fluorouracil has been researched along with Enlarged Liver in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After perioperative adjuvant chemotherapy of a sigma-adenocarcinoma with 400 mg peptichemio and 500 mg 5-fluorouracil a 61-year-old woman developed a severe intoxication: myelosuppression with pancytopenia, gastroenteritis and ulcerative proctitis, toxic hepato- and myocardiopathy, impaired renal function and alopecia." | 7.66 | [Severe intoxication after combined chemotherapy of a sigma-adenocarcinoma with peptichemio and 5-fluorouracil (author's transl)]. ( Gasser, RW; Schmalzl, F, 1982) |
| "After perioperative adjuvant chemotherapy of a sigma-adenocarcinoma with 400 mg peptichemio and 500 mg 5-fluorouracil a 61-year-old woman developed a severe intoxication: myelosuppression with pancytopenia, gastroenteritis and ulcerative proctitis, toxic hepato- and myocardiopathy, impaired renal function and alopecia." | 3.66 | [Severe intoxication after combined chemotherapy of a sigma-adenocarcinoma with peptichemio and 5-fluorouracil (author's transl)]. ( Gasser, RW; Schmalzl, F, 1982) |
| " Increasing ascites requiring repeated paracentesis had not responded to chemotherapy including infusion of 5-fluorouracil and vincristine into the coeliac artery." | 3.65 | Carcinoid heart disease: successful tricuspid valve replacement. ( Honey, M; Paneth, M, 1975) |
| "route." | 2.64 | A double-blind comparison of intensive course 5-flourouracil by oral vs. intravenous route in the treatment of colorectal carcinoma. ( Bruckner, HW; Hahn, RG; Moertel, CG; Schutt, AJ, 1975) |
| "Presence of hepatomegaly emerged as the more significant (P = 0." | 1.28 | Prognostic factors in patients with liver metastases from colorectal carcinoma treated with discontinuous intra-arterial hepatic chemotherapy. ( Ducreux, M; Elias, D; Lasser, PH; Lumbroso, J; Pignon, JP; Rougier, P; Ruffie, P; Tigaud, JM, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GREENSPAN, EM | 1 |
| Han, HS | 1 |
| Park, SR | 1 |
| Kim, SY | 1 |
| Park, YI | 1 |
| Lee, JS | 1 |
| Kook, MC | 1 |
| Choi, IJ | 1 |
| Kim, CG | 1 |
| Lee, JR | 1 |
| Cho, SJ | 1 |
| Kim, NK | 1 |
| Gasser, RW | 1 |
| Schmalzl, F | 1 |
| Hahn, RG | 1 |
| Moertel, CG | 1 |
| Schutt, AJ | 1 |
| Bruckner, HW | 1 |
| Honey, M | 1 |
| Paneth, M | 1 |
| Rougier, P | 1 |
| Ducreux, M | 1 |
| Pignon, JP | 1 |
| Elias, D | 1 |
| Tigaud, JM | 1 |
| Lumbroso, J | 1 |
| Ruffie, P | 1 |
| Lasser, PH | 1 |
| Champeau, M | 1 |
| Arsac, M | 1 |
| Pineau, P | 1 |
| Bessot, M | 1 |
| Thevenin, F | 1 |
| Fays, J | 1 |
| Grilliat, JP | 1 |
| Anderson, JM | 1 |
| Linder, GT | 1 |
| Crook, JN | 1 |
| Cohn, I | 1 |
1 trial available for fluorouracil and Enlarged Liver
| Article | Year |
|---|---|
A double-blind comparison of intensive course 5-flourouracil by oral vs. intravenous route in the treatment of colorectal carcinoma.
Topics: Adenocarcinoma; Administration, Oral; Clinical Trials as Topic; Colonic Neoplasms; Evaluation Studie | 1975 |
9 other studies available for fluorouracil and Enlarged Liver
| Article | Year |
|---|---|
REGRESSION OF METASTATIC HEPATOMEGALY FROM MAMMARY CARCINOMA. CYTOTOXIC COMBINATION CHEMOTHERAPY WITH 5-FU.
Topics: Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Hepatomegaly; Humans; L | 1964 |
Tumor lysis syndrome after capecitabine plus cisplatin treatment in advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoco | 2008 |
[Severe intoxication after combined chemotherapy of a sigma-adenocarcinoma with peptichemio and 5-fluorouracil (author's transl)].
Topics: Adenocarcinoma; Alopecia; Candidiasis, Oral; Diarrhea; Female; Fluorouracil; Hepatomegaly; Humans; M | 1982 |
Carcinoid heart disease: successful tricuspid valve replacement.
Topics: Adult; Ascites; Carcinoid Heart Disease; Carcinoid Tumor; Cardiac Catheterization; Edema; Female; Fl | 1975 |
Prognostic factors in patients with liver metastases from colorectal carcinoma treated with discontinuous intra-arterial hepatic chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Female; Fluorouracil; Gastrointestinal Diseases; Hep | 1991 |
[Primary cancer of the liver in a child detected by angiography and treated by exeresis and antimitotics].
Topics: Adolescent; Angiography; Carcinoma, Hepatocellular; Cholangiography; Diagnosis, Differential; Echino | 1968 |
[Apropos of a hepatoma: rôle of regional chemotherapy].
Topics: Adult; Carcinoma, Hepatocellular; Fluorouracil; Hepatomegaly; Humans; Liver Neoplasms; Male; Perfusi | 1968 |
Infusion of liver tumours.
Topics: Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Hepatomegaly; Hum | 1968 |
Primary liver carcinoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Biopsy; Bone Neoplasms; Carcinoma, Hepatocellular; | 1974 |