fluorouracil has been researched along with Ear Diseases in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Ear Diseases: Pathological processes of the ear, the hearing, and the equilibrium system of the body.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of applied 5-Fluorouracil is effective in the treatment of cholesteatoma." | 7.67 | [A new medical therapeutic approach to cholesteatoma. 5-fluorouracil in local treatment]. ( Boniver, R; Hutten, R, 1987) |
| "5-Fluorouracil was introduced in the early 1960s as a topical chemotherapeutic agent and has become increasingly accepted because of its efficacy, economy, and relative absence of side effects in treating many pre-cancerous conditions, certain benign and malignant tumors, and dermatoses." | 5.27 | The topical use of 5-fluorouracil in the ear in the management of cholesteatoma and excessive mucous secretion. ( Smith, MF, 1985) |
| "The use of applied 5-Fluorouracil is effective in the treatment of cholesteatoma." | 3.67 | [A new medical therapeutic approach to cholesteatoma. 5-fluorouracil in local treatment]. ( Boniver, R; Hutten, R, 1987) |
| "5-Fluorouracil was introduced in the early 1960s as a topical chemotherapeutic agent and has become increasingly accepted because of its efficacy, economy, and relative absence of side effects in treating many pre-cancerous conditions, certain benign and malignant tumors, and dermatoses." | 1.27 | The topical use of 5-fluorouracil in the ear in the management of cholesteatoma and excessive mucous secretion. ( Smith, MF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Zhou, J | 1 |
| Zhang, T | 1 |
| Zhang, H | 1 |
| Zhu, H | 1 |
| Cheng, Y | 1 |
| Gust, R | 1 |
| Shim, HJ | 1 |
| Kim, HJ | 1 |
| Hwang, JE | 1 |
| Bae, WK | 1 |
| Chung, IJ | 1 |
| Lee, DH | 1 |
| Mi, YT | 1 |
| Lee, JK | 1 |
| Lim, SC | 1 |
| Chung, JW | 1 |
| Cho, SH | 1 |
| Atef, AM | 1 |
| Hamouda, MM | 1 |
| Mohamed, AH | 1 |
| Fattah, AF | 1 |
| Takahashi, H | 1 |
| Funabiki, K | 1 |
| Hasebe, S | 1 |
| Fukuda-Yamamoto, T | 1 |
| Kaieda, S | 1 |
| Iwanaga, T | 1 |
| Kumagami, H | 1 |
| Takasaki, K | 1 |
| Sala, DT | 1 |
| Kriukov, AI | 1 |
| Sharkov, SM | 1 |
| Shubin, MN | 1 |
| Kalashnikova, EA | 1 |
| Khamzalieva, RB | 1 |
| Akhmedov, ShM | 1 |
| Hutten, R | 1 |
| Boniver, R | 1 |
| Smith, MF | 1 |
1 trial available for fluorouracil and Ear Diseases
| Article | Year |
|---|---|
Topical 5-fluorouracil for granular myringitis: a double-blinded study.
Topics: Acetic Acid; Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Antimetabolit | 2010 |
7 other studies available for fluorouracil and Ear Diseases
| Article | Year |
|---|---|
Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Cell Prol | 2012 |
Long term complications and prognostic factors in locally advanced nasopharyngeal carcinoma treated with docetaxel, cisplatin, 5-fluorouracil induction chemotherapy followed by concurrent chemoradiotherapy: A retrospective cohort study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplati | 2020 |
Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic | 2005 |
Topical applications of 5-fluorouracil in the medical treatment of cholesteatoma of the middle ear.
Topics: Administration, Topical; Cholesteatoma; Ear Diseases; Ear, Middle; Fluorouracil; Humans | 1994 |
[Prevention of postoperative scar processes in otorhinolaryngology experimental rationale].
Topics: Antimetabolites; Cell Movement; Cicatrix; Ear Diseases; Fibroblasts; Fluorouracil; Humans; Otologic | 2001 |
[A new medical therapeutic approach to cholesteatoma. 5-fluorouracil in local treatment].
Topics: Cholesteatoma; Ear Diseases; Fluorouracil; Humans | 1987 |
The topical use of 5-fluorouracil in the ear in the management of cholesteatoma and excessive mucous secretion.
Topics: Adolescent; Adult; Aged; Child; Cholesteatoma; Ear Diseases; Ear, Middle; Fluorouracil; Humans; Midd | 1985 |