fluorouracil has been researched along with Experimental Hepatoma in 163 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC)." | 7.79 | MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. ( Feng, Y; Man, K; Tsao, SW; Wang, N; Zhang, Z; Zhu, M, 2013) |
| "To investigate the synergistic inhibitory effects of the combination of 5-fluorouracil (5-FU) with the natural flavanoid oroxylin A on human hepatocellular carcinoma cells HepG2 in vitro and on transplanted murine hepatoma 22 (H22) tumors in vivo and the preliminary mechanisms." | 7.76 | Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. ( Chen, Z; Guo, QL; Mu, R; Qi, Q; Wang, J; Yang, L; You, QD; Zhao, L; Zhao, Q, 2010) |
| "Five fluorouracil (5-FU) is extensively used in the treatment of hepatocellular carcinoma (HCC)." | 7.76 | Novel biochemical pathways for 5-Fluorouracil in managing experimental hepatocellular carcinoma in rats. ( Abdel-Hamid, NM; Morsy, MA, 2010) |
| "We investigated the antiproliferative effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) in combination on a hepatocellular carcinoma (HCC) cell line." | 7.73 | Antiproliferative effects of 5-fluorouracil and interferon-alpha in combination on a hepatocellular carcinoma cell line in vitro and in vivo. ( Kojiro, M; Kojiro, S; Momosaki, S; Nishida, N; Ogasawara, S; Takemoto, Y; Yano, H, 2006) |
| " The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC)." | 3.79 | MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. ( Feng, Y; Man, K; Tsao, SW; Wang, N; Zhang, Z; Zhu, M, 2013) |
| "To investigate the synergistic inhibitory effects of the combination of 5-fluorouracil (5-FU) with the natural flavanoid oroxylin A on human hepatocellular carcinoma cells HepG2 in vitro and on transplanted murine hepatoma 22 (H22) tumors in vivo and the preliminary mechanisms." | 3.76 | Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. ( Chen, Z; Guo, QL; Mu, R; Qi, Q; Wang, J; Yang, L; You, QD; Zhao, L; Zhao, Q, 2010) |
| "Five fluorouracil (5-FU) is extensively used in the treatment of hepatocellular carcinoma (HCC)." | 3.76 | Novel biochemical pathways for 5-Fluorouracil in managing experimental hepatocellular carcinoma in rats. ( Abdel-Hamid, NM; Morsy, MA, 2010) |
| "We investigated the antiproliferative effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) in combination on a hepatocellular carcinoma (HCC) cell line." | 3.73 | Antiproliferative effects of 5-fluorouracil and interferon-alpha in combination on a hepatocellular carcinoma cell line in vitro and in vivo. ( Kojiro, M; Kojiro, S; Momosaki, S; Nishida, N; Ogasawara, S; Takemoto, Y; Yano, H, 2006) |
| "The regional administration of 5-fluorouracil (5-FU) has been the fundamental therapy against liver metastases for the improvement of patient prognosis; however, there have been few reports about the immunological effects of this agent." | 3.72 | Antitumor effect of a splenic injection of 5-fluorouracil on metastatic liver cancer in mice. ( Asao, T; Kanoh, K; Kuwano, H; Nomoto, K; Shimura, T; Suzuki, H, 2004) |
| "This study was to investigate the effect of capecitabine on recurrent tumor and metastasis after curative resection of liver cancer, xenograft of a highly metastatic human hepatocellular carcinoma (HCC) tumor (LCI-D20), with special reference to the expression of platelet-derived endothelial cell growth factor (PD-ECGF)." | 3.72 | Capecitabine inhibits postoperative recurrence and metastasis after liver cancer resection in nude mice with relation to the expression of platelet-derived endothelial cell growth factor. ( Fan, J; Ji, Y; Li, XM; Liu, YK; Shi, YH; Sun, QM; Tang, ZY; Wu, ZQ; Xiao, YS; Ye, SL; Zhou, J, 2003) |
| " The objective of this study was to test the effect of tamoxifen and tamoxifen in combination with other agents [5-fluorouracil (5-FU) and interferon (IFN)] against experimental liver metastases of human colorectal tumor cells xenografted into nude mice." | 3.69 | Inhibition of experimental liver metastasis by combined treatment with tamoxifen and interferon. ( Bender, E; Katoh, A; Mahaffey, W; Marrangoni, A; McKeating, J; Werner, A, 1996) |
| "To develop a new drug delivery system for the treatment of carcinomatous peritonitis, we constructed 5-fluorouracil poly L-microcapsules (5Fu-mc) by the organic phase separation technique and examined their drug-releasing capacities and anticancer effects." | 3.68 | A new anticancer drug delivery system for the management of carcinomatous peritonitis. ( Iwa, T; Ohhira, M; Sakatoku, M; Watanabe, Y; Yamada, T, 1991) |
| "The present study suggested that BLTA in combination with 5-FU could enhance antitumor effect, with inhibiting TIM-3/TIM-3L pathway, cutting down immunosuppressive activity of CD4(+)CD25(+) T(reg) and enhancing cell-mediated immunity." | 1.38 | Lipoteichoic acid of Bifidobacterium in combination with 5-fluorouracil inhibit tumor growth and relieve the immunosuppression. ( Guo, B; Li, FR; Wang, Q; Wang, Y; Xie, N, 2012) |
| "5-Fluorouracil (5-FU) is an antimetabolite with a broad-spectrum activity against solid tumors." | 1.35 | In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates. ( Huang, Y; Qin, X; Wang, MT; Xiang, QY; Yuan, F; Zhang, ZR; Zhou, D, 2008) |
| "To observe the pharmacokinetic and tissue-distribution characters of 5-flourouracil magnetic albumin deuto-microsphere (5-Fu-MAD) in normal and tumor-bearing mice, HPLC method for the determination of 5-Fu in plasma and tissues was established and applied to determine 5-Fu in mouse plasma and tissue samples." | 1.34 | [Pharmacokinetics and distribution of 5-Fu magnetic albumin deuto-microsphere in normal and tumor-bearing mice]. ( Chen, H; Shi, SJ; Xu, R; Zeng, FD; Zheng, JW; Zhou, SC; Zou, SQ, 2007) |
| "A non-invasive orthotopic hepatocellular carcinoma (HCC) model was created with human HCC cells (HepG-Luc) constitutively expressing luciferase (Luc) in nude mice." | 1.34 | Bioluminescent imaging of hepatocellular carcinoma in live mice. ( Peng, J; Sun, Z; Wang, Y; Zhan, L, 2007) |
| " The pharmacokinetic analysis showed that carbogen increased the rate of tumour uptake of 5FU from the plasma but also increased the rate of removal." | 1.33 | Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours. ( Griffiths, JR; Judson, IR; Leach, MO; McSheehy, PM; Peters, GJ; Port, RE; Robinson, SP; Rodrigues, LM; Stubbs, M; van der Borns, K, 2005) |
