fluorouracil has been researched along with Embolism, Pulmonary in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study aimed to demonstrate the noninferiority of capecitabine to 5-fluorouracil (5-FU)/folinic acid (FA), in relation to progression-free survival (PFS) after first-line treatment of metastatic colorectal cancer and the benefit of adding celecoxib (C) to irinotecan/fluoropyrimidine regimens compared with placebo (P)." | 9.13 | Irinotecan combined with infusional 5-fluorouracil/folinic acid or capecitabine plus celecoxib or placebo in the first-line treatment of patients with metastatic colorectal cancer. EORTC study 40015. ( Becker, K; Bethe, U; Bleiberg, H; Bokemeyer, C; Braumann, D; De Greve, J; Debois, M; Hartmann, JT; Janssens, J; Joosens, E; Köhne, CH; Lang, I; Link, H; Müller, L; Reimer, P; Späth-Schwalbe, E; Van Cutsem, E; Van Den Brande, J; Vergauwe, P; Wilke, HJ, 2008) |
| " Two weeks after, she received her first cycle of cyclophosphamide, methotrexate, and 5FU (CMF) as a part of her breast cancer treatment." | 7.81 | Saddle pulmonary embolus and bronchiolitis obliterans with organizing pneumonia develop simultaneously after first cyclophosphamide, methotrexate, 5FU chemotherapy for breast cancer. ( Al-Hameed, FM, 2015) |
| "Sixteen patients with metastatic colorectal cancer have been treated with a regimen involving an 120 h continuous infusion of rIL-2, 18 x 10(6) iu m-2 day followed by three injections of 5FU 600 mg m-2 at weekly intervals." | 6.67 | A phase-III study of recombinant interleukin 2 and 5-fluorouracil chemotherapy in patients with metastatic colorectal cancer. ( Franks, CR; Hamblin, TJ; Oskam, R; Palmer, P; Sadullah, S; Stevenson, J; Williamson, P, 1993) |
| "The study aimed to demonstrate the noninferiority of capecitabine to 5-fluorouracil (5-FU)/folinic acid (FA), in relation to progression-free survival (PFS) after first-line treatment of metastatic colorectal cancer and the benefit of adding celecoxib (C) to irinotecan/fluoropyrimidine regimens compared with placebo (P)." | 5.13 | Irinotecan combined with infusional 5-fluorouracil/folinic acid or capecitabine plus celecoxib or placebo in the first-line treatment of patients with metastatic colorectal cancer. EORTC study 40015. ( Becker, K; Bethe, U; Bleiberg, H; Bokemeyer, C; Braumann, D; De Greve, J; Debois, M; Hartmann, JT; Janssens, J; Joosens, E; Köhne, CH; Lang, I; Link, H; Müller, L; Reimer, P; Späth-Schwalbe, E; Van Cutsem, E; Van Den Brande, J; Vergauwe, P; Wilke, HJ, 2008) |
| " We performed a randomized trial comparing 12 weeks of chemohormonal therapy (using cyclophosphamide, methotrexate, fluorouracil, vincristine, prednisone, doxorubicin, and tamoxifen) with 36 weeks of chemotherapy (using cyclophosphamide, methotrexate, fluorouracil, vincristine, and prednisone) in patients with Stage II breast cancer." | 5.06 | The thrombogenic effect of anticancer drug therapy in women with stage II breast cancer. ( Arnold, A; De Pauw, S; Gent, M; Goodyear, MD; Hirsh, J; Hryniuk, W; Levine, MN, 1988) |
