fluorouracil has been researched along with Fibrosarcoma in 53 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the inhibitory effect of 5-fluorouracil (5-Fu) on HT-1080 human fibrosarcoma cells in vitro." | 7.78 | [Inhibitory effect of 5-fluorouracil on HT-1080 human fibrosarcoma cells in vitro]. ( Ding, Y; Liu, HW; Niu, XH; Wang, Q; Xu, HR; Zhang, Q, 2012) |
| "Combined application of cyclophosphamide, methotrexate, 5-fluorouracil (CMF) has been followed in the treatment of breast cancer." | 7.71 | Dual role of vitamin C on lipid profile and combined application of cyclophosphamide, methotrexate and 5-fluorouracil treatment in fibrosarcoma-bearing rats. ( Amalan Stanley, V; Muralikrishnan, G; Sadasivan Pillai, K, 2001) |
| "The aim of this study was to evaluate the ability of noninvasive 1H magnetic resonance spectroscopic imaging to detect the response of radiation-induced fibrosarcoma 1 tumors to treatment with 5-fluorouracil (5-FU)." | 7.70 | Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. ( Aboagye, EO; Bhujwalla, ZM; Glickson, JD; Shungu, DC, 1998) |
| "An 18-month-old cross-bred Fjord pony colt presenting a fibrosarcoma of the prepuce with severe infiltrative growth, was treated by topical application of 5-fluorouracil." | 7.70 | Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report). ( De Kruif, A; Ducatelle, R; Roels, S; van De Vijver, B, 1998) |
| "Meth-A fibrosarcoma was subcutaneously inoculated into the backs of syngeneic BALB/c mice." | 5.28 | Comparative effects of a recombinant and a mutein type of granulocyte colony stimulating factor on the growth of Meth-A fibrosarcoma with 5-fluorouracil chemotherapy. ( Fukumoto, M; Kawabata, K; Masai, Y; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M, 1992) |
| "The effects of 5-fluorouracil (5FU, 150 mg/kg, ip) on subcutaneously implanted radiation-induced fibrosarcoma (RIF-1) tumors were monitored by in vivo (1)H MRI to evaluate the water apparent diffusion coefficient (ADC), by single-quantum (SQ) and triple-quantum-filtered (TQF) (23)Na MRI to evaluate compartmental Na(+) content and by positron emission tomography (PET) to evaluate 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) uptake in the tumor." | 3.74 | Monitoring chemotherapeutic response in RIF-1 tumors by single-quantum and triple-quantum-filtered (23)Na MRI, (1)H diffusion-weighted MRI and PET imaging. ( Babsky, AM; Bansal, N; Hekmatyar, SK; Hutchins, GD; Zhang, H, 2007) |
| "The methanolic extract of roots of Streptocaulon juventas, having shown strong antiproliferative activity against the highly metastatic human HT-1080 fibrosarcoma cell line, was subjected to activity-guided isolation to yield 16 cardenolides including five new ones, acovenosigenin A 3-O-beta-digitoxopyranoside (1), digitoxigenin gentiobioside (2), digitoxigenin 3-O-[O-beta-glucopyranosyl-(1-->6)-O-beta-glucopyranosyl-(1-->4)-3-O-acetyl-beta-digitoxopyranoside] (3), digitoxigenin 3-O-[O-beta-glucopyranosyl-(1-->6)-O-beta-glucopyranosyl-(1-->4)-O-beta-digitalopyranosyl-(1-->4)-beta-cymaropyranoside] (4), and periplogenin 3-O-(4-O-beta-glucopyranosyl-beta-digitalopyranoside) (5), and two new hemiterpenoids, (4R)-4-hydroxy-3-isopropylpentyl beta-rutinoside (6) and (R)-2-ethyl-3-methylbutyl beta-rutinoside (7), together with two known phenylpropanoids and a known phenylethanoid." | 3.72 | Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the human HT-1080 fibrosarcoma cell line. ( Banskota, AH; Kadota, S; Saiki, I; Tezuka, Y; Tran, QK; Tran, QL; Ueda, JY, 2003) |
