fluorouracil has been researched along with Glaucoma, Angle Closure in 22 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 2/1991 and 1/1993 twenty-nine eyes of 11 female and 16 male patients with high-risk glaucoma (unsuccessful previous filtering surgery and a high risk of scarring) were treated with subconjunctival injections of 5-Fluorouracil after filtering surgery in the University Eye Hospital Düsseldorf." | 7.68 | [5-fluorouracil injection treatment after fistulating glaucoma operations]. ( Klüppel, M; Reinhard, T; Sundmacher, R, 1993) |
| "Between 2/1991 and 1/1993 twenty-nine eyes of 11 female and 16 male patients with high-risk glaucoma (unsuccessful previous filtering surgery and a high risk of scarring) were treated with subconjunctival injections of 5-Fluorouracil after filtering surgery in the University Eye Hospital Düsseldorf." | 3.68 | [5-fluorouracil injection treatment after fistulating glaucoma operations]. ( Klüppel, M; Reinhard, T; Sundmacher, R, 1993) |
| "Intraocular pressure was 16 mmHg in the right and 36 mmHg in the left eye." | 1.40 | Iridocorneal endothelial syndrome. ( Akhtar, F; Ali, M; Saleem, AA, 2014) |
| "the Wuerzburg bleb classification score (WBCS) aims at an objective and standardized assessment of the developing filtering bleb after trabeculectomy, in order to detect and treat bleb scarring at the earliest possible stage of development." | 1.37 | The prognostic value of the wuerzburg bleb classification score for the outcome of trabeculectomy. ( Ellinger, P; Grehn, F; Guthoff, R; Kann, G; Klink, J; Klink, T, 2011) |
| "Late bleb leaks may follow months to years after filtering surgery especially with the use of antimetabolites." | 1.31 | [Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps]. ( Ayed, T; Hamard, H; Hamard, P; Quesnot, S; Tazartes, M, 2001) |
| " Our study may provide data on the appropriate dosage and indications for the use of this drug after glaucoma surgery." | 1.28 | Trabeculectomy with 5-fluorouracil. ( Iwata, K; Nanba, K; Sawaguchi, S; Watanabe, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, MH | 1 |
| Husain, R | 4 |
| Ang, BC | 1 |
| Gazzard, G | 5 |
| Foster, PJ | 5 |
| Htoon, HM | 2 |
| Wong, TT | 3 |
| Oen, FT | 3 |
| Khaw, PT | 5 |
| Seah, SK | 4 |
| Aung, T | 6 |
| Saleem, AA | 1 |
| Ali, M | 1 |
| Akhtar, F | 1 |
| Devereux, JG | 2 |
| Minassian, D | 1 |
| Tan, SB | 1 |
| Chew, PT | 4 |
| Klink, T | 1 |
| Kann, G | 1 |
| Ellinger, P | 1 |
| Klink, J | 1 |
| Grehn, F | 1 |
| Guthoff, R | 1 |
| Tan, YL | 1 |
| Tsou, PF | 1 |
| Tan, GS | 1 |
| Perera, SA | 1 |
| Ho, CL | 1 |
| Day, AC | 1 |
| Machin, D | 1 |
| Liang, S | 1 |
| Bunce, C | 1 |
| Oen, F | 1 |
| Chew, P | 1 |
| Seah, S | 1 |
| Tomlins, PJ | 1 |
| Savant, V | 1 |
| Quinlan, M | 1 |
| Oh, SY | 1 |
| Youn, DH | 1 |
| Kim, DM | 1 |
| Hong, C | 1 |
| Reinhard, T | 1 |
| Klüppel, M | 1 |
| Sundmacher, R | 1 |
| Egbert, PR | 1 |
| Williams, AS | 1 |
| Singh, K | 1 |
| Dadzie, P | 1 |
| Egbert, TB | 1 |
| Lamba, PA | 2 |
| Pandey, PK | 2 |
| Raina, UK | 2 |
| Krishna, V | 2 |
| Fellman, R | 1 |
| Budenz, D | 1 |
| Alsagoff, Z | 1 |
| Chee, CK | 1 |
| Wong, JS | 1 |
| Hamard, P | 1 |
| Tazartes, M | 1 |
| Ayed, T | 1 |
| Quesnot, S | 1 |
| Hamard, H | 1 |
| Hodge, W | 1 |
| Saheb, N | 1 |
| Balazsi, G | 1 |
| Kasner, O | 1 |
| Watanabe, J | 1 |
| Iwata, K | 1 |
| Sawaguchi, S | 1 |
| Nanba, K | 1 |
| Patitsas, C | 1 |
| Rockwood, EJ | 1 |
| Meisler, DM | 1 |
| McMahon, JT | 1 |
| Krug, JH | 1 |
| Melamed, S | 1 |
| Cohen, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Combined Phacotrabeculectomy and Trabeculectomy Only in the Treatment of Primary Angle-closure Glaucoma[NCT01298635] | 31 participants (Actual) | Interventional | 2005-01-31 | Completed | |||
| Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489] | Phase 4 | 70 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 trials available for fluorouracil and Glaucoma, Angle Closure
| Article | Year |
|---|---|
The Singapore 5-fluorouracil trial: intraocular pressure outcomes at 8 years.
