative ophthalmology & visual science, 1988, Volume: 29, Issue:11

    Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Double-Blind Method; Fluorouracil; Glauco

1988
A prospective, randomized study of 5-fluorouracil and filtration surgery.
    Transactions of the American Ophthalmological Society, 1987, Volume: 85

    Topics: Adolescent; Adult; Aged; Child; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male;

1987
Participants in clinical trial in glaucoma needed.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1986, Volume: 104, Issue:3

    Topics: Clinical Trials as Topic; Conjunctiva; Fluorouracil; Glaucoma; Humans; Postoperative Care

1986
A randomized study of 5-fluorouracil and filtration surgery.
    American journal of ophthalmology, 1987, Sep-15, Volume: 104, Issue:3

    Topics: Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Postoperative Compl

1987

Other Studies

236 other studies available for fluorouracil and Glaucoma

ArticleYear
The Norwich trabeculectomy study: risk factor analysis for the development of adverse, thin cystic blebs.
    Acta ophthalmologica, 2022, Volume: 100, Issue:7

    Topics: Antimetabolites; Conjunctiva; Factor Analysis, Statistical; Fluorouracil; Glaucoma; Humans; Intraocu

2022
Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes.
    Investigative ophthalmology & visual science, 2022, 09-01, Volume: 63, Issue:10

    Topics: Animals; Antimetabolites; Conjunctiva; Dextrans; Fluorouracil; Glaucoma; Intraocular Pressure; Mice;

2022
3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma.
    The Journal of pharmacy and pharmacology, 2023, Feb-08, Volume: 75, Issue:2

    Topics: Chitosan; Delayed-Action Preparations; Fluorouracil; Glaucoma; Humans; Printing, Three-Dimensional

2023
Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma.
    International ophthalmology, 2021, Volume: 41, Issue:3

    Topics: Aged; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Glaucoma, Open-Angle; Humans; Intraocular

2021
Effect of oral statin use on mitomycin-C augmented trabeculectomy outcomes.
    PloS one, 2021, Volume: 16, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucom

2021
Preparation of 5-fluorouracil loaded chitosan microtube via in situ precipitation for glaucoma drainage device application: in vitro and in vivo investigation.
    Journal of biomaterials science. Polymer edition, 2021, Volume: 32, Issue:14

    Topics: Chitosan; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Intraocular Pressure

2021
Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017, Volume: 255, Issue:6

    Topics: Aged; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Glaucoma Drainage Implants; Hu

2017
Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil.
    Ophthalmic research, 2017, Volume: 58, Issue:2

    Topics: Adult; Aged; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Germany; Glaucoma; Humans; Immuno

2017
Subconjunctival injections of 5-fluorouracil for failing Ahmed glaucoma implants.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017, Volume: 255, Issue:11

    Topics: Conjunctiva; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Injections; Intraocular Pre

2017
Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017, Volume: 255, Issue:11

    Topics: Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Injections; Intraocular Pressure; Ocular

2017
Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil.
    International ophthalmology, 2018, Volume: 38, Issue:5

    Topics: Adolescent; Amnion; Antimetabolites, Antineoplastic; Biological Dressings; Child; Child, Preschool;

2018
Trabeculectomy bleb needling and antimetabolite administration practices in the UK: a glaucoma specialist national survey.
    The British journal of ophthalmology, 2018, Volume: 102, Issue:9

    Topics: Antimetabolites; Cross-Sectional Studies; Dose-Response Relationship, Drug; Fluorouracil; Glaucoma;

2018
Bilateral Scheie's procedure with Ophthalmic Viscoelastic Device and 5-Fluorouracil.
    International ophthalmology, 2019, Volume: 39, Issue:1

    Topics: Female; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Immunosuppressive Agents; Inject

2019
Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma.
    International ophthalmology, 2019, Volume: 39, Issue:6

    Topics: Aged; Angiogenesis Inhibitors; Antihypertensive Agents; Bevacizumab; Exfoliation Syndrome; Female; F

2019
Needling With 5-Fluorouracil (5-FU) After XEN Gel Stent Implantation: 6-Month Outcomes.
    Journal of glaucoma, 2018, Volume: 27, Issue:10

    Topics: Aged; Aged, 80 and over; Exfoliation Syndrome; Female; Fluorouracil; Gels; Glaucoma; Glaucoma Draina

2018
Needle revision outcomes after glaucoma filtering surgery: survival analysis and predictive factors.
    European journal of ophthalmology, 2020, Volume: 30, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Gl

2020
Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model.
    Journal of glaucoma, 2019, Volume: 28, Issue:6

    Topics: Absorbable Implants; Animals; Drug Delivery Systems; Drug Implants; Drug Liberation; Endophthalmitis

2019
Comparison of Efficacy and Safety of Bleb Needle Revision With and Without 5-Fluorouracil for Failing Trabeculectomy Bleb.
    Journal of glaucoma, 2019, Volume: 28, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans

2019
Outcomes of Combined Ahmed Glaucoma Valve and Trabeculectomy Revision With Adjunctive Antimetabolite.
    Journal of glaucoma, 2019, Volume: 28, Issue:5

    Topics: Aged; Aged, 80 and over; Antimetabolites; Case-Control Studies; Chemotherapy, Adjuvant; Combined Mod

2019
5-Fluorouracil augmented needle revision of trabeculectomy: does the location of outflow resistance make a difference?
    Journal of glaucoma, 2013, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Child; Conjunctiva; Fem

2013
Impact of application of bio-amniotic membrane immersed in 5-fluorouracil solution in trabeculectomy on rabbit retina.
    Indian journal of ophthalmology, 2013, Volume: 61, Issue:12

    Topics: Amnion; Animals; Chromatography, High Pressure Liquid; Female; Fluorouracil; Glaucoma; Immunosuppres

2013
The effect of bevacizumab on wound healing modulation in an experimental trabeculectomy model.
    Current eye research, 2014, Volume: 39, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Disease Models, An

2014
[Long-term results after trabeculectomy with 5-fluorouracil].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2014, Volume: 111, Issue:8

    Topics: Aged; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Immunosuppressive Agents; I

2014
Nd:YAG laser goniopuncture for late bleb failure after trabeculectomy with adjunctive mitomycin C.
    JAMA ophthalmology, 2014, Volume: 132, Issue:3

    Topics: Aged; Alkylating Agents; Female; Fluorouracil; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; L

2014
Iridocorneal endothelial syndrome.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2014, Volume: 24 Suppl 2

    Topics: Adult; Fluorouracil; Glaucoma; Glaucoma, Angle-Closure; Gonioscopy; Humans; Intraocular Pressure; Ir

2014
Ex-PRESS outcomes using mitomycin-C, Ologen alone, Ologen with 5-fluorouracil.
    International ophthalmology, 2015, Volume: 35, Issue:3

    Topics: Aged; Alkylating Agents; Anthracenes; Antihypertensive Agents; Collagen; Combined Modality Therapy;

