fluorouracil has been researched along with Experimental Neoplasms in 554 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate the influence of low dosage (131)I-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody C50 ((131)I-C50) on tumor growth and the therapeutic efficacy of combination of low dosage (131)I-C50 with chemotherapy using 5-fluorouracil (5-FU) on human colorectal cancer xenografts in nude mice." | 7.72 | [Influence of combination of low dosage 131I-labeled anti-carcinoembryonic antigen antibody C50 and 5-fluorouracil on tumor growth of colorectal cancer xenografts in nude mice]. ( Cai, SR; He, YL; Lin, ZJ; Zhan, WH; Zheng, CX, 2003) |
| "Combined application of cyclophosphamide, methotrexate, 5-fluorouracil (CMF) has been followed in the treatment of breast cancer." | 7.71 | Dual role of vitamin C on lipid profile and combined application of cyclophosphamide, methotrexate and 5-fluorouracil treatment in fibrosarcoma-bearing rats. ( Amalan Stanley, V; Muralikrishnan, G; Sadasivan Pillai, K, 2001) |
| "The aim of this study was to evaluate the ability of noninvasive 1H magnetic resonance spectroscopic imaging to detect the response of radiation-induced fibrosarcoma 1 tumors to treatment with 5-fluorouracil (5-FU)." | 7.70 | Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. ( Aboagye, EO; Bhujwalla, ZM; Glickson, JD; Shungu, DC, 1998) |
| "The effect of various guanine ribonucleotides on the antitumor activity of 5-fluorouracil (FUra) was investigated by its action on adenocarcinoma 755." | 7.67 | Mechanism of potentiation of antitumor activity of 5-fluorouracil by guanine ribonucleotides against adenocarcinoma 755. ( Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z, 1987) |
| "The predictive utility of several biochemical parameters of 5-fluorouracil (5-FUra) action was evaluated in four murine colonic adenocarcinomas: 5-FUra-sensitive Tumor 38 and 5-FUra-resistant Tumors 07/A, 51 and 06/A." | 7.66 | In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. ( Corbett, TH; Heidelberger, C; Moran, RG; Shahinian, AH; Spears, CP, 1982) |
| "The anti-inflammatory drug indomethacin was tested for antitumor activity against transplantable mouse colon adenocarcinoma 38 (colon 38)." | 7.66 | Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin. ( Goto, A; Narisawa, T; Sano, M; Sato, M; Takahashi, T, 1983) |
| "This study was designed to examine the possibilities for increasing the therapeutic index in the treatment of human colon adenocarcinomas maintained as xenografts in immune-deprived mice using combinations of methotrexate (MTX) that preceded 5-fluorouracil (FUra)." | 7.66 | The selectivity of action of methotrexate in combination with 5-fluorouracil in xenografts of human colon adenocarcinomas. ( Houghton, JA; Houghton, PJ; Tice, AJ, 1982) |
| "1-Hexylcarbamoyl-5-fluorouracil (HCFU) and its parent compound 5-fluorouracil (5-FU) were tested PO for antitumor activity against mouse colon adenocarcinoma 26 (colon 26), colon adenocarcinoma 38 (colon 38), and Lewis lung carcinoma." | 7.66 | Inhibition of murine colon adenocarcinomas and Lewis lung carcinoma by 1-hexylcarbamoyl-5-fluorouracil. ( Iida, H; Naganuma, K; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1980) |
| "5-Fluorouracil has been considered as a cornerstone therapy for colorectal cancer; however, it suffers from low therapeutic response rate and severe side effects." | 5.46 | Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma. ( Agnihotri, N; Kaur, S; Kumar, S; Rani, I; Sharma, B, 2017) |
| "5-Fluorouracil (5-Fu) is the first-line chemotherapeutic option for colorectal cancer." | 4.12 | TIMP-2 regulates 5-Fu resistance via the ERK/MAPK signaling pathway in colorectal cancer. ( Chen, E; Huang, X; Luo, X; Meng, Q; Song, Z; Wang, D; Wang, Z; Xu, J; Zhang, G; Zhang, W; Zhou, W, 2022) |
| "Three mouse cancer cell lines [CT26 mouse colon cancer cells, B16 melanoma cells and Lewis lung carcinoma (LLC)], 5 human carcinoma cell lines (human esophageal squamous cell carcinoma cell lines TE8 and HEC46 and the human pancreatic carcinoma cell lines PK-9, AsPC-1 and SUIT-2) and 5 chemotherapeutic agents [mitoxantrone (MIT), mitomycin C(MMC), 5-fluorouracil (5FU), camptothecin (CPT-11) and cisplatin (CDDP)] that are frequently used in a clinical setting for cancer treatment were utilized to investigate the surface expression level of calreticulin and HLA class I after exposure to chemotherapeutic agents." | 3.81 | The key role of calreticulin in immunomodulation induced by chemotherapeutic agents. ( Hirano, S; Kuroda, A; Kuwatani, T; Kyogoku, N; Maki, T; Miyauchi, K; Shichinohe, T; Takeuchi, S; Tsuchikawa, T; Wada, M; Yamamura, Y, 2015) |
| " The purpose of the present study was to investigate whether hypoxia-driven triple suicide gene TK/CD/UPRT expression enhances cytotoxicity to ganciclovir (GCV) and 5-fluorocytosine (5-FC), and sensitizes human colorectal cancer to radiation in vitro and in vivo." | 3.80 | Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells. ( Deng, X; Hsiao, HT; Li, GC; Ling, CC; Sun, X; Xing, L, 2014) |
| " In this study, we investigated antitumor effects of the combined therapy using DC vaccine and irinotecan plus infusional 5-fluorouracil and leucovorin (FOLFIRI) which have been clinically used for the treatment of colorectal cancer." | 3.76 | Dendritic cell vaccine in addition to FOLFIRI regimen improve antitumor effects through the inhibition of immunosuppressive cells in murine colorectal cancer model. ( Kim, HJ; Kim, HS; Kim, SG; Kim, TG; Oh, ST; Park, HM; Park, JS; Sohn, HJ, 2010) |
| "The aim of this study was to investigate the influence of low dosage (131)I-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody C50 ((131)I-C50) on tumor growth and the therapeutic efficacy of combination of low dosage (131)I-C50 with chemotherapy using 5-fluorouracil (5-FU) on human colorectal cancer xenografts in nude mice." | 3.72 | [Influence of combination of low dosage 131I-labeled anti-carcinoembryonic antigen antibody C50 and 5-fluorouracil on tumor growth of colorectal cancer xenografts in nude mice]. ( Cai, SR; He, YL; Lin, ZJ; Zhan, WH; Zheng, CX, 2003) |
| " 5-Fluorouracil microspheres were formulated by an emulsion-extraction method, and evaluated on a C6 glioma model." | 3.72 | Therapeutic efficacy study of novel 5-FU-loaded PMM 2.1.2-based microspheres on C6 glioma. ( Benoit, JP; Colin, N; Fournier, E; Lemaire, L; Menei, P; Passirani, C; Sagodira, S; Vonarbourg, A, 2003) |
| "Combined application of cyclophosphamide, methotrexate, 5-fluorouracil (CMF) has been followed in the treatment of breast cancer." | 3.71 | Dual role of vitamin C on lipid profile and combined application of cyclophosphamide, methotrexate and 5-fluorouracil treatment in fibrosarcoma-bearing rats. ( Amalan Stanley, V; Muralikrishnan, G; Sadasivan Pillai, K, 2001) |
| "The aim of this study was to evaluate the ability of noninvasive 1H magnetic resonance spectroscopic imaging to detect the response of radiation-induced fibrosarcoma 1 tumors to treatment with 5-fluorouracil (5-FU)." | 3.70 | Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. ( Aboagye, EO; Bhujwalla, ZM; Glickson, JD; Shungu, DC, 1998) |
| "The effects of 1-beta-D-arabinosylcytosine (ara-C) and 5-fluorouracil (5-FU) on body weight, and the contents of putrescine, spermidine and spermine in 14 different tissues were examined in rats given these drugs for 5 days." | 3.68 | Polyamine increase in rat tissues treated with 1-beta-D-arabinosylcytosine and 5-fluorouracil. ( Nagase, S; Saito, T; Sato, S; Watanabe, S, 1993) |
| ") administration of 5-fluorouracil (5-FU) or 5-fluoro-2'-deoxyuridine (FUdR) in BDF1 mice bearing murine mammary adenocarcinoma 755 and athymic mice bearing the transplantable human colon adenocarcinoma LS174T." | 3.68 | Antitumor effect and tumor level of 5-fluoro-2'-deoxyuridylate following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate. ( Hoshi, A; Iigo, M; Nakajima, Y, 1992) |
| "Implantable collagen-poly(HEMA) hydrogels containing the anticancer drug 5-fluorouracil (5-FU) have been prepared and evaluated for their efficacy towards a solid tumour fibrosarcoma in Wistar rats." | 3.68 | Solid tumour chemotherapy using implantable collagen-poly (HEMA) hydrogel containing 5-fluorouracil. ( Jeyanthi, R; Nagarajan, B; Rao, KP, 1991) |
| "The effect of various guanine ribonucleotides on the antitumor activity of 5-fluorouracil (FUra) was investigated by its action on adenocarcinoma 755." | 3.67 | Mechanism of potentiation of antitumor activity of 5-fluorouracil by guanine ribonucleotides against adenocarcinoma 755. ( Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z, 1987) |
| "Bestatin enhanced the antitumor effects of mitomycin C, 5-fluorouracil and cis-dichlorodiammineplatinum against a syngeneic solid tumor of colon adenocarcinoma 26 in BALB/c mice." | 3.67 | Enhancement of antitumor effect of cytotoxic agents by bestatin. ( Abe, F; Ashizawa, J; Horinishi, H; Ishizuka, M; Matsuda, A; Shibuya, K; Takahashi, K; Takeuchi, T; Umezawa, H, 1985) |
| "Combinations of retinol palmitate (RP) and six different anticancer agents were examined to determine their effects on the life-span of mice bearing ascites sarcoma 180 or P388 leukemia." | 3.67 | Potentiation by vitamin A of the action of anticancer agents against murine tumors. ( Akiyama, S; Komiyama, S; Kuwano, M; Nakagawa, M; Ogata, J; Shiraishi, N; Ueda, H; Yamaguchi, T, 1985) |
| "The predictive utility of several biochemical parameters of 5-fluorouracil (5-FUra) action was evaluated in four murine colonic adenocarcinomas: 5-FUra-sensitive Tumor 38 and 5-FUra-resistant Tumors 07/A, 51 and 06/A." | 3.66 | In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. ( Corbett, TH; Heidelberger, C; Moran, RG; Shahinian, AH; Spears, CP, 1982) |
| " The antitumor activity of this compound was superior to those of 5-FU and 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, Ftorafur) in the treatment of transplantable tumors, not only 5-FU-sensitive tumors such as adenocarcinoma 755, lymphosarcoma LS-1, and plasmacytoma X5563, but also 5-FU-resistant tumors such as Lewis lung carcinoma and Walker carcinosarcoma 256." | 3.66 | Antitumor activity of methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranosid)uronate against various experimental tumors. ( Arakawa, M; Inomata, T; Sasagawa, K; Shimizu, F; Shinkai, K, 1981) |
| " Results of treatment of B16 melanoma and Lewis lung carcinoma with 3,4-dihydroxybenzohydroxamic acid are used to demonstrate this definition." | 3.66 | Drug activity and therapeutic synergism in cancer treatment. ( Campbell, ED; Carter, WH; Stablein, DM; Wampler, GL, 1982) |
| "The combined effect of the polysaccharide levan (previously shown to exert a host-dependent as well as direct antitumoural activity) and the cytotoxic agents cyclophosphamide (CY), methotrexate (MTX), vincristine (VINC) and 5-fluoro-uracil (SFU) was studied in Lewis lung carcinoma and AKR lymphoma." | 3.66 | Combined effect of levan and cytotoxic agents on the growth of experimental tumours in mice. ( Leibovici, J; Stark, Y; Wolman, M, 1983) |
| "The anti-inflammatory drug indomethacin was tested for antitumor activity against transplantable mouse colon adenocarcinoma 38 (colon 38)." | 3.66 | Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin. ( Goto, A; Narisawa, T; Sano, M; Sato, M; Takahashi, T, 1983) |
| "This study was designed to examine the possibilities for increasing the therapeutic index in the treatment of human colon adenocarcinomas maintained as xenografts in immune-deprived mice using combinations of methotrexate (MTX) that preceded 5-fluorouracil (FUra)." | 3.66 | The selectivity of action of methotrexate in combination with 5-fluorouracil in xenografts of human colon adenocarcinomas. ( Houghton, JA; Houghton, PJ; Tice, AJ, 1982) |
| "Antitumor activity of seven 5-fluorouracil derivatives having carbamoyl linkage with amino acid was examined against L-1210 leukemia, adenocarcinoma 755, ascites sarcoma 180, Ehrlich ascites carcinoma and Lewis lung carcinoma by oral administration." | 3.66 | Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration. ( Ando, N; Hoshi, A; Iigo, M; Inomata, M; Kuretani, K, 1981) |
| "1-Hexylcarbamoyl-5-fluorouracil (HCFU) and its parent compound 5-fluorouracil (5-FU) were tested PO for antitumor activity against mouse colon adenocarcinoma 26 (colon 26), colon adenocarcinoma 38 (colon 38), and Lewis lung carcinoma." | 3.66 | Inhibition of murine colon adenocarcinomas and Lewis lung carcinoma by 1-hexylcarbamoyl-5-fluorouracil. ( Iida, H; Naganuma, K; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1980) |
| "A number of chemotherapeutic agents, including L-asparaginase, actinomycin D, chloroethylcyclohexy-nitrosourea, 5-flourouracil, cyclophosphamide, hydroxyurea, cis-platinum, adriamycin and methotrexate, alone and in combination and at variable dose levels, were applied against the Dunning R3327 rat prostatic adenocarcinoma-subline G." | 3.66 | Further experience with chemotherapy in the Dunning prostatic adenocarcinoma. ( Block, NL; Camuzzi, F; Claflin, A; Politano, VA; Stover, B; Troner, M, 1978) |
| "Celecoxib was administered as 400 mg, twice daily starting on day 2 of cycle 1." | 2.73 | Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil. ( Cao, S; Creaven, PJ; Durrani, FA; Iyer, RV; Javle, MM; Lawrence, DD; Noel, DC; Pendyala, L; Rustum, YM; Smith, PF, 2007) |
| " As a result, the extent of toxicity of cancer chemotherapy varies by 50% or more according to dosing time in mice or rats." | 2.68 | [Chrono-chemotherapy and dose intensity]. ( Lévi, F, 1995) |
| " Thus, we attempted to find the dose of a given drug that can reproduce in the nude mouse a plasma level similar to that seen in human patients treated with an effective dose of the drug based on comparative pharmacokinetic studies between man and nude mouse." | 2.66 | Pharmacokinetic approach to rational therapeutic doses for human tumor-bearing nude mice. ( Inaba, M; Kobayashi, T; Sakurai, Y; Tashiro, T, 1988) |
| "Thymidine has been demonstrated to alter the pharmacokinetic parameters of 5-FU in man and in mice, but a selective modification of the antitumor activity of 5-FU has not yet been unequivocally demonstrated." | 2.36 | Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites. ( Au, JL; Danhauser, L; Luccioni, C; Rustum, YM, 1981) |
| "The potential impact on cancer mortality from these treatment results is obvious." | 2.36 | Multimodal primary cancer treatment (adjuvant chemotherapy): current results and future prospects. ( DeVita, VT; Weiss, RB, 1979) |
| " Probe A was selectively and efficiently sensitive to NQO1 with good safety profile and plasma stability, enabling its combination with NQO1 substrates in vivo for NQO1-overexpressing cancer theranostics for the first time." | 1.62 | Rational designed highly sensitive NQO1-activated near-infrared fluorescent probe combined with NQO1 substrates in vivo: An innovative strategy for NQO1-overexpressing cancer theranostics. ( Gong, Q; Hu, J; Li, T; Li, X; Wang, P; Yang, F; Zhang, X, 2021) |
| "Gastric cancer is an important killer disease, and its therapy methods still need improvement." | 1.48 | A novel design of HA-coated nanoparticles co-encapsulating plasmid METase and 5-Fu shows enhanced application in targeting gastric cancer stem cells. ( Xin, L; Yang, W; Zhang, H, 2018) |
| "5-Fluorouracil has been considered as a cornerstone therapy for colorectal cancer; however, it suffers from low therapeutic response rate and severe side effects." | 1.46 | Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma. ( Agnihotri, N; Kaur, S; Kumar, S; Rani, I; Sharma, B, 2017) |
| "5-Fluorouracil (5-FU) was loaded in hollow microspheres to improve its oral bioavailability." | 1.43 | A 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice. ( Huang, Y; Liu, H; Pi, C; Wei, Y; Yang, H; Ye, Y; Zhao, L, 2016) |
