fluorouracil has been researched along with Fibroma, Shope in 35 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ulcers were mostly singular and measured 0." | 5.28 | Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions. ( Helmkamp, BF; Krebs, HB, 1991) |
| "Sixty-two females and 21 males were treated for recurrent HPV infection, with either fluorouracil (Efudex 5%) cream or laser ablation of the lesions." | 5.08 | Interferon as an adjuvant treatment for genital condyloma acuminatum. ( Bergman, A; Klutke, JJ, 1995) |
| "The authors established a protocol for the use of 5-fluorouracil (5FU) adjuvant in lasertherapy for clinical and subclinical HPV infection in immunosuppressed patients, persistent lesions and as reinforcement treatment in cases of poor progress." | 3.72 | Low-dose 5-fluorouracil adjuvant in laser therapy for HPV lesions in immunosuppressed patients and cases of difficult control. ( Costa, RR; Focchi, J; Freitas, VG; Kesselring, F; Ribalta, JC; Speck, NM, 2004) |
| "Four chemotherapeutic agents (cyclophosphamide, 5-fluorouracil (5-FU), methotrexate (MTX), and bleomycin) were given intravenously to rats harboring the avian sarcoma virus-induced glioma." | 3.67 | Chemotherapeutic agent permeability to normal brain and delivery to avian sarcoma virus-induced brain tumors in the rodent: observations on problems of drug delivery. ( Barnett, PA; Frenkel, EP; Neuwelt, EA, 1984) |
| "The treatment of genital warts remains frustrating since it is often painful, expensive, and unsuccessful." | 2.39 | Human papillomavirus infection and genital warts: update on epidemiology and treatment. ( Stone, KM, 1995) |
| "The ulcers were mostly singular and measured 0." | 1.28 | Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions. ( Helmkamp, BF; Krebs, HB, 1991) |
| "To date a 51% recurrence rate has been observed in the over-all population and a 50% recurrence rate was noted in the 20-month followup population." | 1.28 | Long-term followup of subclinical human papillomavirus infection treated with the carbon dioxide laser and intraurethral 5-fluorouracil: a treatment protocol. ( Carpiniello, VL; Malloy, TR; Schoenberg, M, 1990) |
| " During the final 2 years, the protocol incorporated two different 5-fluorouracil (5-FU) regimens: routine once-weekly applications as prophylaxis against postoperative recurrence, and twice-weekly dosing to avoid further laser surgery among patients with early but diffuse failures." | 1.28 | Superficial laser vulvectomy. IV. Extended laser vaporization and adjunctive 5-fluorouracil therapy of human papillomavirus-associated vulvar disease. ( Daoud, Y; Greenberg, MD; Lörincz, AT; Pizzuti, D; Reid, R; Stoler, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (31.43) | 18.7374 |
| 1990's | 22 (62.86) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Speck, NM | 1 |
| Ribalta, JC | 1 |
| Focchi, J | 1 |
| Costa, RR | 1 |
| Kesselring, F | 1 |
| Freitas, VG | 1 |
| Neuwelt, EA | 1 |
| Barnett, PA | 1 |
| Frenkel, EP | 1 |
| Santelli, G | 1 |
| Valeriote, F | 1 |
| Seidel, HJ | 1 |
| Kreja, L | 1 |
| Niccoli, V | 1 |
| Serrao, L | 1 |
| Stone, KM | 1 |
| Dungar, CF | 1 |
| Wilkinson, EJ | 1 |
| Klutke, JJ | 1 |
| Bergman, A | 1 |
| Smotkin, D | 1 |
| Davila, GW | 1 |
| Shroyer, KR | 1 |
| Kotoulas, IG | 1 |
| Cardamakis, E | 1 |
| Relakis, K | 1 |
| Diamantis, A | 1 |
| Papathanasiou, Z | 1 |
| Korantzis, A | 1 |
| Mantouvalos, C | 1 |
| Stefanon, B | 1 |
| Pallucca, A | 1 |
| Merola, M | 1 |
| Bandieramonte, G | 1 |
| Beutner, KR | 1 |
| Ferenczy, A | 1 |
| Holmes, MM | 1 |
| Weaver, SH | 1 |
| Vermillion, ST | 1 |
| Lakatosh, VP | 1 |
| Syed, TA | 1 |
| Qureshi, ZA | 1 |
| Ahmad, SA | 1 |
| Ali, SM | 1 |
| Brodman, M | 1 |
| Dottino, P | 1 |
| Friedman, F | 1 |
| Heller, D | 1 |
| Bleiweiss, I | 1 |
| Sperling, R | 1 |
| Kling, AR | 1 |
| Reid, R | 3 |
| Greenberg, MD | 2 |
| Pizzuti, DJ | 2 |
| Omoto, KH | 1 |
| Rutledge, LH | 1 |
| Soo, W | 1 |
| Krebs, HB | 5 |
| Helmkamp, BF | 1 |
| Van Le, L | 1 |
| Greenberg, M | 1 |
| Goldfarb, MT | 1 |
| Gupta, AK | 1 |
| Gupta, MA | 1 |
| Sawchuk, WS | 1 |
| Epperson, WJ | 1 |
| Carpiniello, VL | 1 |
| Schoenberg, M | 1 |
| Malloy, TR | 1 |
| Odom, LD | 1 |
| Plouffe, L | 1 |
| Butler, WJ | 1 |
| Lörincz, AT | 1 |
| Daoud, Y | 1 |
| Pizzuti, D | 1 |
| Stoler, M | 1 |
| Anderson, FE | 1 |
| Davis, AJ | 1 |
| Emans, SJ | 1 |
| Rosemberg, SK | 2 |
| Sillman, FH | 1 |
| Sedlis, A | 1 |
| Schneider, V | 1 |
| Hurt, WG | 1 |
| Goplerud, DR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons[NCT02437851] | Phase 2 | 16 participants (Actual) | Interventional | 2015-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for fluorouracil and Fibroma, Shope
| Article | Year |
|---|---|
[Human papillomavirus infections in pregnancy].