2015
Outcomes: Trabeculectomy Bleb Needle Revision With 5-Fluorouracil.
    Journal of glaucoma, 2016, Volume: 25, Issue:3

    Topics: Aged; Antihypertensive Agents; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Fol

2016
Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Anterior Eye Segment; Cicatrix; Delayed-Action Preparations; Fluorouracil; Glaucoma; Glauco

2015
A role for antimetabolites in glaucoma tube surgery: current evidence and future directions.
    Current opinion in ophthalmology, 2016, Volume: 27, Issue:2

    Topics: Animals; Antimetabolites; Fibrosis; Fluorouracil; Glaucoma; Humans; Mitomycin; Trabeculectomy

2016
Transconjunctival Revision With Mitomycin-C Following Failed Trabeculectomy.
    Journal of glaucoma, 2016, Volume: 25, Issue:7

    Topics: Aged; Aged, 80 and over; Alkylating Agents; Combined Modality Therapy; Conjunctiva; Female; Fluorour

2016
Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation.
    Clinical & experimental ophthalmology, 2017, Volume: 45, Issue:2

    Topics: Administration, Topical; Aged; Antibiotics, Antineoplastic; Dose-Response Relationship, Drug; Drug T

2017
Aqueous shunts in glaucoma: a report by the American Academy of Ophthalmology.
    Ophthalmology, 2008, Volume: 115, Issue:6

    Topics: Academies and Institutes; Alkylating Agents; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor;

2008
Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes.
    American journal of ophthalmology, 2008, Volume: 146, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkylating Agents; Cataract Extraction; Combined Modalit

2008
Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma.
    Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:7

    Topics: Animals; Antimitotic Agents; Apoptosis; Blister; Cell Death; Cell Proliferation; Cell Survival; Cell

2008
Trabeculectomy with an active postoperative regimen: results and resource utilization.
    Acta ophthalmologica, 2009, Volume: 87, Issue:5

    Topics: Aged; Conjunctiva; Female; Fluorouracil; Glaucoma; Glaucoma, Open-Angle; Humans; Injections; Intraoc

2009
A modified technique of Ahmed glaucoma valve implantation with adjunctive use of antifibrotic agents.
    American journal of ophthalmology, 2008, Volume: 146, Issue:2

    Topics: Alkylating Agents; Combined Modality Therapy; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Drainage Im

2008
Australia and New Zealand survey of antimetabolite and steroid use in trabeculectomy surgery.
    Journal of glaucoma, 2008, Volume: 17, Issue:6

    Topics: Antimetabolites; Australia; Cross-Sectional Studies; Fluorouracil; Glaucoma; Glucocorticoids; Health

2008
Comparison of 90-s versus 5-min intraoperative 5-fluorouracil in trabeculectomy.
    International ophthalmology, 2010, Volume: 30, Issue:1

    Topics: Aged; Antihypertensive Agents; Antimetabolites; Blister; Cicatrix; Female; Fluorouracil; Follow-Up S

2010
Postoperative use of bevacizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbit.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimet

2009
Restricted post-trabeculectomy bleb formation by conjunctival scarring.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2009, Volume: 247, Issue:8

    Topics: Antimetabolites; Blister; Cicatrix; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; C

2009
Long-term outcomes of needle revision of trabeculectomy blebs with mitomycin C and 5-fluorouracil: a comparative safety and efficacy report.
    Journal of glaucoma, 2009, Volume: 18, Issue:7

    Topics: Aged; Alkylating Agents; Antihypertensive Agents; Combined Modality Therapy; Female; Fluorouracil; F

2009
The efficacy of 5-fluorouracil bleb needling performed 1 year or more posttrabeculectomy: a retrospective study.
    Journal of glaucoma, 2009, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Imm

2009
Recurrence of treated ciliary body melanoma following trabeculectomy.
    Clinical & experimental ophthalmology, 2009, Volume: 37, Issue:5

    Topics: Aged; Brachytherapy; Ciliary Body; Combined Modality Therapy; Conjunctival Neoplasms; Eye Enucleatio

2009
Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: synthesis, in vitro and in vivo evaluation.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:12

    Topics: Administration, Topical; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevaciz

2010
Antimetabolite application technique in trabeculectomy surgery.
    Clinical & experimental ophthalmology, 2011, Volume: 39, Issue:6

    Topics: Antimetabolites; Drug Delivery Systems; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraoperative Car

2011
Bleb needling with subconjunctival injection of sodium hyaluronate 1.4%: 1-year outcomes.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2011, Volume: 46, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Conjunctiva; Drug Therapy, Combination; Female; F

2011
Snailtrack corneal changes following subconjunctival injection of 5-fluorouracil.
    Eye (London, England), 2012, Volume: 26, Issue:11

    Topics: Antimetabolites; Conjunctiva; Corneal Diseases; Endothelium, Corneal; Fluorouracil; Glaucoma; Humans

2012
Avastin in glaucoma surgery...
    Clinical & experimental ophthalmology, 2012, Volume: 40, Issue:8

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antimetabolites; Bevacizumab; Female; Fl

2012
Enhanced trabeculectomy in a UK district general hospital setting: is selective use of 5-fluorouracil all that is required?
    International ophthalmology, 2013, Volume: 33, Issue:4

    Topics: Aged; Aged, 80 and over; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Hospita

2013
Trabeculectomy with antiproliferative agents in uveitic glaucoma.
    Journal of glaucoma, 2002, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites, Antineopla

2002
Long-term follow-up of initially successful trabeculectomy with 5-fluorouracil injections.
    Ophthalmology, 2002, Volume: 109, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Child; Child, Preschool; Conjunctiva; F

2002
[Interferon-alpha 2b inhibits proliferation of human tenon capsule fibroblasts].
    Yan ke xue bao = Eye science, 1998, Volume: 14, Issue:4

    Topics: Antimetabolites; Cell Division; Cells, Cultured; Conjunctiva; Fibroblasts; Filtering Surgery; Fluoro

1998
The role of needle revision and 5-fluorouracil application over the filtration site in the management of bleb failure after trabeculectomy: a prospective study.
    Documenta ophthalmologica. Advances in ophthalmology, 2003, Volume: 106, Issue:2

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Fluorou

2003
Postoperative 5-fluorouracil versus intraoperative mitomycin C in high-risk glaucoma filtering surgery: extended follow up.
    Clinical & experimental ophthalmology, 2003, Volume: 31, Issue:3

    Topics: Adult; Aged; Female; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Intrao

2003
Intraoperative 5-fluorouracil application during primary trabeculectomy in Nigeria: a comparative study.
    Eye (London, England), 2003, Volume: 17, Issue:7

    Topics: Aged; Antimetabolites; Developing Countries; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Huma

2003
Late bleb needling.
    The British journal of ophthalmology, 2003, Volume: 87, Issue:11

    Topics: Aged; Drainage; Female; Fluorouracil; Glaucoma; Humans; Immunosuppressive Agents; Male; Reoperation;

