fluorouracil has been researched along with Edema, Laryngeal in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with resectable advanced squamous cell carcinoma of the larynx (tumor stage T3-T4) or hypopharynx (T2-T4), with regional lymph nodes in the neck staged as N0-N2 and with no metastasis, were randomly assigned to treatment in the sequential (or control) or the alternating (or experimental) arm." | 2.74 | Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy. ( Bardet, E; Barzan, L; Bernier, J; Bogaerts, J; Chevalier, D; de Raucourt, D; Geoffrois, L; Horiot, JC; Hupperets, P; Lacombe, D; Leemans, CR; Lefebvre, JL; Licitra, L; Lunghi, F; Rolland, F; Stupp, R; Tesselaar, M; Vermorken, JB, 2009) |
| "Treatment with sodium selenite is well tolerated and easy to deliver." | 2.71 | Selenium in the treatment of radiation-associated secondary lymphedema. ( Bruns, F; Büntzel, J; DeVries, AF; Glatzel, M; Kisters, K; Micke, O; Mücke, R; Schäfer, U; Schönekaes, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lefebvre, JL | 1 |
| Rolland, F | 1 |
| Tesselaar, M | 1 |
| Bardet, E | 1 |
| Leemans, CR | 1 |
| Geoffrois, L | 1 |
| Hupperets, P | 1 |
| Barzan, L | 1 |
| de Raucourt, D | 1 |
| Chevalier, D | 1 |
| Licitra, L | 1 |
| Lunghi, F | 1 |
| Stupp, R | 1 |
| Lacombe, D | 1 |
| Bogaerts, J | 1 |
| Horiot, JC | 1 |
| Bernier, J | 1 |
| Vermorken, JB | 1 |
| Micke, O | 1 |
| Bruns, F | 1 |
| Mücke, R | 1 |
| Schäfer, U | 1 |
| Glatzel, M | 1 |
| DeVries, AF | 1 |
| Schönekaes, K | 1 |
| Kisters, K | 1 |
| Büntzel, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE II STUDY ON LARYNX PRESERVATION COMPARING INDUCTION CHEMOTHERAPY AND RADIOTHERAPY VERSUS ALTERNATING CHEMO-RADIOTHERAPY IN RESECTABLE HYPOPHARYNX AND LARYNX CANCERS[NCT00002839] | Phase 3 | 564 participants (Anticipated) | Interventional | 1996-07-31 | Completed | ||
| The Role of Sodium Selenite Supplementation in Patients With Locally Advanced Head and Neck Cancer Undergoing Concurrent Chemoradiotherapy[NCT05451576] | 60 participants (Anticipated) | Interventional | 2020-08-12 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for fluorouracil and Edema, Laryngeal
| Article | Year |
|---|---|
Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, | 2009 |
Selenium in the treatment of radiation-associated secondary lymphedema.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ci | 2003 |