| " A drug combination offers a new strategy for appropriate use of 5-FU." | 1.42 | Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse. ( Hou, J; Huang, Y; Li, J; Wang, X; Xu, W; Zhang, Y, 2015) |
| "In vitro studies using human and murine colon cancer cell lines demonstrated that both types of nanocarriers significantly increased the antiproliferative effect of the encapsulated drug." | 1.42 | Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer. ( Álvarez, PJ; Áranega, A; Arias, JL; Cabeza, L; Clares, B; Melguizo, C; Ortiz, R; Prados, J; Vélez, C, 2015) |
| "The human colon cancer cell lines SW480, Lovo and HCT116 contain 1." | 1.40 | Characterization of side population cells isolated from the colon cancer cell line SW480. ( Cheng, Y; Hu, X; Ma, L; Xiong, B; Zhang, C, 2014) |
| " Six of the eight pharmacodynamic parameters assume the same value as in the corresponding single drug models." | 1.39 | A predictive pharmacokinetic-pharmacodynamic model of tumor growth kinetics in xenograft mice after administration of anticancer agents given in combination. ( Del Bene, F; Germani, M; Magni, P; Terranova, N, 2013) |
| "Eniluracil is a potent inactivator of dihydropyrimidine dehydrogenase (uracil reductase), the enzyme that rapidly catabolizes 5-fluorouracil (5-FU)." | 1.36 | A possible cause and remedy for the clinical failure of 5-fluorouracil plus eniluracil. ( Cao, S; Spector, T, 2010) |
| " On the other hand, HCT8 cells showed a biphasic [(18)F]FLT flare with lacked TK1 induction in response to the dosage of 5-FU." | 1.36 | Induction of thymidine kinase 1 after 5-fluorouracil as a mechanism for 3'-deoxy-3'-[18F]fluorothymidine flare. ( Chung, JH; Hong, YS; Kim, SY; Kim, TW; Lee, SJ; Moon, DH; Oh, SJ; Ryu, JS, 2010) |
| "The human colon cancer cell line LoVo was injected subcutaneously into the necks of five mice to generate a solid tumor." | 1.35 | A simple colostomy implantation model for evaluating colon cancer. ( Ding, Y; Jin, H; Li, VK; Liu, F; Liu, X; Ni, M; Song, Y; Yun, S; Zhou, S, 2009) |
| "The results suggest that adenovirus-mediated IL-12 gene transfer combined with Ad." | 1.33 | Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice. ( Cho, WK; Hwang, KS; Im, DS; Kim, S; Yoo, J; Yun, HJ, 2005) |
| "With these fluorescent tools, tumors and metastasis in host organs can be externally imaged down to the single-cell level." | 1.33 | Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. ( Hoffman, RM, 2005) |
| "The growth and metastasis of human gastric cancer implanted in SCID mice were significantly inhibited in SU6668 group and combined group, especially in combined group." | 1.33 | [Effect of angiogenesis inhibitor SU6668 on the growth and metastasis of gastric cancer in SCID mice]. ( Jiang, XT; Tao, HQ; Zou, SC, 2006) |
| "1/mIL-12 combined with 5-fluoro-uracilum (5-FU) in treatment of tumor-burdened mice." | 1.32 | [Subcutaneous transplantation of microencapsulated Chinese hamster ovary (CHO) cells/pcDNA 3.1/mIL-12 and subcutaneous transplantation of microencapsulated CHO/pcDNA3.1/mIL-12 combined with 5-fluoro-uracil in treatment of tumor-burdened mice]. ( Cao, J; Pan, YL; Xiao, ZX; Yao, HP; Zheng, S, 2003) |
| "Other than phosphorylation in tumors, [(18)F]FLT was found to be metabolically stable in vivo." | 1.32 | 3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography. ( Aboagye, EO; Barthel, H; Brady, F; Cleij, MC; Collingridge, DR; He, Q; Hutchinson, OC; Luthra, SK; Osman, S; Price, PM, 2003) |
| " For implanted 125I sources of different dose rates and implant times giving a range of total doses, a consistent dose-response relationship was shown between tumor growth time and total dose." | 1.32 | Sensitization to radiation from an implanted 125I source by sustained intratumoral release of chemotherapeutic drugs. ( Berrada, M; Lehnert, SM; Yang, Z, 2004) |
| "Conventional therapy for renal cell carcinoma (RCC) using interferon (IFN) has shown limited antitumor action." | 1.32 | Biochemical modulation of 5-fluorouracil with interferon alpha/beta and gamma on murine renal cell carcinoma. ( Ishii, T; Marumo, K, 2004) |
| " Therefore, we evaluated the anti-proliferative potential of MTA combined with drugs known to exert therapeutic activity against colon cancer, including 5-fluorouracil, oxaliplatin, and SN38, the active metabolite of irinotecan." | 1.31 | Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells. ( Coudray, AM; De Gramont, A; Faivre, S; Gespach, C; Louvet, C; Raymond, E; Tournigand, C, 2002) |
| " This study was designed to investigate the effects of angiogenesis inhibitor TNP-470 in combination with 5-fluorouracil (5-FU) on the growth of human colon cancer cell line, LOVO, in vitro and in vivo." | 1.31 | [Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer]. ( Fan, YF; Huang, ZH; Nie, J, 2002) |
| "5-Fluorouracil (5-FU) is a drug of standard use in chemotherapy of colon carcinoma." | 1.31 | Role for alpha1,2-fucosyltransferase and histo-blood group antigen H type 2 in resistance of rat colon carcinoma cells to 5-fluorouracil. ( Cordel, S; Goupille, C; Hallouin, F; Le Pendu, J; Meflah, K, 2000) |
| " The present results suggest that the BBBA plus TAU combination can provide a better substitute for the massive doses of uridine required to achieve the high levels of uridine necessary to rescue or protect from FUra host toxicities without the toxic side-effects associated with such doses of uridine." | 1.31 | Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine. ( Al Safarjalani, ON; Ashour, OM; el Kouni, MH; Naguib, FN; Panzica, RP, 2000) |
| "The oestrogen receptor positive breast cancer cell lines (MCF-7, T47D) demonstrated an increased level of HSP 27 and 70 expression compared with oestrogen receptor negative cell lines (BT20, HBL100)." | 1.31 | Heat shock protein expression in human tumours grown in severe combined immunodeficient mice. ( Katoh, M; Koninkx, J; Schumacher, U, 2000) |
| "5-Fluorouracil (5FU) treatment (165 mg kg(-1)) caused no significant changes in either pHe or per cent extracellular volume." | 1.30 | Estimations of intra- and extracellular volume and pH by 31P magnetic resonance spectroscopy: effect of therapy on RIF-1 tumours. ( Bhujwalla, ZM; Gillies, RJ; Glickson, JD; McCoy, CL; Stubbs, M, 1998) |
| " Early clinical studies have shown a substantial alteration of the systemic disposition of 5-FU with an increase in 5-FU terminal half-life and have also indicated that EU allows safe oral administration of 5-FU by improving the oral bioavailability of the fluoropyrimidine, which is otherwise too erratic and unpredictable for a drug with such a limited therapeutic window." | 1.30 | In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy. ( Adams, ER; Craig, DJ; Leffert, JJ; Pizzorno, G; Spector, T, 1999) |
| "5 mg/kg), or cisplatin (4 mg/kg, by one shot) to TNP (120-140 mg/kg) with a 6-7 fractionated dosing schedule reduced s." | 1.29 | Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470) and cytotoxic agents in mice. ( Kakinuma, H; Kato, T; Matsuda, Y; Sato, K, 1994) |
| "A new dosage formulation (5-FU-MS), composed of 5-fluorouracil (5-FU) incorporated in polyglactin microspheres, was studied by animal experiments, which revealed the following results." | 1.29 | [Development of 5-fluorouracil incorporated in microspheres for peritoneal carcinomatosis--animal experiments]. ( Fujita, T; Hagiwara, A; Imanishi, T; Ohgaki, M; Ohyama, T; Shimotsuma, M; Shirasu, M; Takahashi, T; Tsujimoto, H; Yamazaki, J, 1995) |
| " Rats were dosed once weekly for 3 weeks with the following regimens: 100 mg/kg 5-FU (maximum tolerated dose), 10 mg/kg 5-FU 1 h after 1 mg/kg 5-EU, or 10 mg/kg 5-FU plus 90 mg/kg 5-FUH2 1 h after 1 mg/kg 5-EU." | 1.29 | Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil. ( Cao, S; Harrington, JA; Porter, DJ; Rustum, YM; Spector, T, 1995) |
| "We have examined the effects of the antitumor polysaccharide SPR-901 in combination with 5-fluorouracil (5-FU) on the antitumor activities against mouse syngeneic tumors." | 1.29 | Effect of antitumor polysaccharide SPR-901 on antitumor activity in combination with 5-FU. ( Miyazaki, H; Nomoto, K; Takeda, Y; Takeo, S; Tanaka, M; Yoshikai, Y, 1994) |
| " 5-FU oral bioavailability was approximately 100% in rats pretreated with 5-EU." | 1.29 | 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. ( Baccanari, DP; Davis, ST; Knick, VC; Spector, T, 1993) |
| "IL-1 protected against the acute reaction produced by fractionated irradiation in the lip mucosa, shifting the dose-response curve by 3." | 1.29 | Interleukin-1 modulatory effect on the action of chemotherapeutic drugs and localized irradiation of the lip, duodenum, and tumor. ( Dorie, MJ; Kallman, RF; Zaghloul, MS, 1993) |
| "PKC activity was reduced in tumors derived from mice treated with either DXR or CGP 41251, but not from those derived from mice treated with the combination." | 1.29 | The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251. ( Beltran, P; Fan, D; Fidler, IJ; Killion, JJ; O'Brian, CA; Wilson, MR; Yoon, SS, 1995) |
| " administration with the Cmax being 29." | 1.28 | Pharmacokinetics and cytotoxicity of B.3839, a molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, in a mouse model. ( Bibby, MC; Double, JA; Loadman, PM; McElhinney, RS, 1992) |
| " The bioavailability of UK-21 given p." | 1.28 | Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25. ( Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O, 1992) |
| " The absence of addition or synergism of toxic side-effects can be explained both by site-specific interactions at the pharmacodynamic level and by interactions at the pharmacokinetic level." | 1.28 | The CMF-regimen. Toxicity patterns following stepwise combinations of cyclophosphamide, methotrexate and fluorouracil. ( De Bruijn, EA; Driessen, OM; Hermans, J, 1991) |
| " The administration of 5'-DFUR resulted in damage to the intestinal mucosal membrane and diarrhea in normal mice, whereas Ro 09-1390 was much less toxic to the intestinal tract." | 1.28 | Comparative antitumor activity and intestinal toxicity of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine. ( Eda, H; Fujimoto, K; Ishida, M; Ishitsuka, H; Miwa, M; Ninomiya, Y; Sahara, H; Umeda, I; Yokose, K, 1990) |
| " Mice bearing murine renal cancer (Renca) were also protected from the acute toxic effects of Cy (450 mg/kg) by pretreatment with rhIL-1 alpha." | 1.28 | Chemoprotective effects of recombinant human IL-1 alpha in cyclophosphamide-treated normal and tumor-bearing mice. Protection from acute toxicity, hematologic effects, development of late mortality, and enhanced therapeutic efficacy. ( Futami, H; Jansen, R; Keller, J; Longo, DL; MacPhee, MJ; McCormick, K; Oppenheim, JJ; Ruscetti, FW; Wiltrout, RH, 1990) |
| " The tumor pool of free 5FU in those human tumors that trapped 5FU was determined to have a half-life of 0." | 1.28 | Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits. ( Albright, MJ; Atkinson, D; Barker, PB; el-Tahtawy, A; King, M; Ong, R; Presant, CA; Ring, R; Servis, KL; Wolf, W, 1990) |
| "Severe toxic side effects of antiproliferative agents limit their clinical usefulness as antitumor drugs." | 1.28 | Epidermal growth factor receptor-mediated selective cytotoxicity of antitumor agents toward human xenografts and murine syngeneic solid tumors. ( Amagase, H; Fuwa, T; Hashimoto, K; Kakimoto, M; Tsukagoshi, S, 1989) |
| " It was concluded that although the 3 assays did not produce identical dose-response curves, the assays were equally valid when used for predictive testing because selection of cut-off points which were based on retrospective correlations between in vitro sensitivity data and response data, as established by other authors, compensated for differences in sensitivity between the assays." | 1.27 | A comparison of three assays used for the in vitro chemosensitivity testing of human tumours. ( Ford, CH; Howell, A; Newman, CE; Wilson, AP, 1984) |
| "Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated." | 1.27 | [Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984) |
| "The effect of 5-fluorouracil (5-FU) in combination with herb medicine on the prolongation of survival rate in tumor bearing mice was studied." | 1.27 | [An approach to prolongation of survival rate in tumor bearing mice using 5-fluorouracil in combination with various kinds of herb medicine]. ( Abe, H; Odashima, S; Ohta, T; Tatsuka, M; Tawara, M, 1983) |
| "A combination chemotherapy regimen for brain tumors was developed, based on investigations of the survival of animals harboring the intracerebral 9L rat brain-tumor model and on analyses of their clonogenic tumor cells." | 1.27 | Improved treatment of a brain-tumor model. Part 2: Sequential therapy with BCNU and 5-fluorouracil. ( Dougherty, DV; Gerosa, MA; Rosenblum, ML; Wilson, CB, 1983) |
| "5-Fluorouracil was administered intraperitoneally in maximally tolerated doses from week 26 onwards and failed to influence significantly the development of either benign or malignant tumours." | 1.27 | Chemotherapy of chemically-induced colorectal tumours. ( Gilbert, JM; Kark, AE; Slavin, G; Thompson, EM, 1983) |
| "Squalene (SQ) was examined for ability to potentiate the cytotoxicity and antitumor activity of anticancer agents." | 1.27 | Potentiation by squalene of the cytotoxicity of anticancer agents against cultured mammalian cells and murine tumor. ( Akiyama, S; Fukawa, H; Komiyama, S; Kuwano, M; Nakagawa, M; Ogata, J; Yamaguchi, T, 1985) |
| "To determine the optimal conditions for clonogenic assay, the antitumor activities of 5-fluorouracil (5-FU) in vitro and in vivo were compared from a pharmacodynamic viewpoint in a human carcinoma xenograft-nude mouse system." | 1.27 | Pharmacodynamic aspects of in vitro and in vivo chemosensitivity tests. ( Abe, O; Asanuma, F; Fukutomi, T; Inada, T; Ishibiki, K; Isobe, Y; Kubota, T; Kurihara, H, 1987) |
| "To determine the optimal condition of the clonogenic assay, the antitumor activities of 5-fluorouracil (5-FU) in vitro and in vivo were investigated from a pharmacodynamic viewpoint using 8 human carcinoma xenografts." | 1.27 | [Pharmacodynamic study of the in vitro clonogenic assay--with reference to dose levels]. ( Isobe, Y, 1988) |
| "5-Fluorouracil (5-FU) was microencapsulated with poly L-lactic acid by the organic phase separation technique." | 1.27 | [A new anticancer preparation, 5-fluorouracil-poly-L-lactic acid microcapsule, and its therapeutic evaluation]. ( Hirano, M; Iwa, T; Kawaura, Y; Kitagawa, S; Sakatoku, M; Yamada, T; Yamashita, R, 1986) |
| " Such cytostatic drugs as cyclophosphamide (alkylating agent) and 5-fluorouracil (antimetabolite) showed a significantly enhanced antitumor and metastation--preventing effect when used in combination with polyene antibiotic amphotericin B and a diuretic drug--diacarb." | 1.27 | [Potentiation of the selective antitumoral effect of cyclophosphamide and 5-fluorouracil by its combination with amphotericin B and diacarb]. ( Bychkov, IA; Iaremenko, KV; Pashinskiĭ, VG, 1986) |
| "In tumor-bearing WAG/Rij rats the interaction of cyclophosphamide and/or 5-fluorouracil (5-FU) with methotrexate as manifested at the pharmacokinetic level was studied." | 1.27 | Pharmacokinetic interactions of cyclophosphamide and 5-fluorouracil with methotrexate in an animal model. ( de Bruijn, EA; Driessen, O; Hermans, J; Leeflang, P; Slee, PH; van den Bosch, N; van Strijen, E, 1986) |
| " As determined by effects on the white blood cell count and by changes in body weight, FUra was least toxic in mice fed the HP diet." | 1.27 | Effect of a high-protein-low-carbohydrate diet on toxicity and antitumor activity of 5-fluorouracil in mice. ( Flanigen-Roat, DT; Ip, MM; Milholland, RJ, 1985) |
| " Dose-response relationships of 3 triple-drug combinations and their component agents were explored, allowing the relative contributions of single agents in each combination to be assessed." | 1.26 | Experimental combination and single-agent chemotherapy in human lung-tumour xenografts. ( Jones, JM; Peckham, MJ; Shorthouse, AJ; Steel, GG, 1982) |
