fluorouracil has been researched along with Gastric Diseases in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " immediately after each dosing of 5-FU significantly reversed the delay in healing by 5-FU, and this effect was attenuated by the chemical ablation of capsaicin-sensitive afferent neurons." | 1.35 | Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons. ( Amagase, K; Hayashi, S; Komatsu, Y; Kotani, T; Murashima, Y; Nakagiri, A; Takeuchi, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Monma, S | 1 |
| Kato, K | 1 |
| Shouji, H | 1 |
| Okita, N | 1 |
| Takashima, A | 1 |
| Honma, Y | 1 |
| Iwasa, S | 1 |
| Hamaguchi, T | 1 |
| Yamada, Y | 1 |
| Shimada, Y | 1 |
| Boku, N | 1 |
| Nagashima, K | 1 |
| Ito, Y | 1 |
| Itami, J | 1 |
| Murashima, Y | 1 |
| Kotani, T | 1 |
| Hayashi, S | 1 |
| Komatsu, Y | 1 |
| Nakagiri, A | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 1 |
| Liaw, CC | 1 |
| Huang, JS | 1 |
| Wang, HM | 1 |
| Wang, CH | 1 |
| Itano, S | 1 |
| Hirai, K | 1 |
| Yoshida, T | 1 |
| Kajiwara, M | 1 |
| Ijuin, H | 1 |
| Ban, S | 1 |
| Sakata, K | 1 |
| Ono, N | 1 |
| Noguchi, H | 1 |
| Sakai, T | 1 |
| Yakabi, K | 1 |
| Nakamura, T | 1 |
| Gasparian, SA | 1 |
| Alimov, AT | 1 |
1 review available for fluorouracil and Gastric Diseases
| Article | Year |
|---|---|
[Acute gastroduodenal mucosal lesion].
Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Duode | 1998 |
5 other studies available for fluorouracil and Gastric Diseases
| Article | Year |
|---|---|
Gastric mucosal injury and hemorrhage after definitive chemoradiotherapy for locally advanced esophageal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 2019 |
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.
Topics: Acetamides; Animals; Antimetabolites, Antineoplastic; Capsaicin; Cell Line; Cell Movement; Cell Prol | 2009 |
Spontaneous gastroduodenal perforation in patients with cancer receiving chemotherapy and steroids. Report of four cases combining 5-fluorouracil infusion and cisplatin with antiemetics dexamethasone.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dexamethasone; Duodenal Dise | 1993 |
[Complication of gastro-duodenum with intra-hepatic arterial infusion chemotherapy using implantable reservoir system for hepatic tumors].
Topics: Carcinoma, Hepatocellular; Cisplatin; Drug Administration Schedule; Duodenal Diseases; Female; Fluor | 1993 |
[Tolerance of the stomach wall to antineoplastic preparations].
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Dogs; Fluorouracil; Melphalan; Stomach Diseases; | 1969 |