fluorouracil has been researched along with Experimental Leukemia in 119 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mouse T-lymphoma (S-49) cell line is useful for individually studying RNA- and DNA-directed effects of 5-fluoropyrimidines." | 7.66 | Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells. ( Day, JL; Mandel, HG; Maybaum, J; Sadee, W; Ullman, B, 1980) |
| "Different methods were compared for the in vitro evaluation of the therapeutic effects of the antineoplastic agents doxorubicin, cisplatin, fluorouracil, and vinblastine sulfate in a model system of murine tumor cell lines consisting of L1210 leukemia, P815 mast cell leukemia, and B16 melanoma." | 3.67 | In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays. ( Atassi, G; Bernheim, JL; Roobol, C; Sips, HC; Theunissen, J, 1984) |
| "The mouse T-lymphoma (S-49) cell line is useful for individually studying RNA- and DNA-directed effects of 5-fluoropyrimidines." | 3.66 | Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells. ( Day, JL; Mandel, HG; Maybaum, J; Sadee, W; Ullman, B, 1980) |
| "The mechanism of antitumor activity of 5-fluorouracil (FU) was studied in mouse leukemia L5178Y cells in vitro." | 3.66 | The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells. ( Hoshi, A; Kuretani, K; Yoshida, M, 1980) |
| "Lambdamycin, a chromoglycoside antibiotic like chartreusin was found to be very active against leukemias L 1210 and P 388 and moderate effective against melanoma B 16 and Lewis lung carcinoma of mice." | 3.66 | [Antineoplastic activity of lambdamycin in different murine test models compared with cyclophosphamide, 6-mercaptopurine and 5-fluorouracil (author's transl)]. ( Fleck, WF; Gutsche, W; Jungstand, W; Wohlrabe, K, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 109 (91.60) | 18.7374 |
| 1990's | 9 (7.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (0.84) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murdock, KC | 2 |
| Child, RG | 1 |
| Fabio, PF | 1 |
| Angier, RB | 2 |
| Wallace, RE | 2 |
| Durr, FE | 2 |
| Citarella, RV | 2 |
| Loeffler, LJ | 1 |
| Sajadi, Z | 1 |
| Hall, IH | 5 |
| Lee, KH | 4 |
| Ibuka, T | 2 |
| Mar, EC | 2 |
| Okamoto, M | 1 |
| Wu, YS | 1 |
| Giorgi-Renault, S | 1 |
| Renault, J | 1 |
| Gebel-Servolles, P | 1 |
| Baron, M | 1 |
| Paoletti, C | 1 |
| Cros, S | 1 |
| Bissery, MC | 1 |
| Lavelle, F | 1 |
| Atassi, G | 2 |
| Jurd, L | 1 |
| Narayanan, VL | 1 |
| Paull, KD | 1 |
| Rosowsky, A | 1 |
| Kim, SH | 1 |
| Wick, M | 1 |
| Sims, D | 1 |
| Muraoka, O | 1 |
| Kiyokawa, H | 1 |
| Kim, HL | 1 |
| Jafek, JL | 1 |
| Shakya, A | 1 |
| Tai, PY | 1 |
| Ibarra, A | 1 |
| Kim, H | 1 |
| Maddox, J | 1 |
| Chumley, J | 1 |
| Spangrude, GJ | 1 |
| Miles, RR | 1 |
| Kelley, TW | 1 |
| Tantin, D | 1 |
| LIEBLING, ME | 1 |
| HUMPHREYS, SR | 2 |
| GOLDIN, A | 6 |
| CHIRIGOS, MA | 2 |
| RAUSCHER, FJ | 1 |
| KAMEL, IA | 1 |
| FANNING, GR | 1 |
| GLYNN, JP | 1 |
| MOLONEY, JB | 1 |
| BURCHENAL, JH | 3 |
| RUTMAN, RJ | 1 |
| Kessel, D | 6 |
| Hall, TC | 5 |
| Wodinsky, I | 3 |
