fluorouracil has been researched along with Epilepsy in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer." | 5.37 | [A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011) |
| " We report the 1st case of capecitabine-induced toxic encephalopathy with epilepsy-like symptoms and diffuse white matter alterations on magnetic resonance imaging." | 3.72 | Toxic encephalopathy induced by capecitabine. ( Herrmann, R; Niemann, B; Pless, M; Rochlitz, C, 2004) |
| " The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer." | 1.37 | [A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011) |
| "Phenytoin levels were subjected to analysis of variance and the dose effect was approached using a multiple comparison test." | 1.37 | Capecitabine-phenytoin interaction is dose dependent with an unexpected time course. ( de Los Ríos la Rosa, F; Privitera, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakurai, M | 1 |
| Kawahara, K | 1 |
| Ueda, R | 1 |
| Fukui, E | 1 |
| Yamada, R | 1 |
| Privitera, M | 1 |
| de Los Ríos la Rosa, F | 1 |
| Rosemergy, I | 1 |
| Findlay, M | 1 |
| Niemann, B | 1 |
| Rochlitz, C | 1 |
| Herrmann, R | 1 |
| Pless, M | 1 |
4 other studies available for fluorouracil and Epilepsy
| Article | Year |
|---|---|
[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer].
Topics: Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycy | 2011 |
Capecitabine-phenytoin interaction is dose dependent with an unexpected time course.
Topics: Aged; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Deoxycytidine; Dose-Re | 2011 |
Phenytoin toxicity as a result of 5-fluorouracil administration.
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Drug Interactions; Epilepsy; Female; Fluorouracil; | 2002 |
Toxic encephalopathy induced by capecitabine.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Epil | 2004 |