| "Combined application of cyclophosphamide, methotrexate, 5-fluorouracil (CMF) has been followed in the treatment of breast cancer." | 3.71 | Dual role of vitamin C on lipid profile and combined application of cyclophosphamide, methotrexate and 5-fluorouracil treatment in fibrosarcoma-bearing rats. ( Amalan Stanley, V; Muralikrishnan, G; Sadasivan Pillai, K, 2001) |
| "The aim of this study was to evaluate the ability of noninvasive 1H magnetic resonance spectroscopic imaging to detect the response of radiation-induced fibrosarcoma 1 tumors to treatment with 5-fluorouracil (5-FU)." | 3.70 | Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. ( Aboagye, EO; Bhujwalla, ZM; Glickson, JD; Shungu, DC, 1998) |
| "An 18-month-old cross-bred Fjord pony colt presenting a fibrosarcoma of the prepuce with severe infiltrative growth, was treated by topical application of 5-fluorouracil." | 3.70 | Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report). ( De Kruif, A; Ducatelle, R; Roels, S; van De Vijver, B, 1998) |
| "The ability of cis-platinum, 5-fluorouracil, and methotrexate to leach out from various types of bone cements was examined in three different experimental systems: (1) in vitro release in physiological solution; (2) in vitro release in the presence of mouse fibrosarcoma cells; and (3) in vivo release in rabbits." | 3.68 | The release of cytotoxic drugs from acrylic bone cement. ( Arad-Yelin, R; Dekel, S; Mazur, Y; Salama, R; Warshawsky, A; Wasserlauf, S, 1993) |
| "19F Magnetic resonance spectroscopy was used to study the impact of the biochemical modulator thymidine (TdR) on the 5-fluorouracil (5FU) metabolism in the livers and radiation-induced fibrosarcoma (RIF-1) tumors of 5FU-treated C3H mice." | 3.68 | Thymidine-modulated 5-fluorouracil metabolism in liver and RIF-1 tumors studied by 19F magnetic resonance spectroscopy. ( Ng, TC; Sijens, PE, 1992) |
| "Implantable collagen-poly(HEMA) hydrogels containing the anticancer drug 5-fluorouracil (5-FU) have been prepared and evaluated for their efficacy towards a solid tumour fibrosarcoma in Wistar rats." | 3.68 | Solid tumour chemotherapy using implantable collagen-poly (HEMA) hydrogel containing 5-fluorouracil. ( Jeyanthi, R; Nagarajan, B; Rao, KP, 1991) |
| "The antitumor effects of recombinant human tumor necrosis factor-alpha (rTNF-alpha) and 5-fluorouracil (5-FU) in combination treatment were examined on Meth A fibrosarcoma implanted intradermally in mice." | 3.68 | The efficacy of combined treatment with recombinant human tumor necrosis factor-alpha and 5-fluorouracil is dependent on the development of capillaries in tumor. ( Manda, T; Masuda, K; Mukumoto, S; Nakamura, T; Nishigaki, F; Shimomura, K, 1990) |