Topics: Adolescent; Adult; Cryosurgery; Electrocoagulation; Female; Fluorouracil; Humans; Interferons; Laser | 1994 |
Human papillomavirus infection and genital warts: update on epidemiology and treatment.
Topics: Condylomata Acuminata; Cryotherapy; Female; Fluorouracil; Humans; Interferons; Laser Therapy; Male; | 1995 |
Human papillomavirus infection of the vagina.
Topics: Acetates; Acetic Acid; Biopsy; Colposcopy; Cryosurgery; Diagnosis, Differential; DNA, Viral; Electro | 1993 |
Therapeutic approaches to genital warts.
Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites; Antiviral Agents; Condylomata Acuminata; C | 1997 |
Genital warts--therapy.
Topics: Condylomata Acuminata; Cryosurgery; Female; Fluorouracil; Humans; Laser Therapy; Male; Papillomaviri | 1992 |
Warts. Fact and fiction.
Topics: Antiviral Agents; Bleomycin; Cryosurgery; Fluorouracil; Formaldehyde; Humans; Interferons; Papilloma | 1985 |
Human papilloma virus infection in the pediatric and adolescent patient.
Topics: Adolescent; Child; Child, Preschool; Female; Fluorouracil; Humans; Infant; Infant, Newborn; Interfer | 1989 |
Anogenital papillomavirus infection and neoplasia in immunodeficient women.
Topics: Acquired Immunodeficiency Syndrome; Combined Modality Therapy; Female; Fluorouracil; Genital Neoplas | 1987 |
7 trials available for fluorouracil and Fibroma, Shope
| Article | Year |
|---|---|
Interferon as an adjuvant treatment for genital condyloma acuminatum.
Topics: Adolescent; Adult; Combined Modality Therapy; Condylomata Acuminata; Female; Fluorouracil; Genital N | 1995 |
Treatment with 5-fluorouracil of 35 patients with clinical or subclinical HPV infection of the vagina.
Topics: Administration, Topical; Adult; Antimetabolites, Antineoplastic; Female; Fluorouracil; Follow-Up Stu | 1996 |
A randomized, double-blind, placebo-controlled trial of 5-fluorouracil for the treatment of cervicovaginal human papillomavirus.
Topics: Administration, Intravaginal; Adolescent; Adult; Antimetabolites, Antineoplastic; Double-Blind Metho | 1999 |
[The treatment of benign processes of the cervix uteri associated with papillomavirus infection in women who have not given birth].
Topics: Adolescent; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Fluorouracil; Glycerol; Huma | 1999 |
Management of intravaginal warts in women with 5-fluorouracil (1%) in vaginal hydrophilic gel: a placebo-controlled double-blind study.
Topics: Administration, Intravaginal; Adolescent; Adult; Antimetabolites; Double-Blind Method; Female; Fluor | 2000 |
Superficial laser vulvectomy. V. Surgical debulking is enhanced by adjuvant systemic interferon.
Topics: Administration, Topical; Condylomata Acuminata; Female; Fluorouracil; Humans; Interferons; Laser The | 1992 |
Prophylactic topical 5-fluorouracil following treatment of human papillomavirus-associated lesions of the vulva and vagina.