| " It can also improve the immunological function and reduce the adverse reactions of chemotherapy." | 1.33 | [Experimental study on effects of shengmai injection: enhancing 5-FU anti-tumor efficacy and reducing its toxicity]. ( Chen, Z; Huang, WX; Liu, LM; Wang, P, 2005) |
| " The sensitivity of H22 cells to 5-FU can be markedly enhanced: The IC(50) dosage of 5-Fu can be decreased from 0." | 1.31 | The effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo. ( Li, Z; Liu, J; Qi, S; Wang, T; Zhang, J; Zhu, H, 2002) |
| "In the rats bearing the Novikoff hepatoma, both modulators increased the amounts of cyctotoxic anabolites of 5-FU, but at the doses administered, the cumulative amounts of 5-FU anabolites formed after MTX were significantly higher than those formed after TMTX or after saline control." | 1.31 | Enhancement of 5-fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models, Walker 256 carcinosarcoma and Novikoff hepatoma, as evaluated by 19F-magnetic resonance spectroscopy. ( Berman, E; Chatterjee-Parti, S; Katzir, I; Shani, J; Wolf, W, 2000) |
| "In the Morris hepatomas, a small 5-FU uptake and no FBAL accumulation were measured." | 1.29 | Mapping the biodistribution and catabolism of 5-fluorouracil in tumor-bearing rats by chemical-shift selective 19F MR imaging. ( Bachert, P; Bellemann, ME; Brix, G; Gerlach, L; Haberkorn, U; Lorenz, WJ, 1995) |
| " Inhibition of thymidylate synthase activity in tumor tissue after dosing of AO-90 (nitrogen 0." | 1.29 | [The mechanism of potentiation of the antitumor effect of 5-fluorouracil by methionine-free intravenous amino acid solution (AO-90) in rats]. ( Hibino, Y; Kawarabayashi, Y; Kohri, H; Tsukagoshi, S; Ueda, N, 1994) |
| "Pancreatic cancer is a disease with essentially no effective treatment." | 1.29 | A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice. ( Furukawa, T; Hoffman, RM; Kitajima, M; Kubota, T; Watanabe, M, 1993) |
| "This metastatic model of human stomach cancer shows that locally growing and metastatic tumors may have different chemosensitivities, and provides the opportunity to test both with various treatment regimens." | 1.29 | Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice. ( Furukawa, T; Hoffman, RM; Kitajima, M; Kubota, T; Kuo, TH; Watanabe, M, 1993) |
| "In this study, a new dosage form for antitumor agents--nanocapsules was prepared from biodegradable butylcyanoacrylate (BCA)." | 1.28 | [Studies of 5-fluorouracil nanocapsules]. ( Hu, J; Pan, WS, 1991) |
| "Azidothymidine (10 microM) was synergistically cytotoxic with 5-fluorouracil (0." | 1.28 | Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells. ( Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G, 1990) |
| "Rats with an experimental solitary liver tumor of a nitrosoguanidine-induced colonic adenocarcinoma were subjected to hepatic artery ligation (HAL) alone or in combination with 5-fluorouracil (5-FU) in three different doses, with or without the addition of allopurinol." | 1.28 | Effect on liver tumor growth in rats of allopurinol and 5-fluorouracil in combination with hepatic artery ligation. ( Carlsson, G; Gustavsson, B; Hafström, L, 1989) |
| " Long-term daily administration was shown to be more effective than intermittent dosage in the treatment of Lewis lung carcinoma." | 1.27 | [Antitumor effect of FU-O-G, new antitumor agent, following long term administration]. ( Arakawa, M; Inomata, T; Mizuno, H; Shimizu, F; Umezawa, T, 1984) |
| " At the optimal dosage the highest selective activity against tumor cells (hepatoma) with low inhibition of normal cells (regenerating liver cells) was seen in the combination cis-platinum + methotrexate." | 1.27 | Effect of combined chemotherapy tested in partially hepatectomized rats bearing Zajdela hepatoma. ( Balázová, E; Drobník, J; Kuzela, S; Tkácová, E; Ujházy, V, 1983) |
| " A modified method was used to evaluate the in vitro dose-response curves." | 1.27 | Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity. ( Bier, H; Bier, J; Maurer, HR; Ohanian, S; Osman, FA; Siegel, T, 1983) |
| "Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated." | 1.27 | [Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984) |
| " These results demonstrate that the enhanced incorporation of 5-FU into tumour RNA in vivo after pretreatment with TdR is related not to local effects on the tumour cells but rather to an increased bioavailability of the drug." | 1.27 | Modulation of 5-fluorouracil metabolism by thymidine. In vivo and in vitro studies on RNA-directed effects in rat liver and hepatoma. ( Engelbrecht, C; Lewan, L; Ljungquist, I; Yngner, T, 1984) |
| " 5-FU depressed the levels of ribonucleotide reductase and thymidine kinase, which are two key enzymes in DNA synthesis, in solid AH-130 tumor when given intraperitoneally at a dose of 60 mg/kg, and this inhibition seemed to be very toxic against cells." | 1.27 | [Studies on the mechanism of cytotoxicity of 5-fluorouracil--through impairment of metabolism]. ( Fujii, S; Ikenaka, K; Kawai, K; Shirasaka, T; Tanaka, H, 1983) |
| " Fifty-one rats with hepatic tumors of colonic origin were randomly assigned to one of three dosage groups (20, 40, or 80 mg/kg) receiving 5-FU by ILP, hepatic artery infusion (HAI), or jugular vein infusion (JVI)." | 1.27 | In vivo isolated liver perfusion technique in a rat hepatic metastasis model: 5-fluorouracil concentrations in tumor tissue. ( Bell, AV; de Brauw, LM; de Bruijn, EA; Hermans, J; Tjaden, UR; van de Velde, CJ; Zwaveling, A, 1988) |
| "All animals received Novikoff hepatoma cells inoculated in the median liver lobe." | 1.27 | Hepatic arterial infusion (HAI) chemotherapy proves to be advantageous in the treatment of experimental liver tumors. ( Aguiar, JL; Bartkowski, R; Berger, M; Dörsam, J; Schlag, P, 1988) |
| "The resistance of a Novikoff hepatoma cell line (N1-S1/FdUrd) to 5-fluorouracil (FUra) was reversed by the inclusion of inosine in the culture medium." | 1.26 | Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells. ( Breland, JC; Carter, GL; Cory, JG, 1979) |