| "HCl], and decaprenoic acid-with anticancer agents were studied in male ICR mice with ascites sarcoma 180 (S180) and in male BALB/c mice with fibrosarcoma Meth A." | 3.67 | Potentiation of anticancer agents by new synthetic isoprenoids. II. Inhibition of the growth of transplantable murine tumors. ( Akiyama, S; Fukawa, H; Ikezaki, K; Kishiye, T; Komiyama, S; Koyama, H; Kuwano, M; Tahara, Y; Takahasi, T; Yamaguchi, T, 1984) |
| "Mice treated with 5-fluorouracil (130 mg/kg) received, 48 h later, a repeat dose of FDG." | 1.31 | Metabolites of 2'-fluoro-2'-deoxy-D-glucose detected by 19F magnetic resonance spectroscopy in vivo predict response of murine RIF-1 tumors to 5-fluorouracil. ( Griffiths, JR; Judson, IR; Leach, MO; McSheehy, PM, 2000) |
| "IL-1 protected against the acute reaction produced by fractionated irradiation in the lip mucosa, shifting the dose-response curve by 3." | 1.29 | Interleukin-1 modulatory effect on the action of chemotherapeutic drugs and localized irradiation of the lip, duodenum, and tumor. ( Dorie, MJ; Kallman, RF; Zaghloul, MS, 1993) |
| "Meth-A fibrosarcoma was subcutaneously inoculated into the backs of syngeneic BALB/c mice." | 1.28 | Comparative effects of a recombinant and a mutein type of granulocyte colony stimulating factor on the growth of Meth-A fibrosarcoma with 5-fluorouracil chemotherapy. ( Fukumoto, M; Kawabata, K; Masai, Y; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M, 1992) |
| " By considering these pharmacokinetic behaviors, a suitable method of administration should be established." | 1.27 | [Chemical modification of anticancer agents from viewpoints of their pharmacokinetics]. ( Fujita, H, 1984) |
| "In combination with chemotherapy [ftorafur (FT)], allogeneic lymphoid cells were transferred to inhibit the growth of a 3-methylcholanthrene-induced transplantable KMT-17 fibrosarcoma in Wistar-King-Aptekman/Hok rats." | 1.26 | Effect of normal allogeneic lymphoid cell transfer in combination with chemotherapy on a transplantable tumor in rats. ( Akiyama, J; Gotohda, E; Hosokawa, M; Kawamura, T; Kobayashi, H; Kodama, T; Yamada, Y, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (22.64) | 18.7374 |
| 1990's | 24 (45.28) | 18.2507 |
| 2000's | 13 (24.53) | 29.6817 |
| 2010's | 4 (7.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tezuka, Y | 4 |
| Gewali, MB | 1 |
| Ali, MS | 1 |
| Banskota, AH | 4 |
| Kadota, S | 4 |
| Tran, QL | 2 |
| Tran, QK | 2 |
| Saiki, I | 2 |
| Usia, T | 1 |
| Kouda, K | 1 |
| Nguyen, NT | 1 |
| Ueda, JY | 1 |
| Mohammad, O | 1 |
| Faisal, SM | 1 |
| Ahmad, N | 1 |
| Rauf, MA | 1 |
| Umar, MS | 1 |
| Mujeeb, AA | 1 |
| Pachauri, P | 1 |
| Ahmed, A | 1 |
| Kashif, M | 1 |
| Ajmal, M | 1 |
| Zubair, S | 1 |
| Wang, J | 1 |
| Fan, Y | 1 |
| An, JY | 1 |
| Li, NN | 1 |
| Geng, Q | 1 |
| Fu, L | 1 |
| Tang, B | 1 |
| Testa, JR | 1 |
| Kruger, WD | 1 |
| Liu, HW | 1 |
| Niu, XH | 1 |
| Xu, HR | 1 |
| Zhang, Q | 1 |
| Ding, Y | 1 |
| Wang, Q | 1 |
| Fei, XF | 1 |
| Wang, BX | 1 |
| Li, TJ | 1 |
