fluorouracil has been researched along with Epithelial Neoplasms in 17 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-fluorouracil (5-FU) has been combined in the past with other drugs for the combination chemotherapy for cancers of the breast, ovary, and colon." | 5.32 | Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms. ( Akbulut, H; Deisseroth, A; Maynard, J; Pizzorno, G; Tang, Y; Zhang, L, 2004) |
| "MTT assays revealed that tumor cells from ascites of primary and type II EOC were more sensitive to paclitaxel (PTX) and carboplatin (CBDCA) than relapse (p = 0." | 3.79 | In vitro chemosensitivity assay of ascites in epithelial ovarian cancer. ( Chen, X; Dai, H; Qian, Z; Wang, Y; Xu, X; Zhao, Y, 2013) |
| "Elafin has been reported to be abundantly expressed in human epithelial ovarian carcinoma (EOC), however, its functions are poorly understood." | 1.38 | Elafin selectively regulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis. ( Hellström, I; Hellström, KE; Wei, H, 2012) |
| "Gastrointestinal perforations were identified in 9%." | 1.33 | Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: A retrospective analysis. ( Gibb, RK; Hagemann, A; Mutch, DG; Norris, L; Powell, MA; Rader, JS; Viviano, D; Wright, JD, 2006) |
| "5-fluorouracil (5-FU) has been combined in the past with other drugs for the combination chemotherapy for cancers of the breast, ovary, and colon." | 1.32 | Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms. ( Akbulut, H; Deisseroth, A; Maynard, J; Pizzorno, G; Tang, Y; Zhang, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Okebalama, VC | 1 |
| Nwadiokwu, JI | 1 |
| Osaze, E | 1 |
| Ayodeji, AA | 1 |
| Chinatu-Nwankwo, OM | 1 |
| Battista, RA | 1 |
| Resnati, M | 1 |
| Facchi, C | 1 |
| Ruggieri, E | 1 |
| Cremasco, F | 1 |
| Paradiso, F | 1 |
| Orfanelli, U | 1 |
| Giordano, L | 1 |
| Bussi, M | 1 |
| Cenci, S | 1 |
| Milan, E | 1 |
| Xu, X | 2 |
| Dai, H | 1 |
| Zhao, Y | 1 |
| Wang, Y | 1 |
| Qian, Z | 1 |
| Chen, X | 1 |
| Chen, J | 1 |
| Wang, J | 1 |
| Zhang, Y | 1 |
| Chen, D | 1 |
| Yang, C | 1 |
| Kai, C | 1 |
| Wang, X | 1 |
| Shi, F | 1 |
| Dou, J | 1 |
| Palmieri, G | 2 |
| Buonerba, C | 1 |
| Ottaviano, M | 1 |
| Federico, P | 2 |
| Calabrese, F | 1 |
| Von Arx, C | 1 |
| De Maio, AP | 1 |
| Marino, M | 2 |
| Lalle, M | 2 |
| Montella, L | 2 |
| Merola, C | 2 |
| Milella, M | 2 |
| Bergaglio, M | 2 |
| Di Lorenzo, G | 2 |
| Damiano, V | 1 |
| Fleming, GF | 1 |
| Schumm, P | 1 |
| Friberg, G | 1 |
| Ratain, MJ | 1 |
| Njiaju, UO | 1 |
| Schilsky, RL | 1 |
| Ishikawa, M | 1 |
| Miyauchi, T | 1 |
| Kashiwagi, Y | 1 |
| Merola, G | 1 |
| Petillo, L | 1 |
| Ceribelli, A | 1 |
| Del Prete, S | 1 |
| De Placido, S | 1 |
| Wei, H | 1 |
| Hellström, KE | 1 |
| Hellström, I | 1 |
| Schneider, HB | 1 |
| Becker, H | 1 |
| Oelmann, E | 1 |
| Haghgu, S | 1 |
| Kulimova, E | 1 |
| Mesters, RM | 1 |
| Kienast, J | 1 |
| Herbst, H | 1 |
| Schmitmann, C | 1 |
| Kolkmeyer, A | 1 |
| Serve, H | 1 |
| Berdel, WE | 1 |
| Akbulut, H | 1 |
| Tang, Y | 1 |
| Maynard, J | 1 |
| Zhang, L | 1 |
| Pizzorno, G | 1 |
| Deisseroth, A | 1 |
| Bendell, JC | 1 |
| Lauwers, GY | 1 |
| Willett, C | 1 |
| Clark, JW | 1 |
| Warshaw, AL | 1 |
| Wain, JC | 1 |
| Ryan, DP | 1 |
| Wright, JD | 1 |
| Hagemann, A | 1 |
| Rader, JS | 1 |
| Viviano, D | 1 |
| Gibb, RK | 1 |
| Norris, L | 1 |
| Mutch, DG | 1 |
| Powell, MA | 1 |
| Pierard, S | 1 |
| Gregoire, V | 1 |
| Weynand, B | 1 |
| Machiels, JP | 1 |
| Hempling, RE | 1 |
| Piver, MS | 1 |
| Baker, TR | 1 |
| O'Neill Mullen, C | 1 |
