fluorouracil has been researched along with Female Genital Diseases in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new intralesional sustained-release chemotherapy is under development as a treatment for condylomata acuminata; it is administered as an injectable gel that consists of fluorouracil and epinephrine with a purified bovine collagen as the gellant (fluorouracil/epinephrine gel)." | 9.08 | Intralesional fluorouracil/epinephrine injectable gel for treatment of condylomata acuminata. A phase 3 clinical study. ( Gordon, S; Korey, A; Kraus, S; McCarty, JM; Orenberg, EK; Phillips, S; Skinner, R; Sperling, M; Swinehart, JM; Webster, GF, 1997) |
| "A new intralesional sustained-release chemotherapy is under development as a treatment for condylomata acuminata; it is administered as an injectable gel that consists of fluorouracil and epinephrine with a purified bovine collagen as the gellant (fluorouracil/epinephrine gel)." | 5.08 | Intralesional fluorouracil/epinephrine injectable gel for treatment of condylomata acuminata. A phase 3 clinical study. ( Gordon, S; Korey, A; Kraus, S; McCarty, JM; Orenberg, EK; Phillips, S; Skinner, R; Sperling, M; Swinehart, JM; Webster, GF, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bakardzhiev, I | 1 |
| Kovachev, E | 1 |
| Pall, A | 1 |
| Mahajan, BB | 1 |
| Puri, KP | 1 |
| Gupta, RR | 1 |
| Oriel, JD | 1 |
| Hatch, KD | 1 |
| Husseinzadeh, N | 1 |
| Guoth, JG | 1 |
| Jayawardena, DS | 1 |
| Swinehart, JM | 1 |
| Sperling, M | 1 |
| Phillips, S | 1 |
| Kraus, S | 1 |
| Gordon, S | 1 |
| McCarty, JM | 1 |
| Webster, GF | 1 |
| Skinner, R | 1 |
| Korey, A | 1 |
| Orenberg, EK | 1 |
| Van Le, L | 1 |
| Pizzuti, DJ | 1 |
| Greenberg, M | 1 |
| Reid, R | 1 |
| Thomas, L | 1 |
| Thivolet, J | 1 |
| Weed, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trichloroacetic Acid Versus Cantharone for the Treatment of Perenial Warts[NCT03625960] | Phase 4 | 12 participants (Actual) | Interventional | 2006-06-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and Female Genital Diseases
| Article | Year |
|---|---|
[Comparative assessment of the methods of treatment of Condylomata acuminata].
Topics: Alphapapillomavirus; Aminoquinolines; Antimetabolites; Caustics; Condylomata Acuminata; Cryotherapy; | 2011 |
Clinical appearance and treatment strategies for human papillomavirus: a gynecologic perspective.
Topics: Condylomata Acuminata; Female; Fluorouracil; Genital Diseases, Female; Humans; Interferons; Laser Th | 1995 |
[Treatment of genital warts and condyloma].
Topics: Antiviral Agents; Bleomycin; Condylomata Acuminata; Cryosurgery; Dinitrofluorobenzene; Electrocoagul | 1988 |
2 trials available for fluorouracil and Female Genital Diseases
| Article | Year |
|---|---|
Therapeutic evaluation of intralesional 5% 5-fluorouracil in condyloma acuminata.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Condylomata Acuminata; Female; Fluorouraci | 2004 |
Intralesional fluorouracil/epinephrine injectable gel for treatment of condylomata acuminata. A phase 3 clinical study.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Condylomata Acuminata; Double-Blind Method | 1997 |
4 other studies available for fluorouracil and Female Genital Diseases
| Article | Year |
|---|---|
Genital warts-recent advances.
Topics: Female; Fluorouracil; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Podophyllin; W | 1982 |
Subclinical cervicovaginal human papillomavirus infections associated with cervical condylomata and dysplasia. Treatment outcomes.
Topics: Adolescent; Adult; Condylomata Acuminata; Female; Fluorouracil; Genital Diseases, Female; Humans; La | 1994 |
Accidental use of low-dose 5-fluorouracil in pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Adolescent; Adult; Female; Fluorouracil; | 1991 |
Office gynecology.
Topics: Adult; Alcohols; Behcet Syndrome; Candidiasis, Vulvovaginal; Colposcopy; Condylomata Acuminata; Cryo | 1972 |