fluorouracil has been researched along with Gastroesophageal Reflux in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obesity is a risk factor for the development of esophageal malignancy." | 1.37 | Esophageal adenocarcinoma after laparoscopic gastric band placement for obesity. ( Mathew, J; Odell, JA; Stauffer, JA, 2011) |
| "Columnar-lined or Barrett's esophagus is a premalignant condition." | 1.29 | Is chemotherapy associated with development of Barrett's esophagus? ( Kleibeuker, JH; Peters, FT; Sleijfer, DT; van Imhoff, GW, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, B | 1 |
| Ji, SQ | 1 |
| Hua, YW | 1 |
| Liu, YQ | 1 |
| Stauffer, JA | 1 |
| Mathew, J | 1 |
| Odell, JA | 1 |
| Peters, FT | 1 |
| Sleijfer, DT | 1 |
| van Imhoff, GW | 1 |
| Kleibeuker, JH | 1 |
| Peracchia, A | 1 |
| Bonavina, L | 1 |
| Via, A | 1 |
| Incarbone, R | 1 |
4 other studies available for fluorouracil and Gastroesophageal Reflux
| Article | Year |
|---|---|
[Application of jejunal interposition after radical proximal gastrectomy].
Topics: Aged; Anastomosis, Surgical; Antineoplastic Combined Chemotherapy Protocols; C-Reactive Protein; Che | 2013 |
Esophageal adenocarcinoma after laparoscopic gastric band placement for obesity.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bariatric Surgery; Deglutition | 2011 |
Is chemotherapy associated with development of Barrett's esophagus?
Topics: Adult; Antineoplastic Agents; Barrett Esophagus; Breast Neoplasms; Cisplatin; Drug Therapy, Combinat | 1993 |
Current trends in the surgical treatment of esophageal and cardia adenocarcinoma.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Barrett Esophagus; Cardia; Chemother | 1999 |