2003
Needling revision of failed filtering blebs after trabeculectomy: a retrospective study.
    Acta ophthalmologica Scandinavica, 2003, Volume: 81, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Child, Preschool; Conjunctiva; Female; Fluorouracil; Follow-Up Studi

2003
Intensified postoperative care versus conventional follow-up: a retrospective long-term analysis of 177 trabeculectomies.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004, Volume: 242, Issue:2

    Topics: Aged; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Middle

2004
The case against glaucoma drainage implant surgery in patients with a poor prognosis for standard filtering procedure.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:1

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Fibrosis; Fluorouracil; Glaucoma; Glau

2004
Trabeculectomy outcomes in a Malaysian general hospital.
    The Medical journal of Malaysia, 2003, Volume: 58, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Combined Modality Therapy;

2003
Trabeculectomy and antimetabolites.
    The British journal of ophthalmology, 2004, Volume: 88, Issue:7

    Topics: Antimetabolites; Cicatrix; Clinical Competence; Fluorouracil; Glaucoma; Humans; Mitomycin; Trabecule

2004
National survey of antimetabolite use in glaucoma surgery in the United Kingdom.
    The British journal of ophthalmology, 2004, Volume: 88, Issue:7

    Topics: Antimetabolites; Fluorouracil; Glaucoma; Health Care Surveys; Humans; Intraoperative Care; Mitomycin

2004
Needle revision of failed filtering blebs using 5-Fluorouracil and a combined ab-externo and ab-interno approach.
    Journal of glaucoma, 2005, Volume: 14, Issue:1

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Conjunctiva; Fe

2005
Augmented trabeculectomy in paediatric glaucoma.
    The British journal of ophthalmology, 2005, Volume: 89, Issue:2

    Topics: Antimetabolites; Child; Child, Preschool; Combined Modality Therapy; Female; Fluorouracil; Glaucoma;

2005
Histopathologic features of conjunctival filtering blebs.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2005, Volume: 123, Issue:2

    Topics: Cell Count; Conjunctiva; Epithelial Cells; Fibrosis; Fluorouracil; Glaucoma; Goblet Cells; Humans; M

2005
2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use.
    Journal of glaucoma, 2005, Volume: 14, Issue:2

    Topics: Antineoplastic Agents; Drug Utilization; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Glauco

2005
[The long-term effect of phacoemulsification combined with trabeculectomy and intraoperative 5-fluorouracil in glaucoma patients].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2005, Volume: 41, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

2005
Ahmed valve drainage implant surgery in the management of paediatric aphakic glaucoma.
    The British journal of ophthalmology, 2005, Volume: 89, Issue:7

    Topics: Adolescent; Antihypertensive Agents; Aphakia, Postcataract; Child; Child, Preschool; Female; Fluorou

2005
Short term experience with "modern" trabeculectomy augmented with intraoperative antimetabolites.
    Bulletin de la Societe belge d'ophtalmologie, 2005, Issue:296

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Fluorouracil; Follow-Up Studies; Glauco

2005
[Subconjuctival application of 5-fluorouracil (5-FU) following surgical treatment of glaucoma with deep sclerectomy--indications, complications and initial evaluation of effectiveness].
    Klinika oczna, 2005, Volume: 107, Issue:4-6

    Topics: Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Female; Fluorouracil; Glaucoma; Hu

2005
Audit of trabeculectomy at a tertiary referral hospital in East Africa.
    Journal of glaucoma, 2005, Volume: 14, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Antimetabolites; Female; Fluorouracil; Glau

2005
Is intraocular pressure in the early postoperative period predictive of antimetabolite-augmented filtration surgery success?
    Journal of glaucoma, 2005, Volume: 14, Issue:6

    Topics: Aged; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Intraocula

2005
[Visual acuty after trabeculectomy].
    Vojnosanitetski pregled, 2005, Volume: 62, Issue:11

    Topics: Antimetabolites; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Tr

2005
Comparison of two clinical Bleb grading systems.
    Ophthalmology, 2006, Volume: 113, Issue:1

    Topics: Blister; Diagnostic Techniques, Ophthalmological; Fluorouracil; Glaucoma; Humans; Mitomycin; Prospec

2006
[Clinical observation of needle revision and 5-fluorouracil subconjunctival injection on the dysfunctional filtering blebs].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2005, Volume: 41, Issue:12

    Topics: Adult; Aged; Combined Modality Therapy; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glauco

2005
Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks.
    The British journal of ophthalmology, 2006, Volume: 90, Issue:2

    Topics: Aged; Blister; Conjunctiva; Conjunctival Diseases; Female; Fluorouracil; Glaucoma; Humans; Intraocul

2006
Review of consecutive phacotrabeculectomies supplemented with early needle revision and antimetabolites.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2006, Volume: 41, Issue:4

    Topics: Aged; Aged, 80 and over; Antimetabolites; Cataract; Female; Fluorouracil; Glaucoma; Humans; Intraocu

2006
[Needle revision of late failing filtering blebs after glaucoma surgery].
    Archivos de la Sociedad Espanola de Oftalmologia, 2006, Volume: 81, Issue:9

    Topics: Aged; Aged, 80 and over; Female; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Immunosuppressiv

2006
Dose, timing and frequency of subconjunctival 5-fluorouracil injections after glaucoma filtering surgery.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007, Volume: 245, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans; Immunosuppressi

2007
Immediate postoperative intraocular pressure measurements after trabeculectomy with releasable sutures.
    Clinical & experimental ophthalmology, 2006, Volume: 34, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; False Negative Reactions; Female; Fluorou

2006
Intraocular pressure outcome in primary 5FU phacotrabeculectomies compared with 5FU trabeculectomies.
    Journal of glaucoma, 2006, Volume: 15, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Cataract; Combined Modality Therapy

2006
[Mitomycin C versus 5-FU in failing blebs needling].
    Archivos de la Sociedad Espanola de Oftalmologia, 2006, Volume: 81, Issue:12

    Topics: Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomycin; Punctures; Treatment Failure

2006
Phacotrabeculectomy study.
    Journal of cataract and refractive surgery, 2007, Volume: 33, Issue:2

    Topics: Alkylating Agents; Antihypertensive Agents; Cataract; Fluorouracil; Glaucoma; Humans; Intraocular Pr

2007
[Late needling with 5-fluorouracil when scarring of filtering bleb seems imminent].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2007, Volume: 104, Issue:4

    Topics: Blister; Cicatrix; Cicatrix, Hypertrophic; Drug Administration Schedule; Filtering Surgery; Fluorour

2007
[Comparison of the suppressing capecitabine and 5-fluorouracil effects on the pronounce of inflammatory cells score in the induction of episcleral fibrosis after trabeculectomy].
    Vojnosanitetski pregled, 2007, Volume: 64, Issue:7

    Topics: Animals; Capecitabine; Deoxycytidine; Fibrosis; Fluorouracil; Glaucoma; Inflammation; Rabbits; Scler

2007
Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up.
    Eye (London, England), 2009, Volume: 23, Issue:2

    Topics: Adult; Aged; Anterior Chamber; Antimetabolites; Blister; Epidemiologic Methods; Female; Fluorouracil