| Tashiro, S | 1 |
| Minami, M | 1 |
| Xing, DJ | 1 |
| Ikejima, T | 1 |
| Collingridge, DR | 1 |
| Glaser, M | 1 |
| Osman, S | 1 |
| Barthel, H | 1 |
| Hutchinson, OC | 1 |
| Luthra, SK | 1 |
| Brady, F | 1 |
| Bouchier-Hayes, L | 1 |
| Martin, SJ | 1 |
| Workman, P | 1 |
| Price, P | 2 |
| Aboagye, EO | 3 |
| Sakamoto, K | 1 |
| Sugimoto, Y | 1 |
| Miyadera, K | 1 |
| Oka, T | 1 |
| Fukushima, M | 1 |
| Yau, K | 1 |
| Pillai, RG | 1 |
| Aboagye, E | 1 |
| Simpson, GR | 1 |
| Han, Z | 1 |
| Liu, B | 1 |
| Wang, Y | 1 |
| Campbell, G | 1 |
| Coffin, RS | 1 |
| Babsky, AM | 1 |
| Zhang, H | 1 |
| Hekmatyar, SK | 1 |
| Hutchins, GD | 1 |
| Bansal, N | 1 |
| Yamaguchi, T | 1 |
| Ikezaki, K | 1 |
| Kishiye, T | 1 |
| Tahara, Y | 1 |
| Koyama, H | 1 |
| Takahasi, T | 1 |
| Fukawa, H | 1 |
| Komiyama, S | 1 |
| Akiyama, S | 1 |
| Kuwano, M | 1 |
| Fujita, H | 1 |
| Yasunaga, T | 1 |
| Ohgaki, K | 1 |
| Inamoto, T | 1 |
| Kan, N | 1 |
| Hikasa, Y | 1 |
| Gotohda, E | 2 |
| Kawamura, T | 2 |
| Yamada, Y | 2 |
| Hosokawa, M | 2 |
| Kodama, T | 2 |
| Kobayashi, H | 2 |
| Akiyama, J | 1 |
| Storme, G | 1 |
| Mareel, MM | 1 |
| Tannock, IF | 1 |
| Yu, NY | 1 |
| Orenberg, EK | 1 |
| Luck, EE | 1 |
| Brown, DM | 1 |
| Itoh, H | 1 |
| Ito, H | 1 |
| Amano, H | 1 |
| Noda, H | 1 |
| Wasserlauf, S | 1 |
| Warshawsky, A | 1 |
| Arad-Yelin, R | 1 |
| Mazur, Y | 1 |
| Salama, R | 1 |
| Dekel, S | 1 |
| Zaghloul, MS | 1 |
| Dorie, MJ | 1 |
| Kallman, RF | 1 |
| Hamuro, J | 1 |
| Kikuchi, T | 1 |
| Takatsuki, F | 1 |
| Suzuki, M | 2 |
| Dachs, GU | 1 |
| Patterson, AV | 1 |
| Firth, JD | 1 |
| Ratcliffe, PJ | 1 |
| Townsend, KM | 1 |
| Stratford, IJ | 1 |
| Harris, AL | 1 |
| Tsuchida, E | 1 |
| Urano, M | 1 |
| Bhujwalla, ZM | 2 |
| Shungu, DC | 2 |
| Glickson, JD | 2 |
| McSheehy, PM | 2 |
| Robinson, SP | 1 |
| Ojugo, AS | 1 |
| Cannell, MB | 1 |
| Leach, MO | 2 |
| Judson, IR | 2 |
| Griffiths, JR | 2 |
| Roels, S | 1 |
| Ducatelle, R | 1 |
| van De Vijver, B | 1 |
| De Kruif, A | 1 |
| Muralikrishnan, G | 1 |
| Amalan Stanley, V | 1 |
| Sadasivan Pillai, K | 1 |
| Davies, MM | 1 |
| Burke, D | 1 |
| Carnochan, P | 1 |
| Glover, C | 1 |
| Kaur, S | 1 |
| Allen-Mersh, TG | 1 |
| Nio, Y | 2 |
| Shiraishi, T | 2 |
| Tsubono, M | 2 |
| Morimoto, H | 2 |
| Tseng, CC | 2 |
| Kawabata, K | 2 |
| Masai, Y | 1 |
| Fukumoto, M | 2 |
| Tobe, T | 2 |
| Sijens, PE | 3 |
| Ng, TC | 3 |
| Li, SJ | 1 |
| Rose, LM | 1 |
| Wehrle, JP | 1 |
| Nomoto, K | 2 |
| Yokokura, T | 1 |
| Ebina, T | 1 |
| Murata, K | 1 |
| Jeyanthi, R | 1 |
| Nagarajan, B | 1 |
| Rao, KP | 1 |
| Ning, SC | 1 |
| Hahn, GM | 1 |
| Akamatsu, K | 1 |
| Endo, K | 1 |
| Tsunenari, T | 1 |
| Matsumoto, T | 2 |
| Kaiho, S | 1 |
| Morikawa, K | 1 |
| Koizumi, M | 1 |
| Mitsui, H | 1 |
| Koizumi, K | 1 |
| Baldwin, NJ | 2 |
| Guerquin-Kern, JL | 1 |
| Leteurtre, F | 1 |
| Croisy, A | 1 |
| Lhoste, JM | 1 |
| Huang, YM | 1 |
| Imai, S | 1 |
| Ouchi, T | 1 |
| Banba, T | 1 |
| Suzuki, S | 1 |
| Manda, T | 1 |
| Nishigaki, F | 1 |
| Mukumoto, S | 1 |
| Masuda, K | 1 |
| Nakamura, T | 1 |
| Shimomura, K | 1 |
