fluorouracil has been researched along with Epidermolysis Bullosa in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Epidermolysis Bullosa: Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dystrophic epidermolysis bullosa is associated with a high incidence of cutaneous squamous cell carcinoma." | 2.38 | Squamous cell carcinoma in epidermolysis bullosa. Treatment with systemic chemotherapy. ( Lentz, SR; Marion, JM; Orlowski, EP; Raish, RJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Has, C | 1 |
| Burger, B | 1 |
| Volz, A | 1 |
| Kohlhase, J | 1 |
| Bruckner-Tuderman, L | 1 |
| Itin, P | 1 |
| Lentz, SR | 1 |
| Raish, RJ | 1 |
| Orlowski, EP | 1 |
| Marion, JM | 1 |
| Niehoff, M | 1 |
1 review available for fluorouracil and Epidermolysis Bullosa
| Article | Year |
|---|---|
Squamous cell carcinoma in epidermolysis bullosa. Treatment with systemic chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Catheterization, Ce | 1990 |
2 other studies available for fluorouracil and Epidermolysis Bullosa
| Article | Year |
|---|---|
Mild clinical phenotype of Kindler syndrome associated with late diagnosis and skin cancer.
Topics: Aged; Aminoquinolines; Antineoplastic Agents; Basement Membrane; Blister; Carcinoma, Basal Cell; Cry | 2010 |
[Case demonstration: Papillomatosis cutis carcinoides (Gottron) in epidermolysis bullosa dystrophica].
Topics: Adult; Bleomycin; Epidermolysis Bullosa; Female; Fluorouracil; Foot; Hand; Humans; Leg; Lymphadeniti | 1974 |