| Madoc-Jones, H | 1 |
| Bruce, WR | 1 |
| Moran, RG | 1 |
| Danenberg, PV | 1 |
| Heidelberger, C | 3 |
| Iigo, M | 4 |
| Hoshi, A | 11 |
| Ardalan, B | 2 |
| Cooney, DA | 1 |
| Jayaram, HN | 1 |
| Carrico, CK | 1 |
| Glazer, RI | 1 |
| Macdonald, J | 1 |
| Schein, PS | 1 |
| Kanzawa, F | 3 |
| Kuretani, K | 9 |
| Maybaum, J | 1 |
| Ullman, B | 1 |
| Mandel, HG | 1 |
| Day, JL | 1 |
| Sadee, W | 1 |
| Yoshida, M | 5 |
| Mulkins, MA | 2 |
| Umeda, Y | 1 |
| Sakamoto, A | 1 |
| Nakamura, J | 1 |
| Ishitsuka, H | 1 |
| Yagi, Y | 1 |
| Herrick, D | 1 |
| Kufe, DW | 2 |
| Hill, BT | 2 |
| Bellamy, AS | 1 |
| Roobol, C | 1 |
| Sips, HC | 1 |
| Theunissen, J | 1 |
| Bernheim, JL | 1 |
| Kishida, K | 1 |
| Makita, T | 1 |
| Parchure, M | 1 |
| Ambaye, RY | 2 |
| Gokhale, SV | 1 |
| Bukhman, VM | 2 |
| Mamedov, FF | 1 |
| Santelli, G | 5 |
| Valeriote, F | 6 |
| Forbes, M | 1 |
| Tezuka, M | 1 |
| Sugiyama, H | 1 |
| Tamemasa, O | 1 |
| Inaba, M | 2 |
| Seidel, HJ | 2 |
| Kreja, L | 1 |
| Delfina Pesce, C | 1 |
| Boccanera, M | 1 |
| Marconi, P | 1 |
| Bistoni, F | 1 |
| Cenci, E | 1 |
| Tissi, L | 1 |
| Cassone, A | 1 |
| Gutsche, W | 1 |
| Wohlrabe, K | 1 |
| Jungstand, W | 1 |
| Fleck, WF | 1 |
| Ross, DW | 1 |
| Vietti, T | 2 |
| Coulter, D | 1 |
| Habs, M | 1 |
| Schmähl, D | 2 |
| Lin, PZ | 1 |
| Tsuruo, T | 1 |
| Naganuma, K | 1 |
| Iida, H | 1 |
| Tsukagoshi, S | 1 |
| Zhao, TH | 1 |
| Ueda, H | 1 |
| Manda, T | 1 |
| Matsumoto, S | 1 |
| Mukumoto, S | 1 |
| Nishigaki, F | 1 |
| Kawamura, I | 1 |
| Shimomura, K | 1 |
| Lee, BC | 1 |
| Shav-Tal, Y | 1 |
| Peled, A | 1 |
| Gothelf, Y | 1 |
| Jiang, W | 1 |
| Toledo, J | 1 |
| Ploemacher, RE | 1 |
| Haran-Ghera, N | 1 |
| Zipori, D | 1 |
| Felczak, K | 1 |
| Gołos, B | 1 |
| Dzik, JM | 1 |
| Rode, W | 1 |
| Bretner, M | 1 |
| Shugar, D | 1 |
| Kulikowski, T | 1 |
| O'Toole, T | 1 |
| Kalaher, K | 1 |
| Chisholm, J | 1 |
| Shani, J | 1 |
| Wolf, W | 1 |
| Schlesinger, T | 1 |
| Atkins, HL | 1 |
| Bradley-Moore, PR | 1 |
| Casella, V | 1 |
| Fowler, JS | 1 |
| Greenberg, D | 1 |
| Ido, T | 1 |
| Lambrecht, RM | 1 |
| MacGregor, R | 1 |
| Mantescu, C | 1 |
| Neirinckx, R | 1 |
| Som, P | 1 |
| Wolf, AP | 1 |
| Meaney, K | 1 |
| Belitskiĭ, GA | 1 |
| Konopleva, IA | 1 |
| Pujman, V | 1 |
| Cernochová, S | 1 |
| Schwartz, PM | 1 |
| Handschumacher, RE | 1 |
| Fujikura, R | 1 |
| Sakurai, Y | 1 |
| Fukushima, M | 1 |
| Ikenaka, K | 1 |
| Shirasaka, T | 1 |
| Fujii, S | 1 |
| Gerasimova, GK | 2 |
| Mokina, VD | 1 |
| Sidorova, TA | 1 |
| Nakeff, A | 1 |
| Valeriote, FA | 1 |
| Belousova, AK | 2 |
| Nakamura, A | 2 |
| Garibjanian, BT | 1 |
| Johnson, RK | 1 |
| Kline, I | 1 |
| Vadlamudi, S | 1 |
| Gang, M | 1 |
| Venditti, JM | 2 |
| Currie, VE | 1 |
| Dowling, MD | 1 |
| Fox, JJ | 2 |
| Krakoff, IH | 1 |
| Reyes, P | 4 |
| Guganig, ME | 1 |
| Sugimoto, K | 1 |
| Taniguchi, S | 1 |
| Ogata, H | 1 |
| Ikehara, S | 1 |
| Fujita, J | 1 |
| Mori, KJ | 1 |
| Nakamura, T | 1 |
| Uchida, M | 1 |
| Ueda, T | 1 |
| Mini, E | 2 |
| Coronnello, M | 1 |
| Carotti, S | 1 |
| Gerli, A | 1 |