2009
Needling revision of trabeculectomies bleb morphology and long-term survival.
    Ophthalmology, 2008, Volume: 115, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans

2008
[Drug-induced eye lesions in the aged].
    Aktuelle Gerontologie, 1983, Volume: 13, Issue:5

    Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases

1983
5-fluorouracil and glaucoma filtering surgery. II. A pilot study.
    Ophthalmology, 1984, Volume: 91, Issue:4

    Topics: Adolescent; Adult; Aged; Cataract Extraction; Child; Cicatrix; Combined Modality Therapy; Dose-Respo

1984
5-fluorouracil and glaucoma filtering surgery: I. An animal model.
    Ophthalmology, 1984, Volume: 91, Issue:4

    Topics: Animals; Aotus trivirgatus; Cicatrix; Combined Modality Therapy; Fibroblasts; Fluorouracil; Glaucoma

1984
Effect of mitomycin C and fluorouracil-supplemented trabeculectomies on the anterior segment.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:5

    Topics: Aged; Anterior Eye Segment; Cataract; Cell Count; Chemotherapy, Adjuvant; Female; Fluorouracil; Glau

1995
Removable sutures in glaucoma surgery.
    Australian and New Zealand journal of ophthalmology, 1994, Volume: 22, Issue:3

    Topics: Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mitomycin; Suture Techniques; Time Factors; Tr

1994
One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction.
    Ophthalmology, 1995, Volume: 102, Issue:1

    Topics: Adult; Aged; Astigmatism; Cataract; Cataract Extraction; Female; Fluorouracil; Follow-Up Studies; Gl

1995
Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1994, Volume: 29, Issue:6

    Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Conjunctiva; Drug Delivery Systems;

1994
Incidence of complications following 5-fluorouracil with trabeculectomies.
    Indian journal of ophthalmology, 1993, Volume: 41, Issue:4

    Topics: Combined Modality Therapy; Corneal Diseases; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Inci

1993
Histopathologic effects of mitomycin C after trabeculectomy in human glaucomatous eyes with persistent hypotony.
    American journal of ophthalmology, 1994, Aug-15, Volume: 118, Issue:2

    Topics: Adult; Aged; Ciliary Body; Combined Modality Therapy; Conjunctiva; Female; Fluorouracil; Glaucoma; H

1994
Single intraoperative applications of 5-fluorouracil during filtration surgery: early results.
    The British journal of ophthalmology, 1994, Volume: 78, Issue:1

    Topics: Adolescent; Adult; Aged; Child, Preschool; Female; Filtration; Fluorouracil; Glaucoma; Humans; Intra

1994
[5-fluorouracil injection treatment after fistulating glaucoma operations].
    Klinische Monatsblatter fur Augenheilkunde, 1993, Volume: 203, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Combined Modality Therapy; Female; Fluorouracil;

1993
[5-fluorouracil in goniotrepanation with poor prognosis. Results of 1-year follow-up].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1993, Volume: 90, Issue:6

    Topics: Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; I

1993
Intra-operative use of 5-fluorouracil in glaucoma filtering surgery.
    Acta ophthalmologica, 1993, Volume: 71, Issue:6

    Topics: Adult; Aged; Combined Modality Therapy; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Infant; I

1993
5-Fluorouracil vs single-plate molteno implantation.
    Ophthalmic surgery, 1994, Volume: 25, Issue:3

    Topics: Combined Modality Therapy; Fluorouracil; Glaucoma; Humans; Prostheses and Implants; Trabeculectomy

1994
[The effect of antimetabolites on healing in anti-glaucoma surgery].
    Ceskoslovenska oftalmologie, 1993, Volume: 49, Issue:5

    Topics: Fluorouracil; Glaucoma; Humans; Postoperative Care

1993
Dangers of direct injection of antimetabolites into filtration blebs.
    Eye (London, England), 1993, Volume: 7 ( Pt 3)

    Topics: Antimetabolites; Contraindications; Fluorouracil; Glaucoma; Humans; Injections

1993
Intraoperative 5-fluorouracil for filtration surgery in the rabbit.
    Investigative ophthalmology & visual science, 1993, Volume: 34, Issue:12

    Topics: Animals; Conjunctiva; Double-Blind Method; Fluorouracil; Glaucoma; Injections; Intraocular Pressure;

1993
Trabeculectomy with 5-fluorouracil vs single-plate Molteno implantation.
    Ophthalmic surgery, 1993, Volume: 24, Issue:10

    Topics: Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure

1993
5-FU-supplemented phacoemulsification, posterior chamber intraocular lens implantation, and trabeculectomy.
    Ophthalmic surgery, 1993, Volume: 24, Issue:10

    Topics: Aged; Cataract Extraction; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure;

1993
The role of 5-fluorouracil in complicated glaucomas.
    Indian journal of ophthalmology, 1993, Volume: 41, Issue:2

    Topics: Adult; Aphakia; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Glaucoma, Neovascular; Humans; In

1993
Filtering surgery with 5-fluorouracil subsequent to Molteno implant.
    Israel journal of medical sciences, 1993, Volume: 29, Issue:11

    Topics: Adolescent; Adult; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraocula

1993
The use of 5-fluorouracil in glaucoma filtration surgery.
    Insight (American Society of Ophthalmic Registered Nurses), 1993, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Female; Fibroblasts; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Inj

1993
Holmium laser sclerectomy. Success and complications.
    Ophthalmology, 1993, Volume: 100, Issue:7

    Topics: Aged; Choroid Hemorrhage; Chronic Disease; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intrao

1993
Sturge-Weber syndrome: management of glaucoma with combined trabeculotomy-trabeculectomy.
    Ophthalmic surgery, 1993, Volume: 24, Issue:6

    Topics: Child; Child, Preschool; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Infant; Infant,

1993
Trabeculectomy with 5-fluorouracil in complicated glaucoma.
    Klinika oczna, 1993, Volume: 95, Issue:2

    Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Glaucom

1993
[The anti-cicatrization effect of low dosage 5-Fu after trabeculectomy in late glaucoma].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1993, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Male; Mid

1993
Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1993, Volume: 111, Issue:2

    Topics: Animals; Biopsy; Conjunctiva; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Flu

1993
Additional failures after filtering with 5-FU.
    Ophthalmology, 1993, Volume: 100, Issue:1

    Topics: Endophthalmitis; Fluorouracil; Glaucoma; Humans; Treatment Failure

1993
[Assessment of anti-proliferative and anti-inflammatory drugs for treatment of ocular fibroblast proliferation using dynamic microscope image processing scanner].
    Nippon Ganka Gakkai zasshi, 1993, Volume: 97, Issue:1

    Topics: 3T3 Cells; Animals; Cell Division; Cell Movement; Colchicine; Fluorouracil; Glaucoma; Image Processi

1993
Anterior chamber reaction after mitomycin and 5-fluorouracil trabeculectomy: a comparative study.
    Ophthalmic surgery, 1993, Volume: 24, Issue:1

