Page last updated: 2024-10-27

fluorouracil and Fecal Incontinence

fluorouracil has been researched along with Fecal Incontinence in 14 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Fecal Incontinence: Failure of voluntary control of the anal sphincters, with involuntary passage of feces and flatus.

Research Excerpts

ExcerptRelevanceReference
"Fecal incontinence was high after sphincter preservation."3.11Quality of life in a randomized trial comparing two neoadjuvant regimens for locally advanced rectal cancer-INCAGI004. ( Araujo, RO; Ferreira, CG; Guaraldi, S; Linhares, E; Martins, I; Thuler, LC; Torres, C; Valadão, M; Victorino, AP; Vieira, FM, 2022)
"Consecutive patients with distal rectal cancer undergoing neoadjuvant chemoradiation (50."2.82Impact of Organ-Preserving Strategies on Anorectal Function in Patients with Distal Rectal Cancer Following Neoadjuvant Chemoradiation. ( Fernandez, LM; Gama-Rodrigues, J; Habr-Gama, A; Jorge, JM; Lynn, PB; Perez, RO; Proscurshim, I; São Julião, GP, 2016)
"Patients (N = 207) with nonresectable rectal cancer were randomized to preoperative CRT or RT (2 Gy × 25 ± 5-fluorouracil/leucovorin)."2.76Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized Phase III study. ( Berglund, Å; Bruheim, K; Brændengen, M; Cvancarova, M; Glimelius, B; Tveit, KM, 2011)
"Celecoxib dosage was fixed."2.75A phase I study of capecitabine, irinotecan, celecoxib, and radiation as neoadjuvant therapy of patients with locally advanced rectal cancer. ( Alqaisi, M; Bernal, P; Bush, D; Byrd, J; Garberoglio, C; Hussein, F; Malik, I, 2010)
" CPT-11 (50 mg/m(2) weekly) and 5-FU (225 mg/m(2)/day continuous infusion, 5 days/week) were concurrently administered with radiation therapy (RT) (45 Gy, 1."2.72A Phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer. ( Aranda, E; Cervantes, A; Dotor, E; Gallén, M; García, JL; Navarro, M; Rivera, F; Sánchez-Rovira, P; Vega-Villegas, ME, 2006)
"Treatment of rectal cancer over the last two decades has evolved with changes in techniques of surgery and radiation based on national and international trials."2.44Total mesorectal excision and management of rectal cancer. ( Phang, PT; Pinsk, I, 2007)
"Fecal incontinence was assessed by patient self-reported data without the use of a validated score."1.39Cumulative incidence of permanent stoma after sphincter preserving low anterior resection of mid and low rectal cancer. ( Buchner, S; Dinnewitzer, A; Jäger, T; Nawara, C; Öfner, D; Wolfgang, H, 2013)
"Intersphincteric resection of low rectal tumors is a surgical technique extending rectal resection into the intersphincteric space."1.33Technique and long-term results of intersphincteric resection for low rectal cancer. ( Feil, W; Hölbling, N; Holzer, B; Novi, G; Renner, K; Rosen, HR; Schiessel, R; Urban, M, 2005)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (42.86)29.6817
2010's7 (50.00)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Araujo, RO1
Vieira, FM1
Victorino, AP1
Torres, C1
Martins, I1
Guaraldi, S1
Valadão, M1
Linhares, E1
Ferreira, CG1
Thuler, LC1
Dinnewitzer, A1
Jäger, T1
Nawara, C1
Buchner, S1
Wolfgang, H1
Öfner, D1
Ihn, MH1
Kang, SB1
Kim, DW1
Oh, HK1
Lee, SY1
Hong, SM1
Habr-Gama, A1
Lynn, PB1
Jorge, JM1
São Julião, GP1
Proscurshim, I1
Gama-Rodrigues, J1
Fernandez, LM1
Perez, RO1
Joseph, K1
Vos, LJ1
Warkentin, H1
Paulson, K1
Polkosnik, LA1
Usmani, N1
Tankel, K1
Severin, D1
Nijjar, T1
Schiller, D1
Wong, C1
Ghosh, S1
Mulder, K1
Field, C1
Canda, AE1
Terzi, C1
Gorken, IB1
Oztop, I1
Sokmen, S1
Fuzun, M1
Malik, I1
Hussein, F1
Bush, D1
Alqaisi, M1
Bernal, P1
Byrd, J1
Garberoglio, C1
Brændengen, M1
Tveit, KM1
Bruheim, K1
Cvancarova, M1
Berglund, Å1
Glimelius, B1
Schiessel, R1
Novi, G1
Holzer, B1
Rosen, HR1
Renner, K1
Hölbling, N1
Feil, W1
Urban, M1
Theisen, J1
Kauer, WK1
Nekarda, H1
Schmid, L1
Stein, HJ1
Siewert, JR1
Navarro, M1
Dotor, E1
Rivera, F1
Sánchez-Rovira, P1
Vega-Villegas, ME1
Cervantes, A1
García, JL1
Gallén, M1
Aranda, E1
Urso, E1
Serpentini, S1
Pucciarelli, S1
De Salvo, GL1
Friso, ML1
Fabris, G1
Lonardi, S1
Ferraro, B1
Bruttocao, A1
Aschele, C1
Nitti, D1
Pinsk, I1
Phang, PT1
Vordermark, D1
Flentje, M1
Sailer, M1
Kölbl, O1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Estudo Randomizado de Fase II Com Capecitabina Versus 5-Fluorouracil/Leucovorin em Bolus Associados à Radioterapia no Tratamento Neoadjuvante de câncer de Reto Localmente avançado: INCAGI004.[NCT03428529]Phase 2/Phase 363 participants (Actual)Interventional2011-01-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Fecal Incontinence