| Pesciullesi, A | 1 |
| Moroson, BA | 1 |
| Mazzei, T | 1 |
| Periti, P | 1 |
| Bertino, JR | 2 |
| Indap, MA | 1 |
| Naik, SD | 1 |
| Chandrasekaran, B | 1 |
| Hrishikeshavan, HJ | 1 |
| Takahashi, K | 1 |
| Iwabuchi, M | 1 |
| McGuire, JJ | 1 |
| Hsieh, P | 1 |
| Armstrong, RD | 1 |
| Lewis, M | 1 |
| Stern, SG | 1 |
| Cadman, EC | 1 |
| Leopold, WR | 1 |
| Dykes, DJ | 1 |
| Griswold, DP | 1 |
| Balázová, E | 1 |
| Koza, I | 1 |
| Baumgart, J | 1 |
| Zhukovskaya, NV | 1 |
| Anisimov, VN | 1 |
| Rustum, YM | 1 |
| Liu, L | 1 |
| Zhang, Z | 1 |
| Keizer, HJ | 1 |
| Pauwels, R | 1 |
| Landuyt, W | 1 |
| Balzarini, J | 2 |
| van der Schueren, E | 1 |
| De Clercq, E | 2 |
| Gresser, I | 1 |
| Maury, C | 1 |
| Belardelli, F | 1 |
| Maunoury, MT | 1 |
| Machover, D | 1 |
| Wampler, GL | 1 |
| Carter, WH | 1 |
| Campbell, ED | 1 |
| Iwata, T | 1 |
| Watanabe, T | 1 |
| Wittes, RE | 1 |
| Machida, S | 1 |
| Ito, Y | 1 |
| Hoshino, A | 1 |
| Powis, G | 1 |
| Harris, RN | 1 |
| Basseches, PJ | 1 |
| Santone, KS | 1 |
| Desgranges, C | 1 |
| Razaka, G | 1 |
| Herdewijn, P | 1 |
| Drouillet, F | 1 |
| Bricaud, H | 1 |
| Marsh, JC | 1 |
| Shoemaker, RH | 1 |
| Suffness, M | 1 |
| Furue, H | 1 |
| Veselỳ, J | 1 |
| Cihák, A | 1 |
| Bradner, WT | 1 |
| Pindell, MH | 1 |
| Bruns, R | 1 |
| Guganig, M | 1 |
| Nahas, A | 1 |
| Capizzi, RL | 1 |
| Frei, E | 1 |
| Schabel, FM | 1 |
| Yancey, ST | 1 |
| Bleyer, WA | 1 |
| Tattersall, MH | 2 |
| Harrap, KR | 2 |
| Merkulov, MF | 1 |
| Leskova, SG | 1 |
| Deacon, J | 1 |
| Coffey, B | 1 |
| Bakamjian, A | 1 |
| Furness, ME | 1 |
| Jackson, S | 1 |
| Meĭren, DV | 1 |
| Dodd, DC | 1 |
| Mishra, LC | 1 |
| Hebborn, P | 1 |
| Carević, O | 1 |
| Sverko, V | 1 |
| Boranić, M | 1 |
| Swiniarski, J | 1 |
| Kensler, CJ | 1 |
| Cooper, GM | 1 |
| Dunning, WF | 1 |
| Greer, S | 1 |
| Eggerding, F | 1 |
| Brambilla, G | 1 |
| Caraceni, CE | 1 |
| Cavanna, M | 1 |
| Parodi, S | 1 |
| Boyse, EA | 1 |
| Old, LJ | 1 |
| Campbell, HA | 1 |
| Mashburn, LT | 1 |
| Ballweg, H | 1 |
| von Wedelstaedt, E | 1 |
| Miller, N | 1 |
| Wempen, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Trial of Romidepsin Given on Days One, Three, and Five in Patients With Thyroid and Other Advanced Cancers[NCT00048334] | Phase 1 | 28 participants (Actual) | Interventional | 2002-10-26 | Completed | ||
| Phase I Study of Topical Romidepsin (Depsipeptide) in Early Stage Cutaneous T-Cell Lymphoma[NCT01445340] | Phase 1 | 6 participants (Actual) | Interventional | 2007-04-21 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and Experimental Leukemia
| Article | Year |
|---|---|
Biochemical modulation of fluoropyrimidines by antifolates and folates in an in vitro model of human leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Folic Acid; Folic Acid An | 1990 |
Unresolved issues in combination chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carmustine; Cell Cycle; Cyclo | 1986 |
Resistance of mammalian tumour cells toward pyrimidine analogues. A review.