Topics: Antihypertensive Agents; Antimetabolites; Combined Modality Therapy; Double-Blind Method; Fluorourac | 2013 |
The singapore 5-Fluorouracil trabeculectomy study: effects on intraocular pressure control and disease progression at 3 years.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Disease Progression; Double | 2009 |
Central corneal thickness and glaucoma in East Asian people.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alkylating Agents; Asian People; Case-Control Studies; Cornea | 2011 |
Cataract surgery after trabeculectomy: the effect on trabeculectomy function.
Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Female; Fluorouracil; Follow-Up Studies; Glaucoma | 2012 |
Intraocular pressure and visual field loss in primary angle closure and primary open angle glaucomas.
Topics: Antimetabolites; Cross-Sectional Studies; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma, O | 2003 |
A prospective trial of intraoperative fluorouracil during trabeculectomy in a black population.
Topics: Adult; Aged; Aged, 80 and over; Black People; Female; Fluorouracil; Follow-Up Studies; Ghana; Glauco | 1993 |
Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas.
Topics: Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Female; Fluorouracil; Glaucoma, Angle-Closure; | 1996 |
Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas.
Topics: Administration, Topical; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Angle-C | 1997 |
Indocyanine green anterior segment angiography for studying conjunctival vascular changes after trabeculectomy.
Topics: Adult; Aged; Anterior Eye Segment; Capillary Permeability; Conjunctiva; Female; Fluorescein Angiogra | 2001 |
13 other studies available for fluorouracil and Glaucoma, Angle Closure
| Article | Year |
|---|---|
Iridocorneal endothelial syndrome.
Topics: Adult; Fluorouracil; Glaucoma; Glaucoma, Angle-Closure; Gonioscopy; Humans; Intraocular Pressure; Ir | 2014 |
The prognostic value of the wuerzburg bleb classification score for the outcome of trabeculectomy.
Topics: Antimetabolites; Blister; Combined Modality Therapy; Conjunctiva; Female; Fluorouracil; Follow-Up St | 2011 |
Postoperative complications after glaucoma surgery for primary angle-closure glaucoma vs primary open-angle glaucoma.
Topics: Aged; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Gonioscopy; Humans; Incid | 2011 |
Failure of intracameral fluorouracil to resolve an epithelial ingrowth following clear corneal cataract surgery.
Topics: Antimetabolites; Cataract Extraction; Corneal Diseases; Epithelium, Corneal; Fluorouracil; Glaucoma, | 2007 |
The effects of intraoperative mitomycin-C or 5-fluorouracil on glaucoma filtering surgery.
Topics: Adult; Aged; Animals; Filtering Surgery; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma, Open-Angle | 1994 |
[5-fluorouracil injection treatment after fistulating glaucoma operations].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Combined Modality Therapy; Female; Fluorouracil; | 1993 |
Malignant glaucoma.
Topics: Anterior Chamber; Chronic Disease; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Angle-Closure; | 1999 |
[Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps].
Topics: Adult; Aged; Antimetabolites; Blister; Combined Modality Therapy; Conjunctival Diseases; Female; Flu | 2001 |
Treatment of encapsulated blebs with 30-gauge needling and injection of low-dose 5-fluorouracil.
Topics: Adult; Aged; Conjunctival Diseases; Cysts; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma, | 1992 |
Trabeculectomy with 5-fluorouracil.
Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Fluorouracil; Follow-Up Studies; Glaucoma, Angle | 1991 |
Infectious crystalline keratopathy occurring in an eye subsequent to glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil.
Topics: Chronic Disease; Eye Infections, Bacterial; Female; Fluorouracil; Glaucoma, Angle-Closure; Humans; K | 1991 |
Adjunctive use of delayed and adjustable low-dose 5-fluorouracil in refractory glaucoma.
Topics: Adolescent; Adult; Aged; Conjunctiva; Dose-Response Relationship, Drug; Drug Administration Schedule | 1990 |
Combined cataract implant and filtering surgery with 5-fluorouracil.
Topics: Aged; Cataract Extraction; Contrast Sensitivity; Female; Fluorouracil; Glaucoma, Angle-Closure; Glau | 1990 |