    Topics: Anterior Chamber; Aqueous Humor; Biological Transport, Active; Blood; Chemotherapy, Adjuvant; Eye Pr

1993
Subconjunctival THC:YAG ("holmium") laser thermal sclerostomy ab externo. A one-year report.
    Ophthalmology, 1993, Volume: 100, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cohort Studies; Conjunctiva; Female; Fluorouracil

1993
Effects of intraoperative 5-fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit.
    Ophthalmology, 1993, Volume: 100, Issue:3

    Topics: Animals; Double-Blind Method; Drug Evaluation, Preclinical; Fluorouracil; Glaucoma; Intraocular Pres

1993
Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil.
    American journal of ophthalmology, 1993, Apr-15, Volume: 115, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Child; Child, Preschool; Eye Dis

1993
Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil.
    American journal of ophthalmology, 1993, Apr-15, Volume: 115, Issue:4

    Topics: Fluorouracil; Glaucoma; Humans; Macula Lutea; Middle Aged; Ocular Hypotension; Retinal Diseases; Tra

1993
Surgical management of post-traumatic angle recession glaucoma.
    Ophthalmology, 1993, Volume: 100, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Chamber; Child; Combined Modality Therapy; Drai

1993
Treatment of failing glaucoma filtering cystic blebs with tissue plasminogen activator (tPA).
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Fall, Volume: 11, Issue:3

    Topics: Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Drug Therapy, Combination; Female; Filtering Surger

1995
Trabeculectomy at the inferior limbus.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Chemotherapy, Adjuvant; Child; Chi

1996
Encapsulated filtering blebs.
    Ophthalmology, 1996, Volume: 103, Issue:1

    Topics: Filtering Surgery; Fluorouracil; Glaucoma; Gloves, Surgical; Humans; Incidence; Postoperative Compli

1996
Late visual loss secondary to filtering bleb exuberance.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:6

    Topics: Chemotherapy, Adjuvant; Conjunctiva; Fluorouracil; Glaucoma; Humans; Immunosuppressive Agents; Male;

1996
Purity and stability assessment of a semi-solid poly(ortho ester) used in drug delivery systems.
    Biomaterials, 1996, Volume: 17, Issue:9

    Topics: Argon; Biocompatible Materials; Drug Delivery Systems; Drug Stability; Drug Storage; Fluorouracil; G

1996
5-FU loaded pHEMA drainage implants for glaucoma-filtering surgery: device design and in vitro release kinetics.
    Biomaterials, 1996, Volume: 17, Issue:9

    Topics: Animals; Biocompatible Materials; Cell Division; Combined Modality Therapy; Dogs; Drug Implants; Equ

1996
[Biodegradable controlled-release 5-FU implant in the surgery for glaucoma. Experimental study].
    Journal francais d'ophtalmologie, 1996, Volume: 19, Issue:2

    Topics: Animals; Antimetabolites; Biocompatible Materials; Delayed-Action Preparations; Fluorouracil; Glauco

1996
[Subconjunctival 5-fluorouracil polyphase liposome interference with scar formation in experimental filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1996, Volume: 32, Issue:1

    Topics: Animals; Cicatrix; Drug Carriers; Female; Filtering Surgery; Fluorouracil; Glaucoma; Liposomes; Male

1996
"Late endophthalmitis"--filtering surgery time bomb?
    Ophthalmology, 1996, Volume: 103, Issue:8

    Topics: Antimetabolites; Aqueous Humor; Bacteria; Chemotherapy, Adjuvant; Endophthalmitis; Eye Infections, B

1996
A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies.
    Journal of biomaterials science. Polymer edition, 1996, Volume: 7, Issue:10

    Topics: Administration, Topical; Animals; Antibiotics, Antineoplastic; Conjunctiva; Cornea; Delayed-Action P

1996
In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly(D,L-lactide-co-glycolide).
    Pharmaceutical research, 1996, Volume: 13, Issue:7

    Topics: Animals; Biocompatible Materials; Conjunctiva; Delayed-Action Preparations; Drug Implants; Fluoroura

1996
Corneal ectasia secondary to excessive ocular massage following trabeculectomy with 5-fluorouracil.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1996, Volume: 31, Issue:5

    Topics: Adult; Antimetabolites; Corneal Diseases; Dilatation, Pathologic; Fluorouracil; Glaucoma; Humans; Ma

1996
Five-year follow-up of the Fluorouracil Filtering Surgery Study.
    American journal of ophthalmology, 1996, Volume: 122, Issue:5

    Topics: Antimetabolites; Filtering Surgery; Fluorouracil; Follow-Up Studies; Glaucoma; Humans

1996
Low-dose perioperative 5-fluorouracil in trabeculectomy.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:11

    Topics: Antimetabolites; Drug Administration Routes; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Huma

1996
Ultrasonographic findings of the optic disc in congenital glaucoma.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:12

    Topics: Antimetabolites; Corneal Opacity; Cryotherapy; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Hu

1996
[Antiproliferative therapy with 5-fluorouracil in erbium:YAG laser sclerostomy ab externo].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1996, Volume: 93, Issue:5

    Topics: Antimetabolites; Cell Division; Cicatrix; Combined Modality Therapy; Female; Fluorouracil; Glaucoma;

1996
Results of intraoperative 5-fluorouracil or lower dose mitomycin-C administration on initial trabeculectomy surgery.
    Journal of glaucoma, 1997, Volume: 6, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites; Chemotherapy, Adjuvant

1997
Needling revision of glaucoma drainage device filtering blebs.
    Ophthalmology, 1997, Volume: 104, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Drainage; Female; Fluoroura

1997
Use of antifibrosis agents and glaucoma drainage devices in the American and Japanese Glaucoma Societies.
    Journal of glaucoma, 1997, Volume: 6, Issue:3

    Topics: Chemotherapy, Adjuvant; Data Collection; Dose-Response Relationship, Drug; Drainage; Fibrosis; Fluor

1997
Late onset of sequential multifocal bleb leaks after glaucoma filtration surgery with 5-fluorouracil and mitomycin C.
    American journal of ophthalmology, 1997, Volume: 124, Issue:1

    Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Female; Flu

1997
Small incision trabeculectomy avoiding Tenon's capsule. A new procedure for glaucoma surgery.
    Ophthalmology, 1997, Volume: 104, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Conjunctiva; Connective Tissue; Fluorouracil; Follow-Up Studies; Gla

1997
5-Fluorouracil in primary combined glaucoma surgery.
    Ophthalmology, 1997, Volume: 104, Issue:10

    Topics: Antimetabolites; Cornea; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Lenses, Intraocular;

1997
Temporal corneal phacoemulsification in filtered glaucoma patients.
    Transactions of the American Ophthalmological Society, 1997, Volume: 95

    Topics: Aged; Aged, 80 and over; Case-Control Studies; Cornea; Female; Fluorouracil; Follow-Up Studies; Glau

