fluorouracil has been researched along with Eye Diseases in 33 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Eye Diseases: Diseases affecting the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied 105 patients (105 eyes) operated on for glaucoma with adjunctive fluorouracil, who were followed up for 12 to 48 months (mean, 34." | 7.68 | Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil. ( Ophir, A; Ticho, U, 1993) |
| "To test the efficacy of a biodegradable device for the intravitreal sustained release of fluorouracil in the treatment of tractional retinal detachment due to proliferative vitreoretinopathy." | 3.69 | Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. ( Cousins, SW; Davis, PA; Hernandez, E; O'Grady, GE; Rubsamen, PE, 1994) |
| "We studied 105 patients (105 eyes) operated on for glaucoma with adjunctive fluorouracil, who were followed up for 12 to 48 months (mean, 34." | 3.68 | Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil. ( Ophir, A; Ticho, U, 1993) |
| "The rate of retinal detachment in fellow control eyes of rabbits following fibroblast administration is progressively lower with increased dose of 5-Fluorouracil in the test eyes." | 3.68 | Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil. ( Ophir, A, 1991) |
| "Fluorouracil effectively inhibits epiretinal membrane formation and traction retinal detachment after vitrectomy surgery." | 3.66 | Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy. ( Anderson, DH; Erickson, PA; Fisher, SK; Guerin, CJ; Lewis, GP; O'Donnell, JJ; Stern, WH, 1983) |
| "Pursuant to this, the North Central Cancer Treatment Group has developed a series of clinical trials designed to study antidotes for these pathologic processes." | 2.39 | Alleviation of cytotoxic therapy-induced normal tissue damage. ( Foote, RL; Loprinzi, CL; Michalak, J, 1995) |
| "In the total 70 cases including those of undifferentiated carcinoma and adenocarcinoma, the 3-year and 5-year actual survival rates were 75." | 1.26 | Analysis of the results of our combined therapy for maxillary cancer. ( Inoue, S; Konno, A; Togawa, K, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (42.42) | 18.7374 |
| 1990's | 13 (39.39) | 18.2507 |
| 2000's | 5 (15.15) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saleh, MGA | 1 |
| Parikh, M | 1 |
| Lin, P | 1 |
| Shaikh, AA | 1 |
| Damji, KF | 1 |
| Mintsioulis, G | 1 |
| Gupta, SK | 1 |
| Kertes, PJ | 1 |
| Eiseman, AS | 1 |
| Flanagan, JC | 1 |
| Brooks, AB | 1 |
| Mitchell, EP | 1 |
| Pemberton, CH | 1 |
| Heller, J | 1 |
| Abraham, LM | 1 |
| Selva, D | 1 |
| Casson, R | 1 |
| Leibovitch, I | 1 |
| Labbé, A | 1 |
| Khammari, C | 1 |
| Baudouin, C | 1 |
| Slezak, H | 1 |
| Konno, A | 1 |
| Togawa, K | 1 |
| Inoue, S | 1 |
| Sunalp, M | 1 |
| Wiedemann, P | 2 |
| Sorgente, N | 1 |
| Ryan, SJ | 1 |
| Avni, I | 1 |
| Belkin, M | 1 |
| Hercberg, A | 1 |
| Blumenthal, M | 1 |
| Kulnig, W | 1 |
| Binder, S | 1 |
| Riss, B | 1 |
| Skorpik, C | 1 |
| Stern, WH | 2 |
| Lewis, GP | 2 |
| Erickson, PA | 1 |
| Guerin, CJ | 1 |
| Anderson, DH | 1 |
| Fisher, SK | 1 |
| O'Donnell, JJ | 1 |
| Griffin, JD | 1 |
| Garnick, MB | 1 |
| Fraunfelder, FT | 1 |
| Loprinzi, CL | 1 |
| Foote, RL | 1 |
| Michalak, J | 1 |
| Rubsamen, PE | 1 |
| Davis, PA | 1 |
| Hernandez, E | 1 |