| " The recommended dosage for daily oral administration of FD-1 is 6-12 mg/kg/day." | 1.26 | Review of a new antimetabolic agent, 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1). ( Taguchi, T, 1980) |
| "These xenografts were 1 line of rectal cancer (H-26), two lines of gastric cancer (H-08 and H-22), and 1 line of breast cancer (H-62)." | 1.26 | Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient. ( Fujita, M; Hayata, S; Taguchi, T, 1980) |
| " The results confirm that it is possible to compare phenotypical normal with nude mice both with regard to dosage levels and therapeutic activity." | 1.26 | Toxicologic and therapeutic examinations with ftorafur in different mouse strains. ( Arnold, W; Fichtner, I; Naundorf, H, 1981) |
| "Urinary bladder tumors were induced in 18 of 20 rats (90." | 1.26 | [Effect of FT-207 on bladder cancer in rats induced by BBN. II: The effect of oral administration of FT-207 during oncogenesis of bladder cancer]. ( Babaya, K; Hiramatsu, T; Hirao, Y; Ijuin, M; Kihoin, K; Maruyama, Y; Ohara, S; Okajima, E; Tanaka, M, 1982) |
| " After 5-fluorouracil treatment, 2 to 5 X 10(5) feeder cells were required to maximize surviving fractions for each drug concentration and to generate a biphasic dose-response curve." | 1.26 | Effect of feeder cell-released substances on the survival of clonogenic 9L cells after treatment with antimetabolites. ( Deen, DF; Weizsaecker, M, 1980) |
| "Eighty three patients suffering from brain tumors have been treated by anticancer pellets containing 5-FU, urokinase, mitomycin and BUdR in dimethylsiloxan (Silastic) for three years." | 1.26 | [Treatment of brain tumors with anticancer pellet--experimental and clinical study (author's transl)]. ( Handa, H; Hashi, K; Kieler, J; Kobayashi, A; Mori, K; Murata, T; Oda, Y; Tokuriki, Y; Uchida, Y, 1982) |
| "Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice." | 1.26 | Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours. ( Bibby, MC; Double, JA; Mughal, MA, 1981) |
| "In the chemotherapy for gastric cancer, the most sensitive anticancer agent against individual tumors should be prescribed." | 1.26 | Sensitivity of anticancer agents of human gastric cancers transplanted into nude mice. ( Hattori, T; Nishimawari, K; Nosoh, Y; Tani, T, 1981) |
| "Human malignant melanoma was transplanted to the cheek pouch of immunosuppressed (corticosteroid-treated) hamsters." | 1.26 | Chemotherapy against human melanoma in the hamster cheek pouch. ( Dufour, FD; Mah, SG; Morton, DL; Okada, GT, 1980) |
| "N1-S1/FdUrd Novikoff hepatoma cells, which lack thymidine kinase activity, are resistant to 5-fluorouracil (FUra) as well as 5-fluorodeoxyuridine (FdUrd), suggesting that the pathway, FUra leads to FdUrd leads to FdUMP, is utilized for the conversion of FUra to FdUMP." | 1.26 | Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells. ( Crumley, J; Wilkinson, DS, 1977) |
| " Comparison of the effects of single vs fractionated dosage was made on 2 types of experimental solid tumour with different growth, cell kinetic, histological and metastasizing properties." | 1.26 | Solid tumour models for the assessment of different treatment modalities: VII: single vs fractionated doses of 5-fluorouracil on two solid tumours and their hosts. ( Hopkins, HA; Looney, WB; Macleod, MS, 1978) |
| "Cell free supernatants from human breast tumors produce less total phosphorylation than murine tumors and some specimens produce only monophosphates whereas others produce mono-, di and triphosphates." | 1.26 | Studies on mechanisms of 5-fluorouracil resistance in murine and human tumors. ( Ardalan, B; Cooney, D; Macdonald, JS; Schein, PS, 1979) |
| " These results showed that the maximum tolerated dosage of the agents administered intrarectally suppressed the development of new tumors after start of the treatment and also the growth of tumors which were detected by endoscopy before the treatment." | 1.26 | Cancer chemotherapy model using autochthonous large bowel cancer in rats. ( Kono, K; Narisawa, T; Takahashi, T; Yamaguchi, T, 1978) |
| "Cure following surgery of bladder cancer is limited by recurrence of the original tumor or by the development of new primary tumors." | 1.26 | Effectiveness of long-term chemotherapy and/or BCG on murine bladder cancer. ( Soloway, MS, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 368 (66.43) | 18.7374 |
| 1990's | 74 (13.36) | 18.2507 |
| 2000's | 48 (8.66) | 29.6817 |
| 2010's | 51 (9.21) | 24.3611 |
| 2020's | 13 (2.35) | 2.80 |
| Authors | Studies |
|---|---|
| Yasumoto, M | 2 |
| Moriyama, A | 1 |
| Unemi, N | 2 |
| Hashimoto, S | 2 |
| Suzue, T | 1 |
| Yamawaki, I | 1 |
| Marunaka, T | 2 |
| Murdock, KC | 2 |
| Child, RG | 1 |
| Fabio, PF | 1 |
| Angier, RB | 2 |
| Wallace, RE | 2 |
| Durr, FE | 3 |
| Citarella, RV | 2 |
| Lee, KH | 1 |
| Wu, YS | 1 |
| Hall, IH | 1 |
| Giorgi-Renault, S | 1 |
| Renault, J | 1 |
| Gebel-Servolles, P | 1 |
| Baron, M | 2 |
| Paoletti, C | 1 |
| Cros, S | 1 |
| Bissery, MC | 2 |
| Lavelle, F | 1 |
| Atassi, G | 1 |
| Bobek, M | 1 |
| An, SH | 1 |
| Skrincosky, D | 1 |
| De Clercq, E | 1 |
| Bernacki, RJ | 1 |
| Lin, TS | 1 |
| Wang, L | 4 |
| Antonini, I | 1 |
| Cosby, LA | 1 |
| Shiba, DA | 1 |
| Kirkpatrick, DL | 1 |
| Sartorelli, AC | 2 |
| Hronowski, LJ | 1 |
| Szarek, WA | 1 |
| Kametani, T | 2 |
| Kigasawa, K | 2 |
| Hiiragi, M | 2 |
| Wakisaka, K | 2 |
| Haga, S | 1 |
| Nagamatsu, Y | 1 |
| Sugi, H | 1 |
| Fukawa, K | 3 |
| Irino, O | 3 |
| Yamamoto, T | 1 |
| Nishimura, N | 3 |
| Taguchi, A | 2 |
| Okada, T | 3 |
| Nakayama, M | 1 |
| Bi, Y | 1 |
| Xu, J | 3 |
| Wu, X | 1 |
| Ye, W | 1 |
| Yuan, S | 1 |
| Zhang, L | 1 |
| Wang, J | 3 |
| Xie, S | 1 |
| Li, Y | 4 |
| Guo, Y | 1 |
| Ma, Y | 2 |
| Zhao, J | 2 |
| Phanstiel, O | 1 |
| Wang, C | 1 |
| Wang, G | 1 |
| Li, C | 2 |
| He, L | 1 |
| Lei, K | 1 |
| Wang, F | 1 |
| Pu, Y | 1 |
| Yang, Z | 2 |
| Cao, D | 1 |
| Ma, L | 2 |
| Chen, J | 1 |
| Sang, Y | 1 |
| Liang, X | 1 |
| Xiang, M | 1 |
| Peng, A | 1 |
| Wei, Y | 2 |
| Chen, L | 2 |
| Wu, LT | 1 |
| Jiang, Z | 1 |
| Shen, JJ | 1 |
| Yi, H | 1 |
| Zhan, YC | 1 |
| Sha, MQ | 1 |
| Wang, Z | 3 |
| Xue, ST | 1 |
| Li, ZR | 1 |
| Abdel-Rahman, SA | 1 |
| El-Gohary, NS | 1 |
| El-Bendary, ER | 1 |
| El-Ashry, SM | 1 |
| Shaaban, MI | 1 |
| Mohammed, YHE | 1 |
| Malojirao, VH | 1 |
| Thirusangu, P | 1 |
| Al-Ghorbani, M | 1 |
| Prabhakar, BT | 1 |
| Khanum, SA | 1 |
| Jiang, Y | 1 |
| Li, X | 2 |
| Hou, J | 2 |
| Huang, Y | 4 |
| Wang, X | 4 |
| Jia, Y | 1 |
| Wang, Q | 1 |
| Xu, W | 2 |
| Zhang, J | 3 |
| Zhang, Y | 6 |
| Lu, S | 1 |
| Obianom, ON | 1 |
| Ai, Y | 1 |
| Wei, G | 1 |
| Sun, J | 1 |
| Hou, Z | 1 |
| Luan, W | 1 |
| Wang, S | 2 |
| Cui, S | 1 |
| Cheng, M | 2 |
| Liu, Y | 3 |
| Shen, QK | 1 |
| Deng, H | 1 |
| Wang, SB | 1 |
| Tian, YS | 1 |
| Quan, ZS | 1 |
| Qi, B | 1 |
| Zhong, L | 1 |
| He, J | 1 |
| Zhang, H | 4 |
| Li, F | 1 |
| Wang, T | 2 |
| Zou, J | 1 |
| Lin, YX | 1 |
| Zhang, C | 3 |
| Guo, X | 1 |
| Li, R | 1 |
| Shi, J | 2 |
| Fu, DJ | 1 |
| Song, J | 2 |
| Zhu, T | 1 |
| Pang, XJ | 1 |
| Wang, SH | 1 |
| Zhang, YB | 1 |
| Wu, BW | 1 |
| Wang, JW | 1 |
| Zi, X | 1 |
| Zhang, SY | 1 |
| Liu, HM | 1 |
| Liu, ZY | 1 |
| Tang, ML | 1 |
| Ning, JF | 1 |
| Hao, YP | 1 |
| Zhou, L | 1 |
| Sun, X | 2 |
| Jia, X | 1 |
| Liu, Q | 1 |
| Zeng, B | 1 |
| Du, G | 1 |
| Yang, WS | 1 |
| Qi, XR | 1 |
| Xu, QZ | 1 |
| Yuan, CH | 1 |
| Yi, YH | 1 |
| Tang, HF | 1 |
| Shen, L | 1 |
| Han, H | 1 |
| Gong, Q | 1 |
| Yang, F | 1 |
| Hu, J | 1 |
| Li, T | 1 |
| Wang, P | 1 |
| Zhang, X | 2 |
| Feng, Y | 1 |
| Lu, Y | 1 |
| Li, J | 2 |
| Li, Z | 1 |
| Feng, H | 1 |
| Deng, X | 2 |
| Liu, D | 1 |
| Shi, T | 1 |
| Jiang, W | 1 |
| He, Y | 1 |
| Zhang, G | 1 |
| Luo, X | 1 |
| Zhang, W | 1 |
| Chen, E | 1 |
| Meng, Q | 1 |
| Wang, D | 2 |
| Huang, X | 1 |
| Zhou, W | 1 |
| Song, Z | 1 |
| Liu, XY | 1 |
| Zheng, CB | 1 |
| Zhang, M | 1 |
| Gou, LS | 1 |
| Jin, L | 1 |
| Qi, X | 1 |
| Zeng, X | 1 |
| Li, H | 2 |
| Qiu, S | 1 |
| Zhang, P | 1 |
| Winters, K | 1 |
| Kiser, K | 1 |
| Baboli, M | 1 |
| Kim, SG | 2 |
| Cui, R | 1 |
| Zhao, P | 1 |
| Yan, Y | 2 |
| Bao, G | 1 |
| Damirin, A | 1 |
| Liu, Z | 1 |
| Kong, X | 1 |
| Houzong, R | 1 |
| Fu, J | 1 |
| Shao, K | 1 |
| Cai, B | 2 |
| Pan, J | 2 |
| Chen, H | 2 |
| Chen, X | 2 |
| Ye, Z | 1 |
| Yuan, H | 1 |
| Sun, H | 4 |
| Wan, P | 2 |
| Rani, I | 1 |
| Sharma, B | 1 |
| Kumar, S | 1 |
| Kaur, S | 1 |
| Agnihotri, N | 1 |
| Hu, B | 1 |
| Yuan, Y | 1 |
| Zhou, X | 1 |
| Kan, Q | 1 |
| Li, S | 3 |
| Birma Bwatanglang, I | 1 |
| Mohammad, F | 1 |
| Yusof, NA | 1 |
| Elyani Mohammed, N | 1 |
| Abu, N | 1 |
| Alitheen, NB | 1 |
| Abdullah, J | 1 |
| Zubir Hussein, M | 1 |
| Abba, Y | 1 |
| Nordin, N | 1 |
| Rizi Zamberi, N | 1 |
| Iqbal, S | 1 |
| Rashid, MH | 1 |
| Arbab, AS | 1 |
| Khan, M | 1 |
| Yang, W | 1 |
| Xin, L | 1 |
| Denslow, A | 1 |
| Świtalska, M | 1 |
| Jarosz, J | 1 |
| Papiernik, D | 1 |
| Porshneva, K | 1 |
| Nowak, M | 1 |
| Wietrzyk, J | 1 |
| Linnekamp, JF | 1 |
| Hooff, SRV | 1 |
| Prasetyanti, PR | 1 |
| Kandimalla, R | 1 |
| Buikhuisen, JY | 1 |
| Fessler, E | 1 |
| Ramesh, P | 1 |
| Lee, KAST | 1 |
| Bochove, GGW | 1 |
| de Jong, JH | 1 |
| Cameron, K | 1 |
| Leersum, RV | 1 |
| Rodermond, HM | 1 |
| Franitza, M | 1 |
| Nürnberg, P | 1 |
| Mangiapane, LR | 1 |
| Clevers, H | 1 |
| Vermeulen, L | 1 |
| Stassi, G | 1 |
| Medema, JP | 1 |
| Zhang, Q | 1 |
| Xu, Y | 1 |
| Lv, J | 1 |
| Wu, Y | 1 |
| Cao, K | 1 |
| Mou, X | 1 |
| Fan, Q | 1 |
| Zykova, T | 1 |
| Zhu, F | 1 |
| Lim, DY | 1 |
| Yao, K | 1 |
| Roh, E | 1 |
| Yoon, SP | 1 |
| Kim, HG | 2 |
| Bae, KB | 1 |
| Wen, W | 1 |
| Shin, SH | 1 |
| Nadas, J | 1 |
| Ma, W | 2 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Khosravianfar, N | 1 |
| Hadjati, J | 1 |
| Namdar, A | 1 |
| Boghozian, R | 1 |
| Hafezi, M | 1 |
| Ashourpour, M | 1 |
| Kheshtchin, N | 1 |
| Banitalebi, M | 1 |
| Mirzaei, R | 1 |
| Razavi, SA | 1 |
| Sahu, P | 1 |
| Kashaw, SK | 1 |
| Sau, S | 1 |
| Kushwah, V | 1 |
| Jain, S | 2 |
| Agrawal, RK | 1 |
| Iyer, AK | 1 |
| Zhuang, J | 1 |
| Zheng, W | 1 |
| Yang, S | 1 |
| Zhu, G | 1 |
| Lin, X | 1 |
| Ye, J | 1 |
| Terranova, N | 1 |
| Germani, M | 1 |
| Del Bene, F | 1 |
| Magni, P | 1 |
| Alishekevitz, D | 1 |
| Bril, R | 1 |
| Loven, D | 1 |
| Miller, V | 1 |
| Voloshin, T | 1 |
| Gingis-Velistki, S | 1 |
| Fremder, E | 1 |
| Scherer, SJ | 1 |
| Shaked, Y | 1 |
| Karakhanova, S | 1 |
| Mosl, B | 1 |
| Harig, S | 1 |
| von Ahn, K | 1 |
| Fritz, J | 1 |
| Schmidt, J | 1 |
| Jäger, D | 1 |
| Werner, J | 1 |
| Bazhin, AV | 1 |
| Sivakumar, B | 1 |
| Aswathy, RG | 1 |
| Sreejith, R | 1 |
| Nagaoka, Y | 1 |
| Iwai, S | 1 |
| Suzuki, M | 2 |
| Fukuda, T | 1 |
| Hasumura, T | 1 |
| Yoshida, Y | 4 |
| Maekawa, T | 1 |
| Sakthikumar, DN | 1 |
| Hsiao, HT | 1 |
| Xing, L | 1 |
| Ling, CC | 1 |
| Li, GC | 1 |
| Xiong, B | 1 |
| Hu, X | 1 |
| Cheng, Y | 1 |
| Yamamura, Y | 1 |
| Tsuchikawa, T | 1 |
| Miyauchi, K | 1 |
| Takeuchi, S | 1 |
| Wada, M | 1 |
| Kuwatani, T | 1 |
| Kyogoku, N | 1 |
| Kuroda, A | 1 |
| Maki, T | 1 |
| Shichinohe, T | 1 |
| Hirano, S | 1 |
| Le, VM | 1 |
| Wang, JJ | 1 |
| Yuan, M | 1 |
| Nguyen, TL | 1 |
| Yin, GF | 1 |
| Zheng, YH | 1 |
| Shi, WB | 1 |
| Lang, MD | 1 |
| Xu, LM | 1 |
| Liu, JW | 1 |
| Dun, J | 1 |
| Gao, H | 1 |
| Ortiz, R | 1 |
| Cabeza, L | 1 |
| Arias, JL | 1 |
| Melguizo, C | 1 |
| Álvarez, PJ | 1 |
| Vélez, C | 1 |
| Clares, B | 1 |
| Áranega, A | 1 |
| Prados, J | 1 |
| Wei, B | 1 |
| Tao, Y | 1 |
| Tang, R | 1 |
| Wang, R | 1 |
| Qiu, L | 1 |
| Hirt, C | 1 |
| Papadimitropoulos, A | 1 |
| Muraro, MG | 1 |
| Mele, V | 1 |
| Panopoulos, E | 1 |
| Cremonesi, E | 1 |
| Ivanek, R | 1 |
| Schultz-Thater, E | 1 |
| Droeser, RA | 1 |
| Mengus, C | 1 |
| Heberer, M | 1 |
| Oertli, D | 1 |
| Iezzi, G | 1 |
| Zajac, P | 1 |
| Eppenberger-Castori, S | 1 |
| Tornillo, L | 1 |
| Terracciano, L | 1 |
| Martin, I | 1 |
| Spagnoli, GC | 1 |
| Yang, H | 1 |
| Pi, C | 1 |
| Liu, H | 1 |
| Ye, Y | 1 |
| Zhao, L | 1 |
| Han, R | 1 |
| Sun, Y | 1 |
| Kang, C | 1 |
| Wei, W | 1 |
| Zhu, X | 1 |
| Huang, T | 1 |
| Li, Q | 1 |
| Ma, S | 1 |
| Zhang, K | 1 |
| Yang, B | 1 |
| Guan, F | 1 |
| Wu, J | 1 |
| Zhou, Y | 1 |
| Qu, D | 1 |
| Zhu, WH | 1 |
| Tian, H | 1 |
| Eley, HL | 1 |
| McDonald, PS | 1 |
| Russell, ST | 1 |
| Tisdale, MJ | 1 |
| Ganzinelli, M | 1 |
| Carrassa, L | 1 |
| Crippa, F | 1 |
| Tavecchio, M | 1 |
| Broggini, M | 1 |
| Damia, G | 1 |
| Akbulut, H | 1 |
| Tang, Y | 1 |
| Akbulut, KG | 1 |
| Maynard, J | 1 |
| Deisseroth, A | 1 |
| Jin, H | 1 |
| Liu, X | 1 |
| Li, VK | 1 |
| Ding, Y | 1 |
| Yun, S | 1 |
| Liu, F | 1 |
| Zhou, S | 1 |
| Song, Y | 1 |
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| Baker, JH | 1 |
| Lam, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase-II Clinical Trial to Evaluate the Accuracy of FDG-/FLT-PET for Early Prediction of Non-progression in Patients With Advanced NSCLC Treated With Erlotinib and to Associate PET Findings With Molecular Markers[NCT00568841] | Phase 2 | 40 participants (Anticipated) | Interventional | 2007-10-31 | Active, not recruiting | ||
| TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.[NCT04392479] | Phase 3 | 202 participants (Anticipated) | Interventional | 2020-09-02 | Active, not recruiting | ||
| A Phase I, Open-Label, Non-Randomized, Dose-Escalating Safety, Tolerability and Pharmacokinetic Study of TAS-114 in Combination With S-1 in Patients With Advanced Solid Tumors[NCT02454062] | Phase 1 | 120 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| Prospective Randomized Phase III Study of Concurrent Capecitabine and Radiotherapy With or Without Oxaliplatin as Adjuvant Treatment for Stage II and III Rectal Cancer[NCT00714077] | 570 participants (Anticipated) | Observational | 2008-04-30 | Recruiting | |||
| Estudo Randomizado de Fase II Com Capecitabina Versus 5-Fluorouracil/Leucovorin em Bolus Associados à Radioterapia no Tratamento Neoadjuvante de câncer de Reto Localmente avançado: INCAGI004.[NCT03428529] | Phase 2/Phase 3 | 63 participants (Actual) | Interventional | 2011-01-12 | Completed | ||
| Analysis of the Effect of Teduglutide Treatment on Intestinal Malabsorption and Paneth Cell Numbers in Patients With Steroid-refractory Gastrointestinal Graft Versus Host Disease (SR-GI-GVHD).[NCT04290429] | Early Phase 1 | 6 participants (Actual) | Interventional | 2017-12-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
36 reviews available for fluorouracil and Experimental Neoplasms
| Article | Year |
|---|---|
EXPERIMENTAL AND CLINICAL USE OF FLUORINATED PYRIMIDINES IN CANCER CHEMOTHERAPY.
Topics: Breast Neoplasms; Carbon Isotopes; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Me | 1963 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum | 1963 |
Focus on gastric cancer.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cadheri | 2004 |
The target cell determinants of the antitumor actions of 5-FU: does FU incorporation into RNA play a role?
Topics: Animals; DNA, Bacterial; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Mice; Neoplasms, Experim | 1981 |
[Biological response modifying effect of chemotherapeutic agents against cancer].
Topics: Animals; Antineoplastic Agents; Cell Wall; Doxorubicin; Fluorouracil; Immunity, Cellular; Killer Cel | 1984 |
An update on the biochemistry of 5-fluorouracil.
Topics: Animals; Biotransformation; DNA-Directed RNA Polymerases; DNA, Neoplasm; Fluorouracil; Mice; Neoplas | 1981 |
Studies of analogs of fluorinated pyrimidine in Japan.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouraci | 1981 |
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluoroura | 1981 |
Cancer chronotherapy: is there a right time in the day to treat?
Topics: Animals; Antineoplastic Agents; Circadian Rhythm; Floxuridine; Fluorouracil; Humans; Neoplasms; Neop | 1995 |
In vivo monitoring of fluoropyrimidine metabolites: magnetic resonance spectroscopy in the evaluation of 5-fluorouracil.