1997
Long-term results and complications after trabeculectomy with a single per-operative application of 5-fluorouracil.
    Eye (London, England), 1997, Volume: 11 ( Pt 5)

    Topics: Adult; Aged; Antimetabolites; Eye Diseases; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Human

1997
Modification of trabeculectomy with single-dose intraoperative 5-Fluorouracil application.
    Acta ophthalmologica Scandinavica, 1998, Volume: 76, Issue:1

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

1998
Late removal of releasable sutures after trabeculectomy or combined trabeculectomy with cataract extraction supplemented with antifibrotics.
    Journal of glaucoma, 1998, Volume: 7, Issue:2

    Topics: Aged; Cataract Extraction; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pr

1998
Late-onset bleb leaks after glaucoma filtering surgery.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1998, Volume: 116, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aqueous Humor; Cataract Extraction; Chemotherapy, Adjuva

1998
[A case of Cogan-Reese syndrome (iris nevus syndrome)].
    Klinika oczna, 1997, Volume: 99, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; F

1997
Antimetabolites in glaucoma surgery: our experiences and results.
    Acta ophthalmologica Scandinavica. Supplement, 1997, Issue:224

    Topics: Antimetabolites; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Intraopera

1997
[Peroperative administration of 5-fluorouracil during trabeculectomy in complicated glaucoma in children].
    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 1998, Volume: 54, Issue:2

    Topics: Adolescent; Antimetabolites; Child; Child, Preschool; Female; Fluorouracil; Glaucoma; Humans; Intrao

1998
Management of large, leaking, and inadvertent filtering blebs with the neodymium:YAG laser.
    Ophthalmology, 1998, Volume: 105, Issue:6

    Topics: Aged; Aqueous Humor; Female; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pressure

1998
Needling revision of glaucoma drainage device filtering blebs.
    Ophthalmology, 1998, Volume: 105, Issue:7

    Topics: Chemotherapy, Adjuvant; Drainage; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pre

1998
Trabeculectomy with intraoperative 5-fluorouracil.
    Ophthalmic surgery and lasers, 1998, Volume: 29, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Fluorouracil; Glaucoma; Humans; Int

1998
Trabeculectomy survival with and without intra-operative 5-fluorouracil application in an Asian population.
    Australian and New Zealand journal of ophthalmology, 1998, Volume: 26, Issue:4

    Topics: Administration, Topical; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

1998
Occlusive ligature and standardized fenestration of a Baerveldt tube with and without antimetabolites for early postoperative intraocular pressure control.
    Ophthalmology, 1998, Volume: 105, Issue:12

    Topics: Aged; Antimetabolites; Aqueous Humor; Female; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Hu

1998
Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents.
    Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:5

    Topics: Aged; Cataract; Chemotherapy, Adjuvant; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraocular Pressu

1999
[Use of "low dose" 5-fluorouracil during trabeculectomy].
    Bulletin de la Societe belge d'ophtalmologie, 1999, Volume: 272

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma;

1999
[The inhibitory effect of tissue plasminogen activator combined with 5-fluorouracil polyphase liposome on the scar formation in experimental filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1997, Volume: 33, Issue:5

    Topics: Animals; Cicatrix; Drug Carriers; Drug Synergism; Drug Therapy, Combination; Female; Fibrosis; Fluor

1997
Late-onset, bleb-associated endophthalmitis following glaucoma filtering surgery with or without antifibrotic agents.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1999, Volume: 15, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Endophthalmitis; Female; Filtration; Fluoro

1999
Collagen type I and III synthesis by Tenon's capsule fibroblasts in culture: individual patient characteristics and response to mitomycin C, 5-fluorouracil, and ascorbic acid.
    Transactions of the American Ophthalmological Society, 1999, Volume: 97

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Ascorbic Acid; Cells, Cultured; Child;

1999
Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma.
    Ophthalmology, 2000, Volume: 107, Issue:10

    Topics: Adolescent; Adult; Aged; Antimetabolites; Child; Female; Fluorouracil; Follow-Up Studies; Glaucoma;

2000
After-cataract and secondary glaucoma in the aphakic infant rabbit.
    Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:9

    Topics: Animals; Animals, Newborn; Anterior Chamber; Aphakia, Postcataract; Cataract; Fluorouracil; Glaucoma

2000
Risk factors for development of post-trabeculectomy endophthalmitis.
    The British journal of ophthalmology, 2000, Volume: 84, Issue:12

    Topics: Aged; Antimetabolites; Case-Control Studies; Diabetes Complications; Endophthalmitis; Female; Fluoro

2000
Outcomes of combined cataract extraction, lens implantation, and trabeculectomy surgeries.
    American journal of ophthalmology, 2000, Volume: 130, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Cataract; Cataract Extraction; Female;

2000
Success criteria and success rates in trabeculectomy with and without intraoperative antimetabolites using intensified postoperative care (IPC).
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Female; Fluorouracil; Glaucoma; Humans; Intraocular

2000
[Use of 5-fluorouracil in trabeculectomy].
    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 2000, Volume: 56, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male;

2000
Should antiproliferatives be used in filtering surgery of normal tension glaucoma?
    The British journal of ophthalmology, 2001, Volume: 85, Issue:6

    Topics: Antineoplastic Agents; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mito

2001
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome.
    Ophthalmology, 2001, Volume: 108, Issue:10

    Topics: Adult; Antihypertensive Agents; Corneal Diseases; Endothelium, Corneal; Fluorouracil; Follow-Up Stud

2001
Slow release of the antimetabolite 5-fluorouracil (5-FU) from modified Baerveldt glaucoma drains to prolong drain function.
    Biomaterials, 2001, Volume: 22, Issue:24

    Topics: Animals; Antimetabolites; Biocompatible Materials; Collagen; Delayed-Action Preparations; Drug Impla

2001
Glaucoma surgery treatment patterns of ASCRS members--2000 survey.
    Journal of cataract and refractive surgery, 2001, Volume: 27, Issue:11

    Topics: Cross-Sectional Studies; Filtering Surgery; Fluorouracil; Glaucoma; Health Surveys; Humans; Middle A

2001
The efficacy and safety of intraoperative and/or postoperative 5-fluorouracil in trabeculectomy and phacotrabeculectomy.
    Clinical & experimental ophthalmology, 2001, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Cataract; Female; Fluorouracil; Glaucom

2001
Risk factors for failure of 5-fluorouracil needling revision for failed conjunctival filtration blebs.
    American journal of ophthalmology, 2001, Volume: 132, Issue:6

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Cataract Extraction; Conjunctiva; Female;

2001
[Influence on tear film of postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2001, Volume: 37, Issue:1

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Conjunctiva; Dry Eye Synd

2001
Predictors for success of needle revision of failing filtration blebs.
    Ophthalmology, 2002, Volume: 109, Issue:4

    Topics: Aged; Antimetabolites; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Ma

2002
Needling revision with subconjunctival 5-fluorouracil in failing filtering blebs.
    Chang Gung medical journal, 2002, Volume: 25, Issue:2