| "For inbred rats with Morris hepatoma 3924A, increases in tumor size were accompanied by increases in weight and DNA content of spleen, DNA content of tibial marrow, and peripheral white cell concentrations of blood." | 1.26 | Cell proliferation in organs of rats bearing hepatoma 3924A: effects of X-rays of surgery. ( Hobson, AS; Hopkins, HA; Kovacs, CJ; Looney, WB; Morris, HP; Wakefield, JA, 1977) |
| "When lentinan was administered in combination with bacterial lipopolysaccharide (LPS), the group given lentinan for 5 consecutive days from the third day after tumor transplantation and 30 micrograms LPS i." | 1.26 | Antitumor effect of polysaccharide lentinan on MH-134 ascites hepatoma in C3H/He mice. ( Moriyama, M, 1982) |
| "Cells of the Morris hepatoma 7777 cultured in vitro have elevated levels of cytoplasmic thymidine kinase similar to those found in vivo." | 1.26 | Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro. ( Grishaver, MA; Jones, OW; Taylor, A, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (34.36) | 18.7374 |
| 1990's | 46 (28.22) | 18.2507 |
| 2000's | 35 (21.47) | 29.6817 |
| 2010's | 24 (14.72) | 24.3611 |
| 2020's | 2 (1.23) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, H | 1 |
| Ge, S | 1 |
| Guo, J | 1 |
| Chen, S | 1 |
| Huang, M | 1 |
| Yang, J | 1 |
| Sun, S | 1 |
| Ling, Y | 1 |
| Shi, Y | 1 |
| Wang, F | 2 |
| Li, J | 2 |
| Chen, C | 1 |
| Qi, H | 1 |
| Huang, K | 1 |
| Hu, S | 1 |
| Kumar, P | 1 |
| Agarwal, A | 1 |
| Singh, AK | 1 |
| Gautam, AK | 1 |
| Chakraborti, S | 1 |
| Kumar, U | 1 |
| Kumar, D | 1 |
| Bhattacharya, B | 1 |
| Panda, P | 1 |
| Saha, B | 1 |
| Qidwai, T | 1 |
| Maity, B | 1 |
| Saha, S | 1 |
| Zhang, Z | 3 |
| Hu, K | 1 |
| Miyake, K | 1 |
| Kiyuna, T | 1 |
| Oshiro, H | 1 |
| Wangsiricharoen, S | 1 |
| Kawaguchi, K | 1 |
| Higuchi, T | 1 |
| Razmjooei, S | 1 |
| Miyake, M | 1 |
| Chawla, SP | 1 |
| Singh, SR | 1 |
| Hoffman, RM | 4 |
| Nanda, A | 1 |
| Suyila, Q | 1 |
| Xian, L | 1 |
| Xiulan, S | 1 |
| Kim, M | 1 |
| Fisher, DT | 1 |
| Powers, CA | 1 |
| Gabriel, EM | 1 |
| Korman, AM | 1 |
| Sexton, S | 1 |
| Gudkov, AV | 1 |
| Skitzki, JJ | 1 |
| Aketa, H | 1 |
| Tatsumi, T | 1 |
| Kohga, K | 1 |
| Tsunematsu, H | 1 |
| Aono, S | 1 |
| Shimizu, S | 1 |
| Kodama, T | 1 |
| Nawa, T | 1 |
| Shigekawa, M | 1 |
| Hikita, H | 1 |
| Sakamori, R | 1 |
| Hosui, A | 1 |
| Miyagi, T | 1 |
| Hiramatsu, N | 1 |
| Kanto, T | 1 |
| Hayashi, N | 1 |
| Takehara, T | 1 |
| Lu, Z | 1 |
| Zhang, TY | 2 |
| Han, MM | 1 |
| Bai, FL | 2 |
| Wu, W | 2 |
| Tian, GY | 1 |
| Ren, GP | 2 |
| Li, DS | 2 |
| Thalheimer, A | 1 |
| Korb, D | 1 |
| Bönicke, L | 1 |
| Wiegering, A | 1 |
| Mühling, B | 1 |
| Schneider, M | 1 |
| Koch, S | 1 |
| Riedel, SS | 1 |
| Germer, CT | 1 |
| Beilhack, A | 1 |
| Brändlein, S | 1 |
| Otto, C | 1 |
| Wang, N | 1 |
| Zhu, M | 1 |
| Tsao, SW | 1 |
| Man, K | 1 |
| Feng, Y | 1 |
| Cheng, M | 2 |
| Xu, H | 3 |
| Wang, Y | 3 |
| Chen, H | 2 |
| He, B | 3 |
| Gao, X | 1 |
| Li, Y | 1 |
| Han, J | 3 |
| Lv, Z | 1 |
| Yin, JC | 1 |
| Wang, H | 1 |
| Sun, T | 1 |
| Chen, LQ | 1 |
| Yang, T | 1 |
| Liu, X | 1 |
| Tian, Y | 1 |
| Chen, X | 2 |
| Yuan, R | 1 |
| Su, S | 1 |
| Lin, X | 1 |
| Du, G | 1 |
| Teryukova, NP | 1 |
| Pogodina, ON | 1 |
| Ivanov, VA | 1 |
| Lv, J | 1 |
| Lv, CQ | 1 |
| Wang, BL | 2 |
| Mei, P | 1 |
| Xu, L | 1 |
| Dai, ZJ | 2 |
| Wang, XJ | 2 |
| Ji, ZZ | 2 |
| Li, ZF | 1 |
| Tang, W | 1 |
| Kang, HF | 2 |
| Ma, XB | 2 |
| Liu, L | 1 |
| Yuan, F | 2 |
| Qin, X | 1 |
| Zhou, D | 1 |
| Xiang, QY | 1 |
| Wang, MT | 1 |
| Zhang, ZR | 2 |
| Huang, Y | 2 |
| Liu, XX | 1 |
| Xue, Q | 1 |
| Guan, HT | 1 |
| Ren, HT | 1 |
| Wang, J | 3 |
| Xiao, B | 1 |
| Zheng, J | 1 |
| Zou, S | 1 |
| Saletti, P | 1 |
| Sessa, C | 1 |
| Cavalli, F | 1 |
| Yang, YX | 1 |
| Mao, CY | 1 |
| Hua, HJ | 1 |
| Chen, P | 1 |
| Yu, DC | 1 |
| Cao, J | 1 |
| Teng, LS | 1 |
| Zhao, L | 1 |
| Chen, Z | 2 |
| Yang, L | 1 |
| Zhao, Q | 1 |
| Qi, Q | 1 |
| Mu, R | 1 |
| You, QD | 1 |
| Guo, QL | 1 |
| Wu, FY | 1 |
| Huang, GS | 1 |
| Jiang, JW | 1 |
| Xu, XD | 1 |
| Peng, DY | 1 |
| Abdel-Hamid, NM | 1 |
| Morsy, MA | 1 |
| Pohlen, U | 5 |
| Reszka, R | 3 |
| Buhr, HJ | 5 |
| Berger, G | 5 |
| Bae, WK | 1 |
| Lee, JH | 1 |
| Lee, SJ | 1 |
| Park, MS | 1 |
| Hwang, JE | 1 |
| Shim, HJ | 1 |
| Cho, SH | 1 |
| Guo, DD | 1 |
| Cho, CS | 1 |
| Park, IK | 1 |
| Chung, IJ | 1 |
| Jin, Y | 2 |
| Ren, X | 1 |
| Wang, W | 3 |
| Ke, L | 1 |
| Ning, E | 1 |
| Du, L | 1 |
| Bradshaw, J | 1 |
| Xie, N | 1 |
| Wang, Q | 1 |
| Li, FR | 1 |
| Guo, B | 1 |
| Cao, Z | 1 |
| Liao, L | 1 |
| Lan, L | 1 |
| Hu, H | 1 |
| Liu, Z | 1 |
| Chen, L | 1 |
| Huang, S | 1 |
| Du, J | 1 |
| Li, Q | 2 |
| Zha, B | 1 |
| Wu, J | 1 |
| Zhou, R | 1 |
| Ye, T | 2 |
| Hou, Y | 1 |
| Guo, R | 1 |
| Cheng, L | 1 |
| Zhao, Y | 1 |
| Zhang, J | 3 |
| Liu, C | 1 |
| Zhou, H | 1 |
| Jia, L | 1 |
| Cheng, MR | 1 |
| Wan, T | 1 |
| Chen, HX | 1 |
| Yang, FX | 1 |
| Xu, HZ | 1 |
| Zha, BB | 1 |
| Liu, J | 1 |
| Qi, S | 1 |
| Zhu, H | 1 |
| Li, Z | 1 |
| Wang, T | 1 |
| Yao, M | 1 |
| Kargman, S | 1 |
| Lam, EC | 1 |
| Kelly, CR | 1 |
| Zheng, Y | 1 |
| Luk, P | 1 |
| Kwong, E | 1 |
| Evans, JF | 1 |
| Wolfe, MM | 1 |
| Li, XH | 1 |
| Li, XK | 1 |
| Cai, SH | 1 |
| Tang, FX | 1 |
| Zhong, XY | 1 |
| Ren, XD | 1 |
| MORSE, PA | 1 |
| POTTER, VR | 1 |
| Bödeker, H | 2 |
| Kamphorst, EJ | 2 |
| Wünsch, PH | 1 |
| Linnemann, U | 2 |
| Berger, MR | 4 |
| Jung, M | 2 |
| Rezska, R | 1 |
| Regenstein, J | 1 |
| Lucas, S | 1 |
| Kanoh, K | 1 |
| Shimura, T | 1 |
| Suzuki, H | 1 |
| Nomoto, K | 1 |
| Asao, T | 2 |
| Kuwano, H | 1 |
| Zhou, J | 1 |
| Tang, ZY | 2 |
| Fan, J | 1 |
| Wu, ZQ | 1 |
| Ji, Y | 1 |
| Xiao, YS | 1 |
| Shi, YH | 1 |
| Li, XM | 1 |
| Sun, QM | 1 |
| Liu, YK | 1 |
| Ye, SL | 1 |
| Zhao, JG | 1 |
| Feng, GS | 1 |
| Kong, XQ | 1 |
| Li, X | 2 |
| Li, MH | 1 |
| Cheng, YS | 1 |
| Binnenhei, M | 2 |
| McSheehy, PM | 2 |
| Port, RE | 1 |
| Rodrigues, LM | 2 |
| Robinson, SP | 1 |
| Stubbs, M | 1 |
| van der Borns, K | 1 |
| Peters, GJ | 2 |
| Judson, IR | 2 |
| Leach, MO | 2 |
| Griffiths, JR | 2 |
| Rong, LF | 1 |
| Li, YH | 1 |
| Guo, L | 1 |
| Xu, SY | 1 |
| Rieger, H | 1 |
| Reszka, RC | 1 |
| Wang, P | 1 |
| Huang, WX | 1 |
| Liu, LM | 1 |
| Kojiro, S | 1 |
| Yano, H | 1 |
| Ogasawara, S | 1 |
| Momosaki, S | 1 |
| Takemoto, Y | 1 |
| Nishida, N | 1 |
| Kojiro, M | 1 |
| Zhou, SL | 1 |