Topics: Animals; Antimetabolites; Azacitidine; Azauridine; Bromouracil; Carcinoma, Ehrlich Tumor; Cell Line; | 1973 |
116 other studies available for fluorouracil and Experimental Leukemia
| Article | Year |
|---|---|
Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones.
Topics: Animals; Anthracenes; Antineoplastic Agents; Leukemia, Experimental; Mice; Neoplasms, Experimental; | 1979 |
Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids.
Topics: Acetonitriles; Amino Acids; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlic | 1977 |
Antitumor agents. 31. Helenalin sym-dimethylethylenediamine reaction products and related derivatives.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cells, Cultured; Chemical Phenomena; Chemistry; E | 1978 |
Antitumor agents 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma 256, Walker; Cells, Cultured; Cyclopentanes; L | 1978 |
Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Lactones; Leukemia, Experimental; Male; Melan | 1977 |
Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione.
Topics: Animals; Antineoplastic Agents; Aziridines; Breast Neoplasms; Cell Division; Cell Line; Drug Screeni | 1991 |
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topois | 1987 |
Synthesis and antitumor activity of an acyclonucleoside derivative of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia, Experimental; Mice | 1981 |
Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Evaluation; Leukemia, Experimental; Mice; Sesquiter | 1981 |
Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
Topics: Animals; Bone Marrow; Bone Marrow Failure Disorders; CDX2 Transcription Factor; Cell Transformation, | 2019 |
Studies of 5-fluorouracil in the treatment of L1210 leukemia in mice.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia, Experimental; Mice; Uracil | 1959 |
STUDIES WITH THE MURINE LEUKEMOGENIC RAUSCHER VIRUS. II. CHEMOTHERAPY OF VIRUS-INDUCED LYMPHOID LEUKEMIA.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cyclophosphamide; Fluorouracil; Leukemia; Leukemia | 1963 |
CHEMOTHERAPY STUDIES WITH VIRUS-INDUCED LEUKEMIA IN MICE.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Leukemia; Leukemia, Experimental; Me | 1964 |
III. IMPROVEMENT OF CANCER CHEMOTHERAPY IN MAN.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorouracil; Leukemia; Leukemia, Experimental; Mercap | 1964 |
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, E | 1964 |
Nucleotide formation as adeterminant of 5-fluorouracil response in mouse leukemias.
Topics: Animals; Carbon Isotopes; Chromatography, Gas; Dinitrophenols; Fluorouracil; Leukemia, Experimental; | 1966 |
Sensitivity of L cells in exponential and stationary phase to 5-fluorouracil.
Topics: Animals; Culture Techniques; Fluorouracil; L Cells; Leukemia, Experimental; Lymphoma; Mice; Mitosis | 1967 |
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytosol; Deoxyuracil Nucleotides; Flo | 1982 |
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Floxuridine; Fluorouracil; Guanosine; Leukemia P388; | 1984 |
Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.