| " Two weeks after, she received her first cycle of cyclophosphamide, methotrexate, and 5FU (CMF) as a part of her breast cancer treatment." | 3.81 | Saddle pulmonary embolus and bronchiolitis obliterans with organizing pneumonia develop simultaneously after first cyclophosphamide, methotrexate, 5FU chemotherapy for breast cancer. ( Al-Hameed, FM, 2015) |
| "We report our experience with 2 male patients (71 and 74 years old, respectively) with advanced esophageal cancer who exhibited pulmonary embolism during treatment with neoadjuvant chemotherapy with cisplatin (CDDP) and 5-fluorouracil (5- FU)." | 3.80 | [Pulmonary embolism in esophageal cancer patients receiving neoadjuvant chemotherapy with CDDP and 5-FU]. ( Fujiwara, H; Ichikawa, D; Ikoma, H; Kitagawa, M; Komatsu, S; Konishi, H; Kuriu, Y; Murayama, Y; Nakanishi, M; Okamoto, K; Otsuji, E; Sakakura, C; Shiozaki, A, 2014) |
| "Thirty patients with an advanced bronchogenic carcinoma were treated with a combination of adriamycin and 5-fluorouracil; in eight the size of the tumour or its metastases was reduced by over 50%, and eight further patients experienced useful relief of symptoms." | 3.65 | Treatment of advanced bronchogenic carcinoma with adriamycin and 5-fluorouracil. ( Anderson, G; Bugaighis, A; Rees, GJ, 1975) |
| "Patients with metastatic colorectal cancer received either FOLFOX-4 + bev or FOLFIRI + bev." | 2.75 | Management of venous thromboembolism in colorectal cancer patients treated with bevacizumab. ( Chin, K; Fujiwara, Y; Hatake, K; Ichimura, T; Kobayashi, K; Konishi, F; Kuboki, Y; Matsueda, K; Matsusaka, S; Mizunuma, N; Ogura, M; Ozaka, M; Shinozaki, E; Suenaga, M, 2010) |
| "Sixteen patients with metastatic colorectal cancer have been treated with a regimen involving an 120 h continuous infusion of rIL-2, 18 x 10(6) iu m-2 day followed by three injections of 5FU 600 mg m-2 at weekly intervals." | 2.67 | A phase-III study of recombinant interleukin 2 and 5-fluorouracil chemotherapy in patients with metastatic colorectal cancer. ( Franks, CR; Hamblin, TJ; Oskam, R; Palmer, P; Sadullah, S; Stevenson, J; Williamson, P, 1993) |
| "We report two cases of venous thrombosis confirmed during the bevacizumab combination chemotherapy for colorectal cancer." | 1.36 | [Two cases of venous thrombosis confirmed during the bevacizumab combination chemotherapy for colorectal cancer]. ( Hosokawa, T; Iwao, Y; Koshiishi, H; Koshinaga, T; Matsuyama, T; Nishida, K; Okamura, T; Sakamoto, K; Tokita, H, 2010) |
| "There were upper gastrointestinal hemorrhage in 3 cases, hepatic failure in 4, pulmonary embolism in 1, cholecystitis in 4, hepatic encephalopathy in 2, gastric perforation in 1, and intrahepatic biloma in 2 cases." | 1.35 | [Analysis of severe complications after transcatheter arterial chemoembolization for primary hepatocellular carcinoma]. ( Feng, B; Liang, SN; Liu, LL; Su, HY; Xu, K; Zhao, GS, 2008) |
| "Suspected pulmonary embolism was demonstrated by CT scan." | 1.31 | [Complicated antiphospholid antibody syndrome]. ( Eifrig, B; Hegewisch-Becker, S; Hossfeld, DK; Langer, F; Marx, G; Neuber, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Jimi, S | 1 |
| Oohata, Y | 1 |
| Tamura, T | 1 |
| Takahata, S | 1 |
| Kamei, T | 1 |
| White, KE | 1 |
| Elder, CT | 1 |
| Shirono, T | 1 |
| Koga, H | 1 |
