fluorouracil has been researched along with EHS Tumor in 95 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In earlier studies we showed that a supra-additive cytotoxic effect was obtained with combined treatment with cisplatin and 5-fluorouracil (5-FU) of Bp8 ascites tumor growing in vivo in mice." | 7.69 | The effect of 5-fluorouracil on cisplatin induced DNA interstrand cross-linking in a mouse ascites tumor growing in vivo. ( Lewin, F; Ringborg, U; Skog, S; Tribukait, B, 1995) |
| "Oral administration of a liposome-encapsulated agent triggering the synthesis of interferon--poly(I) poly (C)--to mice bearing solid sarcoma 37 was followed by (a) production of an interferon which circulates for a longer period after preliminary administration of "empty" liposomes; (b) lengthening of the period of tumor latency; in some cases tumor failed to appear at all; (c) higher efficacy of radiation treatment which was manifested by a higher inhibition of tumor growth or complete regression; (d) increased antitumor effect of 5-fluorouracil, and (e) suppression of proliferative activity of tumor." | 7.67 | [Effect of combined exposure to an interferon inducer, irradiation and 5-fluorouracil on sarcoma 37 in mice]. ( Ershov, FI; Karakulov, RK; Pelevina, II; Popov, GA; Poverennyĭ, AM, 1984) |
| "In earlier studies we showed that a supra-additive cytotoxic effect was obtained with combined treatment with cisplatin and 5-fluorouracil (5-FU) of Bp8 ascites tumor growing in vivo in mice." | 3.69 | The effect of 5-fluorouracil on cisplatin induced DNA interstrand cross-linking in a mouse ascites tumor growing in vivo. ( Lewin, F; Ringborg, U; Skog, S; Tribukait, B, 1995) |
| "The ability of cis-platinum, 5-fluorouracil, and methotrexate to leach out from various types of bone cements was examined in three different experimental systems: (1) in vitro release in physiological solution; (2) in vitro release in the presence of mouse fibrosarcoma cells; and (3) in vivo release in rabbits." | 3.68 | The release of cytotoxic drugs from acrylic bone cement. ( Arad-Yelin, R; Dekel, S; Mazur, Y; Salama, R; Warshawsky, A; Wasserlauf, S, 1993) |
| "Oral administration of a liposome-encapsulated agent triggering the synthesis of interferon--poly(I) poly (C)--to mice bearing solid sarcoma 37 was followed by (a) production of an interferon which circulates for a longer period after preliminary administration of "empty" liposomes; (b) lengthening of the period of tumor latency; in some cases tumor failed to appear at all; (c) higher efficacy of radiation treatment which was manifested by a higher inhibition of tumor growth or complete regression; (d) increased antitumor effect of 5-fluorouracil, and (e) suppression of proliferative activity of tumor." | 3.67 | [Effect of combined exposure to an interferon inducer, irradiation and 5-fluorouracil on sarcoma 37 in mice]. ( Ershov, FI; Karakulov, RK; Pelevina, II; Popov, GA; Poverennyĭ, AM, 1984) |
| "Aspirin is a salicylate drug that is widely used, and recently it has been shown to influence the development of various types of cancers." | 1.39 | Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model. ( Jia, Q; Wang, Z; Wu, L; Zhang, W; Zhang, X; Zhang, Y, 2013) |
| "The effectiveness of 5-fluorouracil (5-FU), FT-207 and FT-207 + uracil in combination with two repetitions of 43 degrees C hyperthermia in the treatment of the Meth-A-Fibrosarcoma and Sarcoma-180 was examined in vivo in BALB/c mice." | 1.29 | The antitumor effect of hyperthermia combined with fluorouracil and its analogues. ( Harada, S; Matsuo, M; Miyata, M; Obara, T; Oikawa, H; Ping, L; Takahashi, T; Yanagisawa, T, 1995) |
| " The reduction of gastrointestinal (GI) toxicity, induced in the host by 5-FU, was modulated by potassium oxonate (Oxo), an inhibitor of orotate phosphoribosyltransferase that catalyzes the phosphorylation of 5-FU, a process believed to be responsible for the toxic effects of 5-FU." | 1.29 | Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. ( Fukushima, M; Kato, T; Ohshimo, H; Shimamato, Y; Shirasaka, T; Yamaguchi, M; Yonekura, K, 1996) |
| "Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated." | 1.27 | [Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984) |
| "We found that this conversion in human tumors was catalyzed not by uridine phosphorylase but by thymidine phosphorylase." | 1.27 | [5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues]. ( Hara, Y, 1984) |