| Teicher, BA | 1 |
| McIntosh-Lowe, NL | 1 |
| Rose, CM | 1 |
| Komiyama, K | 1 |
| Hirokawa, Y | 1 |
| Zhibo, Y | 1 |
| Umezawa, I | 1 |
| Hata, T | 1 |
| Costanzi, JJ | 1 |
| Coltman, CA | 1 |
| Yron, I | 1 |
| Weiss, DW | 1 |
| Robinson, E | 1 |
| Cohen, D | 1 |
| Adelberg, MG | 1 |
| Mekori, T | 1 |
| Haber, M | 1 |
| Klein, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1B Study of Intralesional Injection of RP1 in Patients With Resectable Cutaneous SCC[NCT05858229] | Phase 1/Phase 2 | 12 participants (Anticipated) | Interventional | 2023-06-16 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
53 other studies available for fluorouracil and Fibrosarcoma
| Article | Year |
|---|---|
Eleven novel diarylheptanoids and two unusual diarylheptanoid derivatives from the seeds of Alpinia blepharocalyx.
Topics: Animals; Antineoplastic Agents; China; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fibrosar | 2001 |
New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Doxorubicin; Fibrosarcoma; Humans; Li | 2001 |
Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Cell Survival; Colonic Neoplasms | 2002 |
Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the human HT-1080 fibrosarcoma cell line.
Topics: Cardenolides; Drug Screening Assays, Antitumor; Esterification; Fibrosarcoma; Humans; Hydrolysis; Mo | 2003 |
Bio-mediated synthesis of 5-FU based nanoparticles employing orange fruit juice: a novel drug delivery system to treat skin fibrosarcoma in model animals.
Topics: Animals; Antineoplastic Agents; Apoptosis; Calorimetry, Differential Scanning; Caspase 9; Citrus sin | 2019 |
[Clinicopathologic characteristics of primary breast leiomyosarcoma: report of a case].
Topics: Actins; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Calcium-Binding Pro | 2013 |
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
Topics: Adenosine; Animals; Cell Line; Cell Line, Tumor; Disease Models, Animal; Fibrosarcoma; Fluorouracil; | 2012 |
[Inhibitory effect of 5-fluorouracil on HT-1080 human fibrosarcoma cells in vitro].
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Cell Cycle; Cell Line, Tumor; Cell Pro | 2012 |
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; b | 2003 |
In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope.
Topics: Animals; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; Deoxyadenosines; Enzyme Inhibitors; | 2003 |
[Preparation of anti-OPRT antibody for immunochemical detection].
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Fibrosarcoma; Fluorouracil; Humans; Immunoblot | 2005 |
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors.
Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Ne | 2006 |
Combination of a fusogenic glycoprotein, prodrug activation, and oncolytic herpes simplex virus for enhanced local tumor control.
Topics: Animals; Biotransformation; Cell Fusion; Combined Modality Therapy; Cytosine Deaminase; Fibrosarcoma | 2006 |
Monitoring chemotherapeutic response in RIF-1 tumors by single-quantum and triple-quantum-filtered (23)Na MRI, (1)H diffusion-weighted MRI and PET imaging.
