fluorouracil and Facial Neoplasms studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

Excerpt	Relevance	Reference
"An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead."	7.69	Myocardial ischemia induced by topical use of 5-fluorouracil. ( Gotsman, MS; Gurewich, J; Rozenman, Y, 1995)
"to evaluate the feasibility, tolerance/toxicity and therapeutic efficacy of 5-fluorouracil (5-FU) by topical application and systemic use, in facial carcinoma associated with XP."	3.73	[Topical and systemic chemotherapy with 5-fluouracil in facial carcinoma secondary to xeroderma pigmentosum]. ( Boussen, H; Boussen, I; Ferjaoui, M; Gritli, S; Khader, A; Ladgham, A; Nouira, R; Oueslati, Z, 2005)
"An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead."	3.69	Myocardial ischemia induced by topical use of 5-fluorouracil. ( Gotsman, MS; Gurewich, J; Rozenman, Y, 1995)
"The increased incidence of skin cancer and its possible cause is briefly discussed and the role of immunobiologic factors in the development of squamous cell carcinomas is mentioned."	1.26	Squamous cell carcinoma. Case report of an unusually aggressive skin cancer. ( Biro, L; Price, E, 1979)

Research

Studies (41)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Hazard Ratio for Surgically Treated KC

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (63.41)	18.7374
1990's	4 (9.76)	18.2507
2000's	4 (9.76)	29.6817
2010's	6 (14.63)	24.3611
2020's	1 (2.44)	2.80

Authors	Studies
Means, AD	1
Leader, NF	1
Siegel, JA	1
Arron, ST	1
Walker, JL	1
Pomerantz, H	2
Beatson, M	1
Weinstock, MA	2
Schulze Schwering, M	1
Schwering, MS	1
Chagaluka, G	1
Molyneux, E	1
Chen, YY	1
Sheen, YT	1
Lin, CP	1
Sheen, MC	1
Poulalhon, N	1
Dalle, S	1
Balme, B	1
Thomas, L	1
Jambusaria-Pahlajani, A	1
Ortman, S	1
Schmults, CD	1
Liang, C	1
Korgavkar, K	1
Lee, KC	1
Lew, R	1
Meeks, NM	1
Burden, JG	1
Carroll, BT	1
Warchoł, R	1
Szymański, L	1
Seichter, A	1
JESSE, RH	1
VILLARREAL, R	1
LETAYF, V	1
RUFINO, C	1
HICKEY, RC	1
Khader, A	1
Gritli, S	1
Boussen, I	1
Oueslati, Z	1
Ferjaoui, M	1
Nouira, R	1
Ladgham, A	1
Boussen, H	1
Resnik, KS	1
DiLeonardo, M	1
Gibbons, G	1
Zide, MF	1
Swanson, NA	1
Cesteleyn, L	1
Akuamoa-Boateng, E	1
Monheit, GD	1
Rozenman, Y	1
Gurewich, J	1
Gotsman, MS	1
Bellman, B	1
Gregory, NA	1
Silvers, D	1
Fountain, KS	1
Cutilli, T	2
Papola, F	2
Corbacelli, A	2
Di Emidio, P	1
Miki, Y	1
Kawatsu, T	1
Matsuda, H	1
Yamada, T	1
Kahata, A	1
Esser, E	1
Kroh, HD	1
Schumann, J	1
Wannenmacher, M	1
Takahashi, T	1
Kono, K	1
Yamaguchi, T	1
Biro, L	1
Price, E	1
Andrews, JM	1
Avant, WH	1
Huff, RC	1
Evenou, P	1
Cvitkovic, E	1
Mamelle, G	1
Duvillard, P	1
Klijanienko, G	1
Wagner, L	1
Noble, JP	1
Wendling, JL	1
Guillaume, JC	1
Avril, MF	1
VaLlicioni, J	1
Demard, F	1
Santini, J	1
Schneider, M	1
Chauvel, P	1
Mayer, M	1
Colon, J	1
Richard, JM	1
Sancho, H	1
Fain, WR	1
Conn, JH	1
Chavez, CM	1
Dickinson, JT	1
Rooker, DW	1
Leonard, JR	1
Sparwald, E	1
Müllensiefen, C	1
Lange, G	1
Slanina, I	1
The, KK	1
Weber, G	1
Meinert, W	1
Littlewood, M	1
Murray, DS	1
Gleason, MC	1
Lopes, CF	1
Armond, S	1
Cavins, JA	1
Banzet, P	1
De la Caffinière, JY	1
Dufourmentel, C	1
Uthida-Tanaka, AM	1
Nakamura, S	1
de Britto-Costa, R	1
de Tavares Mello, E	1
Bréhant, J	1
Montagnier, J	1
Meunier, JP	1
Ebner, H	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial[NCT00847912]	Phase 4	954 participants (Actual)	Interventional	2009-06-26	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

