fluorouracil has been researched along with Experimental Radiation Injuries in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A dose-response experiment showed that Peg-IL-6 and IL-6 increased platelet counts in a dose-dependent fashion at a plateau stimulation level of 0." | 1.29 | A highly enhanced thrombopoietic activity by monomethoxy polyethylene glycol-modified recombinant human interleukin-6. ( Inoue, H; Kabaya, K; Kadoya, T; Mikayama, T; Mori, KJ; Nishi, N; Ohsawa, M; Sato, M; Tachibana, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Strom, E | 1 |
| Sathe, S | 1 |
| Komarov, PG | 1 |
| Chernova, OB | 1 |
| Pavlovska, I | 1 |
| Shyshynova, I | 1 |
| Bosykh, DA | 1 |
| Burdelya, LG | 1 |
| Macklis, RM | 1 |
| Skaliter, R | 1 |
| Komarova, EA | 1 |
| Gudkov, AV | 1 |
| Wang, N | 1 |
| Yin, J | 1 |
| You, N | 1 |
| Yang, S | 1 |
| Guo, D | 1 |
| Zhao, Y | 1 |
| Ru, Y | 1 |
| Liu, X | 1 |
| Cheng, H | 1 |
| Ren, Q | 1 |
| Cheng, T | 1 |
| Ma, X | 1 |
| Si, S | 1 |
| Nakajima-Takagi, Y | 1 |
| Iga, T | 1 |
| Tsuji, M | 1 |
| Hou, L | 1 |
| Oshima, M | 1 |
| Koide, S | 1 |
| Saraya, A | 1 |
| Yamazaki, S | 1 |
| Takubo, K | 1 |
| Kubota, Y | 1 |
| Minamino, T | 1 |
| Iwama, A | 1 |
| Li, X | 1 |
| Slayton, WB | 1 |
| Bounous, G | 1 |
| Inoue, H | 1 |
| Kadoya, T | 1 |
| Kabaya, K | 1 |
| Tachibana, K | 1 |
| Nishi, N | 1 |
| Sato, M | 1 |
| Ohsawa, M | 1 |
| Mikayama, T | 1 |
| Mori, KJ | 1 |
| Lee, BC | 1 |
| Shav-Tal, Y | 1 |
| Peled, A | 1 |
| Gothelf, Y | 1 |
| Jiang, W | 1 |
| Toledo, J | 1 |
| Ploemacher, RE | 1 |
| Haran-Ghera, N | 1 |
| Zipori, D | 1 |
| Orazi, A | 1 |
| Du, X | 1 |
| Yang, Z | 1 |
| Kashai, M | 1 |
| Williams, DA | 1 |
| Cohen-Solal, K | 1 |
| Villeval, JL | 1 |
| Titeux, M | 1 |
| Lok, S | 1 |
| Vainchenker, W | 1 |
| Wendling, F | 1 |
| Hassenstein, E | 1 |
| Renner, K | 1 |
| Bendel, V | 1 |
| Wolf, R | 1 |
| Kojima, E | 1 |
| Tsuboi, A | 1 |
| von der Maase, H | 1 |
| Overgaard, J | 1 |
| Vaeth, M | 1 |
| Rosendaal, M | 1 |
| Adam, J | 1 |
| Leer, JW | 1 |
| Landuyt, W | 1 |
| van der Schueren, E | 1 |
| Kurpeshev, OK | 1 |
| Goldmann, L | 1 |
| Igelman, JM | 1 |
| Kitzmiller, K | 1 |
| Ringleb, D | 1 |
| Bosnar, M | 1 |
| Krieg, R | 1 |
| Sauer, D | 1 |
| Steckenmesser, R | 1 |
| Urano, M | 1 |
| Morimoto, H | 1 |
| Tanaka, N | 1 |
| Shimazaki, S | 1 |
| Reissmann, KR | 1 |
| Samorapoompichit, S | 1 |
19 other studies available for fluorouracil and Experimental Radiation Injuries
| Article | Year |
|---|---|
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Line; Dexamethasone; Gamma R | 2006 |
TWIST1 preserves hematopoietic stem cell function via the CACNA1B/Ca2+/mitochondria axis.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Calcium Channel Blockers; Calcium Channels, N-Type; Calc | 2021 |
Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.