    Topics: Adult; Aged; Antimetabolites; Female; Fluorouracil; Glaucoma; Humans; Male; Middle Aged; Needles; Po

2002
[Antimetabolites in glaucoma surgery--long-term results].
    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 2002, Volume: 58, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Fluorouracil; Glaucoma; Humans; Intraocular Pressur

2002
Complications of 5-fluorouracil after trabeculectomy.
    Eye (London, England), 1992, Volume: 6 ( Pt 6)

    Topics: Adult; Fluorouracil; Glaucoma; Humans; Postoperative Care; Trabeculectomy

1992
Antimetabolites in the surgical treatment of glaucomas.
    Bulletin de la Societe belge d'ophtalmologie, 1992, Volume: 244

    Topics: Animals; Aotidae; Cell Division; Fibroblasts; Fluorouracil; Glaucoma; Humans; Intraocular Pressure;

1992
Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease.
    Ophthalmology, 1992, Volume: 99, Issue:4

    Topics: Adolescent; Adult; Aged; Cataract Extraction; Conjunctiva; Female; Fluorouracil; Follow-Up Studies;

1992
Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil.
    American journal of ophthalmology, 1992, Nov-15, Volume: 114, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorescein Angiography; Fluorouracil; Fundus Oculi; Glaucom

1992
Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy.
    Ophthalmic research, 1992, Volume: 24, Issue:5

    Topics: Adult; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Inclusion Bodie

1992
[Use of 5-fluorouracil in complicated cases of glaucoma--personal experience].
    Ceskoslovenska oftalmologie, 1992, Volume: 48, Issue:4

    Topics: Adolescent; Adult; Aged; Female; Fluorouracil; Glaucoma; Humans; Injections; Male; Middle Aged; Trab

1992
Intraoperative and post operative treatment with 5-fluorouracil and mitomycin-c: long term effects in vivo on subconjunctival and scleral fibroblasts.
    International ophthalmology, 1992, Volume: 16, Issue:4-5

    Topics: Animals; Cell Division; Cells, Cultured; Conjunctiva; Fibroblasts; Fluorouracil; Glaucoma; Injection

1992
Intraoperative application of 5-fluorouracil during trabeculectomy.
    Ophthalmic surgery, 1992, Volume: 23, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Cicatrix; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

1992
Who should receive antimetabolites after filtering surgery?
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:8

    Topics: Antimetabolites; Fluorouracil; Glaucoma; Humans; Mitomycin; Postoperative Care

1992
Combined cataract extraction and filtering surgery.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc, 1992, Volume: 18, Issue:3

    Topics: Cataract Extraction; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Lenses, In

1992
Phacoemulsification, foldable IOL, Holmium laser sclerostomy, and 5-FU.
    Ophthalmic surgery, 1992, Volume: 23, Issue:8

    Topics: Cataract Extraction; Fluorouracil; Glaucoma; Humans; Injections; Laser Therapy; Lenses, Intraocular;

1992
Subconjunctival injection of 5-fluorouracil following trabeculectomy for congenital and infantile glaucoma.
    Ophthalmic surgery, 1992, Volume: 23, Issue:3

    Topics: Child; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraocul

1992
Molteno implants.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:5

    Topics: Cysts; Eye Diseases; Fluorouracil; Glaucoma; Humans; Injections; Postoperative Complications; Prosth

1992
Design and results of trabeculectomy operation for use with 5-fluorouracil.
    Ophthalmic surgery, 1992, Volume: 23, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male;

1992
Inhibition of human subconjunctival fibroblast proliferation by immunotoxin.
    Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:7

    Topics: Antibodies, Monoclonal; Cell Count; Cell Division; Cell Survival; Cells, Cultured; Conjunctiva; Fibr

1992
In vitro release of hydrophobic drugs from polyanhydride disks.
    Ophthalmic surgery, 1991, Volume: 22, Issue:11

    Topics: Alkaloids; Cell Division; Cells, Cultured; Decanoic Acids; Delayed-Action Preparations; Dicarboxylic

1991
Indications for postoperative fluorouracil therapy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:1

    Topics: Aqueous Humor; Drainage; Fibroblasts; Fluorouracil; Glaucoma; Humans; Postoperative Care; Prostheses

1992
5-FU trabeculectomy.
    Ophthalmology, 1992, Volume: 99, Issue:1

    Topics: Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Trabeculectomy

1992
Regulating the dose of 5-fluorouracil to prevent filtering bleb scarring.
    Annals of ophthalmology, 1991, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Chamber; Child; Cicatrix; Conjunctiva; Dosage F

1991
Effect of gamma-interferon on fibroblast proliferation and collagen synthesis after glaucoma filtering surgery in white rabbits.
    Korean journal of ophthalmology : KJO, 1991, Volume: 5, Issue:2

    Topics: Animals; Anterior Chamber; Cell Division; Collagen; Fibroblasts; Fluorouracil; Glaucoma; Interferon-

1991
[5-Fu as remedy for unsuccessful glaucoma filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1991, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Child; Female; Fluorouracil; Glaucoma; Humans; Injections; Intraocular Pressure;

1991
Glaucoma filtration surgery: new horizontal mattress closure of conjunctival incision.
    Ophthalmic surgery, 1991, Volume: 22, Issue:5

    Topics: Cataract Extraction; Conjunctiva; Fluorouracil; Glaucoma; Humans; Surgical Wound Dehiscence; Suture

1991
Initial 5-fluorouracil trabeculectomy in uncomplicated glaucoma.
    Ophthalmology, 1991, Volume: 98, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Evaluation Studies as Topic; Female; Fluorouracil; Follo

1991
Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil.
    Ophthalmology, 1991, Volume: 98, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Child, Preschool; Endophth

1991
Subconjunctival THC:YAG laser thermal sclerostomy.
    Ophthalmology, 1991, Volume: 98, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Child; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucom

1991
5-fluorouracil and beyond.
    The British journal of ophthalmology, 1991, Volume: 75, Issue:10

    Topics: Child; Cicatrix; Fluorouracil; Glaucoma; Humans; Trabeculectomy

1991
5-Fluorouracil and filtering surgery.
    Australian and New Zealand journal of ophthalmology, 1991, Volume: 19, Issue:3

    Topics: Fluorouracil; Glaucoma; Humans; Prognosis; Trabeculectomy; Wound Healing

1991
Remission of anterior uveitis by subconjunctival fluorouracil.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:1

    Topics: Aged; Conjunctiva; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Middle A

1991
5-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome.
    Ophthalmology, 1991, Volume: 98, Issue:3

    Topics: Adult; Cataract Extraction; Conjunctiva; Corneal Diseases; Endothelium, Corneal; Fluorouracil; Follo

1991
Corneal penetration of 5-fluorouracil and its improvement by prodrug derivatization in the albino rabbit: implication in glaucoma filtration surgery.
    Current eye research, 1991, Volume: 10, Issue:1

    Topics: Animals; Atenolol; Cornea; Female; Fluorouracil; Glaucoma; Histological Techniques; Hydrolysis; Osmo