Topics: Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Fluorine; Fluorouracil; Humans; Mag | 1994 |
[Development of fluorinated pyrimidines in Japan].
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Fluorode | 1993 |
Rationale for adjuvant chemotherapy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carmustine; Cyclophosphamide; Cytarabine; Doxorubi | 1977 |
The biologic basis of malignant brain tumor therapy.
Topics: Animals; BCG Vaccine; Brain Neoplasms; Carcinoma, Hepatocellular; Culture Techniques; DNA, Neoplasm; | 1976 |
Multimodal primary cancer treatment (adjuvant chemotherapy): current results and future prospects.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Colonic Neoplasms; Evaluation Stud | 1979 |
Intravesical and systemic chemotherapy of murine bladder cancer.
Topics: Animals; Antineoplastic Agents; BCG Vaccine; Carcinoma, Transitional Cell; Cisplatin; Cyclophosphami | 1977 |
1977 Henry H. Janeway lecture: fundamental mechanisms in combined modality therapy of cancer.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Dactinomycin; DNA Repair; DNA, Neoplasm; Electron | 1977 |
Experimental investigations on immunodepressive properties of carcinogenic substances in male Sprague-Dawley rats.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antibody Formation; Antimetabolites, Antine | 1975 |
[Effect of antifolates and folates on the antineoplastic action of fluoropyrimidines].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Inte | 1992 |
Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators.
Topics: Animals; Fluorodeoxyuridylate; Fluorouracil; Humans; Neoplasms; Neoplasms, Experimental; Pyrimidines | 1991 |
The role of low-dose PALA in biochemical modulation.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Clinical Trials as Topic; Dose-Response Relationship, | 1990 |
Enhancement of the antitumor effects of 5-fluorouracil by folinic acid.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Synergism; F | 1990 |
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
5-Fluorouracil containing combinations in murine tumor systems.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; | 1989 |
[Potentiation of the antitumor activity of 5-fluorouracil by biochemical modulators].
Topics: Animals; Drug Synergism; Fluorouracil; Interferon Inducers; Neoplasms, Experimental; RNA, Neoplasm | 1988 |
Role of thymidine in biochemical modulation: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic A | 1987 |
Biochemical modulation: application of laboratory models to the clinic.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Dose-Response Re | 1986 |
Magnets, molecules and medicine.
Topics: Adipose Tissue; Anesthetics; Animals; Fluorouracil; Fourier Analysis; Humans; Lipids; Magnetic Reson | 1985 |
Resistance of mammalian tumour cells toward pyrimidine analogues. A review.
Topics: Animals; Antimetabolites; Azacitidine; Azauridine; Bromouracil; Carcinoma, Ehrlich Tumor; Cell Line; | 1973 |
Clinical use of radiation sensitizing agents.
Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura | 1974 |
[Molecular basis of the relation between the cytotoxic effect of antineoplastic compounds and the cell cycle phase].
Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Alkylating Agents; Androgens; Animals; Antibiotics, Ant | 1972 |
[Use of optical quantum generators (lasers) in oncology].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bronchial Neoplasms; Carcinoma, Basal Cell; Carcinom | 1972 |
Obstacles to the improvement of radiotherapy of rectal cancer.
Topics: Adenocarcinoma; Animals; Cyclophosphamide; Fluorouracil; Humans; Laparotomy; Lymphography; Methods; | 1973 |
Present experiences with hepatic dearterialization in liver neoplasm.
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Cathe | 1974 |
[Various aspects of the problem of selectivity in the chemotherapy of cancer].
Topics: Animals; Antimetabolites; Antineoplastic Agents; Chemical Phenomena; Chemistry; DNA, Neoplasm; Fluor | 1969 |
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.
Topics: Animals; Antineoplastic Agents; Arginase; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Divisi | 1970 |
[Side-effects of cytostatic therapy with special reference to potential carcinogenic effects].
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Bus | 1971 |
9 trials available for fluorouracil and Experimental Neoplasms
| Article | Year |
|---|---|
Influence of interferon-alpha combined with chemo (radio) therapy on immunological parameters in pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Che | 2014 |
Metabolism of a novel nucleoside analogue, OGT 719, in the isolated perfused rat liver model, in rats, in tumour models and in patients.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Biotransformation; Fetuins; Fluorine Radioisotopes | 2003 |
Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celeco | 2007 |
[Chrono-chemotherapy and dose intensity].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chronobiology | 1995 |
Enhancement of the antitumor effects of 5-fluorouracil by folinic acid.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Synergism; F | 1990 |
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
Pharmacokinetic approach to rational therapeutic doses for human tumor-bearing nude mice.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Tolera | 1988 |
[Modulation of the anti-tumor effect of BRM under various nutritional or endocrine conditions].
Topics: Animals; Combined Modality Therapy; Endocrine Glands; Female; Fluorouracil; Humans; Lentinan; Mammar | 1986 |
[Radiotherapy of malignant neoplasms following synchronisation of cell division rhythm. Experiences following two years of clinical use].
Topics: Animals; Carcinoma; Carcinoma, Squamous Cell; Clinical Trials as Topic; Fluorouracil; Humans; Infusi | 1972 |
511 other studies available for fluorouracil and Experimental Neoplasms
| Article | Year |
|---|---|
Studies of antitumor agents. 1. Resolution of racemic 1-(tetrahydro-2-furanyl)-k-fluorouracil into the R and S isomers and examination of the biological activities of the isomers.
Topics: Animals; Bacteria; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; Neoplasms, Expe | 1977 |
Studies on antitumor agents, 2. Syntheses and antitumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Fluorouracil; Letha | 1978 |
Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones.
Topics: Animals; Anthracenes; Antineoplastic Agents; Leukemia, Experimental; Mice; Neoplasms, Experimental; | 1979 |
Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Lactones; Leukemia, Experimental; Male; Melan | 1977 |
Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione.
Topics: Animals; Antineoplastic Agents; Aziridines; Breast Neoplasms; Cell Division; Cell Line; Drug Screeni | 1991 |
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Topics: Animals; Arabinonucleosides; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Female; F | 1989 |
(o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil derivatives as potential conjugated bioreductive alkylating agents.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia P388; Mice; Neoplasm | 1986 |
Synthesis and biological evaluation of novel pyrimidine nucleoside analogues of 1,4-oxathiane, 1,4-dithiane, and 1,4-dioxane.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Hetero | 1982 |
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Female; Fluorouracil; Lethal Dose 50; | 1980 |
Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.
Topics: Animals; Antineoplastic Agents; Betulinic Acid; Carboxylic Acids; Cell Line, Tumor; Esters; Humans; | 2007 |
Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Mice; Neoplasms, Exper | 2008 |
Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Chalcone; Dose-Response R | 2014 |
Design, synthesis and biological evaluation of novel benzimidazole-2-substituted phenyl or pyridine propyl ketene derivatives as antitumour agents.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Cell Cycle; Cell Proliferation; Dose-Response Relati | 2016 |
Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Bacteria; Cell Line; Cell | 2017 |
The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death.
Topics: Acetamides; Animals; Antineoplastic Agents; Cell Death; Cell Proliferation; Dose-Response Relationsh | 2018 |
Synthesis and biological characterization of ubenimex-fluorouracil conjugates for anti-cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relat | 2018 |
Novel cinnamaldehyde-based aspirin derivatives for the treatment of colorectal cancer.
Topics: Acrolein; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Cell Cycle Checkpoints; Cell Line, Tum | 2018 |
Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Products; Cell Proliferation; Dose-Response Re | 2018 |
Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Diterpenes, K | 2019 |
Discovery of Inhibitors of Aurora/PLK Targets as Anticancer Agents.
Topics: Animals; Antineoplastic Agents; Aurora Kinase A; Cell Cycle Proteins; Cell Proliferation; Cell Survi | 2019 |
Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo.
Topics: Amides; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, D | 2020 |
Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Colorectal Neoplasms; Docetaxel | 2020 |
Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbamates; Cell Line, Tumor; Cell Survival; Drug Screeni | 2020 |
A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Glycosides; Huma | 2021 |
Rational designed highly sensitive NQO1-activated near-infrared fluorescent probe combined with NQO1 substrates in vivo: An innovative strategy for NQO1-overexpressing cancer theranostics.
Topics: A549 Cells; Animals; Antineoplastic Agents; Benzoquinones; Cell Survival; Dose-Response Relationship | 2021 |
Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Differentiation; Cell Proliferation; Dos | 2022 |
TIMP-2 regulates 5-Fu resistance via the ERK/MAPK signaling pathway in colorectal cancer.
Topics: Aged; Animals; Butadienes; Cell Survival; Colorectal Neoplasms; Cytokines; Drug Resistance, Neoplasm | 2022 |
SPZ1 promotes deregulation of Bim to boost apoptosis resistance in colorectal cancer.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Bcl-2-Like Protein | 2020 |
Assessment of tumor treatment response using active contrast encoding (ACE)-MRI: Comparison with conventional DCE-MRI.
Topics: Animals; Antineoplastic Agents; Bevacizumab; Cell Line, Tumor; Contrast Media; Fluorouracil; Gadolin | 2020 |
Outstanding Drug-Loading/Release Capacity of Hollow Fe-Metal-Organic Framework-Based Microcapsules: A Potential Multifunctional Drug-Delivery Platform.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Proliferation; Cell Survival; Drug Carrier | 2021 |
Application of a novel thermo-sensitive injectable hydrogel in therapy in situ for drug accurate controlled release.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; | 2020 |
Oyster polysaccharides ameliorate intestinal mucositis and improve metabolism in 5-fluorouracil-treated S180 tumour-bearing mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Butyric Acid; Cell Line, Tumor; DNA | 2021 |
Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma.
Topics: Animals; Apoptosis; Carcinoma; Cell Proliferation; Colonic Neoplasms; Dextran Sulfate; DNA Damage; D | 2017 |
Preparation and evaluation of a novel anticancer drug delivery carrier for 5-Fluorouracil using synthetic bola-amphiphile based on lysine as polar heads.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Delivery Systems; Fluorouracil; Hep G2 Cells; Humans; | 2017 |
Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chitosan; Female; Fluorouracil; Man | 2017 |
Encapsulation of Anticancer Drugs (5-Fluorouracil and Paclitaxel) into Polycaprolactone (PCL) Nanofibers and In Vitro Testing for Sustained and Targeted Therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Delayed-Action Preparat | 2017 |
A novel design of HA-coated nanoparticles co-encapsulating plasmid METase and 5-Fu shows enhanced application in targeting gastric cancer stem cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carbon-Sulfur Lyases; Cell Movement; Cell Proli | 2018 |
Clopidogrel in a combined therapy with anticancer drugs-effect on tumor growth, metastasis, and treatment toxicity: Studies in animal models.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Clopidogrel; Fluorouracil; Humans; Male; Mice; Neo | 2017 |
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Differentiation; Cell Proliferati | 2018 |
New utilization of Polygonum multiflorum polysaccharide as macromolecular carrier of 5-fluorouracil for controlled release and immunoprotection.
Topics: Animals; Cytokines; Delayed-Action Preparations; Drug Carriers; Fallopia multiflora; Female; Fluorou | 2018 |
Targeting PRPK Function Blocks Colon Cancer Metastasis.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic N | 2018 |
Myeloid-derived Suppressor Cells Elimination by 5-Fluorouracil Increased Dendritic Cell-based Vaccine Function and Improved Immunity in Tumor Mice.
Topics: Animals; Cancer Vaccines; CD8-Positive T-Lymphocytes; Dendritic Cells; Female; Fluorouracil; Humans; | 2018 |
pH Responsive 5-Fluorouracil Loaded Biocompatible Nanogels For Topical Chemotherapy of Aggressive Melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; | 2019 |
TMEM100 expression suppresses metastasis and enhances sensitivity to chemotherapy in gastric cancer.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Cell Survival; | 2020 |
A predictive pharmacokinetic-pharmacodynamic model of tumor growth kinetics in xenograft mice after administration of anticancer agents given in combination.
Topics: Algorithms; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, | 2013 |
Differential therapeutic effects of anti-VEGF-A antibody in different tumor models: implications for choosing appropriate tumor models for drug testing.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antineoplastic | 2014 |
Bacterial exopolysaccharide based magnetic nanoparticles: a versatile nanotool for cancer cell imaging, targeted drug delivery and synergistic effect of drug and hyperthermia mediated cancer therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Tracking; Combined Modality Therapy | 2014 |
Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Chemoradiotherapy; Colorectal Neopla | 2014 |
Characterization of side population cells isolated from the colon cancer cell line SW480.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Drug Resistance, Neop | 2014 |
The key role of calreticulin in immunomodulation induced by chemotherapeutic agents.
Topics: Animals; Antigens, Surface; Antineoplastic Agents; Apoptosis; Calreticulin; Camptothecin; Carcinoma, | 2015 |
An investigation of antitumor efficiency of novel sustained and targeted 5-fluorouracil nanoparticles.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relat | 2015 |
Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proli | 2015 |
Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse.
Topics: Animals; Antimetabolites, Antineoplastic; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; CHO C | 2015 |
Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; C | 2015 |
Surface-Eroding Poly(ortho ester amides) for Highly Efficient Oral Chemotherapy.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Delayed-Actio | 2015 |
Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo".
Topics: Antimetabolites, Antineoplastic; Batch Cell Culture Techniques; Biomimetics; Bioreactors; Cell Proli | 2015 |
Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Crassostrea; Dietary Supplements; Dose-Response Re | 2016 |
A 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Delivery Systems; Fluorouracil | 2016 |
Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Breast Neoplasms; | 2017 |
β-Carotene synergistically enhances the anti-tumor effect of 5-fluorouracil on esophageal squamous cell carcinoma in vivo and in vitro.
Topics: Animals; Antineoplastic Agents; Apoptosis; beta Carotene; Carcinoma, Squamous Cell; Cell Line, Tumor | 2016 |
Real-time near-infrared bioimaging of a receptor-targeted cytotoxic dendritic theranostic agent.
Topics: A549 Cells; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Computer Systems; Cyclobutan | 2017 |
Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition.
Topics: Animals; Antimetabolites, Antineoplastic; Blotting, Western; Cell Proliferation; Deoxycytidine; eIF- | 2009 |
Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Cell Cycle; Cell Line, | 2008 |
Chemotherapy targeted to cancer tissue potentiates antigen-specific immune response induced by vaccine for in vivo antigen loading and activation of dendritic cells.
Topics: Adenoviridae; Animals; Antigens, Neoplasm; Antineoplastic Agents; Base Sequence; Cancer Vaccines; De | 2008 |
A simple colostomy implantation model for evaluating colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; Colostomy; Disease Mo | 2009 |
Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Hypoxia; Doxorubicin; Fluorouracil; Humans; Image | 2008 |
A possible cause and remedy for the clinical failure of 5-fluorouracil plus eniluracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relatio | 2010 |
Chemotherapy-induced myelotoxicity and incidence of lung metastasis in an animal model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Cisplatin; Colonic Ne | 2011 |
Induction of thymidine kinase 1 after 5-fluorouracil as a mechanism for 3'-deoxy-3'-[18F]fluorothymidine flare.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Culture Techniques; Cell Line, Tumor; Dideoxynucleosi | 2010 |
Spheres derived from the human SK-RC-42 renal cell carcinoma cell line are enriched in cancer stem cells.
Topics: Animals; Antigens, CD; Antimetabolites, Antineoplastic; Carcinoma, Renal Cell; Cell Adhesion; Cell C | 2010 |
Dendritic cell vaccine in addition to FOLFIRI regimen improve antitumor effects through the inhibition of immunosuppressive cells in murine colorectal cancer model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cancer Vaccines; Carcinoembry | 2010 |
Pharmacokinetics, dosimetry and comparative efficacy of 188Re-liposome and 5-FU in a CT26-luc lung-metastatic mice model.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Bone Marrow; Colonic Neoplasms; Fluorourac | 2012 |
Slow-cycling therapy-resistant cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Drug | 2012 |
Therapeutic effect of genetically modified human neural stem cells encoding cytosine deaminase on experimental glioma.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Combined Modality Therapy; Cytosine Deami | 2012 |
Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Antigens, Neoplasm; CD8-Positive T-Lympho | 2012 |
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Topics: Animals; beta-Galactosidase; Cell Line; DNA Repair; Fibroblasts; Fluorouracil; Gene Targeting; Genet | 2012 |
Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Fluorouracil; Fun | 2012 |
Antitumor and immunopotentiating activity of polysaccharide PST001 isolated from the seed kernel of Tamarindus indica: an in vivo study in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Ce | 2012 |
In vivo distribution of 5-Fluorouracil after peritumoral implantation using a biodegradable micro-device in tumor-bearing mice.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Chromatography, High Pressure Liquid; Dr | 2013 |
Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Division; Cell Survival; | 2002 |
[Double promoters induct suicide gene target killing of 5-FU drug-fast cancer cells].
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Drug Delivery Systems; Fluorouraci | 2002 |
[Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer].
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Cyclohexanes; Disease Models, Animal; Drug C | 2002 |
[Influence of combination of low dosage 131I-labeled anti-carcinoembryonic antigen antibody C50 and 5-fluorouracil on tumor growth of colorectal cancer xenografts in nude mice].
Topics: Animals; Antibodies; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colorectal Neoplasms | 2003 |
Effect of Indigofera aspalathoides against Dalton's ascitic lymphoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Ascites; Fluorouracil; Indigofera; Injections, Intraperi | 2003 |
[Subcutaneous transplantation of microencapsulated Chinese hamster ovary (CHO) cells/pcDNA 3.1/mIL-12 and subcutaneous transplantation of microencapsulated CHO/pcDNA3.1/mIL-12 combined with 5-fluoro-uracil in treatment of tumor-burdened mice].
Topics: Animals; Antimetabolites, Antineoplastic; CHO Cells; Cricetinae; Disease Models, Animal; Drug Compou | 2003 |
An experimental study on the pharmacokinetics of 5-fluorouracil regional chemotherapy for pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Dogs; Duodenum; Female; Fluorouracil; Infusions, Intra-Art | 2003 |
3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography.
Topics: Adenosine Triphosphate; Animals; Dideoxynucleosides; Drug Monitoring; Fluorine Radioisotopes; Fluoro | 2003 |
[Experimental studies on 5-fluorouracil, a cytostatic agent].
Topics: Animals; Antineoplastic Agents; Cytostatic Agents; Fluorouracil; Hematopoietic System; Humans; Neopl | 1957 |
Effects of arsenic-azoproteins on mouse lymphoma cells in vivo; with observations on the effects of other anti-lymphoma agents, and on the susceptibility to these effects of lymphoma cells of various types.
Topics: Animals; Antineoplastic Agents; Arsenic; Arsenicals; Fluorouracil; Guinea Pigs; Lymphoma; Mice; Neop | 1958 |
Effect of 5-fluorouracil on mammary tumors in mice.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Mice; Neoplasms, Experimental; Uracil | 1959 |
Ineffectiveness of five compounds on spontaneous mammary tumors of mice.