| O'Grady, GE | 1 |
| Cousins, SW | 1 |
| Forbes, JE | 1 |
| Brazier, DJ | 1 |
| Spittle, M | 1 |
| Ward, T | 1 |
| Hartzer, M | 1 |
| Blumenkranz, M | 1 |
| Lin, LR | 1 |
| Ticho, U | 2 |
| Ophir, A | 3 |
| Bell, RW | 1 |
| Habib, NE | 1 |
| O'Brien, C | 1 |
| Allen, LE | 1 |
| Manuchehri, K | 1 |
| Corridan, PG | 1 |
| Miyamoto, K | 1 |
| Tanaka, T | 1 |
| Isawa, S | 1 |
| Yamashita, T | 1 |
| Matsuda, A | 1 |
| Chan, RC | 1 |
| Shukovsky, LJ | 1 |
| Salamon, T | 1 |
| Stojaković, M | 1 |
| Bogdanović, B | 1 |
| Ortiz, JM | 1 |
| Maurice, D | 1 |
| Moorhead, LC | 1 |
| Sepahban, S | 1 |
| Armeniades, CD | 1 |
| Davidorf, F | 1 |
| Campochiaro, PA | 1 |
| Glaser, BM | 1 |
| Heath, TD | 1 |
| Lopez, NG | 1 |
| Heimann, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| trūFreeze® Spray Cryotherapy Patient Registry[NCT01802203] | 275 participants (Actual) | Observational [Patient Registry] | 2013-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for fluorouracil and Eye Diseases
| Article | Year |
|---|---|
Ocular delivery using poly(ortho esters).
Topics: Animals; Delayed-Action Preparations; Drug Administration Routes; Drug Delivery Systems; Eye Disease | 2005 |
The clinical applications of fluorouracil in ophthalmic practice.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Cell Proliferation; Eye Diseases; Eye Neop | 2007 |
[Wound healing modulation in glaucoma surgery].
Topics: Adult; Animals; Cataract Extraction; Child; Cicatrix; Eye Diseases; Filtering Surgery; Fluorouracil; | 2007 |
Eye toxicity of cancer chemotherapy: a review of the literature.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Busulfan; Drug Therapy, Combination; Estrogen Antago | 1981 |
Alleviation of cytotoxic therapy-induced normal tissue damage.
Topics: Chlorhexidine; Clinical Trials as Topic; Cryotherapy; Dermatitis; Esophagitis; Eye Diseases; Fluorou | 1995 |
28 other studies available for fluorouracil and Eye Diseases
| Article | Year |
|---|---|
Treatment of Epithelial Downgrowth Masquerading as Unilateral Hypopyon Uveitis in a HLA-B27+ Individual.
Topics: Aged, 80 and over; Anterior Chamber; Cryotherapy; Diagnosis, Differential; Epithelium, Corneal; Eye | 2018 |
Bilateral epithelial downgrowth managed in one eye with intraocular 5-fluorouracil.
Topics: Aged; Anterior Chamber; Epithelium; Eye Diseases; Female; Fluorouracil; Humans; Injections; Secondar | 2002 |
Ocular surface, ocular adnexal, and lacrimal complications associated with the use of systemic 5-fluorouracil.
Topics: Adult; Antimetabolites, Antineoplastic; Black or African American; Cohort Studies; Drug Eruptions; E | 2003 |
[Drug-induced eye lesions in the aged].
Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases | 1983 |
Analysis of the results of our combined therapy for maxillary cancer.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell | 1980 |
Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Doxorubicin; Eye Diseases; Female; Fibroblas | 1984 |
Intravitreal 5-fluorouracil in the prevention of post-traumatic vitreous proliferation.
Topics: Animals; Eye Diseases; Eye Injuries; Female; Fluorouracil; Male; Rabbits; Vitreous Body | 1984 |
Inhibition of experimental intraocular proliferation with intravitreous 5-fluouracil. A transmission electron-microscopic study in rabbits.