1991
Subconjunctival 5-fluorouracil and herpes simplex keratitis.
    Ophthalmic surgery, 1991, Volume: 22, Issue:2

    Topics: Eye Diseases; Fluorouracil; Glaucoma; Humans; Keratitis, Dendritic; Male; Middle Aged; Postoperative

1991
Restoring the function of the failed bleb.
    Australian and New Zealand journal of ophthalmology, 1991, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drainage; Female; Fluorouracil; Glaucoma; Humans;

1991
Filtering surgery with 5-fluorouracil: a second course.
    Eye (London, England), 1990, Volume: 4 ( Pt 6)

    Topics: Adult; Aged; Combined Modality Therapy; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans; Injecti

1990
Using fluorouracil in surgical therapy for glaucoma.
    The Western journal of medicine, 1990, Volume: 153, Issue:2

    Topics: Combined Modality Therapy; Drainage; Fluorouracil; Glaucoma; Humans; Postoperative Care

1990
Primate trabeculectomies with 5-fluorouracil collagen implants.
    American journal of ophthalmology, 1990, Nov-15, Volume: 110, Issue:5

    Topics: Animals; Collagen; Drug Implants; Fluorouracil; Glaucoma; Macaca; Trabeculectomy

1990
Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.
    Ophthalmic surgery, 1990, Volume: 21, Issue:10

    Topics: Anterior Chamber; Cataract Extraction; Cell Division; Corneal Diseases; Epithelium; Eye Enucleation;

1990
[Prevention of scarring of filtering bleb by 5-fluorouracil].
    Harefuah, 1990, Nov-15, Volume: 119, Issue:10

    Topics: Conjunctiva; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Postoperative Care; Trab

1990
Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma.
    American journal of ophthalmology, 1990, Feb-15, Volume: 109, Issue:2

    Topics: Adult; Aged; Female; Fluorometholone; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Inflammatio

1990
Fluorouracil filtering surgery study one-year follow-up.
    American journal of ophthalmology, 1990, May-15, Volume: 109, Issue:5

    Topics: Cataract Extraction; Combined Modality Therapy; Fluorouracil; Glaucoma; Humans; Trabeculectomy

1990
Needle revision with and without 5-fluorouracil for the treatment of failed filtering blebs.
    American journal of ophthalmology, 1990, Sep-15, Volume: 110, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Male; Mid

1990
5-Fluorouracil and glaucoma filtering surgery. III. Intermediate follow-up of a pilot study.
    Ophthalmology, 1986, Volume: 93, Issue:12

    Topics: Aphakia; Conjunctiva; Eye; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Neovascula

1986
Delivery of antifibroblast agents as adjuncts to filtration surgery--Part II: Delivery of 5-fluorouracil and bleomycin in a collagen implant: pilot study in the rabbit.
    Ophthalmic surgery, 1986, Volume: 17, Issue:12

    Topics: Animals; Bleomycin; Cell Division; Collagen; Drug Implants; Eye; Female; Fibroblasts; Fluorouracil;

1986
Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects.
    Ophthalmology, 1987, Volume: 94, Issue:5

    Topics: Adult; Aged; Female; Fluorouracil; Glaucoma; Humans; Inflammation; Intraocular Pressure; Iris; Male;

1987
[Treatment of neovascular glaucoma by seton and 5-FU].
    Nippon Ganka Gakkai zasshi, 1987, Volume: 91, Issue:11

    Topics: Combined Modality Therapy; Diabetes Complications; Fluorouracil; Glaucoma; Humans; Male; Methods; Mi

1987
[Complications of antiglaucoma surgery associated with 5FU. Apropos of a case].
    Bulletin des societes d'ophtalmologie de France, 1989, Volume: 89, Issue:12

    Topics: Adult; Choroid Diseases; Female; Fluorouracil; Glaucoma; Humans; Ocular Motility Disorders; Reoperat

1989
Low-dose 5-fluorouracil and glaucoma filtration surgery.
    Ophthalmic surgery, 1989, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Cornea; Epithelial Cells; Fluorouracil; Follow-Up Studies; Glaucoma;

1989
External limbal sclerostomy with contact Nd:YAG laser versus surgical knife.
    International ophthalmology, 1989, Volume: 13, Issue:3

    Topics: Animals; Anterior Chamber; Cell Division; Conjunctiva; Fluorouracil; Glaucoma; Intraocular Pressure;

1989
Polyvinyl alcohol membrane permeability characteristics of 5-fluorouracil.
    Journal of ocular pharmacology, 1988,Summer, Volume: 4, Issue:2

    Topics: Delayed-Action Preparations; Diffusion; Fluorouracil; Glaucoma; Humans; Membranes, Artificial; Perme

1988
A randomized study of 5-fluorouracil and filtration surgery.
    American journal of ophthalmology, 1988, Apr-15, Volume: 105, Issue:4

    Topics: Fluorouracil; Glaucoma; Humans; Random Allocation

1988
Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil.
    Ophthalmology, 1987, Volume: 94, Issue:12

    Topics: Animals; Biodegradation, Environmental; Double-Blind Method; Drug Implants; Fluorouracil; Glaucoma;

1987
[Use of 5-fluorouracil in the surgery of glaucoma].
    Journal francais d'ophtalmologie, 1987, Volume: 10, Issue:10

    Topics: Conjunctiva; Female; Fibrosis; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressu

1987
Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery.
    Ophthalmic surgery, 1987, Volume: 18, Issue:3

    Topics: Aged; Aged, 80 and over; Conjunctiva; Conjunctival Diseases; Corneal Diseases; Fluorouracil; Glaucom

1987
5-Fluorouracil for trabeculectomy in glaucoma.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1987, Volume: 225, Issue:6

    Topics: Cicatrix; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Pos

1987
Glaucoma filtering surgery with 5-fluorouracil.
    Ophthalmology, 1987, Volume: 94, Issue:9

    Topics: Actuarial Analysis; Conjunctiva; Fluorouracil; Glaucoma; Humans; Injections; Pilot Projects; Postope

1987
Vital importance of clinical trials.
    Ophthalmic surgery, 1986, Volume: 17, Issue:5

    Topics: Clinical Trials as Topic; Fluorouracil; Glaucoma; Humans

1986
Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil.
    American journal of ophthalmology, 1987, Feb-15, Volume: 103, Issue:2

    Topics: Aged; Corneal Diseases; Corneal Ulcer; Female; Fluorouracil; Glaucoma; Humans; Male; Middle Aged; Po

1987
Topical fluorouracil. II. Postoperative administration in an animal model of glaucoma filtering surgery.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1986, Volume: 104, Issue:1

    Topics: Administration, Topical; Animals; Aotus trivirgatus; Electroretinography; Eye; Fluorouracil; Glaucom

1986
[Xeroderma pigmentosum, universal alopecia and associated neuro-ocular symptoms].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:5

    Topics: Administration, Topical; Alopecia; Brain Diseases; Fluorouracil; Glaucoma; Humans; Male; Middle Aged

1973