fluorouracil has been researched along with Exfoliation Syndrome in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Exfoliation Syndrome: The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the outcomes of trabeculectomy with 5-fluorouracil (5-FU) with or without subconjunctival bevacizumab in the surgical management of pseudoexfoliation glaucoma (PXG)." | 7.91 | Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma. ( Çolak, S; Elgin, U; Sen, E; Yılmazbas, P, 2019) |
| "To investigate the outcomes of trabeculectomy with 5-fluorouracil (5-FU) with or without subconjunctival bevacizumab in the surgical management of pseudoexfoliation glaucoma (PXG)." | 3.91 | Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma. ( Çolak, S; Elgin, U; Sen, E; Yılmazbas, P, 2019) |
| "Intraocular pressure was 20 mmHg or lower in 94% of 5-FU eyes and in 73% of control eyes (P < 0." | 2.67 | 5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study. ( Gieser, DK; Goldenfeld, M; Krupin, T; Liebmann, JM; Ritch, R; Rosenberg, LF; Ruderman, JM; Wong, PC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elgin, U | 1 |
| Sen, E | 1 |
| Çolak, S | 1 |
| Yılmazbas, P | 1 |
| Arnljots, TS | 1 |
| Kasina, R | 1 |
| Bykov, VJN | 1 |
| Economou, MA | 1 |
| Carassa, RG | 1 |
| Bettin, P | 1 |
| Fiori, M | 1 |
| Brancato, R | 1 |
| Goldenfeld, M | 1 |
| Krupin, T | 1 |
| Ruderman, JM | 1 |
| Wong, PC | 1 |
| Rosenberg, LF | 1 |
| Ritch, R | 2 |
| Liebmann, JM | 2 |
| Gieser, DK | 1 |
| Spiegel, D | 1 |
| Sachs, H | 1 |
| Yanes, G | 1 |
| Samuelson, TW | 1 |
| Rothman, RF | 1 |
1 review available for fluorouracil and Exfoliation Syndrome
| Article | Year |
|---|---|
Management of coincident glaucoma and cataract.
Topics: Cataract; Cataract Extraction; Exfoliation Syndrome; Fluorouracil; Glaucoma; Humans; Lenses, Intraoc | 1995 |
2 trials available for fluorouracil and Exfoliation Syndrome
| Article | Year |
|---|---|
Viscocanalostomy versus trabeculectomy in white adults affected by open-angle glaucoma: a 2-year randomized, controlled trial.
Topics: Aged; Anterior Eye Segment; Conjunctiva; Exfoliation Syndrome; Female; Fluorouracil; Glaucoma, Open- | 2003 |
5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study.
Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Exfoliation Syndrome; Female; Fluorouracil; Foll | 1994 |
4 other studies available for fluorouracil and Exfoliation Syndrome
| Article | Year |
|---|---|
Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma.
Topics: Aged; Angiogenesis Inhibitors; Antihypertensive Agents; Bevacizumab; Exfoliation Syndrome; Female; F | 2019 |
Needling With 5-Fluorouracil (5-FU) After XEN Gel Stent Implantation: 6-Month Outcomes.
Topics: Aged; Aged, 80 and over; Exfoliation Syndrome; Female; Fluorouracil; Gels; Glaucoma; Glaucoma Draina | 2018 |
[Single dose intraoperative administration of 5-fluorouracil (5-FU) in trabeculectomy. Long-term results of a pilot study].
Topics: Aged; Antimetabolites; Cell Division; Exfoliation Syndrome; Female; Fluorouracil; Glaucoma, Open-Ang | 1996 |
Noninfectious crystalline keratopathy after postoperative subconjunctival 5-fluorouracil.
Topics: Aged; Antimetabolites; Conjunctiva; Cornea; Corneal Diseases; Diagnosis, Differential; Exfoliation S | 1999 |