fluorouracil has been researched along with Esophageal Fistula in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Esophageal Fistula: Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite its significant toxicity for esophageal fistula, this concurrent CT-RT protocol of protracted 5-fluorouracil infusion and cisplatin appears feasible and effective for T4 esophageal cancer with or without fistulas." | 3.71 | Prospective trial of concurrent chemoradiotherapy with protracted infusion of 5-fluorouracil and cisplatin for T4 esophageal cancer with or without fistula. ( Kanamori, S; Nakamatsu, K; Nishimura, Y; Shigeoka, H; Suzuki, M; Yagyu, Y, 2002) |
| "Esophageal stenosis was the only significant risk factor for esophageal fistula formation both in univariate (Pā=ā0." | 2.82 | Risk Factors for Esophageal Fistula Associated With Chemoradiotherapy for Locally Advanced Unresectable Esophageal Cancer: A Supplementary Analysis of JCOG0303. ( Fukuda, H; Honma, Y; Igaki, H; Kato, K; Kitagawa, Y; Mizusawa, J; Nakamura, K; Shinoda, M; Sudo, K; Tsubosa, Y; Tsushima, T, 2016) |
| "We report the case of a long-term esophageal cancer survivor treated by esophageal bypass operation for ERF after chemoradiotherapy (CRT)." | 1.51 | Long-term Esophageal Cancer Survivor Treated by Bypass for Esophagobronchial Fistula After Chemoradiotherapy: A Case Report. ( Emi, M; Hamai, Y; Ibuki, Y; Miyata, Y; Ohsawa, M; Okada, M, 2019) |
| "Esophageal fistula was observed in 28 patients (24%)." | 1.48 | Risk factors for esophageal fistula in thoracic esophageal squamous cell carcinoma invading adjacent organs treated with definitive chemoradiotherapy: a monocentric case-control study. ( Fukutomi, A; Hamauchi, S; Kawakami, T; Kito, Y; Machida, N; Ogawa, H; Omae, K; Onozawa, Y; Shirasu, H; Todaka, A; Tsushima, T; Yamazaki, K; Yasui, H; Yokota, T; Yoshida, Y, 2018) |
| "Following recurrence of cancer of the sigmoid colon, the patient received a course of XELOX plus bevacizumab(Bmab)to treat peritoneal dissemination and lung metastases." | 1.43 | [A Case of Aortoesophageal Fistula Rupture Due to Descending Thoracic Aortic Dissection with Recurrent Colon Cancer during Chemotherapy Containing Bevacizumab]. ( Fujii, T; Funahashi, K; Kaneko, H; Kaneko, T; Katayanagi, T; Koda, T; Koike, J; Kurihara, A; Masuhara, H; Sawaguchi, Y; Shimada, H; Shiokawa, H; Suzuki, T; Ushigome, M; Watanabe, Y, 2016) |
| "All tumors were squamous cell carcinomas." | 1.35 | Concurrent chemoradiotherapy for esophageal cancer with malignant fistula. ( Kanamori, S; Koike, R; Nakamatsu, K; Nishimura, Y; Shibata, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawakami, T | 1 |
| Tsushima, T | 2 |
| Omae, K | 1 |
| Ogawa, H | 1 |
| Shirasu, H | 1 |
| Kito, Y | 1 |
| Yoshida, Y | 1 |
| Hamauchi, S | 1 |
| Todaka, A | 1 |
| Machida, N | 1 |
| Yokota, T | 1 |
| Yamazaki, K | 1 |
| Fukutomi, A | 1 |
| Onozawa, Y | 1 |
| Yasui, H | 1 |
| Ohsawa, M | 1 |
| Hamai, Y | 1 |
| Ibuki, Y | 1 |
| Emi, M | 1 |
| Miyata, Y | 2 |
| Okada, M | 1 |
| Wong, S | 1 |
| Hennequin, C | 1 |
| Quero, L | 1 |
| Mizusawa, J | 1 |
| Sudo, K | 1 |
| Honma, Y | 1 |
| Kato, K | 1 |
| Igaki, H | 1 |
| Tsubosa, Y | 1 |
| Shinoda, M | 1 |
| Nakamura, K | 1 |
| Fukuda, H | 1 |
| Kitagawa, Y | 1 |
| Koda, T | 1 |
| Koike, J | 1 |
| Masuhara, H | 1 |
| Kurihara, A | 1 |
| Shiokawa, H | 1 |
| Ushigome, M | 1 |
| Kaneko, T | 1 |
| Suzuki, T | 1 |
| Sawaguchi, Y | 1 |
| Katayanagi, T | 1 |
| Fujii, T | 2 |
| Watanabe, Y | 1 |
| Funahashi, K | 1 |
| Shimada, H | 1 |
| Kaneko, H | 1 |
| Hanazono, K | 1 |
| Natsugoe, S | 1 |
| Okumura, H | 1 |
| Matsumoto, M | 1 |
| Oowaki, T | 1 |
| Setoyama, T | 1 |
| Hiraki, Y | 1 |
| Arimura, K | 1 |
| Nakamura, F | 1 |
| Nakajo, M | 1 |
| Aikou, T | 1 |
| Koike, R | 1 |