Topics: Alkaline Phosphatase; Animals; Antimetabolites, Antineoplastic; Biological Transport; Cell Line; Dru | 1980 |
Influence of molar ratio on the combination effect of 5-fluorouracil with guanosine 5'-monophosphate on P388 and L1210 leukemias.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Fluoroura | 1984 |
Mechanism of cytotoxicity of 5-fluorouracil: distinction between the irreversible cytotoxic effect of 5-fluorouridine and the reversible cytotoxic effect of 5-fluoro-2'-deoxyuridine on murine lymphoma L5178Y cells in culture.
Topics: Animals; Cell Division; Cell Line; Floxuridine; Fluorouracil; Leukemia, Experimental; Mice; Uridine | 1980 |
Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Leu | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemi | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leuke | 1980 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug R | 1982 |
Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays.
Topics: Animals; Carmustine; Fluorouracil; Immunosuppression Therapy; Killer Cells, Natural; Leukemia L1210; | 1983 |
Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA.
Topics: Animals; Cell Line; Cell Survival; Fluorouracil; Kinetics; Leukemia, Experimental; Mice; Nucleic Aci | 1984 |
Preclinical screening for drugs effective against 5-fluorouracil-resistant cells with a murine L5178Y cell line in vitro.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Resistance; Fluorouracil; Leukemia L5178; Leukem | 1983 |
Murine L5178Y cells resulting in altered drug sensitivities from fractionated radiation exposure in vitro.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etop | 1984 |
In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays.
Topics: Animals; Cell Line; Cell Survival; Cisplatin; DNA Replication; Doxorubicin; Fluorouracil; Kinetics; | 1984 |
Whole body autoradiography of 5-fluorouracil-6-14C in nude mice bearing murine leukemia cells P388.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Fluorouracil; Injections, Intraperitoneal; Leukemia | 1983 |
Combination of anticancer agents with folic acid in the treatment of murine leukaemia P388.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Evaluation, Preclinical; D | 1984 |
Inhibition of phosphoribosylation of 5-fluorouracil by purines.
Topics: Adenine; Animals; Fluorouracil; Inosine; Kinetics; Leukemia L5178; Leukemia, Experimental; Mice; Pen | 1980 |
[Protective effect of allopurinol during chemotherapy with 5-fluorouracil of mouse blast leukemia].
Topics: Acute Disease; Administration, Oral; Allopurinol; Animals; Drug Therapy, Combination; Fluorouracil; | 1983 |
In vivo potentiation of 5-fluorouracil cytotoxicity against AKR leukemia by purines, pyrimidines, and their nucleosides and deoxynucleosides.
Topics: AKR murine leukemia virus; Animals; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; | 1980 |
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.
Topics: Animals; Anthracenes; Antineoplastic Agents; Doxorubicin; Drug Administration Schedule; Drug Evaluat | 1982 |
Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Line; Cell Separation; Drug Resist | 1982 |
Biochemical characteristics of a 5-fluorouracil-resistant subline of P388 leukemia.
Topics: Animals; Biotransformation; Cell Line; Cell Membrane Permeability; Drug Resistance; Fluorouracil; Le | 1982 |
Hematopoietic stem cells in Friend murine leukemia virus-infected mice undergoing chemotherapy: effects of 5-FU.
Topics: Animals; Cell Division; Erythropoiesis; Fluorouracil; Friend murine leukemia virus; Hematopoietic St | 1982 |
[Further study of immunopotentiation in experimental antiblastic therapy by inactivated yeasts and glucan].
Topics: Adjuvants, Immunologic; Animals; Carmustine; Combined Modality Therapy; Female; Fluorouracil; Glucan | 1982 |
[Antineoplastic activity of lambdamycin in different murine test models compared with cyclophosphamide, 6-mercaptopurine and 5-fluorouracil (author's transl)].
Topics: Animals; Benzopyrans; Carcinoma; Cyclophosphamide; Fluorouracil; Glycosides; Leukemia, Experimental; | 1981 |
Volume increase in L5222 leukemic cells following chemotherapy: manifestation of leukemic cell damage.
Topics: Animals; Ascitic Fluid; Cytarabine; Daunorubicin; Fluorouracil; Hydroxyurea; Leukemia, Experimental; | 1981 |
Cytotoxic effect of 5-fluorouracil plus cyclophosphamide against transplantable leukemias.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Cyclophosphamide; Dose-Response Relationship, Dr | 1981 |
Carcinogenic activity in rats of combined treatment with cyclophosphamide, methotrexate and 5-fluorouracil.