| Niizeki, T | 1 |
| Nagamatsu, H | 1 |
| Iwamoto, H | 1 |
| Shimose, S | 1 |
| Nakano, M | 1 |
| Okamura, S | 1 |
| Noda, Y | 1 |
| Kamachi, N | 1 |
| Kuromatsu, R | 1 |
| Ogo, E | 1 |
| Torimura, T | 1 |
| Khanna, A | 1 |
| Reece-Smith, AM | 1 |
| Cunnell, M | 1 |
| Madhusudan, S | 1 |
| Thomas, A | 1 |
| Bowrey, DJ | 1 |
| Parsons, SL | 1 |
| Muñoz Martín, AJ | 1 |
| García Alfonso, P | 1 |
| Rupérez Blanco, AB | 1 |
| Pérez Ramírez, S | 1 |
| Blanco Codesido, M | 1 |
| Martín Jiménez, M | 1 |
| Kitagawa, M | 1 |
| Shiozaki, A | 1 |
| Fujiwara, H | 1 |
| Konishi, H | 1 |
| Komatsu, S | 1 |
| Ichikawa, D | 1 |
| Okamoto, K | 1 |
| Murayama, Y | 1 |
| Kuriu, Y | 1 |
| Ikoma, H | 1 |
| Nakanishi, M | 1 |
| Sakakura, C | 1 |
| Otsuji, E | 1 |
| Al-Hameed, FM | 1 |
| Redana, S | 1 |
| Sharp, A | 1 |
| Lote, H | 1 |
| Mohammed, K | 1 |
| Papadimitraki, E | 1 |
| Capelan, M | 1 |
| Ring, A | 1 |
| Liang, SN | 1 |
| Liu, LL | 1 |
| Su, HY | 1 |
| Feng, B | 1 |
| Zhao, GS | 1 |
| Xu, K | 1 |
| Suenaga, M | 1 |
| Mizunuma, N | 1 |
| Kobayashi, K | 1 |
| Shinozaki, E | 1 |
| Matsusaka, S | 1 |
| Chin, K | 1 |
| Kuboki, Y | 1 |
| Ichimura, T | 1 |
| Ozaka, M | 1 |
| Ogura, M | 1 |
| Fujiwara, Y | 1 |
| Matsueda, K | 1 |
| Konishi, F | 1 |
| Hatake, K | 1 |
| Goto, A | 1 |
| Suzuki, K | 1 |
| Hasegawa, Y | 1 |
| Sukawa, Y | 1 |
| Fujii, K | 1 |
| Nishimura, S | 1 |
| Yonezawa, K | 1 |
| Abe, T | 1 |
| Shinomura, Y | 1 |
| Hosokawa, T | 1 |
| Tokita, H | 1 |
| Matsuyama, T | 1 |
| Sakamoto, K | 1 |
| Nishida, K | 1 |
| Iwao, Y | 1 |
| Koshiishi, H | 1 |
| Okamura, T | 1 |
| Koshinaga, T | 1 |
| Köhne, CH | 1 |
| De Greve, J | 1 |
| Hartmann, JT | 1 |
| Lang, I | 1 |
| Vergauwe, P | 1 |
| Becker, K | 1 |
| Braumann, D | 1 |
| Joosens, E | 1 |
| Müller, L | 1 |
| Janssens, J | 1 |
| Bokemeyer, C | 1 |
| Reimer, P | 1 |
| Link, H | 1 |
| Späth-Schwalbe, E | 1 |
| Wilke, HJ | 1 |
| Bleiberg, H | 1 |
| Van Den Brande, J | 1 |
| Debois, M | 1 |
| Bethe, U | 1 |
| Van Cutsem, E | 1 |
| Hamblin, TJ | 1 |
| Sadullah, S | 1 |
| Williamson, P | 1 |
| Stevenson, J | 1 |
| Oskam, R | 1 |
| Palmer, P | 1 |
| Franks, CR | 1 |
| Langer, F | 1 |
| Eifrig, B | 1 |
| Hegewisch-Becker, S | 1 |
| Marx, G | 1 |
| Neuber, K | 1 |
| Hossfeld, DK | 1 |
| Cuschieri, A | 1 |
| Swain, C | 1 |
| Rees, GJ | 1 |
| Bugaighis, A | 1 |
| Anderson, G | 1 |
| Levine, MN | 1 |
| Gent, M | 1 |
| Hirsh, J | 1 |
| Arnold, A | 1 |
| Goodyear, MD | 1 |
| Hryniuk, W | 1 |
| De Pauw, S | 1 |
| Karim, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Irinotecan Combined With Infusional 5-FU/Folinic Acid or Capecitabine and the Role of Celecoxib in Patients With Metastatic Colorectal Cancer[NCT00064181] | Phase 3 | 86 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for fluorouracil and Embolism, Pulmonary
| Article | Year |
|---|---|
Management of venous thromboembolism in colorectal cancer patients treated with bevacizumab.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies | 2010 |
Irinotecan combined with infusional 5-fluorouracil/folinic acid or capecitabine plus celecoxib or placebo in the first-line treatment of patients with metastatic colorectal cancer. EORTC study 40015.