Topics: Animals; Antineoplastic Agents; Diffusion Magnetic Resonance Imaging; Drug Monitoring; Fibrosarcoma; | 2007 |
Potentiation of anticancer agents by new synthetic isoprenoids. II. Inhibition of the growth of transplantable murine tumors.
Topics: Animals; Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Evaluation, Preclinical; Drug Synergism | 1984 |
[Chemical modification of anticancer agents from viewpoints of their pharmacokinetics].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Doxorubicin; Fibrosarcoma; | 1984 |
Protective effect of vitamin E against immunosuppression induced by adriamycin, mitomycin C and 5-fluorouracil in mice.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Fibrosarcoma; Fluorouracil; Immunity, Cellular; I | 1983 |
Therapeutic effect dependent on timing of combination treatment with chemotherapy and allogeneic lymphoid cell transfer in rats.
Topics: Animals; Cell Transformation, Neoplastic; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; | 1980 |
Effect of normal allogeneic lymphoid cell transfer in combination with chemotherapy on a transplantable tumor in rats.
Topics: Animals; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Immunotherapy; Lym | 1980 |
Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro.
Topics: Animals; Benzimidazoles; Carbamates; Chick Embryo; Fibrosarcoma; Fluorouracil; Mice; Microtubules; M | 1981 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte | 1980 |
Antitumor effect of intratumoral administration of fluorouracil/epinephrine injectable gel in C3H mice.
Topics: Animals; Cell Survival; Delayed-Action Preparations; Drug Carriers; Epinephrine; Female; Fibrosarcom | 1995 |
Inhibitory action of a (1-->6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Meth A fibrosarcoma-bearing mice and its antitumor mechanism.
Topics: Agaricus; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Synergism; Erythrocytes; Fema | 1994 |
The release of cytotoxic drugs from acrylic bone cement.
Topics: Animals; Antineoplastic Agents; Bone Cements; Buffers; Cisplatin; Diffusion; Fibrosarcoma; Fluoroura | 1993 |
Interleukin-1 modulatory effect on the action of chemotherapeutic drugs and localized irradiation of the lip, duodenum, and tumor.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Duodenum; Female; Fibrosarcoma; Fluorou | 1993 |
Cancer cell progression and chemoimmunotherapy--dual effects in the induction of resistance to therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Avian Sarcoma Viruses; Combined Modality Th | 1996 |
Targeting gene expression to hypoxic tumor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Hypoxia; Cytosine Deaminase; DNA-Binding Proteins; Fi | 1997 |
The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality The | 1997 |
Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Fibrosarcoma; Fluorouracil; Humans; Lac | 1998 |
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
Topics: Animals; Biological Transport; Carbon Dioxide; Fibrosarcoma; Fluorouracil; Hydrogen-Ion Concentratio | 1998 |
Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report).
Topics: Animals; Antimetabolites, Antineoplastic; Fibrosarcoma; Fluorouracil; Horse Diseases; Horses; Ki-67 | 1998 |
Metabolites of 2'-fluoro-2'-deoxy-D-glucose detected by 19F magnetic resonance spectroscopy in vivo predict response of murine RIF-1 tumors to 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Extracts; Fibrosarcoma; Fluorodeoxyglucose F18; Fluor | 2000 |
Dual role of vitamin C on lipid profile and combined application of cyclophosphamide, methotrexate and 5-fluorouracil treatment in fibrosarcoma-bearing rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Breast Neoplasms; Cholestero | 2001 |
Basic fibroblast growth factor infusion increases tumour vascularity, blood flow and chemotherapy uptake.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Blood Flow Velocity; Fibroblast Growth Fac | 2002 |
Comparative effects of a recombinant and a mutein type of granulocyte colony stimulating factor on the growth of Meth-A fibrosarcoma with 5-fluorouracil chemotherapy.
Topics: Amino Acid Sequence; Animals; Combined Modality Therapy; Drug Synergism; Fibrosarcoma; Fluorouracil; | 1992 |
Thymidine-modulated 5-fluorouracil metabolism in liver and RIF-1 tumors studied by 19F magnetic resonance spectroscopy.
