Page last updated: 2024-10-27

fluorouracil and Epilepsy

fluorouracil has been researched along with Epilepsy in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
" The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer."5.37[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011)
" We report the 1st case of capecitabine-induced toxic encephalopathy with epilepsy-like symptoms and diffuse white matter alterations on magnetic resonance imaging."3.72Toxic encephalopathy induced by capecitabine. ( Herrmann, R; Niemann, B; Pless, M; Rochlitz, C, 2004)
" The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer."1.37[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011)
"Phenytoin levels were subjected to analysis of variance and the dose effect was approached using a multiple comparison test."1.37Capecitabine-phenytoin interaction is dose dependent with an unexpected time course. ( de Los Ríos la Rosa, F; Privitera, M, 2011)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sakurai, M1
Kawahara, K1
Ueda, R1
Fukui, E1
Yamada, R1
Privitera, M1
de Los Ríos la Rosa, F1
Rosemergy, I1
Findlay, M1
Niemann, B1
Rochlitz, C1
Herrmann, R1
Pless, M1

Other Studies

4 other studies available for fluorouracil and Epilepsy

ArticleYear
[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:5

    Topics: Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycy

2011
Capecitabine-phenytoin interaction is dose dependent with an unexpected time course.
    Anti-cancer drugs, 2011, Volume: 22, Issue:10

    Topics: Aged; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Deoxycytidine; Dose-Re

2011
Phenytoin toxicity as a result of 5-fluorouracil administration.
    The New Zealand medical journal, 2002, Aug-09, Volume: 115, Issue:1159

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Drug Interactions; Epilepsy; Female; Fluorouracil;

2002
Toxic encephalopathy induced by capecitabine.
    Oncology, 2004, Volume: 66, Issue:4

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Epil

2004