fluorouracil has been researched along with Equine Diseases in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An 18-month-old cross-bred Fjord pony colt presenting a fibrosarcoma of the prepuce with severe infiltrative growth, was treated by topical application of 5-fluorouracil." | 7.70 | Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report). ( De Kruif, A; Ducatelle, R; Roels, S; van De Vijver, B, 1998) |
| "An 18-month-old cross-bred Fjord pony colt presenting a fibrosarcoma of the prepuce with severe infiltrative growth, was treated by topical application of 5-fluorouracil." | 3.70 | Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report). ( De Kruif, A; Ducatelle, R; Roels, S; van De Vijver, B, 1998) |
| "25 horses with 27 T2-stage periocular squamous cell carcinomas." | 2.68 | Comparison of intratumoral administration of cisplatin versus bleomycin for treatment of periocular squamous cell carcinomas in horses. ( Carlson, G; Madigan, JE; Metzger, L; Pascoe, JR; Théon, AP, 1997) |
| "Squamous cell carcinoma was found in 4 horses and appears to be the most common bladder tumor in the horse." | 1.27 | Neoplasia of the equine urinary bladder as a cause of hematuria. ( Carlson, GP; Fischer, AT; Hackett, RP; Spier, S, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stewart, AA | 1 |
| Rush, B | 1 |
| Davis, E | 1 |
| Fortier, LA | 1 |
| Mac Harg, MA | 1 |
| Théon, AP | 1 |
| Pascoe, JR | 1 |
| Madigan, JE | 1 |
| Carlson, G | 1 |
| Metzger, L | 1 |
| Paterson, S | 1 |
| Roels, S | 1 |
| Ducatelle, R | 1 |
| van De Vijver, B | 1 |
| De Kruif, A | 1 |
| Ndiritu, CG | 1 |
| Enos, LR | 1 |
| Fischer, AT | 1 |
| Spier, S | 1 |
| Carlson, GP | 1 |
| Hackett, RP | 1 |
| Roberts, WD | 1 |
1 trial available for fluorouracil and Equine Diseases
| Article | Year |
|---|---|
Comparison of intratumoral administration of cisplatin versus bleomycin for treatment of periocular squamous cell carcinomas in horses.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bleomy | 1997 |
7 other studies available for fluorouracil and Equine Diseases
| Article | Year |
|---|---|
The efficacy of intratumoural 5-fluorouracil for the treatment of equine sarcoids.
Topics: Animals; Antimetabolites, Antineoplastic; Equidae; Female; Fluorouracil; Horse Diseases; Horses; Mal | 2006 |
Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988-1992).
Topics: Administration, Topical; Animals; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Debridement; Fem | 1994 |
Treatment of superficial ulcerative squamous cell carcinoma in three horses with topical 5-fluorouracil.
Topics: Administration, Topical; Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Female; | 1997 |
Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report).
Topics: Animals; Antimetabolites, Antineoplastic; Fibrosarcoma; Fluorouracil; Horse Diseases; Horses; Ki-67 | 1998 |
Adverse reactions to drugs in a veterinary hospital.
Topics: Amphotericin B; Anaphylaxis; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Chloral Hydrate; | 1977 |
Neoplasia of the equine urinary bladder as a cause of hematuria.
Topics: Animals; Biopsy; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cystoscopy; Female; Fibroma | 1985 |
Experimental treatment of equine sarcoid.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Horse Diseases; Horses; Immunotherapy; Neoplasms, Conn | 1970 |