fluorouracil has been researched along with Fanconi Anemia in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Fanconi Anemia: Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a new independent cohort of 191 breast cancer patients treated with adjuvant 5-fluorouracil, epirubicin, and cyclophosphamide, a positive assay result predicted 5-year relapse-free survival with a hazard ratio of 0." | 3.80 | Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer. ( Boyle, D; Bylesjo, M; Couch, FJ; Davison, TS; Deharo, S; Hill, LA; Irwin, G; James, CR; James, J; Johnston, PG; Keating, KE; Kennedy, RD; Kerr, P; Lindor, NM; McDyer, FA; Mullan, PB; Mulligan, JM; O'Brien, E; Paul Harkin, D; Proutski, V; Quinn, JE; Raji, OY; Salto-Tellez, M; Walker, SM, 2014) |
| " However, the optimal dosage of chemoradiotherapy and the treatment strategy for esophageal cancer in patients with Fanconi anemia remain unclear, and outcomes are generally extremely poor." | 1.36 | Successful treatment of esophageal squamous cell carcinoma in a patient with Fanconi anemia. ( Hirashima, Y; Hosoya, Y; Jinbu, Y; Lefor, A; Muroi, K; Nakazawa, M; Nokubi, M; Yamaguti, T; Yasuda, Y, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voter, AF | 1 |
| Manthei, KA | 1 |
| Keck, JL | 1 |
| Mulligan, JM | 1 |
| Hill, LA | 1 |
| Deharo, S | 1 |
| Irwin, G | 1 |
| Boyle, D | 1 |
| Keating, KE | 1 |
| Raji, OY | 1 |
| McDyer, FA | 1 |
| O'Brien, E | 1 |
| Bylesjo, M | 1 |
| Quinn, JE | 1 |
| Lindor, NM | 1 |
| Mullan, PB | 1 |
| James, CR | 1 |
| Walker, SM | 1 |
| Kerr, P | 1 |
| James, J | 1 |
| Davison, TS | 1 |
| Proutski, V | 1 |
| Salto-Tellez, M | 1 |
| Johnston, PG | 1 |
| Couch, FJ | 1 |
| Paul Harkin, D | 1 |
| Kennedy, RD | 1 |
| Du, W | 1 |
| Amarachintha, S | 1 |
| Erden, O | 1 |
| Wilson, A | 1 |
| Meetei, AR | 1 |
| Andreassen, PR | 1 |
| Namekawa, SH | 1 |
| Pang, Q | 1 |
| Hosoya, Y | 1 |
| Lefor, A | 1 |
| Hirashima, Y | 1 |
| Nokubi, M | 1 |
| Yamaguti, T | 1 |
| Jinbu, Y | 1 |
| Muroi, K | 1 |
| Nakazawa, M | 1 |
| Yasuda, Y | 1 |
4 other studies available for fluorouracil and Fanconi Anemia
| Article | Year |
|---|---|
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
Topics: Antineoplastic Agents; DNA Damage; DNA Helicases; DNA Repair; Drug Screening Assays, Antitumor; Fanc | 2016 |
Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer.
Topics: Adult; Aged; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemo | 2014 |
Fancb deficiency impairs hematopoietic stem cell function.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cell P | 2015 |
Successful treatment of esophageal squamous cell carcinoma in a patient with Fanconi anemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow Transplantation; Carcinom | 2010 |