ArticleYear
Total mesorectal excision and management of rectal cancer.
    Expert review of anticancer therapy, 2007, Volume: 7, Issue:10

    Topics: Adenocarcinoma; Anastomosis, Surgical; Antineoplastic Agents; Combined Modality Therapy; Disease Man

2007

Trials

8 trials available for fluorouracil and Fecal Incontinence

ArticleYear
Quality of life in a randomized trial comparing two neoadjuvant regimens for locally advanced rectal cancer-INCAGI004.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherapy; Fecal Incontinence;

2022
Impact of Organ-Preserving Strategies on Anorectal Function in Patients with Distal Rectal Cancer Following Neoadjuvant Chemoradiation.
    Diseases of the colon and rectum, 2016, Volume: 59, Issue:4

    Topics: Adenocarcinoma; Aged; Anal Canal; Antimetabolites, Antineoplastic; Chemoradiotherapy; Fecal Incontin

2016
Patient reported quality of life after helical IMRT based concurrent chemoradiation of locally advanced anal cancer.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, Volume: 120, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carc

2016
A phase I study of capecitabine, irinotecan, celecoxib, and radiation as neoadjuvant therapy of patients with locally advanced rectal cancer.
    American journal of clinical oncology, 2010, Volume: 33, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitab

2010
Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized Phase III study.
    International journal of radiation oncology, biology, physics, 2011, Nov-15, Volume: 81, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chemoradiotherapy; Diagnostic

2011
A Phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer.
    International journal of radiation oncology, biology, physics, 2006, Sep-01, Volume: 66, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Combined Modality Therapy

2006
Complications, functional outcome and quality of life after intensive preoperative chemoradiotherapy for rectal cancer.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2006, Volume: 32, Issue:10

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera

2006
Intracavitary afterloading boost in anal canal carcinoma. Results, function and quality of life.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2001, Volume: 177, Issue:5

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Brachythera

2001

Other Studies

5 other studies available for fluorouracil and Fecal Incontinence

ArticleYear
Cumulative incidence of permanent stoma after sphincter preserving low anterior resection of mid and low rectal cancer.
    Diseases of the colon and rectum, 2013, Volume: 56, Issue:10

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anal Canal; Anastomosis, Surgical; Anastomotic Leak;

2013
Risk factors for bowel dysfunction after sphincter-preserving rectal cancer surgery: a prospective study using the Memorial Sloan Kettering Cancer Center bowel function instrument.
    Diseases of the colon and rectum, 2014, Volume: 57, Issue:8

    Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab

2014
Effects of preoperative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patients.
    International journal of colorectal disease, 2010, Volume: 25, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anal Canal; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant;

2010
Technique and long-term results of intersphincteric resection for low rectal cancer.
    Diseases of the colon and rectum, 2005, Volume: 48, Issue:10

    Topics: Adenocarcinoma; Adenoma, Villous; Aged; Anal Canal; Antineoplastic Combined Chemotherapy Protocols;

2005
Neoadjuvant radiochemotherapy for patients with locally advanced rectal cancer leads to impairment of the anal sphincter.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006, Volume: 10, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anal Canal; Antimetabolites, Antineoplastic; Antineoplastic Agents;

2006