| Nishimura, Y | 2 |
| Nakamatsu, K | 2 |
| Kanamori, S | 2 |
| Shibata, T | 1 |
| Ohtsu, A | 2 |
| Yoshida, S | 1 |
| Boku, N | 2 |
| Oda, Y | 1 |
| Koba, I | 1 |
| Muro, K | 1 |
| Ohnaka, O | 1 |
| Shimizu, W | 1 |
| Gaspar, LE | 2 |
| Qian, C | 1 |
| Kocha, WI | 2 |
| Coia, LR | 2 |
| Herskovic, A | 2 |
| Graham, M | 2 |
| Winter, K | 1 |
| Morihiro, M | 1 |
| Miyamoto, S | 1 |
| Ishikura, S | 1 |
| Suzuki, M | 1 |
| Yagyu, Y | 1 |
| Shigeoka, H | 1 |
| Gabrail, NY | 1 |
| Harrison, BR | 1 |
| Sunwoo, YC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Definitive Concurrent Chemoradiotherapy With Docetaxel Plus Cisplatin Versus 5-fluorouracil Plus Cisplatin in Patients With Esophageal Squamous Cell Carcinoma: a Phase II Randomized Controlled Trial[NCT02969473] | Phase 2 | 120 participants (Anticipated) | Interventional | 2010-10-31 | Active, not recruiting | ||
| A Prospective Single-arm Phase ā ” Study of Toripalimab Plus Neoadjuvant Chemotherapy Combined With Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma[NCT04844385] | Phase 2 | 83 participants (Anticipated) | Interventional | 2021-02-20 | Recruiting | ||
| A Prospective, Phase ā ” Study of S-1 Plus Moderately Hypofractionated Conformal Radiation for Esophageal Squamous Cell Carcinoma[NCT03660449] | Phase 2 | 58 participants (Actual) | Interventional | 2017-10-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Esophageal Fistula
| Article | Year |
|---|---|
[Brachytherapy for oesophageal cancer].
Topics: Antimetabolites, Antineoplastic; Brachytherapy; Chemoradiotherapy; Clinical Trials, Phase II as Topi | 2013 |
3 trials available for fluorouracil and Esophageal Fistula
9 other studies available for fluorouracil and Esophageal Fistula
| Article | Year |
|---|---|
Risk factors for esophageal fistula in thoracic esophageal squamous cell carcinoma invading adjacent organs treated with definitive chemoradiotherapy: a monocentric case-control study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; C-Reactive Protein; Case-Control Studie | 2018 |
Long-term Esophageal Cancer Survivor Treated by Bypass for Esophagobronchial Fistula After Chemoradiotherapy: A Case Report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bronchial Fistula; Chemoradiotherapy; Cisplat | 2019 |
[A Case of Aortoesophageal Fistula Rupture Due to Descending Thoracic Aortic Dissection with Recurrent Colon Cancer during Chemotherapy Containing Bevacizumab].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aortic Diseases; Bevacizumab; Capecitabine; Co | 2016 |
[An effective treatment by chemoradiation therapy after stent insertion for advanced esophageal cancer with esophago-pulmonary fistula--report of a case].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 2007 |
Concurrent chemoradiotherapy for esophageal cancer with malignant fistula.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Co | 2008 |
Small cell carcinoma of the esophagus with an esophago-mediastinal fistula successfully treated by chemoradiation therapy and intubation: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Cobalt Radioisotop | 1993 |
Advanced esophageal cancer with esophago-bronchial fistula successfully treated by chemoradiation therapy with additional endoscopic resection: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bronchial Fistula; Carcinoma, Squamous Cell; Cisplat | 2002 |
Prospective trial of concurrent chemoradiotherapy with protracted infusion of 5-fluorouracil and cisplatin for T4 esophageal cancer with or without fistula.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined | 2002 |
Chemo-irradiation induced aortoesophageal fistula.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta, Thoracic; Aortic Diseases; Cisplatin; Combine | 1991 |