fluorouracil has been researched along with External Ophthalmoplegia in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity." | 3.65 | Oculomotor disturbances associated with 5-fluorouracil chemotherapy. ( Bixenman, WW; Nicholls, JV; Warwick, OH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| López-Estévez, S | 1 |
| Ferrer, G | 1 |
| Torres-Torronteras, J | 1 |
| Mansilla, MJ | 1 |
| Casacuberta-Serra, S | 1 |
| Martorell, L | 1 |
| Hirano, M | 1 |
| Martí, R | 1 |
| Barquinero, J | 1 |
| Bixenman, WW | 1 |
| Nicholls, JV | 1 |
| Warwick, OH | 1 |
2 other studies available for fluorouracil and External Ophthalmoplegia
| Article | Year |
|---|---|
Thymidine phosphorylase is both a therapeutic and a suicide gene in a murine model of mitochondrial neurogastrointestinal encephalomyopathy.
Topics: Animals; Capecitabine; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine; Disease Models, A | 2014 |
Oculomotor disturbances associated with 5-fluorouracil chemotherapy.
Topics: Adenocarcinoma; Adult; Brain Stem; Cerebellar Diseases; Colonic Neoplasms; Eye Movements; Female; Fl | 1977 |