Topics: Animals; Chlorprothixene; Fluorouracil; Hydrocarbons; Mammary Neoplasms, Animal; Mice; Naphthoquinon | 1963 |
STUDIES ON RESISTANCE AGAINST 5-FLUOROURACIL. IV. EVIDENCE FOR AN ALTERED URIDINE KINASE IN RESISTANT CELLS.
Topics: Chromatography; Fluorouracil; Neoplasms; Neoplasms, Experimental; Pharmacology; Phosphotransferases; | 1963 |
GROWTH INHIBITION OF A SPECTRUM OF TRANSPLANTED MOUSE TUMORS BY COMBINATIONS OF INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS AND ALKYLATING AGENTS.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; | 1963 |
CHEMOTHERAPEUTIC STUDIES WITH OSTEOGENIC SARCOMA HE10734.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Fl | 1964 |
CHEMOTHERAPY STUDIES WITH VIRUS-INDUCED LEUKEMIA IN MICE.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Leukemia; Leukemia, Experimental; Me | 1964 |
POTENTIATION OF CHEMOTHERAPY OF EXPERIMENTAL TUMORS BY DEUTERIUM OXIDE.
Topics: Animals; Cyclophosphamide; Deuterium; Deuterium Oxide; Fluorouracil; Mercaptopurine; Mice; Neoplasms | 1964 |
RATIONALE FOR THE DESIGN OF FLUORINATED PYRIMIDINES.
Topics: Animals; Antimetabolites; DNA; Floxuridine; Fluorouracil; Halogenation; Ligases; Mice; Neoplasms; Ne | 1964 |
TREATMENT OF BLADDER TUMORS BY DIRECT INSTILLATION OF 5-FLUOROURACIL. EXPERIMENTAL OBSERVATIONS IN DOGS.
Topics: Amines; Animals; Carcinogens; Carcinoma; Carcinoma, Transitional Cell; Dogs; Fluorouracil; Gastroent | 1964 |
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, E | 1964 |
HYPERBARIC OXYGEN AND 5-FLUOROURACIL IN THE TREATMENT OF EXPERIMENTAL MELANOMA.
Topics: Animals; Fluorouracil; Hyperbaric Oxygenation; Melanoma; Melanoma, Experimental; Mice; Neoplasms; Ne | 1964 |
INFLUENCE OF PURINE AND PYRIMIDINE COMPOUNDS ON DNA-SYNTHESIS OF ASCITES-TUMOUR CELLS.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Cytosine Nucleotides; DNA; DNA, Neoplasm; Fluorouracil; | 1964 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liv | 1965 |
Combined action of 5-fluorouracil and other cytotoxic agents with crystalline ribonuclease on mouse ascites tumor.
Topics: Animals; Antineoplastic Agents; Ascites; Carcinoma, Ehrlich Tumor; Cytotoxins; Fluorouracil; Mice; N | 1961 |
Therapeutic efficacy study of novel 5-FU-loaded PMM 2.1.2-based microspheres on C6 glioma.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Carriers; Drug Delivery Systems; Female; Fluorouracil | 2003 |
The oncolytic effect of recombinant vesicular stomatitis virus is enhanced by expression of the fusion cytosine deaminase/uracil phosphoribosyltransferase suicide gene.
Topics: Animals; Cell Line, Tumor; Cytosine Deaminase; Escherichia coli; Flucytosine; Fluorouracil; Genetic | 2003 |
Effect of carcinomatosis and intraperitoneal 5-fluorouracil on peritoneal blood flow modulated by vasopressin in the rat as measured with the 133Xe-clearance technique.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Fluorouracil; Hemostatics; Infusions, Intraveno | 2004 |
Sensitization to radiation from an implanted 125I source by sustained intratumoral release of chemotherapeutic drugs.
Topics: Animals; Brachytherapy; Cisplatin; DNA Repair; Drug Delivery Systems; Drug Implants; Female; Fluorou | 2004 |
Biochemical modulation of 5-fluorouracil with interferon alpha/beta and gamma on murine renal cell carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Dose-Response Relati | 2004 |
Liposomes modified with cyclic RGD peptide for tumor targeting.
Topics: Animals; Cells, Cultured; Fluorouracil; Humans; Liposomes; Male; Mice; Mice, Inbred BALB C; Neoplasm | 2004 |
Preclinical investigations of drug and radionuclide conjugates of bisphosphonates for the treatment of metastatic bone cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Diphosphonates; Female; Fluorouracil; Huma | 2004 |
Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, | 2005 |
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Renal Cell; Cell Line; C | 2005 |
Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; | 2005 |
Mitogenic influence of human R-spondin1 on the intestinal epithelium.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cell Line; Cell Line, Tumor; Cell Proliferation; Chime | 2005 |
Combined tumor therapy by using radiofrequency ablation and 5-FU-laden polymer implants: evaluation in rats and rabbits.
Topics: Animals; Antimetabolites, Antineoplastic; Catheter Ablation; Chromatography, High Pressure Liquid; C | 2005 |
Inducing intestinal growth.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cell Proliferation; Fluorouracil; Intestinal Mucosa; I | 2005 |
Potassium oxonate, an enzyme inhibitor compounded in S-1, reduces the suppression of antitumor immunity induced by 5-fluorouracil.
Topics: Animals; Drug Combinations; Enzyme Inhibitors; Fluorouracil; Immunophenotyping; Interleukin-2; Kille | 2006 |
Synergistic and tumour selective effects of chemotherapy and ultrasound treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; Flu | 2006 |
[Effect of angiogenesis inhibitor SU6668 on the growth and metastasis of gastric cancer in SCID mice].
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Drug Synergism; Fluorouracil; Humans; | 2006 |
The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relati | 2007 |
Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Chromatography, Thin Layer; Cytosine Deaminase; F | 2007 |
Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabine, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice.
Topics: Animals; Antineoplastic Agents; Capecitabine; Deoxycytidine; Diffusion; Female; Fluorouracil; HT29 C | 2007 |
Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cel | 2007 |
A model system for examining the action of anti-cancer agents at the cellular level in vivo.
Topics: Animals; Antineoplastic Agents; Azaserine; Cyclophosphamide; Dactinomycin; Fluorouracil; Hematopoies | 1967 |
Evaluation of chemical agents against the plasma cell tumor LPC-1 in mice.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cyclophosphamide; Electrophoresis; Fluorouracil; | 1967 |
[5-fluorouracil and its carcinostatic effects].
Topics: Adult; Aged; Animals; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Mice; Middle A | 1967 |
Enzymes of the de novo and salvage pathways for pyrimidine biosynthesis in normal colon, colon carcinoma, and xenografts.
Topics: Adenocarcinoma; Animals; Carboxy-Lyases; Colon; Colonic Neoplasms; Fluorouracil; Humans; Intestinal | 1984 |
External carotid artery infusion with single-and multiple-drug regimens in the rat.
Topics: Animals; Antineoplastic Agents; Bleomycin; Body Weight; Carcinoma, Squamous Cell; Carotid Artery, Ex | 1980 |
[Experimental studies on rat ear duct tumor. Part 2: Effects of anticancer drugs on rat ear duct tumor induced by DMBA and DAS (author's transl)].
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 9,10-Dimethyl-1,2-benzanthracene; Animal | 1980 |
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Inj | 1982 |
Phosphoribosyl pyrophosphate, pool size and tissue levels as a determinant of 5-fluorouracil response in murine colonic adenocarcinomas.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Resistance; Fluorouracil; Leukemia P388; Mice; Neop | 1982 |
Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma.
Topics: Adenocarcinoma; Allopurinol; Animals; Colonic Neoplasms; Female; Fluorouracil; Humans; Hypoxanthines | 1983 |
A comparison of three assays used for the in vitro chemosensitivity testing of human tumours.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Line; Cell Survival; Cisplatin; Cytarabine; Dose-Res | 1984 |
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei; | 1984 |
Tumor specific conversion of a pyrimidine antimetabolite.
Topics: Animals; Antineoplastic Agents; Cell Line; Floxuridine; Fluorouracil; Isomerism; Mice; Neoplasms, Ex | 1984 |
Experimental combination and single-agent chemotherapy in human lung-tumour xenografts.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carc | 1982 |
Potentiation of the chemotherapeutic effect of 5-fluorouracil by combination with guanosine 5'-monophosphate.
Topics: Adenocarcinoma; Animals; Drug Therapy, Combination; Fluorouracil; Guanine Nucleotides; Guanosine Mon | 1983 |
[Antineoplastic effect of UFT therapy (uracil-FT-207 combination therapy) on experimental pancreatic cancer transplanted in the pancreas and subcutaneous region].
Topics: Animals; Antineoplastic Agents; Carcinoma, Intraductal, Noninfiltrating; Cricetinae; Drug Therapy, C | 1982 |
[Experimental studies on the enhancing effects of the combined therapy with tegafur and cytochrome C].
Topics: Animals; Carbon Tetrachloride Poisoning; Cytochrome c Group; Drug Synergism; Drug Therapy, Combinati | 1983 |
Influence of some sulfhydryl compounds on the antineoplastic effectiveness of 5-fluorouracil and 6-mercaptopurine.
Topics: Animals; Cysteine; Drug Synergism; Fluorouracil; Glutathione; Insulin; Leukemia L1210; Mercaptopurin | 1984 |
[Effect of cepharanthin on peripheral leukocytopenia caused by antineoplastic agents].
Topics: Alkaloids; Animals; Benzylisoquinolines; Fluorouracil; Leukopenia; Lymphoma; Mice; Mice, Inbred Stra | 1983 |
[Effect of solcoseryl and combined therapy of solcoseryl and FT-207 for mice bearing meth-A tumor].
Topics: Actihaemyl; Animals; Drug Therapy, Combination; Fluorouracil; Methylcholanthrene; Mice; Mice, Inbred | 1983 |
[An approach to prolongation of survival rate in tumor bearing mice using 5-fluorouracil in combination with various kinds of herb medicine].
Topics: Animals; Drug Therapy, Combination; Drugs, Chinese Herbal; Fluorouracil; Mice; Mitomycin; Mitomycins | 1983 |
The significance of ascorbic acid, thiamin and retinol in cancer.
Topics: Animals; Ascorbic Acid; Breast Neoplasms; Fluorouracil; Humans; Lung Neoplasms; Mice; Neoplasms; Neo | 1983 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug | 1984 |
[Pharmacological compatibility of the antineoplastic drugs ftorafur and 5-fluorouracil with the psychotropic drugs aminazine and phenazepam (an experimental study)].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlorpromazine; Drug Interactions; | 1984 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate | 1980 |
[Experimental toxicologic and therapeutic studies on the activity of the CMF(cyclophosphamide-methotrexate-5-fluorouracil) scheme versus the VMF(vincristine-methotrexate-5-fluorouracil) scheme].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma 256, Walker; Cyclophosphamide; Fe | 1984 |
[Chemotherapeutic responses of a primary tumor and its pulmonary metastases in murine tumor systems in relation to its proliferative properties].
Topics: Animals; Carcinoma; Fluorouracil; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Ne | 1984 |
Potentiation of the antitumor effect of 5-fluorouracil by some nucleotides, and their possible role in the potentiation.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cell Line; Drug Synergism; Fluorouracil; Mice; Mice, Inb | 1983 |
Anti-tumor effect of new 5-fluorouracil derivatives and their influences on the immune response.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Immunity; Injection | 1983 |
Review of a new antimetabolic agent, 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1).
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Delayed-Action Preparations; Dogs; Drug Evalu | 1980 |
Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient.
Topics: Adult; Animals; Cytarabine; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Humans | 1980 |
Chemoprevention of development of colonic adenomatosis and carcinomatosis with 5-fluorouracil and ftorafur on animal model.
Topics: Adenoma; Animals; Carcinoma; Colon; Colonic Neoplasms; Female; Fluorouracil; Methylnitrosourea; Neop | 1980 |
High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Fluorouracil; Gas Chromatograph | 1980 |
Toxicologic and therapeutic examinations with ftorafur in different mouse strains.
Topics: Animals; Female; Fluorouracil; Male; Mice; Mice, Nude; Neoplasms, Experimental; Sex Factors; Tegafur | 1981 |
Studies on the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil co-administered orally to tumor-bearing rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Combinations; Fluorouracil; Intestinal Ab | 1980 |
Antitumor activity of methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranosid)uronate against various experimental tumors.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Female; Fluorouracil; Lung Neoplas | 1981 |
Chemotherapy of pancreatic adenocarcinoma: initial report on two transplantable models in the Syrian hamster.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cricetinae; Cyclophosphamide; Disease Models, Animal | 1982 |
Prostaglandin E augments the effect of chemotherapy on B-16 melanoma in vivo.
Topics: Animals; Antineoplastic Agents; Dopamine; Doxorubicin; Drug Therapy, Combination; Female; Fluorourac | 1982 |
Drug activity and therapeutic synergism in cancer treatment.
Topics: Animals; Antineoplastic Agents; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration S | 1982 |
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; Colonic Neoplasms; Dimethylhydra | 1982 |
[Heterotransplantation of human stomach carcinomas into nude nice. 3. Effects of MMC and 5FU on 7 strains of transplantable human gastric cancer in nude mice].
Topics: Animals; Fluorouracil; Humans; Male; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantati | 1982 |
[Anticancer effect of levamisole and tegafur on 1,2-dimethylhydrazine (DMH)-induced colonic cancers in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Fluoro | 1982 |
[Effect of FT-207 on bladder cancer in rats induced by BBN. II: The effect of oral administration of FT-207 during oncogenesis of bladder cancer].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Butylhydroxybutylnitrosamine; Flu | 1982 |
Improved treatment of a brain-tumor model. Part 2: Sequential therapy with BCNU and 5-fluorouracil.
Topics: Animals; Brain Neoplasms; Carmustine; Clone Cells; Disease Models, Animal; Drug Therapy, Combination | 1983 |
Apparent ineffectiveness of adriamycin for growth of androgen-dependent Shionogi carcinoma 115 in the mouse.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Doxorubicin; Drug Resistance; Fluoroura | 1983 |
Enhancement and depression by inosine of the growth inhibitory action of 5-fluorouracil on cultured Jensen tumor cells.
Topics: Animals; Cell Division; Cells, Cultured; Cytidine; Drug Synergism; Fluorouracil; Inosine; Neoplasms, | 1983 |
Chemotherapy of chemically-induced colorectal tumours.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Female; Fluorouracil; Neopla | 1983 |
Therapeutic activity of pretazettine, standard drugs, and the combinations on intraperitoneally implanted Lewis lung carcinoma in mice.
Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, | 1983 |
Noncarcinogenic chemotherapy with a combination of vincristine, methotrexate and 5-fluorouracil (VMF) in rats.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Ther | 1983 |
Combined effect of levan and cytotoxic agents on the growth of experimental tumours in mice.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Co | 1983 |
Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Indomethacin; M | 1983 |
[Hematopoietic resistance to the damaging action of cytostatics in the occurrence of tumor drug resistance].
Topics: Animals; Daunorubicin; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Fla | 1981 |
Schedule-dependent cytotoxicity of 5-fluorouracil and cyclophosphamide in experimental cancer chemotherapy.
Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Leukemia L1210; Lung Neoplasm | 1980 |
5-fluorouracil.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Drug Interactions; Female; Fetal Death; Fluorou | 1981 |
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemi | 1981 |
Association of host immunity with 5-fluorouracil-initiated cure of plasmacytoma LPC-1 in BALB/c mice.
Topics: Animals; Antigens, Neoplasm; Cytotoxicity, Immunologic; Fluorouracil; Immunity, Cellular; Mice; Mice | 1980 |
Effect of feeder cell-released substances on the survival of clonogenic 9L cells after treatment with antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line; Cell Survival; Clone Cells; Co | 1980 |
Immunopotentiation of anticancer chemotherapy by Candida albicans, other yeasts and insoluble glucan in an experimental lymphoma model.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Candida albicans; Carmustine; Cell Wall; Cry | 1982 |
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.
Topics: Animals; Anthracenes; Antineoplastic Agents; Doxorubicin; Drug Administration Schedule; Drug Evaluat | 1982 |
Tumor-associated surface membrane antigens on CFUs: characterization using the fluorescent activated cell sorter.
Topics: Animals; Antigens, Neoplasm; Antigens, Surface; Binding Sites, Antibody; Bone Marrow; Cell Different | 1982 |
Dosimetry and preliminary human studies of 18F-5-fluorouracil.
Topics: Animals; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Fluorine; Fluorouracil; Half-Life; Hu | 1982 |
The assessment of response of murine transplantable colon tumors to combination chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carmustine; Cell Line; Colonic Neoplasms; Dimethylhy | 1982 |
Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture.
Topics: Cell Nucleus; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Fluorouracil; Humans | 1982 |
[Treatment of brain tumors with anticancer pellet--experimental and clinical study (author's transl)].
Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Drug Implants; Female; Fluorouracil; Humans; | 1982 |
High-dose 5-fluorouracil with delayed uridine "rescue" in mice.
Topics: Animals; Colonic Neoplasms; Fluorouracil; Kinetics; Leukopenia; Mice; Mice, Inbred BALB C; Neoplasms | 1982 |
Sensitization to low dose 5-fluorouracil. Subsequent enhancement of its systemic antitumor effect in the rat.
Topics: Animals; Female; Fluorouracil; Male; Mammary Neoplasms, Experimental; Methotrexate; Neoplasm Metasta | 1982 |
Studies on the synthesis of chemotherapeutics. 12. Synthesis and antitumor activity of N-phthalidyl-5-fluorouracil derivatives.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Female; Fluorouracil; Lethal Dose 50; | 1982 |
The selectivity of action of methotrexate in combination with 5-fluorouracil in xenografts of human colon adenocarcinomas.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Methotr | 1982 |
[Intramural injection of anticancer emulsion by gastroendoscopy].
Topics: Animals; Dogs; Emulsions; Fluorouracil; Gastroscopy; Injections; Male; Mice; Neoplasms, Experimental | 1982 |
[Experimental studies on antitumor effects of lysozyme].
Topics: Animals; Antineoplastic Agents; Drug Synergism; Female; Fluorouracil; Mice; Mitomycins; Muramidase; | 1982 |
Search for the biochemical parameters of tumor cell sensitivity and resistance to antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Fluo | 1980 |
Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro.
Topics: Animals; Benzimidazoles; Carbamates; Chick Embryo; Fibrosarcoma; Fluorouracil; Mice; Microtubules; M | 1981 |
[Effect of chemotherapy on the growth of human gastrointestinal tumor strains].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Fluorouracil; Humans; Liver Neoplasms, Experimental; Mic | 1980 |
[Therapeutic effectiveness of carminomycin (CRM) in combination with dibromodulcitol (DBD) compared with the combination vincristine, cyclophosphamide, methotrexate, 5-fluorouracil (VCMF) on some tumor systems (author's transl)].
Topics: Animals; Antineoplastic Agents; Carubicin; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination | 1980 |
An experimental model for treatment of mesothelioma.
