fluorouracil has been researched along with Enlarged Spleen in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated development of splenomegaly and its association with treatment outcome and genetic polymorphisms following adjuvant 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) in colorectal cancer (CRC) patients." | 3.83 | Splenomegaly and Its Associations with Genetic Polymorphisms and Treatment Outcome in Colorectal Cancer Patients Treated with Adjuvant FOLFOX. ( Bang, YJ; Cha, Y; Han, SW; Im, SA; Kim, MJ; Kim, SH; Kim, TY; Lee, DW; Lee, KH; Oh, DY, 2016) |
| "Stage II-III colorectal cancer patients treated with adjuvant FOLFOX or fluorouracil/leucovorin (5-FU/LV) at Roswell Park Cancer Institute between 2002 and 2006 were identified." | 3.75 | Adjuvant FOLFOX chemotherapy and splenomegaly in patients with stages II-III colorectal cancer. ( Angitapalli, R; Fakih, MG; Kumar, PR; Litwin, AM; Lombardo, J; Mashtare, T; Nasser, E; Wilding, GE, 2009) |
| "We report a case of advanced rectal cancer treated with chemotherapy, for which laparoscopic splenectomy had been effective for thrombocytopenia." | 1.39 | [Successful management using laparoscopic splenectomy for splenomegaly and thrombocytopenia caused by oxaliplatin-based chemotherapy for advanced rectal cancer]. ( Arita, S; Koike, N; Ohshima, Y; Shinozaki, E; Takeuchi, T, 2013) |
| "Furthermore pathogenesis of liver fibrosis is not well known." | 1.39 | A case of liver fibrosis with splenomegaly after oxaliplatin-based adjuvant chemotherapy for colon cancer. ( Jeong, HY; Kang, DY; Kang, GH; Kim, SH; Lee, BS; Lee, ES; Lee, HY; Moon, HS; Sung, JK, 2013) |
| " The incidences of grade 3 or 4 adverse events and grade 2 or greater histopathological sinusoidal injury were significantly higher in the SVI ≥ +30% than in the SVI < +30% group." | 1.37 | Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy. ( Arai, T; Kobayashi, S; Koike, J; Koizumi, S; Makizumi, R; Miura, K; Miyajima, N; Nakano, H; Otsubo, T; Sakurai, J; Shimamura, T; Yamada, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koike, N | 1 |
| Ohshima, Y | 1 |
| Takeuchi, T | 1 |
| Arita, S | 1 |
| Shinozaki, E | 1 |
| Kang, GH | 1 |
| Moon, HS | 1 |
| Lee, ES | 1 |
| Kim, SH | 2 |
| Sung, JK | 1 |
| Lee, BS | 1 |
| Jeong, HY | 1 |
| Lee, HY | 1 |
| Kang, DY | 1 |
| Aksinenko, SG | 1 |
| Suslov, NI | 1 |
| Povet'eva, TN | 1 |
| Nesterova, YV | 1 |
| Kharina, TG | 1 |
| Kravtsova, SS | 1 |
| Kim, MJ | 1 |
| Han, SW | 1 |
| Lee, DW | 1 |
| Cha, Y | 1 |
| Lee, KH | 1 |
| Kim, TY | 2 |
| Oh, DY | 1 |
| Im, SA | 1 |
| Bang, YJ | 1 |
| Angitapalli, R | 1 |
| Litwin, AM | 1 |
| Kumar, PR | 1 |
| Nasser, E | 1 |
| Lombardo, J | 1 |
| Mashtare, T | 1 |
| Wilding, GE | 1 |
| Fakih, MG | 1 |
| Miura, K | 1 |
| Nakano, H | 1 |
| Sakurai, J | 1 |
| Kobayashi, S | 1 |
| Koizumi, S | 1 |
| Arai, T | 1 |
| Shimamura, T | 1 |
| Makizumi, R | 1 |
| Yamada, K | 1 |
| Miyajima, N | 1 |
| Otsubo, T | 1 |
| Koike, J | 1 |
| Toi, H | 1 |
| Morita, T | 1 |
| Nakamura, T | 1 |
| Muranaga, S | 1 |
| Hase, T | 1 |
| CHIRIGOS, MA | 1 |
| RAUSCHER, FJ | 1 |
| KAMEL, IA | 1 |
| FANNING, GR | 1 |
| GOLDIN, A | 1 |
8 other studies available for fluorouracil and Enlarged Spleen
| Article | Year |
|---|---|
[Successful management using laparoscopic splenectomy for splenomegaly and thrombocytopenia caused by oxaliplatin-based chemotherapy for advanced rectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Fatal Outcome; Fluorouracil; Humans; Laparoscopy; Le | 2013 |
A case of liver fibrosis with splenomegaly after oxaliplatin-based adjuvant chemotherapy for colon cancer.
Topics: Actins; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Coloni | 2013 |
Antitoxic Activity of Extract from Salix Viminalis Leaves under Conditions of 5-Fluorouracil Treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Bone Marrow; Carcinoma, Lewis Lung; Cyto | 2015 |
Splenomegaly and Its Associations with Genetic Polymorphisms and Treatment Outcome in Colorectal Cancer Patients Treated with Adjuvant FOLFOX.
Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Co | 2016 |
Adjuvant FOLFOX chemotherapy and splenomegaly in patients with stages II-III colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; | 2009 |
Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy.
Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Comb | 2011 |
[Splenomegaly Associated with FOLFOX Therapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Leucovorin; Male | 2011 |
STUDIES WITH THE MURINE LEUKEMOGENIC RAUSCHER VIRUS. II. CHEMOTHERAPY OF VIRUS-INDUCED LYMPHOID LEUKEMIA.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cyclophosphamide; Fluorouracil; Leukemia; Leukemia | 1963 |