fluorouracil and Enteritis
fluorouracil has been researched along with Enteritis in 20 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Enteritis: Inflammation of any segment of the SMALL INTESTINE.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Objective To investigate the effect of hydroxychloroquine (HCQ) on 5-fluorouracil (5-FU)-induced enteritis in mice and its mechanism." | 7.96 | [Hydroxychloroquine alleviates 5-fluorouracil-induced enteritis in mice and its mechanism]. ( Li, X; Sun, E; Sun, Y; Zhang, J, 2020) |
" We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model." | 7.80 | Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model. ( Aihara, M; Asakura, M; Furukita, Y; Goto, M; Harada, N; Mawatari, K; Minato, T; Nakaya, Y; Nishino, T; Seike, J; Takechi, H; Takizawa, H; Tangoku, A; Yamai, H; Yamamoto, Y; Yoshida, T; Yuasa, Y, 2014) |
"Capecitabine is an oral 5-fluorouracil prodrug with antimetabolite activity commonly used in advanced colorectal and breast cancer." | 7.01 | Capecitabine-associated enterocolitis: Narrative literature review of a rare adverse event and a case presentation. ( Gomatou, G; Kanellis, G; Kotteas, EA; Lagou, S; Rapti, VE; Syrigos, NK; Trontzas, IP, 2023) |
"Radiation enteritis is the main acute side-effect during pelvic irradiation." | 5.34 | Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer. ( Bendahl, PO; Gunnlaugsson, A; Johnsson, A; Kjellén, E; Nilsson, P; Willner, J, 2007) |
" We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model." | 3.80 | Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model. ( Aihara, M; Asakura, M; Furukita, Y; Goto, M; Harada, N; Mawatari, K; Minato, T; Nakaya, Y; Nishino, T; Seike, J; Takechi, H; Takizawa, H; Tangoku, A; Yamai, H; Yamamoto, Y; Yoshida, T; Yuasa, Y, 2014) |
"Capecitabine is an oral 5-fluorouracil prodrug with antimetabolite activity commonly used in advanced colorectal and breast cancer." | 3.01 | Capecitabine-associated enterocolitis: Narrative literature review of a rare adverse event and a case presentation. ( Gomatou, G; Kanellis, G; Kotteas, EA; Lagou, S; Rapti, VE; Syrigos, NK; Trontzas, IP, 2023) |
"Transforming growth factor-beta1 is related to adverse events in radiochemotherapy." | 2.77 | Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant. ( Becker, H; Beissbarth, T; Brockmöller, J; Christiansen, H; Conradi, LC; Gaedcke, J; Ghadimi, M; Hennies, S; Herrmann, MK; Hess, CF; Jo, P; Mergler, CP; Rave-Fränk, M; Schirmer, MA; Wolff, HA, 2012) |
"Severe treatment-related diarrhea may result in chemotherapy discontinuation." | 1.51 | Fluoropyrimidine-induced intestinal mucosal injury is associated with the severity of chemotherapy-related diarrhea. ( Goto, M; Harada, S; Higuchi, K; Hirata, Y; Kakimoto, K; Kii, T; Kojima, Y; Ota, K; Ozaki, H; Sugawara, N; Takeuchi, T; Terazawa, T; Yamaguchi, T, 2019) |
" Emu Oil combined with Lyprinol™ partially reduced acute small intestinal inflammation." | 1.43 | Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis. ( Bajic, JE; Cheah, KY; Eden, GL; Howarth, GS; Lampton, LS; Lymn, KA; Mashtoub, S, 2016) |
"Radiation enteritis is the main acute side-effect during pelvic irradiation." | 1.34 | Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer. ( Bendahl, PO; Gunnlaugsson, A; Johnsson, A; Kjellén, E; Nilsson, P; Willner, J, 2007) |
Research
Studies (20)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (15.00) | 18.7374 |
1990's | 2 (10.00) | 18.2507 |
2000's | 4 (20.00) | 29.6817 |
2010's | 9 (45.00) | 24.3611 |
2020's | 2 (10.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Trontzas, IP | 1 |
Rapti, VE | 1 |
Syrigos, NK | 1 |
Gomatou, G | 1 |
Lagou, S | 1 |
Kanellis, G | 1 |
Kotteas, EA | 1 |
Sun, Y | 1 |
Zhang, J | 1 |