Topics: Adrenal Gland Neoplasms; Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, | 1981 |
Lymph node metastasis and effects of 1-beta-D-arabinofuranosylcytosine, 5-fluorouracil, and their lipophilic derivatives in an experimental model system using P388 leukemia.
Topics: Animals; Cytarabine; Female; Fluorouracil; Leukemia, Experimental; Lymphatic Metastasis; Mice; Solub | 1980 |
[Immunoprophylactic and immunotherapeutic effects of adoptively transferred LAK cells on L615 leukemia suffering mice].
Topics: Animals; Combined Modality Therapy; Female; Fluorouracil; Immunotherapy, Adoptive; Interferons; Inte | 1993 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
A hematopoietic organ-specific 49-kD nuclear antigen: predominance in immature normal and tumor granulocytes and detection in hematopoietic precursor cells.
Topics: Acute Disease; Animals; Antigens, Neoplasm; Bone Marrow; Cell Differentiation; Cell Nucleus; Cells, | 1996 |
Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth.
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; | 1998 |
Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.
Topics: Ancitabine; Animals; Cells, Cultured; Cisplatin; Cytarabine; Drug Resistance; Drug Synergism; Drug T | 1977 |
Distribution of 18F-5-fluorouracil in tumor-bearing mice and rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Fluo | 1978 |
In vivo enhancement of 5-fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Drug Synergism; Drug Therapy, Combination; Femal | 1978 |
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Me | 1979 |
Combined therapy of leukemia La with Damvar and cytostatics.
Topics: Animals; Antimetabolites, Antineoplastic; Cyclophosphamide; Drug Synergism; Drug Therapy, Combinatio | 1979 |
Selective antagonism of 5-fluorouracil cytotoxicity by 4-hydroxypyrazolopyrimidine (allopurinol) in vitro.
Topics: Allopurinol; Animals; Cell Line; Cell Survival; Drug Therapy, Combination; Fluorouracil; Humans; Leu | 1979 |
Comparative study of in vivo development of resistance to various classes of antitumor agents in P388 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance; Female; Fluorouracil; Leukemia P388; Leuk | 1979 |
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Topics: Animals; Cells, Cultured; DNA-Directed DNA Polymerase; DNA, Neoplasm; Fluorouracil; Leukemia, Experi | 1979 |
[Comparison of free ribonucleotide pool in the spleens of C57BL and DBA/2 mice and in leukemia cells sensitive and resistant to 5-fluorouracil].
Topics: Animals; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbre | 1978 |
Mode of action of 5-fluorouridine 5'-phosphate in vivo and in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Cytarabine; Fluorouracil; Leukemia L1210; | 1978 |
Effect of a transplantable leukemia on hematopoietic stem cells in AKR mice.
Topics: Animals; Bone Marrow; Cell Division; Cells, Cultured; Cyclophosphamide; Female; Fluorouracil; Hemato | 1978 |
[Search for biochemical criteria of sensitivity and resistance of tumor cells to antimetabolites].
Topics: Animals; DNA, Neoplasm; Drug Resistance; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Merca | 1978 |
Prevention of antitumor effect of 5-fluorouracil by hypoxanthine.
Topics: Animals; Cell Division; Cell Line; Fluorouracil; Hypoxanthines; Leukemia, Experimental; Mice; Thymid | 1978 |
Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fluorouracil; Leukemia, Ex | 1978 |
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leu | 1976 |
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.
Topics: Adenocarcinoma; Administration, Oral; Animals; Ascites; Carcinoma, Ehrlich Tumor; Female; Fluorourac | 1976 |
Experimental and clinical studies on nucleoside analogs as antitumor agents.
Topics: Aged; Animals; Cytarabine; Drug Resistance; Flucytosine; Fluorouracil; Humans; Leukemia L1210; Leuke | 1975 |
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Carboxylic Acids; Cells, Cultured; Centrifugation, De | 1975 |
Production of a negative regulator of IL-3 by bone marrow cells in response to the supernatant of IL-3-producing STIL-3 leukemia cells.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Culture Media, Conditioned; Flu | 1992 |
[Clinical pharmacology of anticancer agents (Part 4). Antimetabolites (1)].
