Page last updated: 2024-10-27

fluorouracil and Enteritis

fluorouracil has been researched along with Enteritis in 20 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Enteritis: Inflammation of any segment of the SMALL INTESTINE.

Research Excerpts

ExcerptRelevanceReference
"Objective To investigate the effect of hydroxychloroquine (HCQ) on 5-fluorouracil (5-FU)-induced enteritis in mice and its mechanism."7.96[Hydroxychloroquine alleviates 5-fluorouracil-induced enteritis in mice and its mechanism]. ( Li, X; Sun, E; Sun, Y; Zhang, J, 2020)
" We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model."7.80Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model. ( Aihara, M; Asakura, M; Furukita, Y; Goto, M; Harada, N; Mawatari, K; Minato, T; Nakaya, Y; Nishino, T; Seike, J; Takechi, H; Takizawa, H; Tangoku, A; Yamai, H; Yamamoto, Y; Yoshida, T; Yuasa, Y, 2014)
"Capecitabine is an oral 5-fluorouracil prodrug with antimetabolite activity commonly used in advanced colorectal and breast cancer."7.01Capecitabine-associated enterocolitis: Narrative literature review of a rare adverse event and a case presentation. ( Gomatou, G; Kanellis, G; Kotteas, EA; Lagou, S; Rapti, VE; Syrigos, NK; Trontzas, IP, 2023)
"Radiation enteritis is the main acute side-effect during pelvic irradiation."5.34Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer. ( Bendahl, PO; Gunnlaugsson, A; Johnsson, A; Kjellén, E; Nilsson, P; Willner, J, 2007)
" We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model."3.80Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model. ( Aihara, M; Asakura, M; Furukita, Y; Goto, M; Harada, N; Mawatari, K; Minato, T; Nakaya, Y; Nishino, T; Seike, J; Takechi, H; Takizawa, H; Tangoku, A; Yamai, H; Yamamoto, Y; Yoshida, T; Yuasa, Y, 2014)
"Capecitabine is an oral 5-fluorouracil prodrug with antimetabolite activity commonly used in advanced colorectal and breast cancer."3.01Capecitabine-associated enterocolitis: Narrative literature review of a rare adverse event and a case presentation. ( Gomatou, G; Kanellis, G; Kotteas, EA; Lagou, S; Rapti, VE; Syrigos, NK; Trontzas, IP, 2023)
"Transforming growth factor-beta1 is related to adverse events in radiochemotherapy."2.77Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant. ( Becker, H; Beissbarth, T; Brockmöller, J; Christiansen, H; Conradi, LC; Gaedcke, J; Ghadimi, M; Hennies, S; Herrmann, MK; Hess, CF; Jo, P; Mergler, CP; Rave-Fränk, M; Schirmer, MA; Wolff, HA, 2012)
"Severe treatment-related diarrhea may result in chemotherapy discontinuation."1.51Fluoropyrimidine-induced intestinal mucosal injury is associated with the severity of chemotherapy-related diarrhea. ( Goto, M; Harada, S; Higuchi, K; Hirata, Y; Kakimoto, K; Kii, T; Kojima, Y; Ota, K; Ozaki, H; Sugawara, N; Takeuchi, T; Terazawa, T; Yamaguchi, T, 2019)
" Emu Oil combined with Lyprinol™ partially reduced acute small intestinal inflammation."1.43Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis. ( Bajic, JE; Cheah, KY; Eden, GL; Howarth, GS; Lampton, LS; Lymn, KA; Mashtoub, S, 2016)