| Li, P | 1 |
| Cao, MM | 1 |
| Zhang, JR | 1 |
| Xu, R | 1 |
| Shi, SJ | 1 |
| Zhou, SC | 1 |
| Zheng, JW | 2 |
| Zou, SQ | 2 |
| Zeng, FD | 1 |
| Hiraoka, K | 1 |
| Kimura, T | 1 |
| Logg, CR | 1 |
| Tai, CK | 1 |
| Haga, K | 1 |
| Lawson, GW | 1 |
| Kasahara, N | 1 |
| Wang, JM | 1 |
| Xiao, BL | 1 |
| Chen, HB | 1 |
| Sun, Z | 1 |
| Peng, J | 1 |
| Zhan, L | 1 |
| Manekeller, S | 1 |
| Sioutis, M | 1 |
| Hirner, A | 1 |
| Minor, T | 1 |
| Zhang, Y | 1 |
| Ma, H | 1 |
| Liu, S | 1 |
| Liu, Y | 1 |
| Zheng, D | 1 |
| Zheng, JL | 1 |
| Liang, LJ | 1 |
| Hu, WJ | 1 |
| Shen, SL | 1 |
| Hirano, M | 1 |
| Osman, FA | 1 |
| Bier, J | 1 |
| Bier, H | 1 |
| Siegel, T | 1 |
| Maurer, HR | 1 |
| Ohanian, S | 1 |
| Matsuzaki, T | 1 |
| Kato, I | 1 |
| Yokokura, T | 1 |
| Mutai, M | 1 |
| Engelbrecht, C | 1 |
| Ljungquist, I | 1 |
| Lewan, L | 1 |
| Yngner, T | 1 |
| Cory, JG | 2 |
| Carter, GL | 2 |
| Abe, Y | 3 |
| Fukuda, H | 2 |
| Ishiwata, K | 3 |
| Yoshioka, S | 1 |
| Yamada, K | 1 |
| Endo, S | 2 |
| Kubota, K | 1 |
| Sato, T | 1 |
| Matsuzawa, T | 3 |
| Takahashi, T | 2 |
| Ido, T | 3 |
| Monma, M | 1 |
| Iwata, R | 1 |
| Tsurumi, Y | 1 |
| Kameyama, M | 1 |
| Ikenaka, K | 5 |
| Tanaka, H | 1 |
| Kawai, K | 1 |
| Shirasaka, T | 4 |
| Fujii, S | 4 |
| Satomura, T | 1 |
| Asanuma, K | 1 |
| Samaru, Y | 1 |
| Sekiguchi, M | 1 |
| Fujii, G | 1 |
| Mizuno, H | 1 |
| Inomata, T | 1 |
| Umezawa, T | 1 |
| Shimizu, F | 1 |
| Arakawa, M | 1 |
| Balázová, E | 1 |
| Tkácová, E | 1 |
| Kuzela, S | 1 |
| Drobník, J | 1 |
| Ujházy, V | 1 |
| Sakita, M | 1 |
| Kasuga, M | 1 |
| Yamane, T | 1 |
| Torii, T | 1 |
| Imai, H | 1 |
| Kageyama, N | 1 |
| Fujita, Y | 1 |
| Majima, S | 1 |
| Moriyama, M | 2 |
| Miwa, H | 1 |
| Moriya, N | 1 |
| Orita, K | 2 |
| Tryfiates, GP | 1 |
| Morris, HP | 2 |
| Sonidis, GP | 1 |
| Staub, M | 1 |
| Szpaszokukockaja, T | 1 |
| Bencsáth, M | 1 |
| Antoni, F | 1 |
| Lapis, K | 1 |
| Revazova, ES | 1 |
| Moore, JV | 1 |
| Hopkins, HA | 3 |
| Looney, WB | 3 |
| Bolanowska, W | 1 |
| Gessner, T | 1 |
| Wohlhueter, RM | 1 |
| McIvor, RS | 1 |
| Plagemann, PG | 1 |
| Reztsova, VV | 2 |
| Stukov, AN | 2 |
| Filov, VA | 2 |
| Taylor, A | 1 |
| Jones, OW | 1 |
| Grishaver, MA | 1 |
| Le Bricon, T | 1 |
| Gugins, S | 1 |
| Cynober, L | 1 |
| Baracos, VE | 1 |
| Brix, G | 5 |
| Bellemann, ME | 5 |
| Haberkorn, U | 5 |
| Gerlach, L | 4 |
| Bachert, P | 1 |
| Lorenz, WJ | 2 |
| Carlsson, G | 2 |
| Gustavsson, B | 2 |
| Frösing, R | 1 |
| Odin, E | 1 |
| Hafström, LO | 1 |
| Spears, CP | 1 |
| Larsson, PA | 1 |
| Sakai, S | 1 |
| Yamakawa, T | 1 |
| Kano, N | 1 |
| Kaminishi, M | 1 |
| Oohara, T | 1 |
| Roos, G | 3 |
| Stenram, U | 4 |
| Liu, PC | 2 |
| Guo, JY | 2 |
| Hu, GD | 2 |
| Wang, CY | 1 |
| Huang, ZC | 2 |
| Liu, SC | 2 |
| Hibino, Y | 1 |
| Kawarabayashi, Y | 1 |
| Kohri, H | 1 |
| Ueda, N | 1 |
| Tsukagoshi, S | 1 |
| Furukawa, T | 2 |
| Kubota, T | 2 |
| Watanabe, M | 2 |
| Kitajima, M | 2 |
| Naomoto, Y | 1 |
| Gochi, A | 1 |
| Hizuta, A | 1 |
| Iwagaki, H | 1 |
| Matsuno, T | 1 |
| Hamazaki, K | 1 |
| Tanaka, N | 1 |
| Daemen, T | 1 |
| Dontje, BH | 1 |
| Regts, J | 1 |
| Scherphof, GL | 1 |
| Kuo, TH | 1 |
| Kurth, S | 1 |
| Bulian, D | 1 |
| Kreft, B | 1 |
| Riemenschneider, T | 1 |
| Werner, A | 1 |
| Bender, E | 1 |
| Mahaffey, W | 1 |
| McKeating, J | 1 |
| Marrangoni, A | 1 |
| Katoh, A | 3 |
| Sugiyama, Y | 1 |
| Saji, S | 1 |
| Miya, K | 1 |
| Fukada, D | 1 |
| Umemoto, T | 1 |
| Kunieda, K | 1 |
| Takao, H | 1 |
| Kato, M | 1 |
| Kawai, M | 1 |
| Dworkin, MJ | 1 |
| Zweit, J | 1 |
| Carnochan, P | 2 |
| Deehan, B | 1 |
| Allen-Mersh, TG | 2 |
| Konovalova, NP | 1 |
| Volkova, LM | 1 |
| Tat'ianenko, LV | 1 |
| Kotel'nikova, RA | 1 |
| Iakushchenko, TN | 1 |
| Kagiia, T | 1 |
| Ciftci, K | 1 |
| Hincal, AA | 1 |
| Kas, HS | 1 |
| Ercan, TM | 1 |
| Sungur, A | 1 |
| Guven, O | 1 |
| Ruacan, S | 1 |
| Seymour, MT | 1 |
| Ojugo, AS | 1 |
| Murakami, K | 1 |
| Matsuura, T | 1 |
| Sano, M | 2 |
| Hashimoto, A | 1 |
| Yonekura, K | 1 |
| Sakukawa, R | 1 |
| Yamada, Y | 1 |
| Saiki, I | 1 |
| Kuriyama, S | 1 |
| Kikukawa, M | 1 |
| Masui, K | 1 |
| Okuda, H | 1 |
| Nakatani, T | 1 |
| Sakamoto, T | 1 |
| Yoshiji, H | 1 |
| Fukui, H | 1 |
| Mullen, CA | 1 |
| Tsujii, T | 1 |
| Koroma, S | 1 |
| Katzir, I | 1 |
| Shani, J | 1 |
| Wolf, W | 1 |
| Chatterjee-Parti, S | 1 |
| Berman, E | 1 |
| Kojima, T | 1 |
| Naruse, T | 1 |
| Lu, CQ | 1 |
| Lu, J | 1 |
| Cui, YZ | 1 |
| Rashidi, B | 1 |
| An, Z | 1 |
| Sun, FX | 1 |
| Moossa, AR | 1 |
| Funahashi, Y | 1 |
| Koyanagi, N | 1 |
| Kitoh, K | 1 |
| Zimmermann, T | 1 |
| Schemmer, P | 1 |
| Berghäuser, KH | 1 |
| Mylo, M | 1 |
| Buhr, J | 1 |
| Padberg, WM | 1 |
| Baqué, P | 1 |
| Pierrefite-Carle, V | 1 |
| Gavelli, A | 1 |
| Brossette, N | 1 |
| Benchimol, D | 1 |
| Bourgeon, A | 1 |
| Staccini, P | 1 |
| Saint-Paul, MC | 1 |
| Rossi, B | 1 |
| Davies, MM | 1 |
| Burke, D | 1 |
| Glover, C | 1 |
| Kaur, S | 1 |
| Ullman, B | 1 |
| Kirsch, J | 1 |
| Keppler, D | 1 |
| Pausch, J | 1 |
| Gerok, W | 1 |
| Schlager, SI | 2 |
| Ohanian, SH | 2 |
| Kitano, S | 1 |
| MacLeod, MS | 1 |
| Ritenour, R | 1 |
| Breland, JC | 1 |
| Fukushima, M | 2 |
| Kovacs, CJ | 1 |
| Wakefield, JA | 1 |
| Hobson, AS | 1 |
| Ogiso, T | 1 |
| Noda, N | 1 |
| Masuda, H | 1 |
| Kato, Y | 1 |
| Lee, M | 1 |
| Price, D | 1 |
| Specht, S | 1 |
| Stemmler, N | 1 |
| Shibata, HR | 1 |
| Batist, G | 1 |
| Brodt, P | 1 |
| Ishida, H | 2 |
| Iwama, T | 2 |
| Ide, A | 1 |
| Nihei, Z | 1 |
| Imajo, M | 2 |
| Mishima, Y | 2 |
| Jakobsson, B | 1 |
| el Hag, IA | 1 |
| Jönsson, PE | 2 |
| Mizutani, J | 1 |
| Hiraoka, T | 1 |
| Yamashita, R | 2 |
| Miyauchi, Y | 1 |
| Kanda, T | 1 |
| Sakamoto, M | 1 |
| Kubo, T | 1 |
| Maruyama, Y | 1 |
| Nishioka, Y | 1 |
| Okubo, Y | 1 |
| Otomo, M | 1 |
| Harada, M | 1 |
| Nishitani, H | 1 |
| Shirahama, T | 1 |
| Koga, K | 1 |
| Miura, I | 1 |
| Pan, WS | 1 |
| Hu, J | 1 |
| Yamada, T | 1 |
| Sakatoku, M | 1 |
| Ohhira, M | 1 |
| Watanabe, Y | 1 |
| Iwa, T | 1 |
| Ouchi, T | 1 |
| Banba, T | 1 |
| Matsumoto, T | 1 |
| Suzuki, S | 1 |
| Suzuki, M | 1 |
| Nagawa, H | 1 |
| Paris, P | 1 |
| Chauffert, B | 1 |
| Martin, F | 1 |
| McBee, P | 1 |
| Petraiuolo, W | 1 |
| Iigo, M | 1 |
| Nishikata, K | 1 |
| Nakajima, Y | 1 |
| Hoshi, A | 1 |