Li, X | 1 |
Sun, E | 1 |
Ota, K | 1 |
Takeuchi, T | 1 |
Kojima, Y | 1 |
Harada, S | 1 |
Ozaki, H | 1 |
Sugawara, N | 1 |
Hirata, Y | 1 |
Yamaguchi, T | 1 |
Terazawa, T | 1 |
Kakimoto, K | 1 |
Kii, T | 1 |
Goto, M | 2 |
Higuchi, K | 1 |
Gurzu, S | 1 |
Jung, I | 1 |
Comsulea, M | 1 |
Kadar, Z | 1 |
Azamfirei, L | 1 |
Molnar, C | 1 |
Takechi, H | 1 |
Mawatari, K | 1 |
Harada, N | 1 |
Nakaya, Y | 1 |
Asakura, M | 1 |
Aihara, M | 1 |
Takizawa, H | 1 |
Nishino, T | 1 |
Minato, T | 1 |
Furukita, Y | 1 |
Yamamoto, Y | 1 |
Yuasa, Y | 1 |
Yamai, H | 1 |
Yoshida, T | 1 |
Seike, J | 1 |
Tangoku, A | 1 |
Dzhugashvili, M | 1 |
Luengo-Gil, G | 1 |
García, T | 1 |
González-Conejero, R | 1 |
Conesa-Zamora, P | 1 |
Escolar, PP | 1 |
Calvo, F | 1 |
Vicente, V | 1 |
Ayala de la Peña, F | 1 |
Mashtoub, S | 1 |
Lampton, LS | 1 |
Eden, GL | 1 |
Cheah, KY | 1 |
Lymn, KA | 1 |
Bajic, JE | 1 |
Howarth, GS | 1 |
Wolff, HA | 3 |
Gaedcke, J | 2 |
Jung, K | 2 |
Hermann, RM | 1 |
Rothe, H | 1 |
Schirmer, M | 1 |
Liersch, T | 1 |
Herrmann, MKA | 1 |
Hennies, S | 3 |
Rave-Fränk, M | 2 |
Hess, CF | 3 |
Christiansen, H | 3 |
Kim, CW | 1 |
Kim, JH | 1 |
Yu, CS | 1 |
Shin, US | 1 |
Park, JS | 1 |
Jung, KY | 1 |
Kim, TW | 1 |
Yoon, SN | 1 |
Lim, SB | 1 |
Kim, JC | 1 |
Raus, I | 1 |
Schüler, P | 1 |
Herrmann, MK | 2 |
Vorwerk, H | 1 |
Hille, A | 1 |
Schirmer, MA | 1 |
Mergler, CP | 1 |
Conradi, LC | 1 |
Jo, P | 1 |
Beissbarth, T | 1 |
Becker, H | 1 |
Ghadimi, M | 1 |
Brockmöller, J | 1 |
Ottewell, PD | 1 |
Duckworth, CA | 1 |
Varro, A | 1 |
Dimaline, R | 1 |
Wang, TC | 1 |
Watson, AJ | 1 |
Dockray, GJ | 1 |
Pritchard, DM | 1 |
Gunnlaugsson, A | 1 |
Kjellén, E | 1 |
Nilsson, P | 1 |
Bendahl, PO | 1 |
Willner, J | 1 |
Johnsson, A | 1 |
Theodossiou, C | 1 |
Temeck, B | 1 |
Vargas, H | 1 |
Yang, J | 1 |
Vargas, M | 1 |
Hahn, S | 1 |
Pass, H | 1 |
Tavakkolizadeh, A | 1 |
Shen, R | 1 |
Abraham, P | 1 |
Kormi, N | 1 |
Seifert, P | 1 |
Edelman, ER | 1 |
Jacobs, DO | 1 |
Zinner, MJ | 1 |
Ashley, SW | 1 |
Whang, EE | 1 |
Yu, J | 1 |
Jiang, Z | 1 |
Li, D | 1 |
Yang, N | 1 |
Bai, M | 1 |
Huang, FS | 1 |
Kemp, CJ | 1 |
Williams, JL | 1 |
Erwin, CR | 1 |
Warner, BW | 1 |
Anderson, N | 1 |
Lokich, J | 1 |
Bern, M | 1 |
Wallach, S | 1 |
Moore, C | 1 |
Williams, D | 1 |
Umprayn, V | 1 |
Bounous, G | 1 |
Hugon, J | 1 |
Gentile, JM | 1 |
Brincker, H | 1 |
Clinical Trials (2)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Translational Validation Study to Examine KFO179-1 Biomarker Scores for the Prediction and Prognosis of Advanced Primary Resectable Rectal Cancer Stages UICC II-IV, With a 5-FU-based Standard Radiochemotherapy Followed by Total Mesorectal Excision.[NCT03034473] | 200 participants (Actual) | Interventional | 2011-08-31 | Active, not recruiting | |||
Prospective Randomised Multicenter Phase-III-study: Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil Plus Oxaliplatin Versus Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil for Locally Advanced Rect[NCT00349076] | Phase 3 | 1,256 participants (Actual) | Interventional | 2006-07-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
1 review available for fluorouracil and Enteritis
Article | Year |
---|---|
Capecitabine-associated enterocolitis: Narrative literature review of a rare adverse event and a case presentation.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Enteritis; Enterocolitis; Fluorouracil | 2023 |
Trials
1 trial available for fluorouracil and Enteritis
Article | Year |
---|---|
Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; C | 2012 |
Other Studies
18 other studies available for fluorouracil and Enteritis
Article | Year |
---|---|
[Hydroxychloroquine alleviates 5-fluorouracil-induced enteritis in mice and its mechanism].