"Radiation enteritis is the main acute side-effect during pelvic irradiation."1.34Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer. ( Bendahl, PO; Gunnlaugsson, A; Johnsson, A; Kjellén, E; Nilsson, P; Willner, J, 2007)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.00)18.7374
1990's2 (10.00)18.2507
2000's4 (20.00)29.6817
2010's9 (45.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Trontzas, IP1
Rapti, VE1
Syrigos, NK1
Gomatou, G1
Lagou, S1
Kanellis, G1
Kotteas, EA1
Sun, Y1
Zhang, J1
Li, X1
Sun, E1
Ota, K1
Takeuchi, T1
Kojima, Y1
Harada, S1
Ozaki, H1
Sugawara, N1
Hirata, Y1
Yamaguchi, T1
Terazawa, T1
Kakimoto, K1
Kii, T1
Goto, M2
Higuchi, K1
Gurzu, S1
Jung, I1
Comsulea, M1
Kadar, Z1
Azamfirei, L1
Molnar, C1
Takechi, H1
Mawatari, K1
Harada, N1
Nakaya, Y1
Asakura, M1
Aihara, M1
Takizawa, H1
Nishino, T1
Minato, T1
Furukita, Y1
Yamamoto, Y1
Yuasa, Y1
Yamai, H1
Yoshida, T1
Seike, J1
Tangoku, A1
Dzhugashvili, M1
Luengo-Gil, G1
García, T1
González-Conejero, R1
Conesa-Zamora, P1
Escolar, PP1
Calvo, F1
Vicente, V1
Ayala de la Peña, F1
Mashtoub, S1
Lampton, LS1
Eden, GL1
Cheah, KY1
Lymn, KA1
Bajic, JE1
Howarth, GS1
Wolff, HA3
Gaedcke, J2
Jung, K2
Hermann, RM1
Rothe, H1
Schirmer, M1
Liersch, T1
Herrmann, MKA1
Hennies, S3
Rave-Fränk, M2
Hess, CF3
Christiansen, H3
Kim, CW1
Kim, JH1
Yu, CS1
Shin, US1
Park, JS1
Jung, KY1
Kim, TW1
Yoon, SN1
Lim, SB1
Kim, JC1
Raus, I1
Schüler, P1
Herrmann, MK2
Vorwerk, H1
Hille, A1
Schirmer, MA1
Mergler, CP1
Conradi, LC1
Jo, P1
Beissbarth, T1
Becker, H1
Ghadimi, M1
Brockmöller, J1
Ottewell, PD1
Duckworth, CA1
Varro, A1
Dimaline, R1
Wang, TC1
Watson, AJ1
Dockray, GJ1
Pritchard, DM1
Gunnlaugsson, A1
Kjellén, E1
Nilsson, P1
Bendahl, PO1
Willner, J1
Johnsson, A1
Theodossiou, C1
Temeck, B1
Vargas, H1
Yang, J1
Vargas, M1
Hahn, S1
Pass, H1
Tavakkolizadeh, A1
Shen, R1
Abraham, P1
Kormi, N1
Seifert, P1
Edelman, ER1
Jacobs, DO1
Zinner, MJ1
Ashley, SW1
Whang, EE1
Yu, J1
Jiang, Z1
Li, D1
Yang, N1
Bai, M1
Huang, FS1
Kemp, CJ1
Williams, JL1
Erwin, CR1
Warner, BW1
Anderson, N1
Lokich, J1
Bern, M1
Wallach, S1
Moore, C1
Williams, D1
Umprayn, V1
Bounous, G1
Hugon, J1
Gentile, JM1
Brincker, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Translational Validation Study to Examine KFO179-1 Biomarker Scores for the Prediction and Prognosis of Advanced Primary Resectable Rectal Cancer Stages UICC II-IV, With a 5-FU-based Standard Radiochemotherapy Followed by Total Mesorectal Excision.[NCT03034473]200 participants (Actual)Interventional2011-08-31Active, not recruiting
Prospective Randomised Multicenter Phase-III-study: Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil Plus Oxaliplatin Versus Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil for Locally Advanced Rect[NCT00349076]Phase 31,256 participants (Actual)Interventional2006-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Enteritis