| De Clercq, E | 1 |
| Radnell, M | 1 |
| Jeppsson, B | 3 |
| Bengmark, S | 3 |
| Weber, G | 1 |
| Ichikawa, S | 1 |
| Nagai, M | 1 |
| Natsumeda, Y | 1 |
| Erichsen, C | 1 |
| Christensson, PI | 1 |
| Jacobsson, B | 1 |
| Guo, YJ | 1 |
| Marquet, RL | 1 |
| Jeekel, J | 1 |
| Pels Rijcken, WR | 1 |
| Telleman, F | 1 |
| Ferwerda, W | 1 |
| Mori, T | 1 |
| Hafström, L | 1 |
| Bartkowski, R | 3 |
| Aguiar, JL | 3 |
| Henne, TH | 2 |
| Dörsam, J | 3 |
| Geelhaar, GH | 2 |
| Schlag, P | 3 |
| Herfarth, C | 2 |
| Schmähl, D | 1 |
| Taguchi, T | 1 |
| Miwa, M | 1 |
| Eda, H | 1 |
| Fujimoto, K | 1 |
| Ishitsuka, H | 1 |
| Order, SE | 1 |
| Klein, JL | 1 |
| Leichner, PK | 1 |
| Ettinger, DS | 1 |
| Kopher, K | 1 |
| Finney, K | 1 |
| Surdyke, M | 1 |
| Leibel, SA | 1 |
| Yamamoto, Y | 1 |
| Amano, T | 1 |
| Imada, T | 1 |
| Tamura, S | 1 |
| Abe, M | 1 |
| Matsumoto, A | 1 |
| Murakami, M | 1 |
| Mack, P | 1 |
| Widlus, D | 1 |
| Hägerstrand, I | 1 |
| de Brauw, LM | 1 |
| van de Velde, CJ | 1 |
| Tjaden, UR | 1 |
| de Bruijn, EA | 1 |
| Bell, AV | 1 |
| Hermans, J | 1 |
| Zwaveling, A | 1 |
| Berger, M | 1 |
| Vagianos, C | 1 |
| Puntis, M | 1 |
| Steen, S | 1 |
| Zoucas, E | 1 |
| Fujita, H | 1 |
| Takao, A | 1 |
| Okamoto, M | 1 |
| Kimura, K | 1 |
| Yata, N | 1 |
| Yamajo, R | 1 |
| Okada, T | 1 |
| Furue, H | 1 |
2 reviews available for fluorouracil and Experimental Hepatoma
| Article | Year |
|---|---|
Vitamin B6 and cancer (review).
Topics: Animals; Biotransformation; Cell Division; Fluorodeoxyuridylate; Fluorouracil; Liver Neoplasms, Expe | 1981 |
[Selective chemotherapy of hepatocellular carcinomas].
Topics: Animals; Carcinoma, Hepatocellular; Doxorubicin; Fluorouracil; Humans; Liver Neoplasms; Liver Neopla | 1978 |
161 other studies available for fluorouracil and Experimental Hepatoma
| Article | Year |
|---|---|
Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cells, Cultured; DNA Damage; Dose-Res | 2018 |
Preparation and synergistic chemo-photothermal therapy of redox-responsive carboxymethyl cellulose/chitosan complex nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; Carbohydrate Conformation; Carboxymethylcellulose Sodium; | 2022 |
Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; | 2019 |
A novel patient-derived orthotopic xenograft (PDOX) mouse model of highly-aggressive liver metastasis for identification of candidate effective drug-combinations.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bevacizumab; Body Weight; C | 2020 |
Hepatoprotective Mongolian prescription II enhances the antitumor effects of chemotherapeutics in hepatocellular carcinoma xenografts.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Fluo | 2017 |
Novel mouse models of hepatic artery infusion.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Female; Fluorouracil; Hepatic A | 2017 |
The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Cytotoxicity, Immunologic; Drug Synergism; Female; Flu | 2013 |
[Antitumor activity of the recombinant rClone30-CD/5-FC system].
Topics: Animals; Antimetabolites, Antineoplastic; Cell Death; Chick Embryo; Cytosine Deaminase; Escherichia | 2013 |
Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Models, Animal; Disease Prog | 2013 |
MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma.
Topics: 3' Untranslated Regions; Animals; Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; Base Sequen | 2013 |
Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Proliferation; Chitosan; Delayed-Action Preparations; | 2013 |
Enhancement of anti-tumor activity of Newcastle disease virus by the synergistic effect of cytosine deaminase.
Topics: Adenoviridae; Animals; Antimetabolites; Combined Modality Therapy; Cytosine Deaminase; Drug Synergis | 2013 |
Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell | 2016 |
[Spontaneous cytotoxicity treated with anti-tumor drugs of splenocytes of rats on a model of hepatoma cell monolayer cultures].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell | 2015 |
Membrane Glycolipids Content Variety in Gastrointestinal Tumors and Transplantable Hepatomas in Mice.
Topics: Animals; Biomarkers, Tumor; Fluorouracil; Gastrointestinal Neoplasms; Glycolipids; Liver Neoplasms, | 2016 |
[Scutellaria barbata extract enhances efficacy and reduces toxicity of chemotherapy in hepatoma H22-bearing mice].
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Synergism; Drug Therapy, Combination; Drugs, Chines | 2008 |
In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates.
Topics: Acrylamides; Animals; Antimetabolites, Antineoplastic; Biological Availability; Cell Survival; Chemi | 2008 |
[Anti-proliferative and apoptosis-inducing activity of Scutellaria barbate containing serum on mouse's hepatoma H22 cells].
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferat | 2008 |
The effect of targeted magnetic nanopaticles on hepatoma and the expression of bcl-2/bax protein.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Drug Carriers; Drug Delivery | 2008 |
Commentary 2008: 25 or 50 years later?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Colorectal Neopl | 2008 |
[In vitro release study, in vivo evaluation of biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates].
Topics: Acrylamides; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Cell Line, Tumor; Drug Carr | 2008 |
Combined use of chemotherapeutics and oncolytic adenovirus in treatment of AFP-expressing hepatocellular carcinoma.
Topics: Adenoviridae; alpha-Fetoproteins; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplas | 2009 |
Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, He | 2010 |
[Survivin antisense oligodeoxynucleotides inhibits the proliferation of hepatocellular carcinoma cells and enhances 5-FU sensitivity].
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolifer | 2010 |
Novel biochemical pathways for 5-Fluorouracil in managing experimental hepatocellular carcinoma in rats.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Fluorouracil; Glucosamine; Glycosaminoglycan | 2010 |
Hepatic arterial infusion in the treatment of liver metastases with PEG liposomes in combination with degradable starch microspheres (DSM) increases tumor 5-FU concentration. an animal study in CC-531 liver tumor-bearing rats.
