fluorouracil has been researched along with Encephalitis, Polio in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation or demyelination was not detected in brains or spinal cords of noninfected SJL mice treated with 5-FU and/or LE." | 1.30 | 5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus. ( Kimmel, DW; Lucchinetti, CF; Pavelko, K; Rodriguez, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campagnola, G | 1 |
| Gong, P | 1 |
| Peersen, OB | 1 |
| LODDO, B | 1 |
| MUNYON, W | 1 |
| SALZMAN, NP | 1 |
| Lucchinetti, CF | 1 |
| Kimmel, DW | 1 |
| Pavelko, K | 1 |
| Rodriguez, M | 1 |
4 other studies available for fluorouracil and Encephalitis, Polio
| Article | Year |
|---|---|
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
Topics: Allosteric Regulation; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; F | 2011 |
[Inhibition of the multiplication in vitro of poliomyelitis virus by the action of guanidine. XI. Potentiation of the anti-poliomyelitic effect of guanidine by 5-fluorouracil].
Topics: Amidines; Fluorouracil; Guanidine; Guanidines; In Vitro Techniques; Poliomyelitis; Poliovirus; Uraci | 1962 |
The incorporation of 5-fluoro-uracil into poliovirus.
Topics: Fluorouracil; Poliomyelitis; Poliovirus; RNA; Uracil | 1962 |
5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus.
Topics: Adjuvants, Immunologic; Animals; Antimetabolites, Antineoplastic; Demyelinating Diseases; Female; Fl | 1997 |