fluorouracil has been researched along with Endocrine Gland Neoplasms in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with advanced endocrine cancers, such as adrenocortical carcinoma and medullary thyroid carcinoma, have few well-validated therapeutic options." | 2.79 | A phase I study of imatinib, dacarbazine, and capecitabine in advanced endocrine cancers. ( Aaron, M; Halperin, DM; Hoff, AO; Hoff, PM; Phan, AT; Yao, JC, 2014) |
| "Liver metastases are the most common cause of death in gastric ECs, and their control is very important for improving the poor prognosis associated with the disease." | 1.34 | A successful treatment for metastatic liver tumors from endocrine carcinoma of the stomach. ( Fujiyama, Y; Nishimura, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamanashi, T | 1 |
| Nishi, T | 1 |
| Yamamoto, T | 1 |
| Toriumi, F | 1 |
| Koshida, Y | 1 |
| Mukai, K | 1 |
| Shimoyama, Y | 1 |
| Halperin, DM | 1 |
| Phan, AT | 1 |
| Hoff, AO | 1 |
| Aaron, M | 1 |
| Yao, JC | 1 |
| Hoff, PM | 1 |
| Maire, F | 1 |
| Hammel, P | 1 |
| Kianmanesh, R | 1 |
| Hentic, O | 1 |
| Couvelard, A | 1 |
| Rebours, V | 1 |
| Zappa, M | 1 |
| Raymond, E | 1 |
| Sauvanet, A | 1 |
| Louvet, C | 1 |
| Lévy, P | 1 |
| Belghiti, J | 1 |
| Ruszniewski, P | 1 |
| Dahan, L | 1 |
| Bonnetain, F | 1 |
| Rougier, P | 1 |
| Raoul, JL | 1 |
| Gamelin, E | 1 |
| Etienne, PL | 1 |
| Cadiot, G | 1 |
| Mitry, E | 1 |
| Smith, D | 1 |
| Cvitkovic, F | 1 |
| Coudert, B | 1 |
| Ricard, F | 1 |
| Bedenne, L | 1 |
| Seitz, JF | 1 |
| Claringbold, PG | 1 |
| Brayshaw, PA | 1 |
| Price, RA | 1 |
| Turner, JH | 1 |
| Tanizaki, K | 1 |
| Kobayashi, K | 1 |
| Takachi, K | 1 |
| Nishioka, K | 1 |
| Aoki, T | 1 |
| Hyuga, S | 1 |
| Igarashi, Y | 1 |
| Yamanaka, C | 1 |
| Komori, T | 1 |
| Matsumoto, T | 1 |
| Uemura, Y | 1 |
| Nishimura, M | 1 |
| Fujiyama, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I/II Study to Evaluate the Efficacy and Toxicity of Imatinib Mesylate in Combination With Dacarbazine and Capecitabine in Medullary Thyroid Carcinoma[NCT00354523] | Phase 1/Phase 2 | 21 participants (Actual) | Interventional | 2004-12-31 | Terminated (stopped due to Study closed following Phase I portion, insufficient activity to continue to Phase II.) | ||
| Clinical Study of Radiopeptide 177Lu-DOTATOC in Combination With Capecitabine and Temozolomide in Advanced, Non-resectable and Progressive Neuroendocrine Tumors With Somatostatin Receptor Overexpression[NCT04194125] | Phase 2 | 25 participants (Anticipated) | Interventional | 2019-02-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Endocrine Gland Neoplasms
| Article | Year |
|---|---|
[A case report of long-term survival of endocrine cell carcinoma of the esophagus with chemo-radiation therapy].
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; End | 2011 |
3 trials available for fluorouracil and Endocrine Gland Neoplasms
| Article | Year |
|---|---|
A phase I study of imatinib, dacarbazine, and capecitabine in advanced endocrine cancers.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cape | 2014 |
Phase III trial of chemotherapy using 5-fluorouracil and streptozotocin compared with interferon alpha for advanced carcinoid tumors: FNCLCC-FFCD 9710.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Disease Progression; E | 2009 |
Phase II study of radiopeptide 177Lu-octreotate and capecitabine therapy of progressive disseminated neuroendocrine tumours.
Topics: Adult; Aged; Aged, 80 and over; Capecitabine; Deoxycytidine; Disease Progression; Endocrine Gland Ne | 2011 |
3 other studies available for fluorouracil and Endocrine Gland Neoplasms
| Article | Year |
|---|---|
[A case of endocrine cell carcinoma of the ascending colon with liver metastasis treated with hepatectomy after excision of the primary lesion and systemic chemotherapy].
Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab | 2014 |
Is adjuvant therapy with streptozotocin and 5-fluorouracil useful after resection of liver metastases from digestive endocrine tumors?
Topics: Adult; Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; E | 2009 |
A successful treatment for metastatic liver tumors from endocrine carcinoma of the stomach.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Endocrine | 2007 |