ArticleYear
Capecitabine-associated enterocolitis: Narrative literature review of a rare adverse event and a case presentation.
    Journal of chemotherapy (Florence, Italy), 2023, Volume: 35, Issue:1

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Enteritis; Enterocolitis; Fluorouracil

2023

Trials

1 trial available for fluorouracil and Enteritis

ArticleYear
Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.
    International journal of radiation oncology, biology, physics, 2012, May-01, Volume: 83, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; C

2012

Other Studies

18 other studies available for fluorouracil and Enteritis

ArticleYear
[Hydroxychloroquine alleviates 5-fluorouracil-induced enteritis in mice and its mechanism].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2020, Volume: 36, Issue:1

    Topics: Animals; Cell Line, Tumor; Dendritic Cells; Enteritis; Fluorouracil; Humans; Hydroxychloroquine; Int

2020
Fluoropyrimidine-induced intestinal mucosal injury is associated with the severity of chemotherapy-related diarrhea.
    Scandinavian journal of gastroenterology, 2019, Volume: 54, Issue:2

    Topics: Administration, Intravenous; Administration, Oral; Adult; Antineoplastic Agents; Capsule Endoscopy;

2019
Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman.
    Diagnostic pathology, 2013, Sep-16, Volume: 8

    Topics: Acute Disease; Adenocarcinoma; Adult; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protoco

2013
Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model.
    The journal of medical investigation : JMI, 2014, Volume: 61, Issue:1-2

    Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Dietary Fib

2014
Role of genetic polymorphisms in NFKB-mediated inflammatory pathways in response to primary chemoradiation therapy for rectal cancer.
    International journal of radiation oncology, biology, physics, 2014, Nov-01, Volume: 90, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Capecitabine; Chemoradiotherapy; Cyclooxygenase 1; Cyclooxygenase 2;

2014
Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis.
    Nutrition and cancer, 2016, Volume: 68, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Biomarkers; Dasyp

2016
High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathologic tumor regression in multimodal treatment of locally advanced rectal cancer.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2010, Volume: 186, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap

2010
Complications after sphincter-saving resection in rectal cancer patients according to whether chemoradiotherapy is performed before or after surgery.
    International journal of radiation oncology, biology, physics, 2010, Sep-01, Volume: 78, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Anal Canal; Anastomosis, Surgical; Antineoplastic Combined Chemotherapy

2010
High-grade acute organ toxicity as a positive prognostic factor in primary radiochemotherapy for anal carcinoma.
    International journal of radiation oncology, biology, physics, 2011, Apr-01, Volume: 79, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols

2011
Gastrin increases murine intestinal crypt regeneration following injury.
    Gastroenterology, 2006, Volume: 130, Issue:4

    Topics: Animals; Benzodiazepinones; Cell Line; Cell Proliferation; Colitis; Dextran Sulfate; Enteritis; Enzy

2006
Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer.
    Acta oncologica (Stockholm, Sweden), 2007, Volume: 46, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Dose Fractionation, Radiation; Dose-R

2007
Cytomegalovirus enteritis after treatment with 5-fluorouracil, leukovorin, cisplatin, and alpha-interferon.
    The American journal of gastroenterology, 1995, Volume: 90, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytomegalovirus Infections; Enteritis; Es

1995
Glucagon-like peptide 2: a new treatment for chemotherapy-induced enteritis.
    The Journal of surgical research, 2000, Jun-01, Volume: 91, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Bromodeoxyuridine; Enteritis; Fluorouracil; G

2000
[Alanyl-glutamine dipeptides protected the liver function by increasing the hepatic glutathione].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1998, Volume: 20, Issue:2

    Topics: Animals; Dipeptides; Enteritis; Fluorouracil; Glutathione; Liver; Liver Function Tests; Male; Parent

1998
Role of epidermal growth factor and its receptor in chemotherapy-induced intestinal injury.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 282, Issue:3

    Topics: Animals; Antineoplastic Agents; Enteritis; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Ge

2002
Combined 5-fluorouracil and floxuridine administered as a 14-day infusion. A phase I study.
    Cancer, 1989, Mar-01, Volume: 63, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Catheterization, Central V

1989
Elemental diet in the management of the intestinal lesion produced by 5-fluorouracil in the rat.
    Canadian journal of surgery. Journal canadien de chirurgie, 1971, Volume: 14, Issue:5

    Topics: Alkaline Phosphatase; Amino Acids; Animals; Blood Cell Count; Body Weight; Depression, Chemical; Die

1971
[Combined cytostatic treatment of solid tumours with cyclophosphamide (Endoxan), vincristine, methylaminopterin (Methotrexate) and 5-fluorouracil].
    Ugeskrift for laeger, 1971, May-14, Volume: 133, Issue:19

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow; Child; Child, Preschool; Cyclophosphami

1971
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