Topics: Animals; Animals, Congenic; Blood Cell Count; Bone Marrow; Endothelial Cells; Endothelium, Vascular; | 2018 |
Molecular mechanisms of platelet and stem cell rebound after 5-fluorouracil treatment.
Topics: Angiopoietin-1; Animals; Blood Platelets; Bone Marrow; Cell Count; Cell Division; Cellular Microenvi | 2013 |
Protection of the gastrointestinal mucosa by elemental diets.
Topics: Animals; Fluorouracil; Food, Formulated; Humans; Hypotension; Intestinal Mucosa; Radiation Injuries; | 1980 |
A highly enhanced thrombopoietic activity by monomethoxy polyethylene glycol-modified recombinant human interleukin-6.
Topics: Animals; Blood Platelets; Colony-Forming Units Assay; Fluorouracil; Hematopoiesis; Interleukin-6; Ma | 1994 |
A hematopoietic organ-specific 49-kD nuclear antigen: predominance in immature normal and tumor granulocytes and detection in hematopoietic precursor cells.
Topics: Acute Disease; Animals; Antigens, Neoplasm; Bone Marrow; Cell Differentiation; Cell Nucleus; Cells, | 1996 |
Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Division; Cytoplasm; Fluorouracil; Interle | 1996 |
Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.
Topics: Animals; Blood Platelets; Female; Fluorouracil; Gene Expression Regulation; Immune Sera; Kidney; Liv | 1996 |
[Animal experiments on the toxicity of tumoricidal agents].
Topics: Animals; Bone Marrow; Female; Fluorouracil; Leukocyte Count; Mice; Piperazines; Platelet Count; Radi | 1978 |
Effects of 5-fluorouracil on hematopoietic stem cells in normal and irradiated mice.
Topics: Animals; Femur; Fluorouracil; Hematopoietic Stem Cells; Male; Mice; Radiation Injuries, Experimental | 1992 |
Effect of cancer chemotherapeutic drugs on radiation-induced lung damage in mice.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cisplatin; Cyclophosphamide; Dose-Response Relationship, | 1986 |
Patterns of haemopoietic recovery after stress--II. Treatment with fluorouracil.
Topics: Animals; Cell Division; Colony-Forming Units Assay; Female; Fluorouracil; Hematopoietic Stem Cells; | 1988 |
Irradiation of murine lip mucosa in combination with 5-fluorouracil, administered by single dose injection or continuous infusion.
Topics: Animals; Combined Modality Therapy; Female; Fluorouracil; Infusion Pumps; Lip; Mice; Mouth Mucosa; R | 1987 |
[Modification of separate and combined effects of hyperthermia and ionizing radiation on normal tissues].
Topics: Animals; Cycloheximide; Dactinomycin; Ethanol; Fluorouracil; Glucose; Hot Temperature; Metronidazole | 1986 |
Investigative studies with DMSO in dermatology.
Topics: Animals; Dermatomycoses; Dimethyl Sulfoxide; Drug Eruptions; Fluocinolone Acetonide; Fluorouracil; G | 1967 |
[Studies on the understanding of problems of radiologic cytostatic combination treatment. 6. Further syncytostatic studies with 5-fluorouracil, natulan and proresid].
Topics: Amides; Animals; Antineoplastic Agents; Cyclophosphamide; Ear, External; Female; Fluorouracil; Granu | 1969 |
Mouse survival time after single administration of 5-fluorouracil.
Topics: Animals; Female; Fluorouracil; Injections, Intraperitoneal; Mice; Radiation Injuries, Experimental; | 1970 |
Effect of erythropoietin on regeneration of hematopoietic stem cells after 5-fluorouracil administration.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Erythropoietin; Fluorouracil; Hematopoietic System; Mice; R | 1969 |