Topics: Administration, Intravaginal; Administration, Topical; Carcinoma in Situ; Combined Modality Therapy; | 1986 |
20 other studies available for fluorouracil and Fibroma, Shope
| Article | Year |
|---|---|
Low-dose 5-fluorouracil adjuvant in laser therapy for HPV lesions in immunosuppressed patients and cases of difficult control.
Topics: Administration, Intravaginal; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Combined Mod | 2004 |
Chemotherapeutic agent permeability to normal brain and delivery to avian sarcoma virus-induced brain tumors in the rodent: observations on problems of drug delivery.
Topics: Animals; Antineoplastic Agents; Avian Sarcoma Viruses; Bleomycin; Blood-Brain Barrier; Brain; Brain | 1984 |
In vivo potentiation of 5-fluorouracil cytotoxicity against AKR leukemia by purines, pyrimidines, and their nucleosides and deoxynucleosides.
Topics: AKR murine leukemia virus; Animals; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; | 1980 |
Hematopoietic stem cells in Friend murine leukemia virus-infected mice undergoing chemotherapy: effects of 5-FU.
Topics: Animals; Cell Division; Erythropoiesis; Fluorouracil; Friend murine leukemia virus; Hematopoietic St | 1982 |
Vaginal columnar cell metaplasia. An acquired adenosis associated with topical 5-fluorouracil therapy.
Topics: Adult; Epithelial Cells; Epithelium; Female; Fluorouracil; Humans; Metaplasia; Middle Aged; Papillom | 1995 |
Topical 5-fluorouracil in the treatment of cervical human papillomavirus infection.
Topics: Administration, Topical; Adult; Biopsy; DNA, Viral; Female; Fluorouracil; Humans; In Situ Hybridizat | 1996 |
Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. IV. Urethral reservoir.
Topics: Adolescent; Adult; Carcinoma in Situ; Condylomata Acuminata; Endothelium; Female; Fluorouracil; Huma | 1996 |
Human papillomavirus-associated lesions of the vagina and cervix. Treatment with a laser and topical 5-fluorouracil.
Topics: Administration, Topical; Biopsy; Clinical Protocols; Combined Modality Therapy; DNA; Female; Fluorou | 1992 |
Treatment of genital condylomata with topical 5-fluorouracil.
Topics: Administration, Topical; Anus Neoplasms; Combined Modality Therapy; Condylomata Acuminata; Female; F | 1991 |
Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions.
Topics: Administration, Intravaginal; Adolescent; Adult; Aged; Cervix Uteri; Chronic Disease; Female; Fluoro | 1991 |
Accidental use of low-dose 5-fluorouracil in pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Adolescent; Adult; Female; Fluorouracil; | 1991 |
Office therapy for human papillomavirus infection in nongenital sites.
Topics: Bleomycin; Cantharidin; Caustics; Cryosurgery; Fluorouracil; Formaldehyde; Glutaral; Humans; Immunot | 1991 |
Androscopy for anogenital HPV.
Topics: Acetates; Acetic Acid; Adult; Anus Neoplasms; Cryosurgery; Female; Fluorouracil; Genital Neoplasms, | 1991 |
Long-term followup of subclinical human papillomavirus infection treated with the carbon dioxide laser and intraurethral 5-fluorouracil: a treatment protocol.
Topics: Combined Modality Therapy; Fluorouracil; Humans; Laser Therapy; Male; Papillomaviridae; Penile Disea | 1990 |
5-fluorouracil exposure during the period of conception: report on two cases.
Topics: Administration, Intravaginal; Adult; Female; Fertilization; Fluorouracil; Humans; Infant, Newborn; P | 1990 |
Superficial laser vulvectomy. IV. Extended laser vaporization and adjunctive 5-fluorouracil therapy of human papillomavirus-associated vulvar disease.
Topics: Cohort Studies; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Human | 1990 |
Sexually transmitted papillomaviral infections: V. Prophylactic use of topical 5-fluorouracil in refractory infection in the male.
Topics: Administration, Topical; Drug Evaluation; Fluorouracil; Follow-Up Studies; Humans; Male; Papillomavi | 1989 |
Sexually transmitted papillomaviral infections: III. Management of male partner.
Topics: Adolescent; Adult; Combined Modality Therapy; Electrocoagulation; Female; Fluorouracil; Follow-Up St | 1988 |
Management of human papillomavirus-associated genital lesions in men.
Topics: Adolescent; Adult; Combined Modality Therapy; Condylomata Acuminata; Cryosurgery; Fluorouracil; Geni | 1989 |
Genital condylomas in immunosuppressed women: a therapeutic challenge.
Topics: Adult; Antineoplastic Agents; Combined Modality Therapy; Condylomata Acuminata; Female; Fluorouracil | 1986 |