Page last updated: 2024-10-27

fluorouracil and Epstein-Barr Virus Infections

fluorouracil has been researched along with Epstein-Barr Virus Infections in 10 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Epstein-Barr Virus Infections: Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).

Research Excerpts

ExcerptRelevanceReference
"As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis."1.36LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. ( Chae, HS; Kang, JH; Kim, JO; Lee, SK; Shin, JY, 2010)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's6 (60.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Liu, SL1
Sun, XS1
Xie, HJ1
Chen, QY1
Lin, HX1
Liang, H1
Liang, YJ1
Li, XY1
Yan, JJ1
Lin, C1
Yang, ZC1
Guo, SS1
Liu, LT1
Tang, QN1
Du, YY1
Tang, LQ1
Guo, L1
Mai, HQ1
Lo, AK1
Lo, KW1
Ko, CW1
Young, LS1
Dawson, CW1
Yanai, H1
Yahara, N1
Furuya, T1
Hayashi, H1
Murakami, T1
Shimokawa, Y1
Sugihara, S1
Chua, ML1
Tan, SH1
Kusumawidjaja, G1
Shwe, MT1
Cheah, SL1
Fong, KW1
Soong, YL1
Wee, JT1
Tan, TW1
Shin, JY1
Kim, JO1
Lee, SK2
Chae, HS1
Kang, JH1
Bossi, P1
Orlandi, E1
Bergamini, C1
Locati, LD1
Granata, R1
Mirabile, A1
Parolini, D1
Franceschini, M1
Fallai, C1
Olmi, P1
Quattrone, P1
Potepan, P1
Gloghini, A1
Miceli, R1
Mattana, F1
Scaramellini, G1
Licitra, L1
Seo, JS1
Kim, TG1
Hong, YS1
Chen, JY1
Rodriguez-Galindo, C1
Wofford, M1
Castleberry, RP1
Swanson, GP1
London, WB1
Fontanesi, J1
Pappo, AS1
Douglass, EC1
Lin, JC1
Chen, KY1
Wang, WY1
Jan, JS1
Liang, WM1
Tsai, CS1
Wei, YH1
Feng, WH1
Israel, B1
Raab-Traub, N1
Busson, P1
Kenney, SC1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Non-inferiority Trial of Radiotherapy Plus Nimotuzumab or Cisplatin in Patients With Favorable Response to Induction Chemotherapy for Low-risk Locoregionally Advanced-Staged Nasopharyngeal Carcinoma[NCT04456322]Phase 3326 participants (Anticipated)Interventional2020-07-06Recruiting
Randomized Phase II Trial of Concurrent Chemoradiotherapy With or Without Nimotuzumab for High Risk Nasopharyngeal Carcinoma After Induction Chemotherapy[NCT04223024]Phase 2246 participants (Actual)Interventional2019-12-12Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for fluorouracil and Epstein-Barr Virus Infections

ArticleYear
Preradiation chemotherapy with methotrexate, cisplatin, 5-fluorouracil, and leucovorin for pediatric nasopharyngeal carcinoma.
    Cancer, 2005, Feb-15, Volume: 103, Issue:4

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cispla

2005

Other Studies

9 other studies available for fluorouracil and Epstein-Barr Virus Infections

ArticleYear
Comparing three induction chemotherapy regimens for patients with locoregionally advanced nasopharyngeal carcinoma based on TNM stage and plasma Epstein-Barr virus DNA level.
    BMC cancer, 2020, Feb-03, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Disease-F

2020
Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells.
    The Journal of pathology, 2013, Volume: 230, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Car

2013
Long-Term Survival of Patient with Epstein-Barr Virus-Positive Gastric Cancer Treated with Chemotherapy: Case Report.
    Journal of gastrointestinal cancer, 2016, Volume: 47, Issue:1

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin;

2016
Neutrophil-to-lymphocyte ratio as a prognostic marker in locally advanced nasopharyngeal carcinoma: A pooled analysis of two randomised controlled trials.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 67

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma; Cisplatin; Deox

2016
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.
    BMC cancer, 2010, Aug-13, Volume: 10

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Cell

2010
Docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease

2011
Docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease

2011
Docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease

2011
Docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease

2011
Contribution of Epstein-Barr virus infection to chemoresistance of gastric carcinoma cells to 5-fluorouracil.
    Archives of pharmacal research, 2011, Volume: 34, Issue:4

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Culture Techniques; Cell Line, T

2011
Detection of Epstein-Barr virus DNA in the peripheral-blood cells of patients with nasopharyngeal carcinoma: relationship to distant metastasis and survival.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, May-15, Volume: 19, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Cisplatin; Combin

2001
Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors.
    Cancer research, 2002, Mar-15, Volume: 62, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Carcinoma; Cisplatin; Dru

2002