Topics: Animals; Axons; Cell Division; Eye; Eye Diseases; Fluorouracil; Microscopy, Electron; Myelin Sheath; | 1984 |
Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy.
Topics: Animals; Autoradiography; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Eye | 1983 |
Interim report: National Registry of possible Drug-induced Ocular Side Effects.
Topics: Contact Lenses; Drug-Related Side Effects and Adverse Reactions; Eye Diseases; Fluorouracil; Humans; | 1980 |
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil.
Topics: Animals; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Delayed-Action Prepara | 1994 |
5-Fluorouracil and ocular toxicity.
Topics: Eye; Eye Diseases; Fluorouracil; Humans; Male; Middle Aged | 1993 |
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorour | 1993 |
Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Child; Child, Preschool; Eye Dis | 1993 |
Long-term results and complications after trabeculectomy with a single per-operative application of 5-fluorouracil.
Topics: Adult; Aged; Antimetabolites; Eye Diseases; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Human | 1997 |
The treatment of encapsulated trabeculectomy blebs in an out-patient setting using a needling technique and subconjunctival 5-fluorouracil injection.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Cysts; Eye Diseases; Fem | 1998 |
[Toxicological studies of bleomycin ointment. Irritative effect of bleomycin ointment on eye mucous membrane and skin (author's transl)].
Topics: Administration, Topical; Animals; Bleomycin; Conjunctiva; Conjunctivitis; Cornea; Erythema; Eye; Eye | 1975 |
Effects of irradiation on the eye.
Topics: Blindness; Cataract; Eye; Eye Diseases; Fluorouracil; Humans; Nose Neoplasms; Paranasal Sinus Neopla | 1976 |
Delayed hypersensitivity in xeroderma pigmentosum.
Topics: Carcinoma, Squamous Cell; Child; Child, Preschool; Eye Diseases; Female; Fluorouracil; Humans; Hyper | 1975 |
Molteno implants.
Topics: Cysts; Eye Diseases; Fluorouracil; Glaucoma; Humans; Injections; Postoperative Complications; Prosth | 1992 |
Liposome suppression of proliferative vitreoretinopathy.
Topics: Animals; Biological Availability; Drug Carriers; Eye Diseases; Fluorouracil; Half-Life; Liposomes; R | 1992 |
Evaluation of drug treatments for proliferative vitreoretinopathy using vitreous microtensiometry.
Topics: Aminopropionitrile; Animals; Cattle; Disease Models, Animal; Drug Combinations; Equipment Design; Ev | 1991 |
Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil.
Topics: Animals; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Follow-Up Studies; Rabbits | 1991 |
Advances in ophthalmology.
Topics: Adrenergic beta-Antagonists; Adult; Child; Eye Diseases; Fluorouracil; Humans; Laser Therapy; Micros | 1990 |
Subconjunctival 5-fluorouracil and herpes simplex keratitis.
Topics: Eye Diseases; Fluorouracil; Glaucoma; Humans; Keratitis, Dendritic; Male; Middle Aged; Postoperative | 1991 |
Mechanisms involved in retinal pigment epithelial cell chemotaxis.
Topics: Biomechanical Phenomena; Cell Movement; Chemotaxis; Colchicine; Cytochalasin B; Cytoskeleton; Dexame | 1986 |
Fluoropyrimidine treatment of ocular cicatricial disease.
Topics: Animals; Cell Division; Cicatrix; Eye Diseases; Fibroblasts; Floxuridine; Fluorouracil; Osmolar Conc | 1986 |
[Proliferative vitreoretinopathy. Pathogenesis and possibilities for treatment with cytostatic drugs].
Topics: Antineoplastic Agents; Cell Division; Daunorubicin; Eye Diseases; Fluorouracil; Humans; Pigment Epit | 1986 |