Topics: Animals; Antimetabolites; Cytarabine; Fluorouracil; Leukemia, Experimental; Nucleotides; Permeabilit | 1992 |
Modulating effect of alpha-[N,N-[bis(2-hydroxyethyl)]-amino-N- (o-methoxyphenyl)-pyrrolidin-2,5-dione on the chemotherapy of murine tumours.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Drug Synergism; F | 1990 |
Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Adm | 1985 |
[Kinetics of etoposide cytotoxicity against mouse P388 leukemia].
Topics: Animals; Bleomycin; Cell Cycle; Cell Survival; Cisplatin; Colony-Forming Units Assay; Cytarabine; Do | 1985 |
Role of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.
Topics: Cell Survival; Drug Synergism; Fluorouracil; Humans; Leukemia, Experimental; Methotrexate; Peptides; | 1985 |
Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism.
Topics: Animals; Cell Nucleus; Cells, Cultured; Cytidine; Cytoplasm; Dose-Response Relationship, Drug; Fluor | 1986 |
Therapeutic synergy of trimetrexate (CI-898) in combination with doxorubicin, vincristine, cytoxan, 6-thioguanine, cisplatin, or 5-fluorouracil against intraperitoneally implanted P388 leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; D | 1987 |
Therapy of P388 leukemia with benzaldehyde.
Topics: Animals; Antineoplastic Agents; Benzaldehydes; Female; Fluorouracil; Leukemia P388; Leukemia, Experi | 1988 |
Carcinogenesis and aging. VIII. Effect of host age on tumour growth, metastatic potential, and chemotherapeutic sensitivity to 1.4-benzoquinone-guanylhydrazonethiosemicarbazone (ambazone) and 5-fluorouracil in mice and rats.
Topics: Adenocarcinoma; Aging; Animals; Antineoplastic Agents; Cell Division; Female; Fluorouracil; Leukemia | 1988 |
Role of dose, schedule and route of administration of 5-formyltetra-hydrofolate: preclinical and clinical investigations.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; | 1988 |
Combined effects of bromovinyldeoxyuridine and fractionated or continuous administration of 5-fluorouracil in P388 leukemia-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bromodeoxyuridine; Female | 1988 |
Effectiveness of mouse interferon alpha/beta compared to single-agent chemotherapy in increasing survival time of mice after intravenous inoculation of Friend erythroleukemia cells.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Friend murine leukemia virus; Interferon Type I; Leuke | 1988 |
Combination of 5-fluorouracil and cyclophosphamide in L1210 and P388 leukemias with changes in optimum treatments as a function of the age of the L1210 tumor at first treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Fluorouracil; Leukemia L1 | 1987 |
Schedule-dependent cytotoxicity of 5-fluorouracil in mice.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Female; Fluorouracil; Kinetics; Leukemia, Expe | 1986 |
Effects of 5-fluorouracil on globin mRNA synthesis in murine erythroleukemia cells.
Topics: Animals; Cell Line; Dimethyl Sulfoxide; Fluorouracil; Globins; Kinetics; Leukemia, Erythroblastic, A | 1986 |
Schedule-dependent antitumor and toxic effects of thymidine and 5-fluorouracil in AKR and L1210 leukemias.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Female; F | 1986 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubi | 1985 |
Effects of advanced leukemia on hepatic drug-metabolizing activity in the mouse.
Topics: Animals; Biphenyl Compounds; Cyclophosphamide; Cytochrome P-450 Enzyme System; Fluorouracil; Indocya | 1986 |
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P38 | 1986 |
Stability of the in vivo P388 leukemia model in evaluation of antitumor activity of natural products.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Evaluation Stu | 1985 |
[590-S].
Topics: Administration, Oral; Adult; Animals; Anorexia; Antineoplastic Agents; Drug Administration Schedule; | 1985 |
Myeloid leukemia C-1498 as a screen for cancer chemotherapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Busulfan; Cyclophospha | 1966 |
Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias.
Topics: Animals; Antineoplastic Agents; Biodegradation, Environmental; Biological Transport; Cell Line; Cell | 1971 |
The synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells.
Topics: Animals; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Cobalt; Culture Techniques; Depre | 1969 |
A new and highly sensitive radiotracer assay for orotate phosphoribosyltransferase.