(NCT00847912)
Timeframe: date of randomization to last visit before end of study follow up (6/30/2013), assessed up to four years

The Time to Diagnosis of the First Keratinocyte Carcinoma (KC) on the Face or Ears for Which Surgery is Performed

Intervention	participants (Number)
Arm 1: 5-fluorouracil	182
Arm 2: Placebo, Vehicle Control	177

Diagnosis of the first Primary Basil Cell Carcinoma (BCC) or primary Squamous Cell Carcinoma (SCC) on the face or ears that was removed surgically. (NCT00847912)
Timeframe: From randomization to last visit prior to end of study date (6/30/2013), assessed up to four years

Article	Year
Rate and Proportion of Malignant Skin Biopsies for Basal Cell and Squamous Cell Carcinoma on the Face and Ears After a Single Course of Topical 5-Fluorouracil: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2021, 04-01, Volume: 47, Issue:4 Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Biopsy; Carcinoma, Basal Cell; Carci	2021
Validation of Photograph-Based Toxicity Score for Topical 5-Fluorouracil Cream Application. Journal of cutaneous medicine and surgery, 2016, Volume: 20, Issue:5 Topics: Administration, Cutaneous; Age Factors; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous C	2016
A clinical trial of the use of 5-fluouracil in the treatment of some cutaneous malignancies. British journal of plastic surgery, 1973, Volume: 26, Issue:2 Topics: Adult; Aged; Carcinoma, Basal Cell; Clinical Trials as Topic; Facial Neoplasms; Female; Fluorouracil	1973
[Therapeutic trial with 5-fluorouracil ointment]. Hospital (Rio de Janeiro, Brazil), 1970, Volume: 77, Issue:4 Topics: Adult; Aged; Carcinoma, Basal Cell; Clinical Trials as Topic; Evaluation Studies as Topic; Facial Ne	1970

