fluorouracil has been researched along with Fetal Death in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No case of epidermoid (squamous cell) cancer of the colon has been previously described in a pregnant woman." | 2.42 | [Colon cancer in pregnancy]. ( Fermeaux, V; Mathonnet, M, 2003) |
| "The combination of low-toxic doses of X-irradiation and 5-FU had a synergistic toxic effect in nonmalignant mouse fetuses in vivo." | 1.31 | Effects of 5-fluorouracil on cell cycle arrest and toxicity induced by X-irradiation in normal mammalian cells. ( Cekan, E; Jonasson, GB; Lewin, F; Nylén, U; Skog, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mathonnet, M | 1 |
| Fermeaux, V | 1 |
| Miccolis, N | 1 |
| Nylén, U | 1 |
| Cekan, E | 1 |
| Jonasson, GB | 1 |
| Lewin, F | 1 |
| Skog, S | 1 |
| Forsthoefel, PF | 1 |
| Williams, ML | 1 |
| Wilson, JG | 1 |
| Lauro, V | 1 |
| Fanelli, A | 1 |
| Dominici, C | 1 |
2 reviews available for fluorouracil and Fetal Death
| Article | Year |
|---|---|
[Colon cancer in pregnancy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cesarean Section; C | 2003 |
Abnormalities of intrauterine development in non-human primates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic | 1972 |
5 other studies available for fluorouracil and Fetal Death
| Article | Year |
|---|---|
5-fluorouracil.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Drug Interactions; Female; Fetal Death; Fluorou | 1981 |
[Effects of immunosuppressive drugs on the fetal-placental unit].
Topics: Animals; Body Weight; Female; Fetal Death; Fetal Resorption; Fluorouracil; Immunosuppressive Agents; | 1980 |
Effects of 5-fluorouracil on cell cycle arrest and toxicity induced by X-irradiation in normal mammalian cells.
Topics: Animals; Cell Cycle; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Embryo | 2001 |
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Deat | 1975 |
[Experimental findings on the effects of administration of fluorouracil in pregnancy. II. Treatment of mice and rabbits with FU].
Topics: Abortion, Spontaneous; Animals; Female; Fetal Death; Fetus; Fluorouracil; Mice; Pregnancy; Pregnancy | 1970 |