Topics: Animals; Carbon Isotopes; Cell Line; Chromatography, Thin Layer; Enzyme Activation; Fluorouracil; Hy | 1972 |
Effect of in vivo treatment with L-asparaginase on the in vitro uptake and phosphorylation of some antileukemic agents.
Topics: Animals; Antimetabolites; Asparaginase; Biological Transport; Cytarabine; Dose-Response Relationship | 1974 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, | 1974 |
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyri | 1973 |
[Use of transplantability indices of tumor cells for evaluation of the cytotoxic effect of antineoplastic agents in vitro].
Topics: Animals; Cell Line; Cells, Cultured; Culture Media; Fluorouracil; Leukemia, Experimental; Male; Melp | 1972 |
Some properties of a pyrimidine phosphoribosyltransferase from murine leukemia cells.
Topics: Ammonium Sulfate; Animals; Carbon Isotopes; Cattle; Cell Line; Chromatography; Dialysis; Dimethyl Su | 1972 |
Changes in the pyrimidine deoxynucleoside triphosphate pools of L5178Y cells after their exposure to methotrexate and 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Deoxyribonucleotides; Fluorouracil; Leukemia, Experiment | 1972 |
[Mechanism of action of ftorafur, a new antineoplastic agent].
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Ehrlich Tumo | 1972 |
Some determinants of drug responsiveness in bovine leukemia cells.
Topics: Animals; Antineoplastic Agents; Cattle; Cells, Cultured; Cytidine; Cytosine Nucleotides; Drug Resist | 1973 |
Peripheral nucleated cell count as a method of assessing the response of antileukemic agents in Rauscher virus-diseased mice.
Topics: Animals; Antineoplastic Agents; Blood; Busulfan; Carbamates; Cell Count; Chlorambucil; Cyclophospham | 1973 |
Effect of Ftorafur on acid phosphatase activity in the liver of mice with transplanted lymphatic leukaemia.
Topics: Acid Phosphatase; Animals; Female; Fluorouracil; Leukemia, Experimental; Leukemia, Lymphoid; Liver; | 1974 |
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouraci | 1974 |
Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.
Topics: Animals; Azo Compounds; Dactinomycin; Depression, Chemical; DNA; DNA, Neoplasm; Fluorouracil; Intest | 1972 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cy | 1972 |
Combined effect of x radiation and 5-fluorouracil on survival of transplanted leukemic cells.
Topics: Animals; Bone Marrow Cells; Cell Line; Cell Survival; Clone Cells; Fluorouracil; In Vitro Techniques | 1971 |
[Evaluation, in newborn Swiss mice, of the carcinogenic activity of some antineoplastic and immunosuppressive compounds].
Topics: Adenoma; Animals; Animals, Newborn; Antineoplastic Agents; Asparaginase; Azathioprine; Fluorouracil; | 1971 |
Suppression of murine leukemias by L-asparaginase. Incidence of sensitivity among leukemias of various types: comparative inhibitory activities of guinea pig serum L-asparaginase and Escherichia coli L-asparaginase.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Asparagine; Azaserine; Blood; Cyclophosphamide; Esc | 1967 |
Influence of ribose donors on the action of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Glucose; Leukemia, Experimental; Mice; Nucleosides; Nu | 1969 |
Metabolism of uracil and 5-fluorouracil in P388 murine leukemia cells.
Topics: Animals; Carbon Isotopes; Cell Line; Cell-Free System; Culture Techniques; Fluorouracil; Leukemia, E | 1969 |
Experimental inhibition of the virus-induced Rauscher leukemia of the mouse.
Topics: Animals; Blood Cell Count; Female; Fluorouracil; Leukemia, Experimental; Male; Melphalan; Mercaptopu | 1968 |
[Studies on the cell division inhibitory effect of some purine and pyrimidine derivatives on Paracentrotus lividus and on sarcoma 180 of mice].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Culture Techniques; Echinod | 1969 |
Nucleosides. XXIX. 1-beta-D-arabinofuranosyl-5-fluorocytosine and related arabino nucleosides.
Topics: Animals; Arabinose; Chemistry, Organic; Cytosine; Fluorouracil; Furans; Idoxuridine; Keratitis, Dend | 1966 |