Topics: Animals; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Embolization, Therap | 2011 |
Enhanced anti-cancer effect of 5-fluorouracil loaded into thermo-responsive conjugated linoleic acid-incorporated poloxamer hydrogel on metastatic colon cancer models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Drug Deli | 2011 |
A 5-fluorouracil-loaded pH-responsive dendrimer nanocarrier for tumor targeting.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Dendrimers; Drug Carriers; Female; Fluor | 2011 |
Lipoteichoic acid of Bifidobacterium in combination with 5-fluorouracil inhibit tumor growth and relieve the immunosuppression.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bifidobacterium; Carcinoma, Hepatocellular; | 2012 |
Enhancement of antitumor activity of low-dose 5-fluorouracil by combination with Fuzheng-Yiliu granules in hepatoma 22 tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Line, Tumor; Cell Proliferation; Drug S | 2013 |
Synthesis of galactosylated chitosan/5-fluorouracil nanoparticles and its characteristics, in vitro and in vivo release studies.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chitosan; Delayed-Action Preparations; F | 2012 |
Glycogenes mediate the invasive properties and chemosensitivity of human hepatocarcinoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2013 |
Galactosylated chitosan/5-fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepat | 2012 |
The effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo.
Topics: Alkaloids; Animals; Antimetabolites, Antineoplastic; Benzylisoquinolines; Calmodulin; Carcinoma, Hep | 2002 |
Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; be | 2003 |
Synergistic effects of nimesulide and 5-fluorouracil on tumor growth and apoptosis in the implanted hepatoma in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Apoptosis; Cycloo | 2003 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liv | 1965 |
Superiority of combined chemo-embolization and portal infusion with 5-fluorouracil over locoregional infusion concepts in Novikoff hepatoma-bearing rats.
Topics: Animals; Combined Modality Therapy; Diatrizoate; Drug Combinations; Embolization, Therapeutic; Fatty | 2003 |
[Tumor regression in long-term follow-up by administration of liposome encapsulated 5-FU. An animal experiment in WAF rats with CC-531 liver tumor].
Topics: Animals; Antimetabolites, Antineoplastic; Cell Survival; Fluorouracil; Infusions, Intra-Arterial; In | 1998 |
[Liposome encapsulation of cystostatic drugs and starch microspheres improve tumor targeting in locoregional therapy. An animal experiment study of CC 531 liver tumor].
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Delivery System | 1998 |
Antitumor effect of a splenic injection of 5-fluorouracil on metastatic liver cancer in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Fluorouracil; Injections; Interleu | 2004 |
Capecitabine inhibits postoperative recurrence and metastasis after liver cancer resection in nude mice with relation to the expression of platelet-derived endothelial cell growth factor.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Hepatocellular; Deoxycytidine; Fl | 2003 |
Changes of tumor microcirculation after transcatheter arterial chemoembolization: first pass perfusion MR imaging and Chinese ink casting in a rabbit model.
Topics: Animals; Carbon; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Contrast Media; Diagnost | 2004 |
Intra-aortal therapy with 5-fluorouracil- polyethylene glycol stealth liposomes: does the metabolism of 5-fluorouracil into 5-fluoro-2'-deoxyuridine depend on ph value?. An animal study in VX-2 liver tumor-bearing rabbits.
Topics: Animals; Antimetabolites, Antineoplastic; Aorta, Abdominal; Cell Line, Tumor; Chromatography, High P | 2004 |
Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours.
Topics: Animals; Carbon Dioxide; Fluorouracil; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscop | 2005 |
Anti-hepatocarcinoma effects of 5-fluorouracil encapsulated by galactosylceramide liposomes in vivo and in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Capsules; Carcinoma, Hepatocellular; Cell Line, | 2005 |
Improvement in 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) concentration by 5-fluorouracil-polyethylene-glycol-liposomes in abdominal stop-flow: treatment of VX2 liver-tumor-bearing rabbits.
Topics: Animals; Biological Availability; Blood Flow Velocity; Chromatography, High Pressure Liquid; Disease | 2005 |
[Experimental study on effects of shengmai injection: enhancing 5-FU anti-tumor efficacy and reducing its toxicity].
Topics: Animals; Antimetabolites, Antineoplastic; Drug Combinations; Drug Synergism; Drugs, Chinese Herbal; | 2005 |
Antiproliferative effects of 5-fluorouracil and interferon-alpha in combination on a hepatocellular carcinoma cell line in vitro and in vivo.
Topics: Angiogenic Proteins; Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; | 2006 |
[Correlation of antitumor drug sensitivity between marrow mesenchymal stem cells (MSCs) and hepatocarcinoma cells in rats].
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cispla | 2006 |
[Pharmacokinetics and distribution of 5-Fu magnetic albumin deuto-microsphere in normal and tumor-bearing mice].
Topics: Albumins; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Cell Line, Tumor; Delayed-Acti | 2007 |
Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
Topics: Animals; Colorectal Neoplasms; Cytosine Deaminase; Disease Models, Animal; Female; Flucytosine; Fluo | 2007 |
Effect of targeted magnetic nanoparticles containing 5-FU on expression of bcl-2, bax and caspase 3 in nude mice with transplanted human liver cancer.
Topics: Animals; Antineoplastic Agents; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Fluorourac | 2007 |
Bioluminescent imaging of hepatocellular carcinoma in live mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, | 2007 |
[Influence of neoadjuvant chemotherapy on liver integrity and ischemic tolerance].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Chemotherapy, Adjuvant; | 2008 |
AAV-mediated TRAIL gene expression driven by hTERT promoter suppressed human hepatocellular carcinoma growth in mice.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Carcinoma, Hep | 2008 |
[Distribution of 5-FU in rat plasma and liver tissue after local 5-FU infusion].
Topics: Animals; Area Under Curve; Female; Fluorouracil; Hepatic Artery; Immunosuppressive Agents; Infusions | 2008 |
[Studies on the new anticancer preparation, 5-fluorouracil-polyglycolic acid-composite and its therapeutic evaluation].
Topics: Aged; Animals; Delayed-Action Preparations; Drug Implants; Female; Fluorouracil; Humans; Liver Neopl | 1984 |
Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cell Line; Cisplatin; Dactinomycin; Dose-Resp | 1983 |
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei; | 1984 |
Modulation of 5-fluorouracil metabolism by thymidine. In vivo and in vitro studies on RNA-directed effects in rat liver and hepatoma.
Topics: Animals; Body Weight; Bone Marrow; Cell Survival; Fluorouracil; Intestinal Mucosa; Liver; Liver Neop | 1984 |
Evidence that 5'-deoxy-5-fluorouridine may not be activated by the same mechanism as 5-fluorouracil.
Topics: Animals; Biotransformation; Cells, Cultured; Floxuridine; Fluorouracil; Inosine; Liver Neoplasms, Ex | 1982 |
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; | 1983 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Ne | 1984 |
[Studies on the mechanism of cytotoxicity of 5-fluorouracil--through impairment of metabolism].
Topics: Animals; Fluorouracil; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Ribonucleoti | 1983 |
[Tumor suppressing effect of systemic hyperthermia with 2350 MHz microwaves combined with 5-fluorouracil in mice].
Topics: Animals; Combined Modality Therapy; Female; Fluorouracil; Liver Neoplasms, Experimental; Mice; Mice, | 1983 |
[Antitumor effect of FU-O-G, new antitumor agent, following long term administration].
Topics: Animals; Antineoplastic Agents; Carbazilquinone; Drug Administration Schedule; Drug Synergism; Femal | 1984 |
Effect of combined chemotherapy tested in partially hepatectomized rats bearing Zajdela hepatoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; DNA; DNA, Neop | 1983 |
Intratumor immunochemotherapy with 5-fluorouracil emulsion and BCG in C3H/HE mice transplanted with MH134.
Topics: Animals; BCG Vaccine; Cell Line; Fluorouracil; Hemolytic Plaque Technique; Liver Neoplasms, Experime | 1982 |
[Antitumor effect of polysaccharide lentinan on C3H/He mice bearing MH134 ascites hepatoma].
Topics: Animals; Cell Migration Inhibition; Cytarabine; Drug Therapy, Combination; Fluorouracil; Lentinan; L | 1982 |
Antitumor effect of polysaccharide lentinan on MH-134 ascites hepatoma in C3H/He mice.
Topics: Animals; Antineoplastic Agents; Cell Migration Inhibition; Cytarabine; Drug Therapy, Combination; Fl | 1982 |
DNA polymerase and thymidine kinase activities in MC-29 virus-induced transplantable hepatoma and the effect of cytostatic treatment of these activities.