Topics: Animals; Cell Line; Female; Fibrosarcoma; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Mice | 1992 |
Determination of absolute phosphate metabolite concentrations in RIF-1 tumors in vivo by 31P-1H-2H NMR spectroscopy using water as an internal intensity reference.
Topics: Animals; Body Water; Chromatography, High Pressure Liquid; Fibrosarcoma; Fluorouracil; Magnetic Reso | 1992 |
Prevention of 5-fluorouracil-induced infection with indigenous Escherichia coli in tumor-bearing mice by nonspecific immunostimulation.
Topics: Animals; Bacterial Vaccines; Escherichia coli Infections; Fibrosarcoma; Fluorouracil; Lacticaseibaci | 1992 |
Antitumor effect of PSK at a distant site: tumor-specific immunity and combination with other chemotherapeutic agents.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols | 1992 |
Solid tumour chemotherapy using implantable collagen-poly (HEMA) hydrogel containing 5-fluorouracil.
Topics: Animals; Collagen; Drug Implants; Female; Fibrosarcoma; Fluorouracil; Hydrogel, Polyethylene Glycol | 1991 |
Combination therapy: lonidamine, hyperthermia, and chemotherapy against the RIF-1 tumor in vivo.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Combined Modality Therapy; Fibrosarcoma; Fluo | 1991 |
[Combination therapy of a new platinum complex, DWA2114R with various antitumor agents against mouse tumors in vivo].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Doxorubicin; | 1992 |
Multinuclear MR investigation of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy.
Topics: Animals; beta-Alanine; Female; Fibrosarcoma; Fluorine; Fluorouracil; Magnetic Resonance Spectroscopy | 1991 |
pH dependence of 5-fluorouracil uptake observed by in vivo 31P and 19F nuclear magnetic resonance spectroscopy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta-Alanine; Fibrosarcoma; Fluorine; Fluorouracil; Hydro | 1991 |
19F magnetic resonance spectroscopy studies of the metabolism of 5-fluorouracil in murine RIF-1 tumors and liver.
Topics: Animals; Female; Fibrosarcoma; Fluorouracil; Hydrogen-Ion Concentration; Liver; Magnetic Resonance S | 1991 |
Low uracil concentration in the liver might be responsible for the decreased antineoplastic activity of fluoropyrimidines in mice with CCl4-induced chronic liver dysfunction.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Resistance; Fi | 1991 |
Synthesis and antitumor activity of conjugates of 5-fluorouracil and chito-oligosaccharides involving a hexamethylene spacer group and carbamoyl bonds.
Topics: Animals; Antineoplastic Agents; Body Weight; Drug Carriers; Female; Fibrosarcoma; Fluorouracil; Inje | 1990 |
The efficacy of combined treatment with recombinant human tumor necrosis factor-alpha and 5-fluorouracil is dependent on the development of capillaries in tumor.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fibrosarcoma; Fluorouracil; Mice; M | 1990 |
Effect of various oxygenation conditions and fluosol-DA on cancer chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Bleomycin; Breast Neoplasms; Carbon Dioxide; Cyclophosphamide; Dose- | 1988 |
[Potentiation of chemotherapeutic activity by a Chinese herb medicine juzen-taiho-toh].
Topics: Animals; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Synergism; Drugs, Chinese Herbal; Female; Fi | 1988 |
Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors.
Topics: Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fibrosarcoma; Fluorouraci | 1969 |
Immunotherapeutic studies in mice with the methanol-extraction residue (mer) fraction of BCG: solid tumors.
Topics: Animals; Antigens, Bacterial; BCG Vaccine; Benzopyrenes; Cyclophosphamide; Female; Fibrosarcoma; Flu | 1973 |
Local chemotherapy of cutaneous neoplasms.
Topics: Adenocarcinoma; Allergy and Immunology; Antineoplastic Agents; Carcinoma, Squamous Cell; Dactinomyci | 1970 |