Topics: Animals; Asbestos; Body Weight; Cricetinae; Cyclophosphamide; Disease Models, Animal; Doxorubicin; F | 1981 |
Chemotherapy of human colorectal tumor xenografts in athymic mice with clinically active drugs: 5-fluorouracil and 1-3-bis-(-2-chloroethyl)-1-nitrosourea (BCNU). Comparison with doxorubicin derivatives: 4'deoxydoxorubicin and 4'-O-methyldoxorubicin.
Topics: Adenocarcinoma; Animals; Carmustine; Colonic Neoplasms; Doxorubicin; Fluorouracil; Humans; Mice; Mic | 1981 |
Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fema | 1981 |
Influence of cells number on directional migration of MO4 cells in vitro.
Topics: Animals; Benzimidazoles; Carbamates; Cell Line; Cell Movement; Fibroblasts; Fluorouracil; Mice; Mice | 1981 |
Studies in an animal model on the effectiveness of adjuvant chemotherapy with 5-FU and BCNU in cases of colorectal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluoroura | 1981 |
[Coenzyme Q10 treatment for the liver damages induced by antineoplastic agents (author's transl)].
Topics: Animals; Fluorouracil; Liver; Male; Membrane Potentials; Mice; Mitomycins; Neoplasms, Experimental; | 1980 |
Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
Topics: Adenocarcinoma; Animals; Cell Survival; Drug Therapy, Combination; Female; Fluorouracil; Lethal Dose | 1981 |
Carcinogenic activity in rats of combined treatment with cyclophosphamide, methotrexate and 5-fluorouracil.
Topics: Adrenal Gland Neoplasms; Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, | 1981 |
Sensitivity of anticancer agents of human gastric cancers transplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Resistance; Female; Fluorouracil; Humans; Mal | 1981 |
Influence of duration of exposure to 5-fluorouracil on antiproliferating activity against cultured murine lymphoma cells.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Fluorouracil; Lymphoma; M | 1981 |
[Effect of 5-fluorouracil (5 Fu) on growth and morphology of human ovarian clear cell carcinoma transplanted into nude mice (author's transl)].
Topics: Adenocarcinoma; Adult; Animals; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplanta | 1981 |
Influence of pyrazofurin on the toxicity and antitumor activity of fluorinated pyrimidines in vivo.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Drug Interactions; Drug Therapy, Combination; Fema | 1980 |
Modulation of 5-FU action by thymidine in murine and human tumors.
Topics: Animals; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Kineti | 1981 |
Chemoprevention of development of colonic adenomatosis and carcinomatosis with intrarectal dose of 5-FU on animal model.
Topics: Adenoma; Animals; Colonic Neoplasms; Female; Fluorouracil; Injections, Intraperitoneal; Methylnitros | 1980 |
Review of a new antimetabolic agent 1-hexylcarbamoyl-5-fluorouracil (HCFU).
Topics: Aged; Animals; Drug Evaluation; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; Male; Mi | 1980 |
Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU)RNA.
Topics: Animals; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Fluorouracil; | 1980 |
Allopurinol modification of the toxicity and antitumor activity of 5-fluorouracil.
Topics: Allopurinol; Animals; Bone Marrow; Cell Division; Drug Administration Schedule; Drug Therapy, Combin | 1980 |
Drug interactions with acetaminophen: effects of phenobarbital, prednisone and 5-fluorouracil in normal and tumor-bearing rats.
Topics: Acetaminophen; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Galactosamine; I | 1980 |
Evaluation of nonhormonal cytotoxic chemotherapy in the Nb rat prostate adenocarcinoma: autonomous tumor (18-Pr and 13-Pr).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Ev | 1980 |
Inhibition of murine colon adenocarcinomas and Lewis lung carcinoma by 1-hexylcarbamoyl-5-fluorouracil.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Fluorouracil; In Vitro Techniques | 1980 |
Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 2. Tumor remission following treatment with 5-FU and VCR of xenotransplanted primary human colorectal adenocarcinomas.
Topics: Adenocarcinoma; Animals; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Mice; Mice, | 1980 |
5-Fluorouracil in combination with hypoxathine and allopurinol: toxicity and metabolism in xenografts of human colonic carcinomas in mice.
Topics: Allopurinol; Animals; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Hypoxanthi | 1980 |
Evaluation of chemotherapeutic responsiveness in Nb rat prostate cancer model. 5-fluorouracil, methotrexate, cyclophosphamide, and adriamycin.
Topics: Animals; Cyclophosphamide; Doxorubicin; Fluorouracil; Male; Methotrexate; Neoplasms, Experimental; P | 1980 |
[Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 1. Experiments to test the feasibility of combined chemotherapy with VCR and 5-FU (author's transl)].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Mice; M | 1980 |
[Effect of dan-shen and anticancer drugs on the cancer cell surface agglutination induced by phytoagglutinin (author's transl)].
Topics: Agglutination; Animals; Antineoplastic Agents; Asparaginase; Carcinoma, Ehrlich Tumor; China; Fluoro | 1980 |
Drug-carrier property of albumin microspheres in chemotherapy. IV. Antitumor effect of single-shot or multiple-shot administration of microsphere-entrapped 5-fluorouracil on Ehrlich ascites or solid tumor in mice.
Topics: Animals; Carcinoma, Ehrlich Tumor; Fluorouracil; Male; Mice; Microspheres; Neoplasms, Experimental; | 1980 |
Chemotherapy against human melanoma in the hamster cheek pouch.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Cheek; Cricetinae; Cyclophosphamide; Da | 1980 |
Chemotherapeutic activity and histopathologic feature of BCNU + 5-FU effect on Lewis lung carcinoma.
Topics: Animals; Carmustine; Drug Therapy, Combination; Fluorouracil; Lung; Lung Neoplasms; Mice; Neoplasms, | 1980 |
[Animal experiments using adjuvant 5-FU and BCNU chemotherapy in stomach cancer].
Topics: Animals; Carmustine; Drug Therapy, Combination; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Nude; | 1980 |
Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470) and cytotoxic agents in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; C | 1994 |
[Development of 5-fluorouracil incorporated in microspheres for peritoneal carcinomatosis--animal experiments].
Topics: Animals; Ascitic Fluid; Delayed-Action Preparations; Fluorouracil; Male; Mice; Microspheres; Neoplas | 1995 |
Storage-phosphor autoradiography: a rapid and highly sensitive method for spatial imaging and quantitation of radioisotopes.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Epinephrine; Female; Fluorouracil; Image Processing, | 1995 |
Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Division; Female; Fluorod | 1995 |
Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil.
Topics: Animals; Drug Interactions; Female; Fluorouracil; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1995 |
Targeted and non-targeted actions of anti-cancer drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Cycloheximide; Deoxycytidine Kinase; Fluorour | 1994 |
Microcirculatory effects of hyperthermia and 5-fluorouracil in the skin of nude mice.
Topics: Animals; Combined Modality Therapy; Female; Fluorouracil; Hyperthermia, Induced; Mice; Mice, Nude; M | 1993 |
Effect of antitumor polysaccharide SPR-901 on antitumor activity in combination with 5-FU.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CD4 Antigens; CD8 Antigens; Drug Synergism; | 1994 |
DNA synthesis after combined treatment with cisplatin and 5-fluorouracil of a mouse ascites tumor growing in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Chromatography, High Pressure L | 1994 |
5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.
Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Dihydrouracil Dehydrogena | 1993 |
Polyamine increase in rat tissues treated with 1-beta-D-arabinosylcytosine and 5-fluorouracil.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Cytarabine; Fluorouracil; Male; Neoplasm | 1993 |
Novel low immunosuppressive derivatives of the antitumor drug fluoropyrimidine, UK-21 and UK-25: effect on delayed type hypersensitivity and tumor immunity.
Topics: Animals; Antineoplastic Agents; Erythrocytes; Female; Fluorouracil; Glycine; Hypersensitivity, Delay | 1993 |
Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cisplatin; Drug Synergism; Fluorou | 1993 |
Interleukin-1 modulatory effect on the action of chemotherapeutic drugs and localized irradiation of the lip, duodenum, and tumor.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Duodenum; Female; Fibrosarcoma; Fluorou | 1993 |
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; | 1995 |
Protective effect of an acidic glycoprotein obtained from culture of Chlorella vulgaris against myelosuppression by 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bacterial Infections; Bone Marrow; | 1996 |
The combined antitumour effect of a new 5-fluorouracil derivative, BOF-A2, and radiation in vivo.
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Fluorouracil; Mice; Mice, Inbred C3H; Neo | 1996 |
Thymic humoral factor-gamma 2 (THF-gamma 2) immunotherapy reduces the metastatic load and restores immunocompetence in 3LL tumor-bearing mice receiving anticancer chemotherapy.
Topics: Animals; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Erythrocytes; Female; Fluo | 1996 |
The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Cell Line; Doxorubicin; Drug Resistance, | 1995 |
Combined effect of clinically relevant doses of emitefur, a new 5-fluorouracil derivative, and radiation in murine tumours.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Squamous Cell; Combined Modality Therapy; Dr | 1996 |
The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Cations; Cholesterol; Cytosine Deaminase; Drug Carriers; E | 1996 |
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.
Topics: Adenoviridae; Adenovirus E1B Proteins; Antigens, Viral; Capsid; Capsid Proteins; Cells, Cultured; Ch | 1997 |
Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antimetabolites, Antineoplastic; | 1997 |
Continuous infusion of 5-fluorouracil plus low-dose cisplatin in tumor-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood; Cisplatin; Dose-Response Relationshi | 1997 |
Changes in tumor vascular permeability in response to experimental radioimmunotherapy: a comparative study of 11 xenografts.
Topics: Animals; Antibodies, Bispecific; Antidotes; Antimetabolites, Antineoplastic; Capillary Permeability; | 1997 |
Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothec | 1997 |
19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Colonic Neoplasms; Enzyme Inhibitors; Fluorine Radioisotopes; Fluorouracil; Magnetic Resona | 1997 |
Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Fibrosarcoma; Fluorouracil; Humans; Lac | 1998 |
Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil.
Topics: Adenoviridae; Animals; Blotting, Northern; Cells, Cultured; DNA Primers; Escherichia coli; Fluoroura | 1998 |
[Liposomal forms of cytostatics in oncology].
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Drug Carriers; Fluorouracil; | 1998 |
Pre-treatment energy status of primary rat tumours as the best predictor of response to 5-fluorouracil chemotherapy: a magnetic resonance spectroscopy study in vivo.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Carcinogens; Energy Metabolism; Fema | 1998 |
Preclinical antitumor efficacy of S-1: a new oral formulation of 5-fluorouracil on human tumor xenografts.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Hum | 1998 |
Estimations of intra- and extracellular volume and pH by 31P magnetic resonance spectroscopy: effect of therapy on RIF-1 tumours.
Topics: Animals; Antimetabolites, Antineoplastic; Extracellular Space; Fluorouracil; Hydrogen-Ion Concentrat | 1998 |
[Human tumor sensitivity to 5-fluorouracil influenced by dihydropyrimidine dehydrogenase mRNA in the tumor].
Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Screening Assays, | 1998 |
Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine.
Topics: Animals; Antimetabolites, Antineoplastic; Artificial Gene Fusion; Cytosine Deaminase; Drug Resistanc | 1998 |
In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Magnetic Resonance Spe | 1999 |
Longevity, stress response, and cancer in aging telomerase-deficient mice.
Topics: Aging; Alopecia; Animals; Body Weight; Bone Marrow Diseases; Fluorouracil; Hair Color; Longevity; Mi | 1999 |
Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Resistance, Neop | 1999 |
Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682).
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Biotransformatio | 1999 |
Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors.
Topics: Animals; Antineoplastic Agents; Biological Availability; Diffusion; Diffusion Chambers, Culture; Dox | 1999 |
Safety and antitumor activity of recombinant soluble Apo2 ligand.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Fluorouracil; Humans; Liga | 1999 |
Modulation of fluorouracil antitumor activity by folic acid in a murine model system.
Topics: Animals; Antidotes; Antimetabolites, Antineoplastic; Diet; Disease Models, Animal; Drug Synergism; F | 1999 |
X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.
Topics: Animals; Antineoplastic Agents; Capecitabine; Combined Modality Therapy; Deoxycytidine; Enzyme Induc | 1999 |
X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.
Topics: Animals; Antineoplastic Agents; Capecitabine; Combined Modality Therapy; Deoxycytidine; Enzyme Induc | 1999 |
X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.
Topics: Animals; Antineoplastic Agents; Capecitabine; Combined Modality Therapy; Deoxycytidine; Enzyme Induc | 1999 |
X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.
Topics: Animals; Antineoplastic Agents; Capecitabine; Combined Modality Therapy; Deoxycytidine; Enzyme Induc | 1999 |
Role for alpha1,2-fucosyltransferase and histo-blood group antigen H type 2 in resistance of rat colon carcinoma cells to 5-fluorouracil.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dru | 2000 |
Sphingomyelin potentiates chemotherapy of human cancer xenografts.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; | 2000 |
Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine.
Topics: Acetates; Animals; Antimetabolites, Antineoplastic; Barbiturates; Drug Interactions; Enzyme Inhibito | 2000 |
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Capecitabine; Carbama | 2000 |
Heat shock protein expression in human tumours grown in severe combined immunodeficient mice.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Colonic Neoplasms; Femal | 2000 |
Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bacterial Infections; Camptothecin; Cell Line; Cell Survi | 2001 |
Dual role of vitamin C on lipid profile and combined application of cyclophosphamide, methotrexate and 5-fluorouracil treatment in fibrosarcoma-bearing rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Breast Neoplasms; Cholestero | 2001 |
Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil.
Topics: Animals; Chlorocebus aethiops; Combined Modality Therapy; Cytosine Deaminase; Flucytosine; Fluoroura | 2001 |
Application of (19)F chemical shift imaging in studies of mice with orally administered 5-fluorouracil.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Female; Fluorine; Fluorouracil; Imag | 2001 |
Comparative study between daily and 5-days-a-week administration of oral 5-fluorouracil chemotherapy in mice: determining the superior regimen.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Drug Administration Schedule; Fluorouracil; M | 2001 |
Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Alanine; Animals; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; N | 1977 |
Chemotherapeutic drugs increase killing of tumor cells by antibody and complement.
Topics: Animals; Antigen-Antibody Reactions; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; | 1975 |
Effects of antineoplastic agents on wound healing in mice.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cyclophosphamide; Dactinomycin; Doxorubicin; | 1975 |
Enhancing effect by metabolic inhibitors on the killing of tumor cells by antibody and complement.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antineoplastic Agents; Azacitidine; Carci | 1975 |
Beta-glucuronidase activity of Yoshida ascites hepatomas of different drug-sensitivity and its change after treatment of host rats with various anticancer agents.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carbazilquinone; Carcinoma, Hepatocellular; Chromomycins; | 1976 |
Chemotherapy studies in autochthonous rat tumors. Forestomach and bladder cancer.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinoma in Situ; Doxorubicin; Drug Combinations; Female | 1977 |
Enhancement of the cancer chemotherapeutic effect by anticancer agents in the form of fat emulsion.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carcinoma, | 1977 |
Effect of chemotherapeutic agents on the growth of rat bladder cancer, BC-47.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cytarabine; Doxorubicin; Fluorouracil; Mitomy | 1978 |
Combination chemotherapy against B16 melanoma: bleomycin/vinblastine, bleomycin/cis-diamminedichloroplatinum, 5-fluorouracil/BCNU and 5-fluorouracil/methyl-CCNU.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cisplatin; Dose-Response Relationship, Drug; | 1978 |
Human gastrointestinal cancer grown in nude mice used to test new chemotherapeutic agents.
Topics: Abrin; Ancitabine; Animals; Colonic Neoplasms; Cytarabine; Drug Evaluation, Preclinical; Female; Flu | 1979 |
Chemotherapy studies in autochthonous rat tumors: carcinomas of the forestomach.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Dimethylnitrosamine; Drug Evaluation, Preclin | 1979 |
[The influences of carcinostatic agents on the host immune response and lymphocytes-dynamics in mice].
Topics: Animals; Bleomycin; Fluorouracil; Immunosuppressive Agents; Lymphocytes; Mice; Neoplasm Metastasis; | 1979 |
Effect of nutritional status and 5-fluorouracil on protein synthesis in parenterally alimented LEW/Mai rats.
Topics: Adenocarcinoma; Animals; Fluorouracil; Neoplasm Proteins; Neoplasms, Experimental; Nutritional Physi | 1979 |
Metabolism of 5-fluorouracil in cultured cells. Protection from 5-fluorouracil cytotoxicity by purines.
Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Cells, Cultured; Fluorouracil; Haplorhini; Leukemia L | 1979 |
Immunobiology and therapeutic manipulation of heterotransplanted Nb rat prostatic adenocarcinoma. Chemotherapy of autonomous tumor, 102 Pr, heterotransplanted into congenitally athymic (nude) mice and syngeneic Nb rats.
Topics: Adenocarcinoma; Animals; Fluorouracil; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, | 1979 |
[Experimental study relating to the anti-cancer effect of FT-207 suppository (author's transl)].
Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorouracil; Methylcholanthrene; Mice; Neoplasms, Experi | 1979 |
Sensitivity tests of tumors to cytostatic agents. I. Comparative investigations on transplanted tumors in vivo and in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Cricetinae; Da | 1975 |
Biochemical aspects of chemotherapy of mouse colon carcinoma: fluoropyrimidines and pyrazofurin.
Topics: Amidophosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcino | 1977 |
Susceptibilities of normal and malignant human lung cells in culture to the cytocidal action of antitumor agents.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Doxorubicin; Drug Evaluat | 1978 |
[Combination of chemotherapy and radiotherapy. I. Differential effect on the intestinal syndrome of irradiation combined with the drug administered in fractional doses and at various times].
Topics: Animals; Drug Administration Schedule; Female; Fluorouracil; Intestinal Neoplasms; Lethal Dose 50; M | 1979 |
A study of trace and minor elements in the solid tumor model 3924A hepatoma before and after treatment with t-fluorouracil.
Topics: Animals; Carcinoma, Hepatocellular; Cattle; Disease Models, Animal; Female; Fluorouracil; Liver; Liv | 1975 |
Effects of 5-fluorouracil on the cell kinetic and growth parameters of hepatoma 3924A.
Topics: Animals; Carcinoma, Hepatocellular; Cell Count; Connective Tissue; Deoxyuridine; DNA, Neoplasm; Dose | 1975 |
Increased urinary excretion of cyclic guanosine monophosphate in rats bearing Morris hepatoma 3924A.
Topics: Animals; Carcinoma, Hepatocellular; Cyclic AMP; Cyclic GMP; Female; Fluorouracil; Liver Neoplasms; N | 1975 |
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Floxuridine; Fluorouracil; In Vitro Techniques; | 1975 |
[Studies on the fate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), a carcinostatic agent. III. Absorption, distribution, excretion and metabolism after rectal administration of FT-207 (author's transl)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Fluorouracil; Liver Neoplasms; Male; Neop | 1975 |
Experimental study on drug sensitivity of the rat ascites hepatoma cells in embryonated eggs.
