fluorouracil has been researched along with Endophthalmitis in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Endophthalmitis: Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy." | 7.68 | Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. ( Liebmann, JM; Marmor, M; Ritch, R; Sassani, JW; Speaker, M; Wolner, B, 1991) |
| "With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections." | 4.82 | Glaucoma-filtering bleb infections. ( Mac, I; Soltau, JB, 2003) |
| "Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU)." | 3.91 | Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. ( Ayyala, RS; Blake, D; Fullerton, M; Greenberg, E; John, V; Le, C; Mancera, N; Margo, C; Muddasani, N; Satija, C; Singh, S; Swann, FB; Wall, J; Zhang, Z; Zurakowski, D, 2019) |
| "The use of adjunctive antimetabolites such as 5-fluorouracil (5-FU) and mitomycin C (MMC) in trabeculectomy has caused an increased concern as to the risk of bleb-associated endophthalmitis." | 3.70 | Late-onset, bleb-associated endophthalmitis following glaucoma filtering surgery with or without antifibrotic agents. ( Frucht-Pery, J; Solomon, A; Ticho, U, 1999) |
| "The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy." | 3.68 | Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. ( Liebmann, JM; Marmor, M; Ritch, R; Sassani, JW; Speaker, M; Wolner, B, 1991) |
| "The mean follow-up time after treatment for endophthalmitis was 6." | 2.41 | Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes. ( Budenz, DL; Flynn, HW; Scott, IU; Song, A, 2002) |
| "The recurrent Candida infection affected primarily the iris and lens, rather than the retina and choroid." | 1.31 | Recurrent endogenous candidal endophthalmitis in a premature infant. ( Calvano, C; Simon, JW; Stern, JH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Swann, FB | 1 |
| Singh, S | 1 |
| Blake, D | 1 |
| John, V | 1 |
| Le, C | 1 |
| Fullerton, M | 1 |
| Margo, C | 1 |
| Zhang, Z | 1 |
| Muddasani, N | 1 |
| Wall, J | 1 |
| Satija, C | 1 |
| Greenberg, E | 1 |
| Mancera, N | 1 |
| Zurakowski, D | 1 |
| Ayyala, RS | 1 |
| Zahid, S | 1 |
| Musch, DC | 1 |
| Niziol, LM | 1 |
| Lichter, PR | 1 |
| Mac, I | 1 |
| Soltau, JB | 1 |
| Rockwood, EJ | 1 |
| Parrish, R | 1 |
| Minckler, D | 1 |
| Solomon, A | 1 |
| Ticho, U | 1 |
| Frucht-Pery, J | 1 |
| Lehmann, OJ | 1 |
| Bunce, C | 1 |
| Matheson, MM | 1 |
| Maurino, V | 1 |
| Khaw, PT | 1 |
| Wormald, R | 1 |
| Barton, K | 1 |
| Stern, JH | 1 |
| Calvano, C | 1 |
| Simon, JW | 1 |
| Song, A | 1 |
| Scott, IU | 1 |
| Flynn, HW | 1 |
| Budenz, DL | 1 |
| Wolner, B | 1 |
| Liebmann, JM | 1 |
| Sassani, JW | 1 |
| Ritch, R | 1 |
| Speaker, M | 1 |
| Marmor, M | 1 |
2 reviews available for fluorouracil and Endophthalmitis
| Article | Year |
|---|---|
Glaucoma-filtering bleb infections.
Topics: Anti-Bacterial Agents; Drug Administration Schedule; Endophthalmitis; Fibrosis; Filtering Surgery; F | 2003 |
Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Bacteria; Endophthalmitis; Eye Infections, Bacteri | 2002 |
1 trial available for fluorouracil and Endophthalmitis
| Article | Year |
|---|---|
Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
Topics: Antimetabolites; Cataract Extraction; Endophthalmitis; Fluorouracil; Follow-Up Studies; Glaucoma, Op | 2013 |
7 other studies available for fluorouracil and Endophthalmitis
| Article | Year |
|---|---|
Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model.
Topics: Absorbable Implants; Animals; Drug Delivery Systems; Drug Implants; Drug Liberation; Endophthalmitis | 2019 |
Additional failures after filtering with 5-FU.
Topics: Endophthalmitis; Fluorouracil; Glaucoma; Humans; Treatment Failure | 1993 |
"Late endophthalmitis"--filtering surgery time bomb?
Topics: Antimetabolites; Aqueous Humor; Bacteria; Chemotherapy, Adjuvant; Endophthalmitis; Eye Infections, B | 1996 |
Late-onset, bleb-associated endophthalmitis following glaucoma filtering surgery with or without antifibrotic agents.
Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Endophthalmitis; Female; Filtration; Fluoro | 1999 |
Risk factors for development of post-trabeculectomy endophthalmitis.
Topics: Aged; Antimetabolites; Case-Control Studies; Diabetes Complications; Endophthalmitis; Female; Fluoro | 2000 |
Recurrent endogenous candidal endophthalmitis in a premature infant.
Topics: Amphotericin B; Betaxolol; Candida albicans; Candidiasis; Drug Therapy, Combination; Endophthalmitis | 2001 |
Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Child, Preschool; Endophth | 1991 |