Article	Year
Treatment of cancer in a child with ocular xeroderma pigmentosa (XP) in Malawi. Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:8 Topics: Antimetabolites, Antineoplastic; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Child, Preschool;	2014
Facial adenocarcinoma treated with intra-arterial chemotherapy. Journal of the American Academy of Dermatology, 2015, Volume: 72, Issue:1 Topics: Adenocarcinoma; Aged, 80 and over; Antimetabolites, Antineoplastic; Facial Neoplasms; Female; Fluoro	2015
Fast-growing cutaneous squamous cell carcinoma in a patient treated with vismodegib. Dermatology (Basel, Switzerland), 2015, Volume: 230, Issue:2 Topics: Aged, 80 and over; Anilides; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Basa	2015
Sequential Curettage, 5-Fluorouracil, and Photodynamic Therapy for Field Cancerization of the Scalp and Face in Solid Organ Transplant Recipients. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2016, Volume: 42 Suppl 1 Topics: Antimetabolites, Antineoplastic; Carcinoma in Situ; Carcinoma, Squamous Cell; Combined Modality Ther	2016
Fluorouracil-Induced Reactive Follicular Squamous Cell Carcinoma. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2016, Volume: 42, Issue:8 Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Facial Neoplasms; Fluorouracil; For	2016
[Rectal adenocarcinoma metastasis to the facial skin--case report]. Otolaryngologia polska = The Polish otolaryngology, 2008, Volume: 62, Issue:1 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Facial Neopl	2008
INTRA-ARTERIAL INFUSION FOR HEAD AND NECK CANCER. Archives of surgery (Chicago, Ill. : 1960), 1964, Volume: 88 Topics: Antineoplastic Agents; Brain Neoplasms; Dactinomycin; Facial Neoplasms; Fluorouracil; Head and Neck	1964
[Topical and systemic chemotherapy with 5-fluouracil in facial carcinoma secondary to xeroderma pigmentosum]. La Tunisie medicale, 2005, Volume: 83, Issue:11 Topics: Administration, Cutaneous; Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents	2005
Clinically occult cutaneous metastases. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6 Topics: Aged; Aged, 80 and over; Anastrozole; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormon	2006
Actinic keratosis: from the skin to the lip. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2008, Volume: 66, Issue:6 Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biopsy; Chemexfoliation; Cryosurgery; Elec	2008
Basal cell carcinoma. Treatment modalities and recommendations. Primary care, 1983, Volume: 10, Issue:3 Topics: Carcinoma, Basal Cell; Cryosurgery; Electrosurgery; Facial Neoplasms; Fluorouracil; Humans; Neoplasm	1983
[Maxillofacial surgical treatment of basaliomas in the basocellular nevus syndrome]. Acta stomatologica Belgica, 1983, Volume: 80, Issue:1 Topics: Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Facial Neoplasms; Female; Fluorouracil; Humans; Ma	1983
Facial blemishes and their treatment. Otolaryngologic clinics of North America, 1980, Volume: 13, Issue:2 Topics: Carcinoma, Basal Cell; Chemexfoliation; Cryosurgery; Curettage; Electrosurgery; Facial Dermatoses; F	1980
Myocardial ischemia induced by topical use of 5-fluorouracil. International journal of cardiology, 1995, Volume: 49, Issue:3 Topics: Administration, Topical; Aged; Aged, 80 and over; Angina Pectoris; Carcinoma, Basal Cell; Drug Thera	1995
Sweat gland carcinoma with metastases to the skin: response to 5-fluorouracil chemotherapy. Cutis, 1995, Volume: 55, Issue:4 Topics: Aged; Bone Marrow Diseases; Bone Neoplasms; Carcinoma, Signet Ring Cell; Facial Neoplasms; Fluoroura	1995
p53 overexpression and mutation, chemoresistance and patient survival in oral and maxillofacial squamous cell carcinoma. Journal of chemotherapy (Florence, Italy), 1997, Volume: 9, Issue:2 Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Sq	1997
p53 tumor suppressor protein and H-RAS oncogene in maxillofacial tumors: immunohistochemical and genetic investigation, induction chemotherapy response and prognosis evaluation. Journal of chemotherapy (Florence, Italy), 1998, Volume: 10, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali	1998
[Topical chemotherapy for carcinoma of the skin (author's transl)]. The Japanese journal of antibiotics, 1975, Volume: 28, Issue:1 Topics: Administration, Topical; Adolescent; Aged; Bleomycin; Bowen's Disease; Carcinoma, Basal Cell; Carcin	1975