Topics: Adenocarcinoma; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemot | 2008 |
A phase-III study of recombinant interleukin 2 and 5-fluorouracil chemotherapy in patients with metastatic colorectal cancer.
Topics: Abdominal Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capillary Permeabi | 1993 |
The thrombogenic effect of anticancer drug therapy in women with stage II breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Dru | 1988 |
15 other studies available for fluorouracil and Embolism, Pulmonary
| Article | Year |
|---|---|
[Successful Management of Deep Vein Thromboembolism and Pulmonary Embolism by Edoxaban for Long-Term 5-FU-Based Chemotherapy for Colon Cancer-A Case Report].
Topics: Aged; Anticoagulants; Colonic Neoplasms; Fluorouracil; Humans; Pulmonary Embolism; Pyridines; Thiazo | 2019 |
Saddle pulmonary embolism with fluorouracil: A case report.
Topics: Adult; Fluorouracil; Humans; Lower Extremity; Male; Pulmonary Embolism; Rivaroxaban; Thrombosis; Tom | 2020 |
Usefulness of a novel transarterial chemoinfusion plus external-beam radiation therapy for advanced hepatocellular carcinoma with tumor thrombi in the inferior vena cava and right atrium: Case study.
Topics: Carcinoma, Hepatocellular; Fluorouracil; Heart Atria; Humans; Liver Neoplasms; Pulmonary Embolism; V | 2022 |
Venous thromboembolism in patients receiving perioperative chemotherapy for esophagogastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cape | 2014 |
Incidence of venous thromboembolism (VTE) in ambulatory pancreatic cancer patients receiving chemotherapy and analysis of Khorana's predictive model.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreati | 2014 |
[Pulmonary embolism in esophageal cancer patients receiving neoadjuvant chemotherapy with CDDP and 5-FU].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Venous Catheters; Cisplatin; Esophagea | 2014 |
Saddle pulmonary embolus and bronchiolitis obliterans with organizing pneumonia develop simultaneously after first cyclophosphamide, methotrexate, 5FU chemotherapy for breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Axilla; Breast Neoplasms; Carcinoma, Ductal, Breast; | 2015 |
Rates of major complications during neoadjuvant and adjuvant chemotherapy for early breast cancer: An off study population.
Topics: Acute Coronary Syndrome; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplas | 2016 |
[Analysis of severe complications after transcatheter arterial chemoembolization for primary hepatocellular carcinoma].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinom | 2008 |
[Pulmonary embolism during palliative chemotherapy including cetuximab for metastatic colorectal cancer].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineop | 2010 |
[Two cases of venous thrombosis confirmed during the bevacizumab combination chemotherapy for colorectal cancer].
Topics: Aged; Angiogenesis Inducing Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antin | 2010 |
[Complicated antiphospholid antibody syndrome].
Topics: Antineoplastic Combined Chemotherapy Protocols; Antiphospholipid Syndrome; Breast Neoplasms; Carcino | 2002 |
Hepatic artery ligation and prolonged cytotoxic therapy in advanced primary and secondary liver tumours.
Topics: Adult; Aged; Antineoplastic Agents; Bilirubin; Biopsy; Catheterization; Female; Fluorouracil; Hepati | 1975 |
Treatment of advanced bronchogenic carcinoma with adriamycin and 5-fluorouracil.
Topics: Alopecia; Carcinoma, Bronchogenic; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1975 |
Impressions on 5-fluorouracil in Bangladesh. Prolonged worthwhile survival in gastrointestinal malignancies.
Topics: Bangladesh; Drug Evaluation; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Hemorrhage; G | 1974 |