fluorouracil has been researched along with Gestational Trophoblastic Disease in 14 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Gestational Trophoblastic Disease: A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome." | 7.78 | Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D. ( Manopunya, M; Suprasert, P, 2012) |
| "This case involved a 33-year-old female suffering from gestational trophoblastic neoplasia and 5-fluorouracil + actinomycin-D chemotherapy." | 4.95 | Early pregnancy following multidrug regimen chemotherapy in a gestational trophoblastic neoplasia patient: A case report. ( Gong, FQ; Niu, G; Shen, HW; Yang, J; Yuan, LJ; Zhu, CX, 2017) |
| "The study aimed to compare the efficacy of methotrexate (MTX) cervical injections + actinomycin-D (ACT-D)(MACT) and 5-fluorouracil (5-Fu) + actinomycin-D (5-Fu plus ACT-D) chemotherapy regimens for low-risk gestational trophoblastic neoplasia (LR-GTN)." | 3.83 | Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia. ( Duan, W; Kong, WM; Miao, JW; Su, L; Wang, T; Wang, Y; Wu, YM, 2016) |
| "A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome." | 3.78 | Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D. ( Manopunya, M; Suprasert, P, 2012) |
| " To determine the plasma dihydrouracil/uracil ratio (DUUR) as a potential index for setting 5-FU/FUDR doses, the authors conducted a prospective study on the relationships of the DUUR with 5-FU/FUDR pharmacokinetic and pharmacodynamic parameters." | 2.71 | Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics. ( Hu, P; Jiang, H; Jiang, J; Lu, J, 2004) |
| "Among them, 3 patients with bladder metastasis received intravesical chemotherapy of fluorouracil." | 1.40 | [Analysis of the treatment and prognosis for gestational trophoblastic neoplasia patients with urinary system and adrenal glands metastasis]. ( Feng, F; Ren, T; Wan, X; Wang, D; Xiang, Y; Yang, J, 2014) |
| "To evaluate the efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm (GTN) patients, and investigate factors influencing the outcome of the surgery combined with chemotherapy." | 1.35 | [Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm]. ( Cao, Y; Feng, FZ; Li, L; Wan, XR; Xiang, Y; Yang, XY, 2008) |
| "Medical records of 62 patients with gestational trophoblastic neoplasia who underwent pulmonary lobectomy or limited resection were reviewed." | 1.35 | Surgical resection in the management of pulmonary metastatic disease of gestational trophoblastic neoplasia. ( Cao, Y; Feng, F; Wan, X; Xiang, Y; Yang, X, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Chen, D | 1 |
| Yu, H | 1 |
| Xia, R | 1 |
| Zhang, X | 1 |
| Zheng, W | 1 |
| Niu, G | 1 |
| Yuan, LJ | 1 |
| Gong, FQ | 1 |
| Yang, J | 3 |
| Zhu, CX | 1 |
| Shen, HW | 1 |
| Ren, T | 1 |
| Wang, D | 1 |
| Feng, F | 2 |
| Wan, X | 3 |
| Xiang, Y | 7 |
| Peng, M | 1 |
| Ding, Y | 1 |
| Yu, L | 1 |
| Deng, Y | 1 |
| Lai, W | 1 |
| Hu, Y | 1 |
| Zhang, H | 1 |
| Wu, X | 1 |
| Fan, H | 1 |
| Ding, H | 1 |
| Wu, Y | 1 |
| Tao, G | 1 |
| Wang, Y | 2 |
| Miao, JW | 1 |
| Wang, T | 1 |
| Wu, YM | 1 |
| Kong, WM | 1 |
| Su, L | 1 |
| Duan, W | 1 |
| Feng, FZ | 2 |
| Cao, Y | 2 |
| Li, L | 1 |
| Wan, XR | 4 |
| Yang, XY | 4 |
| Yang, X | 2 |
| Geng, S | 1 |
| Zhou, Y | 1 |
| Manopunya, M | 1 |
| Suprasert, P | 1 |
| Jiang, H | 1 |
| Lu, J | 1 |
| Jiang, J | 1 |
| Hu, P | 1 |
| Yang, JJ | 2 |
| Li, JG | 1 |
1 review available for fluorouracil and Gestational Trophoblastic Disease
| Article | Year |
|---|---|
Early pregnancy following multidrug regimen chemotherapy in a gestational trophoblastic neoplasia patient: A case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin; Dactinomycin; Dose-Re | 2017 |
1 trial available for fluorouracil and Gestational Trophoblastic Disease
| Article | Year |
|---|---|
Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Antimetabolites, Antineoplastic; Chorionic Gonadotropin; Female; Floxuridine; Fluorouracil; G | 2004 |
12 other studies available for fluorouracil and Gestational Trophoblastic Disease
| Article | Year |
|---|---|
The efficacy evaluation of initial chemotherapy for high-risk gestational trophoblastic neoplasm.
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Gestational Trophoblastic Dise | 2022 |
[Analysis of the treatment and prognosis for gestational trophoblastic neoplasia patients with urinary system and adrenal glands metastasis].
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Antineoplastic Combined Chemotherapy Protocols; China; Fema | 2014 |
Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Female; Fluorouracil; Gestation | 2015 |
Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Female; Fluorouracil; Gestation | 2016 |
[Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human; | 2008 |
Surgical resection in the management of pulmonary metastatic disease of gestational trophoblastic neoplasia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dactinomycin; Drug | 2009 |
[Analysis of prophylactic chemotherapy outcome and clinical characteristics in patients of high-risk hydatidiform mole].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human; | 2011 |
Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Dactinomycin; Female; Fluorou | 2012 |
[The necessity of attaching importance to canonical treatment of gestationcal trophoblastic tumors].
Topics: Antineoplastic Agents; Cyclophosphamide; Diagnosis, Differential; Drug Resistance, Neoplasm; Female; | 2005 |
Recurrent gestational trophoblastic tumor: management and risk factors for recurrence.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human; | 2006 |
[Management and prognosis in stage IV gestational trophoblastic neoplasia patients].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dactinomycin; Fema | 2006 |
[Outcome of gestational trophoblastic neoplasia patients with residual lung tumor after completion of treatment].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human; | 2007 |