Topics: Animals; Carcinoma, Hepatocellular; Chick Embryo; Drug Evaluation, Preclinical; Fluorouracil; Liver | 1975 |
Regression of established tumors and induction of tumor immunity by intratumor chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Carmustine; Dacarbazine; Dactinomycin; Do | 1976 |
Solid tumour models for the assessment of different treatment modalities: IV. the combined effects of radiation and 5-fluorouracil.
Topics: Animals; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Dose-Response Relationship, Ra | 1976 |
Differential recovery of intestine, bone marrow, and thymus of rats with solid tumors following 5-fluorouracil administration.
Topics: Animals; Bone Marrow; Carcinoma, Hepatocellular; Deoxyuridine; DNA; Dose-Response Relationship, Drug | 1976 |
Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Deoxyuridine; DNA Replication; Drug Re | 1977 |
Solid tumor models for assessment of different treatment modalities: therapeutic strategy for sequential chemotherapy with radiotherapy.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver Neoplasms; Neoplasms, Experimental; | 1977 |
Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Drug Resistance; Female; Fluorouracil; Isoenzymes; Ki | 1977 |
[Effect of 5-fluorouracil and thiophosphamide on the activity and fractional content of phosphatases of Zajdela hepatoma].
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Fluorouracil; Liver Neoplasms; Lysoso | 1977 |
Evidence for role of purine nucleoside phosphorylase in sensitivity of Novikoff hepatoma cells to 5-fluorouracil.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Fluorouracil; | 1976 |
Chemotherapy studies in autochthonous rat tumors: hepatomas.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cyclophosphamide; Doxorubicin; Female; Fluorouracil | 1977 |
Synchronization of host and tumor responses for sequential therapy in experimental solid tumors.
Topics: Animals; Bone Marrow Diseases; Carcinoma, Hepatocellular; Cell Cycle; DNA, Neoplasm; Drug Administra | 1978 |
Solid tumour models for the assessment of different treatment modalities: VII: single vs fractionated doses of 5-fluorouracil on two solid tumours and their hosts.
Topics: Animals; Bone Marrow; Carcinoma, Hepatocellular; DNA; Drug Administration Schedule; Fluorouracil; Li | 1978 |
Distribution of 18F-5-fluorouracil in tumor-bearing mice and rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Fluo | 1978 |
Experimental chemotherapy of carcinoma of the human stomach and colon serially transplanted in nude mice.
Topics: Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Female; Fluorouracil; Humans; Mice; Mice, Nude | 1978 |
In vitro incorporation of [3H]TdR in human and murine solid tumours. Influence of 5-fluorouracil and/or hyperbaric oxygen on spatial distribution of labelling.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Fluorouracil; Humans; Mice; Neoplasms; Neoplasms | 1979 |
Schedule dependent effectiveness of CCNU and 5-fluorouracil in experimental chemotherapy.
Topics: Animals; Cell Survival; Drug Therapy, Combination; Fluorouracil; Hematopoietic Stem Cells; Lomustine | 1977 |
Effect of microtubule inhibitors on malignant invasion in vitro.
Topics: Benzimidazoles; Carbamates; Colchicine; Culture Techniques; Demecolcine; Fluorouracil; Microtubules; | 1978 |
Trial of anticancer pellet in malignant brain tumours; 5 FU and urokinase embedded in silastic.
Topics: Animals; Brain Neoplasms; Carcinoma; Drug Implants; Endopeptidases; Fluorouracil; Glioma; Humans; Ne | 1979 |
[Action of ftorafur on the chromosomes of normal and tumorous cells of the Djzungarian hamster in vitro].
Topics: Animals; Cell Line; Cells, Cultured; Chromatids; Chromosomes; Cricetinae; Fluorouracil; In Vitro Tec | 1978 |
[Experimental study on the effects of local administration of anticancer drug to the regional lymph nodes (author's transl)].
Topics: Administration, Topical; Animals; Antineoplastic Agents; Dogs; Fluorouracil; Lymph Nodes; Neoplasms, | 1978 |
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.
Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Li | 1979 |
Studies on mechanisms of 5-fluorouracil resistance in murine and human tumors.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Huma | 1979 |
Nude mouse models as predictors of chemotherapy in man: thymidine and pyrimidines.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouraci | 1979 |
Chemotherapy of Nb rat adenocarcinoma of the prostate heterotransplanted into congenitally athymic (nude) mice: report of 5-fluorouracil and cyclophosphamide.
Topics: Adenocarcinoma; Animals; Cyclophosphamide; Disease Models, Animal; Fluorouracil; Male; Mice; Mice, N | 1979 |
Solid tumor models for the assessment of different treatment modalities: VIII. The scheduling of treatment for a chemotherapeutically resistant experimental solid tumor.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cyclophosphamide; Disease Models, Animal; DNA; Doxorubi | 1979 |
Effect of preoperative intralesional BCG and postoperative 5-FU chemotherapy in three adenocarcinoma lines in rats.
Topics: Adenocarcinoma; Animals; BCG Vaccine; Colonic Neoplasms; Female; Fluorouracil; Male; Mammary Neoplas | 1979 |
Inhibition of DNA synthesis in Harding-Passey melanoma cells by prostaglandins A1 and A2: comparison with chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; DNA Replication; DNA, Neoplasm; Doxo | 1979 |
Design and evaluation of combination chemotherapy trials in experimental animal tumor systems.
Topics: Animals; Antineoplastic Agents; Carmustine; Cisplatin; Colonic Neoplasms; Drug Evaluation, Preclinic | 1979 |
Anti-tumor activities of 1-Acetyl-3-o-Toluyl-5-Fu.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Female; Fluorouracil; HeLa Cells; Leiomyosarcoma; | 1979 |
[Effect of different dosages of chemotherapeutic agents on survival of mice with ascitic tumor (author's transl)].
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cyclophosphamide; Drug Therapy, Combination; Fluorourac | 1979 |
The effect of 5-fluorouracil and adriamycin on heterotransplantation of Noble rat prostatic tumors in congenitally athymic (nude) mice.
Topics: Adenocarcinoma; Animals; Doxorubicin; Fluorouracil; Male; Mice; Mice, Nude; Neoplasm Transplantation | 1979 |
Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--I. 6-[3H]-5-fluorouracil.
Topics: Animals; Carcinoma, Ehrlich Tumor; Fluorouracil; Half-Life; Lung Neoplasms; Male; Mice; Models, Biol | 1979 |
The cytocidal action of metronidazole in combination with other antineoplastic agents.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Colonic Neoplasms; D | 1979 |
Transplantation of experimental ovarian tumors and their sensitivity to carcinostatics.
Topics: Adenocarcinoma; Animals; Female; Fluorouracil; Granulosa Cell Tumor; Humans; Male; Mitomycins; Neopl | 1979 |
Prostate adenocarcinoma model: Nb rat chemotherapy.
Topics: Adenocarcinoma; Animals; Castration; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Doxorub | 1979 |
[Combined drug therapy in transplanted colonic mice tumors].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Cyclophosphamide; Drug Evaluation, Preclinical; Drug The | 1979 |
Evaluation of single-agent therapy in human colorectal tumour xenografts.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Humans; Male; Mice; Neoplas | 1978 |
Cancer chemotherapy model using autochthonous large bowel cancer in rats.
Topics: Administration, Topical; Animals; Drug Evaluation, Preclinical; Female; Fluorouracil; Intestinal Neo | 1978 |
Growth and inhibition of mouse or human tumors in "nude" (athymic) mice monitored by the extent of 125 I-5-Iodo-2'-deoxyuridine(125-IUdR) uptake.
Topics: Animals; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Fluorouracil; HeLa Cells; Humans; Idoxur | 1978 |
Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA, Neoplasm; Fluorodeoxyuridy | 1978 |
[Symposium on cancer and immunity. (5) Experimental and clinical evaluation of chemoimmunotherapy for solid tumors (author's transl)].
Topics: Animals; Antineoplastic Agents; BCG Vaccine; Drug Therapy, Combination; Evaluation Studies as Topic; | 1978 |
Effectiveness of long-term chemotherapy and/or BCG on murine bladder cancer.
Topics: Animals; Antineoplastic Agents; BCG Vaccine; Carcinoma, Transitional Cell; Cyclophosphamide; Doxorub | 1978 |
Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fluorouracil; Leukemia, Ex | 1978 |
Further experience with chemotherapy in the Dunning prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Dactinomycin; Doxoru | 1978 |
Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Fluorouracil; Humans; Intracellular Fluid; Mice; | 1979 |
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leu | 1976 |
[Comparative study of the effect of inhibitors of monoamine oxidase and ftorafur on the growth of de-differentiated astrocytoma].
Topics: Animals; Astrocytoma; Cerebellar Neoplasms; Drug Evaluation; Fluorouracil; Monoamine Oxidase Inhibit | 1976 |
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclini | 1975 |
Combination therapy with mitomycin C,5-fluorouracil, and cytosine arabinoside in P815 ascites and solid mouse neoplasms.
Topics: Animals; Cytarabine; Drug Therapy, Combination; Fluorouracil; Mice; Mitomycins; Neoplasms, Experimen | 1976 |
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.
Topics: Adenocarcinoma; Administration, Oral; Animals; Ascites; Carcinoma, Ehrlich Tumor; Female; Fluorourac | 1976 |
Adjuvant immunochemotherapy of murine neoplasms.
Topics: Adjuvants, Immunologic; Animals; BCG Vaccine; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Inbred | 1976 |
Kinetic aids to proper chemotherapeutic scheduling: labeled nucleoside incorporation studies in vivo.
Topics: Animals; Bone Marrow; Cell Survival; Cyclophosphamide; DNA, Neoplasm; Drug Administration Schedule; | 1976 |
HeLa cell-tumor in nude mice and its response to antitumor agents.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Evalua | 1976 |
Further considerations in the therapy with ara-C.
Topics: Animals; Cytarabine; Drug Resistance; Drug Synergism; Fluorouracil; Mice; Mitomycins; Neoplasms, Exp | 1975 |
Anti-tumour and anti-metastatic activity of 3-(P-Chlorophenyl)-2,3-Dihydro-3-Hydroxythiazolo (3,2-A)-Benzimidazole-2-acetic acid (WY-13,876).
Topics: Animals; Anthelmintics; Antilymphocyte Serum; Antineoplastic Agents; Benzimidazoles; Cyclophosphamid | 1976 |
Changes of the immunogenic properties of a radiation-induced mouse lymphoma following treatment with antitumor drugs.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Cyclophosphamide; Dacarbazine; Fluorouracil; His | 1975 |
Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.
Topics: Animals; Binding Sites; Binding, Competitive; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Met | 1975 |
Proceedings: Combined effect of 5-FU and 60Co on intestine, bone marrow and on transplanted tumour in mice. A possible differential effect between these tissues related to drug and gamma-ray fractionation schemes.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cobalt Radioisotopes; Fluorouracil; Intestines; Mice; Neopl | 1975 |
[Effect of amphotericin B and its combination with 5-fluorouracil on the development of transplantable rat lymphosarcoma].
Topics: Amphotericin B; Animals; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Lymphatic | 1975 |
Effect of N1-(2'-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on nucleic acid and protein biosyntheses in Ehrlich ascites cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Furans; Liver; Male | 1976 |
The inhibition of DNA synthesis by cannabinoids.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cannabidiol; Cannabis; Cyclophosphamide; Cytarabine; DNA; D | 1976 |
Kinetic alterations induced by 5-fluorouracil in bone marrow, intestinal mucosa, and tumor.
Topics: Animals; Bone Marrow; Carcinoma, Ehrlich Tumor; Cell Division; Deoxyuridine; DNA; DNA, Neoplasm; Dos | 1976 |
Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil.
Topics: Amifostine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil | 1992 |
Pharmacokinetics and cytotoxicity of B.3839, a molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, in a mouse model.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Bone Marrow; Chromato | 1992 |
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L | 1992 |
Hyperthermia enhances the inhibition of tumor growth by 1-(2-tetrahydrofuryl)-5-fluorouracil/uracil (1:4) in tumors in mice and humans.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Combined Modality Therapy; D | 1992 |
Antitumor effect and tumor level of 5-fluoro-2'-deoxyuridylate following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Colonic Neoplasms; Fluorodeoxy | 1992 |
[Superior mesenteric arterial infusion chemotherapy in patient with both peritoneal carcinomatosis and liver metastasis].
Topics: Animals; Fluorouracil; Infusions, Intra-Arterial; Intestine, Small; Liver; Liver Neoplasms; Mesenter | 1992 |
Evaluation of the wap-ras transgenic mouse as a model system for testing anticancer drugs.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Disease Models, Animal; Fluorouracil; Genes, ras; | 1992 |
The effect of 5-fluorouracil at elevated temperatures on a spontaneous mouse tumour: Arrhenius analysis and tumour response.
Topics: Animals; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Fluorouracil; H | 1991 |
Solid tumour chemotherapy using implantable collagen-poly (HEMA) hydrogel containing 5-fluorouracil.
Topics: Animals; Collagen; Drug Implants; Female; Fibrosarcoma; Fluorouracil; Hydrogel, Polyethylene Glycol | 1991 |
Hematologic effects of interleukin-1 beta, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor in tumor-bearing mice treated with fluorouracil.
Topics: Animals; Bone Marrow; Colony-Stimulating Factors; Female; Fluorouracil; Granulocyte Colony-Stimulati | 1990 |
Effects of combined therapies with protein-bound polysaccharide (PSK, Krestin) and fluorinated pyrimidine derivatives on experimental liver metastases and on the immunologic capacities of the hosts.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antineoplastic Combined Chemotherapy Protocols; | 1991 |
Tumor bioenergetics and blood flow in RIF-1 murine tumors treated with 5-fluorouracil.
Topics: Animals; Energy Metabolism; Female; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbre | 1991 |
Schedule-dependent therapeutic gain from the combination of fractionated irradiation plus c-DDP and 5-FU or plus c-DDP and cyclophosphamide in C3H/Km mouse model systems.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Cyclo | 1991 |
The CMF-regimen. Toxicity patterns following stepwise combinations of cyclophosphamide, methotrexate and fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Cyclophosphamide; Drug A | 1991 |
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; In | 1990 |
Comparative antitumor activity and intestinal toxicity of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Male; Mice; Mi | 1990 |
Drug resistance following irradiation of RIF-1 tumors: influence of the interval between irradiation and drug treatment.
Topics: Animals; Antineoplastic Agents; Cell Line; Combined Modality Therapy; Dose-Response Relationship, Ra | 1990 |
Chemoprotective effects of recombinant human IL-1 alpha in cyclophosphamide-treated normal and tumor-bearing mice. Protection from acute toxicity, hematologic effects, development of late mortality, and enhanced therapeutic efficacy.
Topics: Animals; Carcinoma; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule | 1990 |
Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic N | 1990 |
[Metabolic characteristics and antitumor activity of BOF-A2, a new 5-fluorouracil derivative].
Topics: Animals; Antineoplastic Agents; Female; Fluorouracil; Male; Mammary Neoplasms, Experimental; Mice; N | 1990 |
[The antitumor properties of honey].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dr | 1990 |
[Antitumor activity and metabolism of BOF-A2, a new 5-fluorouracil derivative, with human cancers xenografted in nude mice].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Colorectal Neoplasms; Fluorouracil; Humans; Li | 1990 |
Potentiation by squalene of the cytotoxicity of anticancer agents against cultured mammalian cells and murine tumor.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Survival; Cisplatin; Cricetinae; Cricetulus; Dose-Re | 1985 |
Effect of L-histidinol on the metabolism of 5-fluorouracil in the BALB/c x DBA/8 F1 murine tumor system.
Topics: Animals; DNA, Neoplasm; Fluorouracil; Histidinol; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Inbre | 1988 |
Epidermal growth factor receptor-mediated selective cytotoxicity of antitumor agents toward human xenografts and murine syngeneic solid tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cisplatin; Dose-Response Rel | 1989 |
Oxalato-platinum or 1-OHP, a third-generation platinum complex: an experimental and clinical appraisal and preliminary comparison with cis-platinum and carboplatinum.
Topics: Animals; Antineoplastic Agents; Carboplatin; Cisplatin; Drug Evaluation; Fluorouracil; Humans; Mice; | 1989 |
[Antitumor effects of 5-fluorouracil-bound organic silicon compound].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Ethyla | 1989 |
Murine studies with 5-fluorouracil and leucovorin.
Topics: Animals; Drug Therapy, Combination; Fluorouracil; Leucovorin; Mice; Neoplasms, Experimental | 1989 |
[Experimental and clinical study of adoptive immunotherapy combined with preadministration of OK-432: a method to augment the therapeutic effect].
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Products; Breast Ne | 1989 |
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Cytidine Deaminase; Deoxyc | 1985 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experime | 1985 |
Enzymatic cleavage of various fluorinated pyrimidine nucleosides to 5-fluorouracil and their antiproliferative activities in human and murine tumor cells.
Topics: Animals; Cell Division; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred Strains; Neoplasms, Ex | 1986 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
Role of uridine phosphorylase in the anabolism of 5-fluorouracil.
Topics: Animals; Bone Marrow; Colonic Neoplasms; Diphosphates; Female; Fluorouracil; Kinetics; Mice; Mice, I | 1985 |
[Sensitivity test of anticancer agents by subrenal capsule assay (SRC assay). II--Determination of tumor sensitivity by percentage inhibition of DNA protein].
Topics: Animals; Antineoplastic Agents; Colony-Forming Units Assay; Cyclophosphamide; DNA, Neoplasm; Fluorou | 1986 |
Comparative study on nude mice isotope assay (NM-IA) and subrenal capsule assay (SRCA) sensitivity tests of anticancer agents.
Topics: Animals; Antineoplastic Agents; Cisplatin; Colony-Forming Units Assay; Cyclophosphamide; Doxorubicin | 1987 |
[N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) is metabolized and converted to 5-fluorouracil in tumor cells].
Topics: Animals; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Mice; Mice, Inbred BALB C; Neoplasms, Experim | 1987 |
Pharmacodynamic aspects of in vitro and in vivo chemosensitivity tests.
Topics: Animals; Biometry; Colony-Forming Units Assay; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Tran | 1987 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neopl | 1985 |
[Sensitivity of human tumor heterografts to a spin-labelled rubomycin derivative].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Daunorubicin; Dose-Respon | 1988 |
[Pharmacodynamic study of the in vitro clonogenic assay--with reference to dose levels].
Topics: Animals; Colony-Forming Units Assay; Fluorouracil; Humans; In Vitro Techniques; Mice; Mice, Inbred B | 1988 |
Restoration of cytolytic T-lymphocyte response with a new immunopotentiator, N-(4-[(4-fluorophenyl)sulfonyl]phenyl)acetamide (CL 259, 763), in mice.