[Experimental research in cycle-synchronizing radiotherapy]. Acta stomatologica Belgica, 1975, Volume: 72, Issue:3 Topics: Animals; Bleomycin; Facial Neoplasms; Fluorouracil; Humans; Maxillary Neoplasms	1975
Enhancement of the cancer chemotherapeutic effect by anticancer agents in the form of fat emulsion. The Tohoku journal of experimental medicine, 1977, Volume: 123, Issue:3 Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carcinoma,	1977
Squamous cell carcinoma. Case report of an unusually aggressive skin cancer. Cutis, 1979, Volume: 23, Issue:3 Topics: Aged; Carcinoma, Squamous Cell; Chin; Facial Neoplasms; Female; Fluorouracil; Humans; Keratosis; Ski	1979
Extensive malignancies of facial skin treated by perfusion with 5-fluorouracil and conservative excision. British journal of plastic surgery, 1979, Volume: 32, Issue:3 Topics: Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Facial Neoplasms; Female; Fluorouracil; Human	1979
Intradermal 5-fluorouracil in the treatment of basal cell carcinoma of the face. Southern medical journal, 1976, Volume: 69, Issue:5 Topics: Aged; Carcinoma, Basal Cell; Facial Neoplasms; Female; Fluorouracil; Humans; Injections, Intradermal	1976
[Cisplatin-5 fluorouracil in cervicofacial cancer recurrence]. Revue de laryngologie - otologie - rhinologie, 1988, Volume: 109, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Facial Neoplasms; Fluorouracil; Head and	1988
[Chemotherapy by intra-arterial path in cancer of the "head and neck" region]. Acta chirurgica Belgica, 1971, Volume: 70, Issue:4 Topics: Antineoplastic Agents; Bleomycin; Facial Neoplasms; Fluorouracil; Head; Head and Neck Neoplasms; Hum	1971
[Intra-arterial chemotherapy of head and neck tumors: statistical study of 129 cases treated at the Institut Gustave Roussy]. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1973, Volume: 18, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma; Carcinoma, Squamous Cell; Facial Neoplasms	1973
Continuous arterial infusion chemotherapy. Experience with 44 cases. The American surgeon, 1967, Volume: 33, Issue:8 Topics: Adenocarcinoma; Arteries; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cath	1967
Minor surgery for benign and malignant facial lesions. American family physician, 1974, Volume: 10, Issue:5 Topics: Acne Vulgaris; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cicatrix; Cortisone; Curettage; Cyst	1974
[Clinical results after synchronised radiotherapy in 21 cases of human malignomas (author's transl)]. Laryngologie, Rhinologie, Otologie, 1974, Volume: 53, Issue:6 Topics: Adult; Aged; Facial Neoplasms; Female; Fluorouracil; Follow-Up Studies; Germany, West; Humans; Laryn	1974
Combined cytostatic and surgical treatment of extensive basal cell epitheliomata. The British journal of dermatology, 1972, Volume: 86, Issue:4 Topics: Aged; Carcinoma, Basal Cell; Facial Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Skin Transpl	1972
Xeroderma pigmentosum--five-year arrest after total resurfacing of the face. Plastic and reconstructive surgery, 1970, Volume: 46, Issue:6 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Child, Preschool; Dermabrasion; Electrosurgery; Fac	1970
Review of a 3-year experience with topical chemotherapy and immunotherapy of superficial cutaneous neoplasms. Journal of surgical oncology, 1971, Volume: 3, Issue:3 Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chlorine; Facial Neoplasms;	1971
[Apropos of 40 cases of malignant tumors treated by local-regional and general chemotherapy in a surgical department]. Journal de chirurgie, 1969, Volume: 97, Issue:3 Topics: Adolescent; Adult; Aminopterin; Back; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemotherapy,	1969
[Topical therapy of precancerous lesions and skin carcinomas using a 5-fluorouracil ointment]. Hospital (Rio de Janeiro, Brazil), 1969, Volume: 76, Issue:6 Topics: Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Facial Neoplasms; Female; Fluorouracil	1969
[Intracarotid chemotherapy in the treatment of advanced cancers of the head and neck. Study of 100 cases]. Bulletin de l'Academie nationale de medecine, 1965, Dec-21, Volume: 149, Issue:34 Topics: Facial Neoplasms; Fluorouracil; Head and Neck Neoplasms; Humans	1965
[Electron microscopy studies on the effect of 5-fluorouracil on basaliomas]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1971, Aug-15, Volume: 46, Issue:16 Topics: Back; Biopsy; Carcinoma, Basal Cell; Facial Neoplasms; Fluorouracil; Humans; Microscopy, Electron; S	1971

fluorouracil and Facial Neoplasms