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fluorouracil and Gastroduodenal Ulcer

fluorouracil has been researched along with Gastroduodenal Ulcer in 8 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"The prognosis of patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is extremely poor."2.70Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases. ( Ando, E; Fukumori, K; Kuromatsu, R; Okuda, K; Sata, M; Sumie, S; Tanaka, M; Yamashita, F; Yano, Y; Yutani, S, 2002)
"Omeprazole was significantly more effective than placebo and misoprostol in reducing the frequency and degree of the endoscopic worsening, either after CMF or after 5-FU (P < 0."2.68Misoprostol and omeprazole in the prevention of chemotherapy-induced acute gastroduodenal mucosal injury. A randomized, placebo-controlled pilot study. ( Abbasciano, V; Nielsen, I; Sartori, S; Tassinari, D; Trevisani, L, 1996)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ando, E1
Tanaka, M1
Yamashita, F1
Kuromatsu, R1
Yutani, S1
Fukumori, K1
Sumie, S1
Yano, Y1
Okuda, K1
Sata, M1
ROTH, JL1
Maruyama, S1
Bright-Asare, P1
Whiten, JT1
Sartori, S1
Trevisani, L1
Nielsen, I1
Tassinari, D1
Abbasciano, V1
Takao, T1
Nishida, M1
Maeda, Y1
Takao, K1
Oka, M1
Jewell, LD1
Fields, AL1
Murray, CJ1
Thomson, AB1
Lapsa, RKh1

Reviews

1 review available for fluorouracil and Gastroduodenal Ulcer

ArticleYear
[Complications of hepatic artery chemotherapy for liver metastases in colorectal cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arterial Occlusive Diseases; Cholangitis, Sclerosing

2003

Trials

2 trials available for fluorouracil and Gastroduodenal Ulcer

ArticleYear
Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases.
    Cancer, 2002, Aug-01, Volume: 95, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Female;

2002
Misoprostol and omeprazole in the prevention of chemotherapy-induced acute gastroduodenal mucosal injury. A randomized, placebo-controlled pilot study.
    Cancer, 1996, Oct-01, Volume: 78, Issue:7

    Topics: Adult; Aged; Anti-Ulcer Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; F

1996

Other Studies

5 other studies available for fluorouracil and Gastroduodenal Ulcer

ArticleYear
ROLE OF DRUGS IN PRODUCTION OF GASTRODUODENAL ULCER.
    JAMA, 1964, Feb-08, Volume: 187

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aspirin; Caffeine; Cats; Fluorouracil; Histami

1964
Prostaglandins, gastroduodenal ulcer and hemorrhagic gastritis.
    Clinical physiology and biochemistry, 1984, Volume: 2, Issue:2-3

    Topics: Animals; Cimetidine; Dogs; Double-Blind Method; Female; Fluorouracil; Gastritis; Gastrointestinal He

1984
[The study of continuous infusion chemotherapy with low-dose cisplatin and 5-fluorouracil for patients with primary liver cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cholangiocarcinoma;

1997
Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy.
    The American journal of gastroenterology, 1985, Volume: 80, Issue:6

    Topics: Adenocarcinoma; Aluminum; Cimetidine; Colonic Neoplasms; Fluorouracil; Gastric Mucosa; Humans; Infus

1985
[The reactivity of the RES in cancer of the gastrointestinal tract and during treatment with fluorofur].
    Voprosy onkologii, 1972, Volume: 18, Issue:12

    Topics: Achlorhydria; Adult; Aged; Colonic Neoplasms; Esophageal Neoplasms; Female; Fluorouracil; Furans; Go

1972