Topics: Adjuvants, Immunologic; Animals; Cyclophosphamide; Cyclosporins; Fluorouracil; Mice; Mice, Inbred St | 1988 |
Failure of high-dose leucovorin to improve therapy with the maximally tolerated dose of 5-fluorouracil: a murine study with clinical relevance?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Leucovorin; Mice; Neo | 1988 |
Immunological mechanisms of antitumor activity of some kinds of Chinese herbs: Meth A-induced delayed type hypersensitivity.
Topics: Animals; Cyclophosphamide; Female; Fluorouracil; Hypersensitivity, Delayed; Lipopolysaccharides; Mal | 1988 |
Role of dose, schedule and route of administration of 5-formyltetra-hydrofolate: preclinical and clinical investigations.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; | 1988 |
Evolution of molecular combinations involving 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Mice; Neoplasms, Experimental; Pharmaceutical Preparat | 1988 |
[Biorhythms and drug therapy].
Topics: Animals; Antineoplastic Agents; Circadian Rhythm; Fluorouracil; Melphalan; Mice; Neoplasms, Experime | 1987 |
Mechanism of potentiation of antitumor activity of 5-fluorouracil by guanine ribonucleotides against adenocarcinoma 755.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Drug Synergi | 1987 |
Three alkaloids as selective destroyers of cancer cells in mice. Synergy with classic anticancer drugs.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Daunorubicin; Drug Synergism; Fl | 1986 |
[A new anticancer preparation, 5-fluorouracil-poly-L-lactic acid microcapsule, and its therapeutic evaluation].
Topics: Adult; Aged; Animals; Capsules; Delayed-Action Preparations; Embolization, Therapeutic; Female; Fluo | 1986 |
[Pharmacokinetics of 1-phthalidyl-5-fluorouracil (PH-FU)].
Topics: Administration, Oral; Animals; Biological Assay; Fluorouracil; Kinetics; Liver Neoplasms, Experiment | 1986 |
[Chronobiological approach in the experimental development of regimens for the combined chemotherapy of tumors].
Topics: Aging; Animals; Antineoplastic Combined Chemotherapy Protocols; Chronobiology Phenomena; Circadian R | 1986 |
Pharmacokinetics of 5-fluorouracil in rabbits in experimental regional chemotherapy.
Topics: Animals; Fluorouracil; Injections, Intra-Arterial; Injections, Intravenous; Kinetics; Metabolic Clea | 1986 |
[Potentiation of the selective antitumoral effect of cyclophosphamide and 5-fluorouracil by its combination with amphotericin B and diacarb].
Topics: Acetazolamide; Amphotericin B; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophospha | 1986 |
Pharmacokinetic interactions of cyclophosphamide and 5-fluorouracil with methotrexate in an animal model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Specimen Collection; Cyclophosphamide | 1986 |
Inhibition of experimental pulmonary metastasis in mice by beta-cyclodextrin-benzaldehyde.
Topics: Animals; Benzaldehydes; beta-Cyclodextrins; Cyclodextrins; Cytotoxicity, Immunologic; Dextrins; Fluo | 1986 |
[Experimental evaluation of tumor therapy with cytostatic agents deposited in the abdominal cavity in acetylcellulose].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cellulose; Cyclophosphamide; Delayed-Action P | 1987 |
[Functional state of the sympatho-adrenal system at late stages of the tumor process after cyclophosphamide and 5-fluorouracil administration].
Topics: Adrenal Cortex; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Fluoroura | 1987 |
[Enhancement of the selectivity of the action of the cytostatics cyclophosphane and 5-fluorouracil by using an extract of the Baikal skullcap in an experiment].
Topics: Animals; Cyclophosphamide; Drug Evaluation, Preclinical; Drug Synergism; Female; Fluorouracil; Male; | 1987 |
Effect of a high-protein-low-carbohydrate diet on toxicity and antitumor activity of 5-fluorouracil in mice.
Topics: Animals; Dietary Carbohydrates; Dietary Proteins; Female; Fluorouracil; Methionine; Mice; Mice, Inbr | 1985 |
Enhancement of antitumor effect of cytotoxic agents by bestatin.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cisplatin; Colonic Neop | 1985 |
Potentiation by vitamin A of the action of anticancer agents against murine tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diterpenes; Doxorubicin; Drug Ev | 1985 |
Development of latent residual drug damage to the hematopoietic marrow during the subsequent growth of tumors.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Busulfan; Cisplatin; Colony-Forming Units Assay; Doxoru | 1986 |
[590-S].
Topics: Administration, Oral; Adult; Animals; Anorexia; Antineoplastic Agents; Drug Administration Schedule; | 1985 |
Synergistic interaction in Jensen tumor cells of two modes of exposure to inosine that potentiate the cytotoxicity of 5-fluorouracil.
Topics: Animals; Cells, Cultured; Drug Synergism; Fluorouracil; Inosine; Neoplasms, Experimental; Rats | 1985 |
Sequential methotrexate (MTX) and 5-fluorouracil (FU) in human tumor xenografts.
Topics: Animals; Carcinoma 256, Walker; Carcinoma, Squamous Cell; Cell Line; Dose-Response Relationship, Dru | 1985 |
Effect of various anticancer agents on DNA polymerase.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Bone | 1971 |
Effect of anticancer chemotherapy on the lymphocyte blastoid transformation.
Topics: Adult; Aged; Animals; Bleomycin; Cyclophosphamide; Fluorouracil; Gastrointestinal Neoplasms; Humans; | 1973 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; | 1974 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides | 1974 |
Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells.
Topics: Animals; Azacitidine; Azaguanine; Carcinoma, Hepatocellular; Cells, Cultured; Cytidine; Dactinomycin | 1974 |
Enhancing effect of clamping of the portal vein on the effectiveness of antitumor agents against abdominal tumor growth.
Topics: Abdominal Neoplasms; Animals; Antineoplastic Agents; Bleomycin; Female; Fluorouracil; Injections, In | 1974 |
Chemotherapy of induced skin tumors in mice.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Benz(a)Anthracenes; Busulfan; Ca | 1968 |
[On the question of preclinical selection of cytostatics in the area of treatment of human tumors].
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Culture Te | 1969 |
The growth of human tumours in immunosuppressed mice and their response to chemotherapy.
Topics: Animals; Chlorambucil; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; | 1974 |
Chemotherapy studies in an animal tumor spectrum. II. Sensitivity of tumors to fourteen antitumor chemicals.
Topics: Animals; Antineoplastic Agents; Arsenicals; Busulfan; Cyclophosphamide; Dactinomycin; Diethylstilbes | 1966 |
Myeloid leukemia C-1498 as a screen for cancer chemotherapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Busulfan; Cyclophospha | 1966 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, N | 1970 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; N | 1970 |
Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymom | 1971 |
Growth inhibition by chemotherapeutic agents on stilbestrol-induced hamster kidney tumor.
Topics: Adenocarcinoma; Animals; Cricetinae; Cyclophosphamide; Dactinomycin; Diethylstilbestrol; Fluorouraci | 1971 |
Distribution of 5-fluorouracil-2- 14 C and its metabolites in a murine glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin | 1972 |
Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Count; Floxuridine; Fluorouracil; Hydroxyurea; | 1973 |
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyurid | 1973 |
Assay of 5-fluorodeoxyuridine 5'-monophosphate deoxyuridine 5'-monophosphate pools following 5-fluorouracil.
Topics: Animals; Cell Line; Clinical Enzyme Tests; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Floxur | 1974 |
[Cytometric studies on tumor cells following 5-fluorouracil treatment].
Topics: Culture Techniques; Fluorouracil; Glioblastoma; HeLa Cells; Humans; Neoplasm Proteins; Neoplasms, Ex | 1967 |
Considerations in the development of a predictive system for cancer chemotherapy.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; DNA; Floxuridine; Fluorouracil; Liver N | 1971 |
[Isolation and study of a conditional mutant of Rous virus with thermosensitive transforming capacity].
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Culture Techniques; D | 1970 |
Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. II. Correlation between the tumor levels of the enzyme and the 5-fluorouracil-promoted increase in survival of tumor-bearing mice.
Topics: Animals; Fluorouracil; Leukemia L1210; Lymphoma; Mice; Neoplasm Transplantation; Neoplasms, Experime | 1969 |
[Radiotherapy following synchronisation of the cell-division rhythm].
Topics: Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Division; DNA; Fluorouracil; Humans; Mice; Neopla | 1972 |
Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Electrophoresis; Fluorine; Fluoroura | 1973 |
The deoxyribonucleoside transport systems of cultured Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane Permeability; Cel | 1974 |
A re-examination of the renal blastema graft model for Wilms tumor production.
Topics: Animals; Autopsy; Cell Differentiation; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Drug | 1974 |
Effects of sodium warfarin and other carcinostatic agents on malignant cells: a study of drug synergy.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Bronchogenic; Carcinoma, Hepatocellular; Carcinoma, Squamo | 1974 |
Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver; Liver Neoplasms; Neoplasms, Experim | 1974 |
Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Fluorouracil; Inje | 1974 |
Studies on the mechanism and prevention of local recurrence of carcinoma at the suture line after colonic resection.
Topics: Animals; Carcinoma, Hepatocellular; Colon; Colonic Neoplasms; Fluorouracil; Intestinal Mucosa; Liver | 1971 |
[Application of morphological and histochemical methods for evaluation of cytostatic effects on organ cultures of malignant tumors].
Topics: Animals; Antineoplastic Agents; Carcinoma; Culture Techniques; Female; Fluorouracil; Histocytochemis | 1974 |
[Characteristics of the cell mitotic cycle and the possibility of enhancing the effect of radiotherapy].
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Deoxyuridine; DNA, Neoplasm; Esopha | 1974 |
ICRF-159 in treatment of germinal testicular tumor in animals.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Dogs; Drug T | 1974 |
[Studies of cancer radiotherapy by combined use of radioprotectors and a radiosensitizer].
Topics: Animals; beta-Aminoethyl Isothiourea; Cysteine; Fluorouracil; Male; Mercaptoethylamines; Mice; Neopl | 1973 |
[The state of parietal carbohydrate hydrolysis following a single administration of antitumor drugs to intact and tumorous animals].
Topics: Animals; Carcinoma; Cyclophosphamide; Digestion; Female; Fluorouracil; Furans; Hydrolysis; Intestine | 1972 |
Study on the sensitivity test of carcinostatic agents by acid phosphatase activity.
Topics: Acid Phosphatase; Adult; Aged; Animals; Antineoplastic Agents; Chromomycins; Cyclophosphamide; Femal | 1972 |
[Synchronized radiotherapy in malignant tumors. Theoretical bases and clinical results].
Topics: Aged; Animals; Cell Division; Evaluation Studies as Topic; Fluorouracil; Humans; Mice; Mouth Neoplas | 1973 |
The role of thymidylate synthetase inhibitors in bromodeoxyuridine-induced neoplasia in Drosophila.
Topics: Animals; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA; Drosophila; Fluorine; Fluorouraci | 1973 |
Age cohort variation of tumor cells.
Topics: Animals; Cell Division; Disease Models, Animal; DNA, Neoplasm; Fluorouracil; Hydroxyurea; Lymphoma; | 1973 |
Chromosome patterns of nontransformed variants from chemically transformed Balb-3T3 cells.
Topics: Animals; Benz(a)Anthracenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome | 1974 |
Synchronization of human tissues and its consequences for cancer therapy in ENT. Cell kinetic and clinical studies.
Topics: Aged; Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Division; DNA Replication; DNA, Neoplasm; E | 1974 |
Influence of age of host on the chemotherapy of murine myeloma LCP-1.
Topics: Age Factors; Aging; Alkylating Agents; Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; | 1974 |
Combination chemotherapy of advanced murine myeloma and subsequent resistance to tumor cell challenge.
Topics: Allyl Compounds; Aniline Compounds; Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, | 1974 |
Relative effects of varying concentrations of cytotoxic drugs in vitro on tumour and reticulo-endothelial tissue.
Topics: Animals; Antineoplastic Agents; DNA; DNA, Neoplasm; Fluorouracil; Glucose; In Vitro Techniques; Mamm | 1968 |
[On selection of antineoplastic agents for local use].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Female; Fluorouracil; In Vitro Techniques; | 1969 |
Evaluation of adjunctive chemotherapy for recurrent cancer.
Topics: Animals; Breast Neoplasms; Female; Fluorouracil; Humans; Mice; Neoplasm Recurrence, Local; Neoplasms | 1970 |
[Use of vitamin B-15 in experimental tumor chemotherapy].
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride Poisoning; Carcinoma; Chemical and Drug Induced | 1970 |
[Time factor in evaluating antineoplastic agents].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Dactinomycin; Fluorouracil; M | 1972 |
[Clinical and experimental results of interstitial Brachy-Curie-therapy combined with radiation sensitizing agents in infiltrative growing brain neoplasms].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinosarcoma; Cytidine; Fluorouracil; Guanosine; Irid | 1972 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cy | 1972 |
Lack of effect of warfarin (NSC-59813) alone or in combination with 5-fluorouracil (NSC-19893) on primary and metastatic L1210 leukemia and adenocarcinoma 755.
Topics: Adenocarcinoma; Animals; Female; Fluorouracil; Leukemia L1210; Mice; Neoplasm Metastasis; Neoplasm T | 1971 |
[Evaluation, in newborn Swiss mice, of the carcinogenic activity of some antineoplastic and immunosuppressive compounds].
Topics: Adenoma; Animals; Animals, Newborn; Antineoplastic Agents; Asparaginase; Azathioprine; Fluorouracil; | 1971 |
[Experimental studies on antineoplastic action of N 1 -(2'-tetrahydrofuryl)-5-fluorouracil (FT-207)--effect on experimental tumors].
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Fluorouracil; Furans; Mice; Neoplasms, Experimental; | 1971 |
Studies on the effects of hydroxyurea and other anticancer drugs upon pyrimidine metabolism.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Cyclophosphamide; Cytarab | 1969 |
Distant metastases from beta-naphthylamine induced vesical tumors in dogs.
Topics: Animals; Carcinogens; Carcinoma, Transitional Cell; Dogs; Female; Fluorouracil; Lung Neoplasms; Naph | 1969 |
Relation between concentration in tissues and activity of anticancer drug.
Topics: Animals; Antineoplastic Agents; Culture Techniques; Fluorouracil; Humans; Mice; Mitomycins; Neoplasm | 1969 |
Progress in the treatment of bladder cancer with special reference to chemotherapy.
Topics: Animals; Cricetinae; Fluorouracil; Humans; Neoplasm Transplantation; Neoplasms, Experimental; Urinar | 1969 |
[Studies on the treatment of experimental renal tumors induced by dimethylnitrosamine. II. The effects of cancer chemotherapeutic drugs, such as mitomycin C, 5-fluorouracil and endoxan on experimentally induced renal tumors].
Topics: Animals; Body Weight; Cyclophosphamide; Fluorouracil; Injections, Intraperitoneal; Kidney Neoplasms; | 1969 |
[Radiotherapy of synchronized skin neoplasms in mice].
Topics: Animals; Benzopyrenes; Cell Division; Fluorouracil; Mice; Neoplasms, Experimental; Periodicity; Skin | 1970 |
[Experimental results of the use of polychemotherapy in malignant tumors].
Topics: Amides; Amputation, Surgical; Animals; Antineoplastic Agents; Benzoates; Carcinoma; Cyclophosphamide | 1970 |
Further studies on chemotherapy of experimental brain tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Ependymoma; Fluorouracil; Glioma; Mice; Neoplasms, | 1970 |
The relation of tumour size to the results of chemotherapy in malignant tumours.
Topics: Amputation, Surgical; Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Mercaptopurine | 1971 |
[Experimental study on 5-fluorouracil].
Topics: Animals; Fluorouracil; Mice; Neoplasm Transplantation; Neoplasms, Experimental | 1967 |
[Effects of combined chemotherapy chiefly with 5-fluorouracil and mitomycin-C].
Topics: Animals; Female; Fibrinogen; Fluorouracil; Immune Sera; Male; Mice; Mitomycins; Neoplasms, Experimen | 1967 |
Differential hypothermia-normothermia as a new tool to enhance the activity of anti-cancer drugs. Radioisotope study.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Cricetinae; Fluorouracil; Hypothermia, Induced; Neo | 1967 |
Cancer of human bladder. Responses of tumor xenografts to chemotherapy and radiotherapy.
Topics: Animals; Computers; Cricetinae; Fluorouracil; Humans; Mitomycins; Neoplasm Transplantation; Neoplasm | 1968 |
Further studies on selective cytotoxicity of triton WR-1339.
Topics: Clone Cells; Fluorouracil; Methotrexate; Neoplasms, Experimental; Prednisone; Surface-Active Agents | 1968 |
Ribonuclease inhibitor in lymphosarcoma P1798: effects of steroid and 5-FU.
Topics: Animals; Fluorouracil; Glucocorticoids; Lymphoma, Non-Hodgkin; Mice; Neoplasms, Experimental; Ribonu | 1968 |
[On relatively new antineoplastic agents].
Topics: Animals; Fluorouracil; Mice; Neoplasms, Experimental | 1968 |
Further studies on human bladder and kidney tumors transplanted to the hamster cheek pouch.
Topics: Adenocarcinoma; Animals; Computers; Cricetinae; Female; Fluorouracil; Humans; Kidney Neoplasms; Male | 1969 |
Relation of thymidine index to pulmonary tumor response in mice receiving urethan and other carcinogens.
Topics: Animals; Autoradiography; Carbamates; Carcinogens; Cytarabine; Dactinomycin; DNA; Fluorouracil; Inje | 1969 |
[Distribution of 5-fluorouracil in blood and organs of mice with NK and AK-755 tumors].
Topics: Animals; Brain Chemistry; Fluorouracil; Kidney; Liver; Lung; Mice; Neoplasms, Experimental; Spleen | 1969 |
Inhibitory effect of DL-2-mercapto-3-hydroxypropanal on growth of transplantable cancers in mice.
Topics: Aldehydes; Animals; Antineoplastic Agents; Fluorouracil; Glyceraldehyde; Injections, Intraperitoneal | 1969 |
Inhibition by 5-fluorouracil of the early stages of chemical carcinogenesis in mouse skin.
Topics: Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Depression, Chemical; Female; Fluorour | 1969 |
Transplantable mouse plasma cell tumors in experimental chemotherapy.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Blood Protein Electrophoresis; Blood Proteins; Ch | 1969 |
Heterotransplantation of bladder cancer in the hamster cheek pouch: in vivo testing of cancer chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cheek; Cricetinae; Fluorouracil; Humans; Mitomycins; Neoplasm Metast | 1966 |
The role of ribonuclease in regression of lymphosarcoma P1798.
Topics: Animals; Chloromercuribenzoates; Chromatography; Corticosterone; Fluorouracil; Freezing; Hydrocortis | 1966 |
Enhancement of 5-fluorouracil action on normothermic tumors by generalized hypothermia.
Topics: Animals; Antineoplastic Agents; Cricetinae; Fluorouracil; Hypothermia, Induced; Male; Neoplasm Regre | 1966 |