| Griffin, TW | 1 |
| Hunter, RA | 1 |
| Cederbaum, AI | 1 |
| Tak, WK | 1 |
| Ward, AD | 1 |
| Schwartz, JH | 1 |
| Halpin, TF | 1 |
| Strauss, GM | 1 |
| Meyer, RN | 1 |
| Liepman, MK | 1 |
1 review available for fluorouracil and Epithelial Neoplasms
| Article | Year |
|---|---|
Impact of dihydropyrimidine dehydrogenase on 5-fluorouracil treatment in cancer patients.
Topics: Antimetabolites, Antineoplastic; Dermatitis; Diarrhea; Dihydropyrimidine Dehydrogenase Deficiency; D | 2003 |
3 trials available for fluorouracil and Epithelial Neoplasms
| Article | Year |
|---|---|
Capecitabine plus gemcitabine in thymic epithelial tumors: final analysis of a Phase II trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fluorouracil; G | 2014 |
Preliminary results of phase II study of capecitabine and gemcitabine (CAP-GEM) in patients with metastatic pretreated thymic epithelial tumors (TETs).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fl | 2010 |
Lack of activity of 5-fluorouracil plus mitomycin-C as salvage therapy in cisplatin-resistant epithelial ovarian cancer: results of a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; CA-125 Antigen; Cisp | 1994 |
13 other studies available for fluorouracil and Epithelial Neoplasms
| Article | Year |
|---|---|
Poorly differentiated carcinoma with neuroendocrine features in two patients with sinonasal tumours: a report of two cases.
Topics: Carcinoma; Carcinoma, Neuroendocrine; Fluorouracil; Humans; Male; Neoplasms, Glandular and Epithelia | 2022 |
Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation.
Topics: Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cisplatin; Docetaxel; Down-Regulation; Drug Resi | 2018 |
In vitro chemosensitivity assay of ascites in epithelial ovarian cancer.
Topics: Antineoplastic Agents; Ascites; Carboplatin; Carcinoma, Ovarian Epithelial; Coloring Agents; Deoxycy | 2013 |
Observation of ovarian cancer stem cell behavior and investigation of potential mechanisms of drug resistance in three-dimensional cell culture.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carboplatin; Carcinogenesis; Carcinoma, Ovarian Epithelia | 2014 |
Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Circadian Rhythm | 2015 |
Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy.
Topics: Aged; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Therapy; Enzyme Activation; Fem | 2008 |
Elafin selectively regulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Ovarian Epithelial; Caspase 3; Cell Line, Tumo | 2012 |
Influence of keratinocyte growth factor on clonal growth of epithelial tumor cells, lymphoma and leukemia cells and on sensitivity of tumor cells towards 5-fluorouracil in vitro.
Topics: Cell Differentiation; Cell Division; Cell Line, Tumor; Fibroblast Growth Factor 7; Fibroblast Growth | 2004 |
Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Camptothecin; Carboxylesterase; Cell Line, T | 2004 |
Pancreatoblastoma in a teenage patient.
Topics: Adolescent; alpha-Fetoproteins; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol | 2006 |
Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: A retrospective analysis.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Ant | 2006 |
Epithelial-myoepithelial carcinoma of the submandibular gland with symptomatic lung metastases treated with chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Combined Modality Therapy; Cyc | 2006 |
Treatment of advanced ovarian cancer with sequential combination chemotherapy.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamid | 1987 |