Topics: Animals; Cell Line, Tumor; Dendritic Cells; Enteritis; Fluorouracil; Humans; Hydroxychloroquine; Int | 2020 |
Fluoropyrimidine-induced intestinal mucosal injury is associated with the severity of chemotherapy-related diarrhea.
Topics: Administration, Intravenous; Administration, Oral; Adult; Antineoplastic Agents; Capsule Endoscopy; | 2019 |
Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman.
Topics: Acute Disease; Adenocarcinoma; Adult; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protoco | 2013 |
Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model.
Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Dietary Fib | 2014 |
Role of genetic polymorphisms in NFKB-mediated inflammatory pathways in response to primary chemoradiation therapy for rectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Capecitabine; Chemoradiotherapy; Cyclooxygenase 1; Cyclooxygenase 2; | 2014 |
Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Biomarkers; Dasyp | 2016 |
High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathologic tumor regression in multimodal treatment of locally advanced rectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap | 2010 |
Complications after sphincter-saving resection in rectal cancer patients according to whether chemoradiotherapy is performed before or after surgery.
Topics: Adenocarcinoma; Adult; Aged; Anal Canal; Anastomosis, Surgical; Antineoplastic Combined Chemotherapy | 2010 |
High-grade acute organ toxicity as a positive prognostic factor in primary radiochemotherapy for anal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols | 2011 |
Gastrin increases murine intestinal crypt regeneration following injury.
Topics: Animals; Benzodiazepinones; Cell Line; Cell Proliferation; Colitis; Dextran Sulfate; Enteritis; Enzy | 2006 |
Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Dose Fractionation, Radiation; Dose-R | 2007 |
Cytomegalovirus enteritis after treatment with 5-fluorouracil, leukovorin, cisplatin, and alpha-interferon.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytomegalovirus Infections; Enteritis; Es | 1995 |
Glucagon-like peptide 2: a new treatment for chemotherapy-induced enteritis.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Bromodeoxyuridine; Enteritis; Fluorouracil; G | 2000 |
[Alanyl-glutamine dipeptides protected the liver function by increasing the hepatic glutathione].
Topics: Animals; Dipeptides; Enteritis; Fluorouracil; Glutathione; Liver; Liver Function Tests; Male; Parent | 1998 |
Role of epidermal growth factor and its receptor in chemotherapy-induced intestinal injury.
Topics: Animals; Antineoplastic Agents; Enteritis; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Ge | 2002 |
Combined 5-fluorouracil and floxuridine administered as a 14-day infusion. A phase I study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Catheterization, Central V | 1989 |
Elemental diet in the management of the intestinal lesion produced by 5-fluorouracil in the rat.
Topics: Alkaline Phosphatase; Amino Acids; Animals; Blood Cell Count; Body Weight; Depression, Chemical; Die | 1971 |
[Combined cytostatic treatment of solid tumours with cyclophosphamide (Endoxan), vincristine, methylaminopterin (Methotrexate) and 5-fluorouracil].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow; Child; Child, Preschool; Cyclophosphami | 1971 |