Page last updated: 2024-10-27

fluorouracil and Equine Diseases

fluorouracil has been researched along with Equine Diseases in 8 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"An 18-month-old cross-bred Fjord pony colt presenting a fibrosarcoma of the prepuce with severe infiltrative growth, was treated by topical application of 5-fluorouracil."7.70Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report). ( De Kruif, A; Ducatelle, R; Roels, S; van De Vijver, B, 1998)
"An 18-month-old cross-bred Fjord pony colt presenting a fibrosarcoma of the prepuce with severe infiltrative growth, was treated by topical application of 5-fluorouracil."3.70Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report). ( De Kruif, A; Ducatelle, R; Roels, S; van De Vijver, B, 1998)
"25 horses with 27 T2-stage periocular squamous cell carcinomas."2.68Comparison of intratumoral administration of cisplatin versus bleomycin for treatment of periocular squamous cell carcinomas in horses. ( Carlson, G; Madigan, JE; Metzger, L; Pascoe, JR; Théon, AP, 1997)
"Squamous cell carcinoma was found in 4 horses and appears to be the most common bladder tumor in the horse."1.27Neoplasia of the equine urinary bladder as a cause of hematuria. ( Carlson, GP; Fischer, AT; Hackett, RP; Spier, S, 1985)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's4 (50.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stewart, AA1
Rush, B1
Davis, E1
Fortier, LA1
Mac Harg, MA1
Théon, AP1
Pascoe, JR1
Madigan, JE1
Carlson, G1
Metzger, L1
Paterson, S1
Roels, S1
Ducatelle, R1
van De Vijver, B1
De Kruif, A1
Ndiritu, CG1
Enos, LR1
Fischer, AT1
Spier, S1
Carlson, GP1
Hackett, RP1
Roberts, WD1

Trials

1 trial available for fluorouracil and Equine Diseases

ArticleYear
Comparison of intratumoral administration of cisplatin versus bleomycin for treatment of periocular squamous cell carcinomas in horses.
    American journal of veterinary research, 1997, Volume: 58, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bleomy

1997

Other Studies

7 other studies available for fluorouracil and Equine Diseases

ArticleYear
The efficacy of intratumoural 5-fluorouracil for the treatment of equine sarcoids.
    Australian veterinary journal, 2006, Volume: 84, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Equidae; Female; Fluorouracil; Horse Diseases; Horses; Mal

2006
Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988-1992).
    Journal of the American Veterinary Medical Association, 1994, Oct-15, Volume: 205, Issue:8

    Topics: Administration, Topical; Animals; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Debridement; Fem

1994
Treatment of superficial ulcerative squamous cell carcinoma in three horses with topical 5-fluorouracil.
    The Veterinary record, 1997, Dec-13, Volume: 141, Issue:24

    Topics: Administration, Topical; Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Female;

1997
Successful treatment of an equine preputial fibrosarcoma using 5-fluorouracil/evaluation of the treatment using quantitative PCNA and Ki67 (MIB 1) immunostaining. (case report).
    Zentralblatt fur Veterinarmedizin. Reihe A, 1998, Volume: 45, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Fibrosarcoma; Fluorouracil; Horse Diseases; Horses; Ki-67

1998
Adverse reactions to drugs in a veterinary hospital.
    Journal of the American Veterinary Medical Association, 1977, Aug-15, Volume: 171, Issue:4

    Topics: Amphotericin B; Anaphylaxis; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Chloral Hydrate;

1977
Neoplasia of the equine urinary bladder as a cause of hematuria.
    Journal of the American Veterinary Medical Association, 1985, Jun-15, Volume: 186, Issue:12

    Topics: Animals; Biopsy; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cystoscopy; Female; Fibroma

1985
Experimental treatment of equine sarcoid.
    Veterinary medicine, small animal clinician : VM, SAC, 1970, Volume: 65, Issue:1

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Horse Diseases; Horses; Immunotherapy; Neoplasms, Conn

1970