Topics: Animals; Antineoplastic Agents; Avian Myeloblastosis Virus; Cyclophosphamide; Cytarabine; Defective | 1982 |
[Effect of chemotherapy on the growth of human gastrointestinal tumor strains].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Fluorouracil; Humans; Liver Neoplasms, Experimental; Mic | 1980 |
Dynamic histology of a rat hepatoma and the response to 5-fluorouracil.
Topics: Animals; DNA, Neoplasm; Female; Fluorouracil; Kinetics; Liver Neoplasms, Experimental; Mitotic Index | 1980 |
Drug interactions with acetaminophen: effects of phenobarbital, prednisone and 5-fluorouracil in normal and tumor-bearing rats.
Topics: Acetaminophen; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Galactosamine; I | 1980 |
Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Cricetinae; Cricetulus; | 1980 |
[Experimental study of the combined effect of 5-fluorouracil and cyclophosphane on growth of Zajdela hepatoma and nucleic acid metabolism].
Topics: Animals; Cyclophosphamide; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, | 1980 |
[Mechanism of the antitumor action of 5-fluorouracil].
Topics: Animals; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Fluorouracil; Liver Neoplasms, Experimental; Male; | 1980 |
Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro.
Topics: Animals; Cell Line; Cell Survival; Fluorouracil; Liver Neoplasms, Experimental; Metabolic Clearance | 1981 |
Negative impact of cancer chemotherapy on protein metabolism in healthy and tumor-bearing rats.
Topics: Animals; Antineoplastic Agents; Cachexia; Cisplatin; Cyclophosphamide; DNA; Eating; Female; Fluorour | 1995 |
Mapping the biodistribution and catabolism of 5-fluorouracil in tumor-bearing rats by chemical-shift selective 19F MR imaging.
Topics: Animals; Fluorouracil; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Magnetic Resonance | 1995 |
Antitumour effects of pure diastereoisomers of 5-formyltetrahydrofolate in hepatic transplants of a rodent colon carcinoma model.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Divis | 1995 |
[Correlation between tissue blood flow and tissue concentration of 5-FU and its metabolite in hepatic metastasis model for rats].
Topics: Animals; Fluorouracil; Liver Neoplasms, Experimental; Male; Rats | 1995 |
Relation between the incorporation of 5-fluorouracil into liver carcinoma and normal tissue RNA at hepatic arterial administration in the rat is altered by overnight starvation.
Topics: Adenocarcinoma; Animals; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Liver Neoplasms, E | 1993 |
Portal vein embolization with lipiodol for treatment of HCC--an experimental study.
Topics: Animals; Chemoembolization, Therapeutic; Diatrizoate; Fluorouracil; Iodized Oil; Liver Neoplasms, Ex | 1995 |
[The mechanism of potentiation of the antitumor effect of 5-fluorouracil by methionine-free intravenous amino acid solution (AO-90) in rats].
Topics: Amino Acids; Animals; Drug Synergism; Fluorouracil; Liver Neoplasms, Experimental; Male; Methionine; | 1994 |
A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice.
Topics: Animals; Disease Models, Animal; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neopl | 1993 |
[In vivo comparative study of the pharmacokinetics of chemotherapeutic agents infused via hepatic artery or portal vein against hepatic metastases. DRC Group].
Topics: Animals; Cisplatin; Fluorouracil; Hepatic Artery; Infusion Pumps; Infusions, Intra-Arterial; Infusio | 1993 |
Chemoimmunotherapy of murine liver metastases with 5-fluorouracil in combination with liposome-encapsulated muramyl dipeptide.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; | 1993 |
Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Combined Modali | 1993 |
Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anticancer drugs for a transplanted experimental liver tumor in rats.
Topics: Angiography; Animals; Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Floxuridin | 1996 |
Inhibition of experimental liver metastasis by combined treatment with tamoxifen and interferon.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineopl | 1996 |
[Locoregional therapy for liver metastases of colorectal cancer].
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colorectal Neoplasm | 1996 |
Effect of regional angiotensin II infusion on the relationship between tumour blood flow and fluorouracil uptake in a liver metastasis animal model.
Topics: Analysis of Variance; Angiotensin II; Animals; Antimetabolites, Antineoplastic; Blood Flow Velocity; | 1996 |
Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: a comparative animal study.
Topics: Animals; Fluorine Radioisotopes; Fluorouracil; Liver; Liver Neoplasms, Experimental; Magnetic Resona | 1996 |
Incorporation of 5-fluorouracil into hepatoma and normal tissue RNA at protein depletion in the rat.
Topics: Animals; DNA, Neoplasm; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Liver; Liver Neopla | 1997 |
[Inhibitory effect of the radiosensitizer AK-2123 on experimental liver metastasis and active transport of calcium ions].
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Calcium Channel Blockers; Female; Fluorour | 1997 |
Solid tumor chemotherapy and in vivo distribution of fluorouracil following administration in poly(L-lactic acid) microspheres.
Topics: Animals; Antimetabolites, Antineoplastic; Biodegradation, Environmental; Chemistry, Pharmaceutical; | 1997 |
A pharmacokinetic and pharmacodynamic study in vivo of human HT29 tumours using 19F and 31P magnetic resonance spectroscopy.
Topics: Animals; Antineoplastic Agents; Fluorouracil; HT29 Cells; Humans; Interferon-alpha; Liver Neoplasms, | 1997 |
Intra- and extracellular fluorouracil uptake: assessment with contrast-enhanced metabolic F-19 MR imaging.
Topics: Animals; Antimetabolites, Antineoplastic; Contrast Media; Fluorine; Fluorouracil; Gadolinium DTPA; H | 1998 |
Direct detection of intratumoral 5-fluorouracil trapping using metabolic 19F MR imaging.
Topics: Animals; Antimetabolites, Antineoplastic; Fluorouracil; Liver Neoplasms, Experimental; Magnetic Reso | 1999 |
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoates; Body Weight | 1998 |
Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice.
Topics: Animals; Cytosine Deaminase; Flucytosine; Fluorouracil; Genetic Therapy; Genetic Vectors; Liver Neop | 1999 |
New technique for superselective arterial (chemo-) embolization of the rat liver.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capillaries; C | 1999 |
Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging.
Topics: Animals; Antimetabolites, Antineoplastic; beta-Alanine; Biotransformation; Bromouracil; Cell Divisio | 1999 |
Enhancement of 5-fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models, Walker 256 carcinosarcoma and Novikoff hepatoma, as evaluated by 19F-magnetic resonance spectroscopy.
Topics: Animals; Carcinoma 256, Walker; Drug Administration Schedule; Fluorine; Fluorouracil; Kinetics; Live | 2000 |
Effect of red blood cells on the antitumor activity of oxycellulose.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blood Proteins; Cisplatin; Cocultur | 2000 |
Changes in ganglioside contents, plasma sialic acid and cAMP levels in experimental hepatoma in mice.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Division; Cyclic AMP; Erythrocyte Membrane; Fluorour | 2000 |
Efficacy of intra-hepatectomy 5-FU on recurrence and metastasis of human hepatocellular carcinoma in nude mice.
Topics: Animals; Combined Modality Therapy; Female; Fluorouracil; Hepatectomy; Humans; Liver Neoplasms, Expe | 2001 |
Effect of E7010 on liver metastasis and life span of syngeneic C57BL/6 mice bearing orthotopically transplanted murine Colon 38 tumor.
Topics: Aminophenols; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Liver Neoplas | 2001 |
Interactions between malignant tumor growth and allogeneic graft rejection in an experimental rat model.
Topics: Animals; Cell Division; Cyclosporine; Fluorouracil; Graft Rejection; Graft Survival; Heart Transplan | 1994 |
Naked DNA injection for liver metastases treatment in rats.
Topics: Animals; Antimetabolites; Colonic Neoplasms; Cytosine Deaminase; Disease Models, Animal; Flucytosine | 2002 |
Basic fibroblast growth factor infusion increases tumour vascularity, blood flow and chemotherapy uptake.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Blood Flow Velocity; Fibroblast Growth Fac | 2002 |
Metabolism of 5-fluorouracil in cultured cells. Protection from 5-fluorouracil cytotoxicity by purines.
Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Cells, Cultured; Fluorouracil; Haplorhini; Leukemia L | 1979 |
Plasma membrane and intracellular lipid synthesis in tumor cells rendered sensitive to humoral immune killing after treatment with metabolic inhibitors.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Cell Membrane; Doxorubicin; Drug Resistance; Fluorour | 1979 |
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.
Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Li | 1979 |
Solid tumor models for the assessment of different treatment modalities. XII. Combined chemotherapy-radiotherapy: variation of time interval between time of administration of 5-fluorouracil and radiation and its effect on the control of tumor growth.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radia | 1979 |
Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells.
Topics: Animals; Cell Line; Drug Resistance; Fluorouracil; Inosine; Liver Neoplasms, Experimental; Methylati | 1979 |
Physico-chemical properties of tumor cells that influence their susceptibility to humoral immune killing.
Topics: Animals; Antibodies, Neoplasm; Antibody Formation; Cell Line; Cell Survival; Complement System Prote | 1979 |
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Topics: Animals; Cells, Cultured; DNA-Directed DNA Polymerase; DNA, Neoplasm; Fluorouracil; Leukemia, Experi | 1979 |
Cell proliferation in organs of rats bearing hepatoma 3924A: effects of X-rays of surgery.
Topics: Animals; Bone Marrow; Cell Division; DNA, Neoplasm; Female; Fluorouracil; Hematopoiesis; Leukocyte C | 1977 |
Antitumor agents. II. Effect of 5-fluorouracil and cyclophosphamide on immunological parameters and liver microsomes of tumor-bearing rats.
Topics: Alkaline Phosphatase; Animals; Body Weight; Cyclophosphamide; Fluorouracil; Immunosuppressive Agents | 1978 |
Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil.
Topics: Animals; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Mice; Rats; S | 1978 |
Interferon modulation of 5-fluorouracil: use in neoadjuvant therapy inhibits experimental liver metastases in nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Fluorouracil; Human | 1992 |
Eradication of hepatic metastases of carcinoma H-59 by combination chemoimmunotherapy with liposomal muramyl tripeptide, 5-fluorouracil, and leucovorin.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Antineoplastic Combined Chemothe | 1992 |
[An experimental study on portal infusion of 5-fluorouracil (the second report)].
Topics: Animals; Fluorouracil; Heparin; Infusions, Intravenous; Killer Cells, Natural; Leukocyte Count; Live | 1992 |
Incorporation of 5-fluorouracil into rat liver tumor and normal tissues and the liver nucleotide profile after administration by the hepatic artery during portal venous branch ligation.
Topics: Animals; DNA, Neoplasm; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Ligation; Liver; Li | 1992 |
Promotion of hepatic metastases by liver resection in the rat.
Topics: Animals; Fluorouracil; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Regeneration; Mi | 1992 |
[Studies on a slow releasing anticancer agent for prevention of peritoneal recurrence of advanced gastrointestinal carcinomas (experimental study)].
Topics: Animals; Delayed-Action Preparations; Fluorouracil; Infusions, Parenteral; Liver Neoplasms, Experime | 1991 |
[An experimental study on portal infusion of 5-fluorouracil].
Topics: Animals; Fluorouracil; Infusions, Intravenous; Liver Neoplasms, Experimental; Male; Portal Vein; Rat | 1991 |
[In-vivo 19F-MRS study of 5-fluorouracil (5-FU) metabolism on tumors].
Topics: Animals; beta-Alanine; Fluorine; Fluorouracil; Liver; Liver Neoplasms, Experimental; Magnetic Resona | 1991 |
Hepatic carcinoma. The possibility of transcatheter chemoembolization through the portal vein.
Topics: Animals; Embolization, Therapeutic; Fluorouracil; Liver Neoplasms, Experimental; p-Dimethylaminoazob | 1991 |
[Studies of 5-fluorouracil nanocapsules].
Topics: Animals; Capsules; Carcinoma, Ehrlich Tumor; Drug Carriers; Enbucrilate; Female; Fluorouracil; Liver | 1991 |
A new anticancer drug delivery system for the management of carcinomatous peritonitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Drug Carriers; Erythrocyte Count; Fluoro | 1991 |
Synthesis and antitumor activity of conjugates of 5-fluorouracil and chito-oligosaccharides involving a hexamethylene spacer group and carbamoyl bonds.
Topics: Animals; Antineoplastic Agents; Body Weight; Drug Carriers; Female; Fibrosarcoma; Fluorouracil; Inje | 1990 |
Treatment of experimental liver metastases in the rat by continuous intraportal infusion of 5-fluorouracil and heparin: a pilot study.
Topics: Adenocarcinoma; Animals; Anticoagulants; Drug Therapy, Combination; Fluorouracil; Heparin; Humans; I | 1990 |
Inhibition of liver metastases in nude mice by the combined action of 5-fluorouracil and interferon.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relatio | 1990 |
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bromodeoxyuridine; Fluoro | 1990 |
A technique for isolated liver perfusion in the rat with survival and results of cytotoxic drug perfusion on liver tumor growth.
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Liver Neoplasms, Experimental; Male | 1990 |
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics | 1990 |
Effects of dosage and infusion time on the incorporation of 5-fluorouracil into DNA and RNA of normal tissues and an adenocarcinoma transplanted to rat liver.
Topics: Adenocarcinoma; Animals; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Fluorouracil; | 1988 |
[Changes of T lymphocyte subsets in BERH-2 hepatoma-bearing rats and effect of different immunotherapies on the tumor].
Topics: Animals; Combined Modality Therapy; Female; Fluorouracil; Immunotherapy; Interferons; Interleukin-2; | 1989 |
Combined effect of 5-fluorouracil and interferon on experimental liver metastases of rat colon carcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorour | 1985 |
Incorporation of 5-fluorouracil into nucleotide sugars and the effect on glycoconjugates in rat hepatoma cells and hepatocytes.
Topics: Animals; Fluorouracil; Glycoconjugates; Glycosylation; Liver; Liver Neoplasms, Experimental; Nucleos | 1989 |
[Experimental study of 5-FU + leucovorin therapy by continuous arterial infusion].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Infusion Pumps; Infus | 1989 |
Effect on liver tumor growth in rats of allopurinol and 5-fluorouracil in combination with hepatic artery ligation.
Topics: Allopurinol; Animals; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fem | 1989 |
Experiments on the efficacy and toxicity of locoregional chemotherapy of liver tumors with 5-fluoro-2'-deoxyuridine (FUDR) and 5-fluorouracil (5-FU) in an animal model.
Topics: Animals; DNA, Neoplasm; Floxuridine; Fluorouracil; Liver; Liver Neoplasms; Liver Neoplasms, Experime | 1986 |
Experiments on the toxicity of locoregional liver chemotherapy with 5-fluoro-2'-deoxyuridine and 5-fluorouracil in an animal model.
Topics: Animals; Female; Floxuridine; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Infusions, Pa | 1986 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
Radiolabeled antibody in the treatment of primary and metastatic liver malignancies.
Topics: Animals; Antibodies; Biliary Tract Neoplasms; Carcinoembryonic Antigen; Carcinoma, Hepatocellular; C | 1986 |
[Effects of OK-432 on UFT activation].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Products; | 1988 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neopl | 1985 |
Combined intermittent dearterialization and intraperitoneal 5-fluorouracil administration for liver tumours in the rat.
Topics: Animals; Constriction; Fluorouracil; Hepatic Artery; Injections, Intraperitoneal; Liver Neoplasms, E | 1988 |
In vivo isolated liver perfusion technique in a rat hepatic metastasis model: 5-fluorouracil concentrations in tumor tissue.
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Chromatography, High Pressure Liquid; Colonic Neo | 1988 |
Hepatic arterial infusion (HAI) chemotherapy proves to be advantageous in the treatment of experimental liver tumors.
Topics: Animals; Female; Fluorouracil; Hepatic Artery; Injections, Intra-Arterial; Ligation; Liver Neoplasms | 1988 |
[Experimental study of an anticancer drug delivery system using polylactic acid].
Topics: Animals; Antineoplastic Agents; Delayed-Action Preparations; Fluorouracil; Infusion Pumps; Lactates; | 1987 |
Increased uptake of 5-FU in experimental liver tumours by simultaneous infusion of norepinephrine.
Topics: Animals; Blood Pressure; Drug Synergism; Fluorouracil; Intestinal Mucosa; Liver; Liver Neoplasms, Ex | 1987 |
[Pharmacokinetics of 1-phthalidyl-5-fluorouracil (PH-FU)].
Topics: Administration, Oral; Animals; Biological Assay; Fluorouracil; Kinetics; Liver Neoplasms, Experiment | 1986 |
Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Female; Fluorouracil; Injections, Subcutaneous | 1985 |
[590-S].
Topics: Administration, Oral; Adult; Animals; Anorexia; Antineoplastic Agents; Drug Administration Schedule; | 1985 |