| " 5-FU depressed the levels of ribonucleotide reductase and thymidine kinase, which are two key enzymes in DNA synthesis, in solid AH-130 tumor when given intraperitoneally at a dose of 60 mg/kg, and this inhibition seemed to be very toxic against cells." | 1.27 | [Studies on the mechanism of cytotoxicity of 5-fluorouracil--through impairment of metabolism]. ( Fujii, S; Ikenaka, K; Kawai, K; Shirasaka, T; Tanaka, H, 1983) |
| " By considering these pharmacokinetic behaviors, a suitable method of administration should be established." | 1.27 | [Chemical modification of anticancer agents from viewpoints of their pharmacokinetics]. ( Fujita, H, 1984) |
| " On the 9th day after transplantation, HCFU (150 mg/kg) and 5-FU (75 mg/kg) were administered with or without hyperthermia (43." | 1.27 | Enhancement of antitumor effects of 1-hexylcarbamoyl-5-fluorouracil combined with hyperthermia on Ehrlich ascites tumor in vivo and Nakahara-Fukuoka sarcoma cell in vitro. ( Takada, K; Tsumura, M; Yoshiga, K, 1988) |
| "Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs." | 1.27 | Modulation of fluoropyrimidine metabolism by chlorpromazine. ( Brooks, M; Cadman, E; Tseng, A, 1986) |
| "The anti-tumor activity of partially purified tumor necrosis factor (TNF) was analysed in combination with chemotherapeutic drugs against intradermally transplanted Meth A sarcoma." | 1.27 | Anti-tumor effects of tumor necrosis factor in combination with chemotherapeutic agents. ( Curschellas, E; Matter, A; Müller, M; Regenass, U, 1987) |
| "In combination with chemotherapy [ftorafur (FT)], allogeneic lymphoid cells were transferred to inhibit the growth of a 3-methylcholanthrene-induced transplantable KMT-17 fibrosarcoma in Wistar-King-Aptekman/Hok rats." | 1.26 | Effect of normal allogeneic lymphoid cell transfer in combination with chemotherapy on a transplantable tumor in rats. ( Akiyama, J; Gotohda, E; Hosokawa, M; Kawamura, T; Kobayashi, H; Kodama, T; Yamada, Y, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (73.68) | 18.7374 |
| 1990's | 20 (21.05) | 18.2507 |
| 2000's | 3 (3.16) | 29.6817 |
| 2010's | 2 (2.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giorgi-Renault, S | 1 |
| Renault, J | 1 |
| Gebel-Servolles, P | 1 |
| Baron, M | 1 |
| Paoletti, C | 1 |
| Cros, S | 1 |
| Bissery, MC | 1 |
| Lavelle, F | 1 |
| Atassi, G | 1 |
| Bobek, M | 1 |
| An, SH | 1 |
| Skrincosky, D | 1 |
| De Clercq, E | 1 |
| Bernacki, RJ | 1 |
| Zhang, X | 1 |
| Wang, Z | 2 |
| Zhang, Y | 1 |
| Jia, Q | 1 |
| Wu, L | 1 |
| Zhang, W | 1 |
| Ren, X | 1 |
| Zheng, N | 1 |
| Gao, Y | 1 |
| Chen, T | 1 |
| Lu, W | 1 |
| Desmoulin, F | 1 |
| Gilard, V | 1 |
| Malet-Martino, M | 1 |
| Martino, R | 1 |
| Molina, C | 1 |
| Smith, P | 1 |
| MACLEOD, RM | 1 |
| KING, CE | 1 |
| HOLLANDER, VP | 1 |
| KASBEKAR, DK | 1 |
| GREENBERG, DM | 1 |
| SAKURAI, Y | 1 |
| MCALISTER, WH | 1 |
| Collingridge, DR | 1 |
| Glaser, M | 1 |
| Osman, S | 1 |
| Barthel, H | 1 |
| Hutchinson, OC | 1 |
| Luthra, SK | 1 |
| Brady, F | 1 |
| Bouchier-Hayes, L | 1 |
| Martin, SJ | 1 |
| Workman, P | 1 |
| Price, P | 1 |
| Aboagye, EO | 2 |
| Evans, RM | 2 |
| Laskin, JD | 2 |
| Hakala, MT | 3 |
| Matsuzaki, T | 1 |
| Kato, I | 1 |
| Yokokura, T | 1 |
| Mutai, M | 1 |
| Hara, Y | 1 |
| Fujii, S | 4 |
| Shirasaka, T | 3 |
| Ikenaka, K | 1 |
| Tanaka, H | 1 |
| Kawai, K | 1 |
| Fujita, H | 1 |
| Yasunaga, T | 1 |
| Ohgaki, K | 1 |
| Inamoto, T | 1 |
| Kan, N | 1 |
| Hikasa, Y | 1 |
| Berger, SH | 1 |
| Karakulov, RK | 1 |
| Poverennyĭ, AM | 1 |
| Ershov, FI | 1 |
| Popov, GA | 1 |
| Pelevina, II | 1 |
| Yamada, Y | 1 |
| Kawamura, T | 1 |
| Gotohda, E | 1 |
| Akiyama, J | 1 |
| Hosokawa, M | 1 |
| Kodama, T | 1 |
| Kobayashi, H | 1 |
| Bertino, JR | 1 |
| Mini, E | 1 |
| Fernandes, DJ | 1 |
| Schabel, FM | 1 |
| Skipper, HE | 1 |
| Trader, MW | 1 |
| Laster, WR | 1 |
| Corbett, TH | 1 |
| Griswold, DP | 1 |
| Mulder, JH | 1 |
| Smink, T | 1 |
| van Putten, LM | 2 |
| Okada, K | 1 |
| Yamada, S | 1 |
| Kawashima, Y | 1 |
| Kitade, F | 1 |
| Okajima, K | 1 |
| Fujimoto, M | 1 |
| Tannock, IF | 3 |
| Usami, M | 1 |
| Zheng, JH | 1 |
| Wang, J | 1 |
| Yasuda, I | 1 |
| Haji, S | 1 |
| Kotani, G | 1 |
| Iso, A | 1 |
| Sun, K | 1 |
| Sakata, K | 1 |
| Ohta, K | 1 |
| Lewin, F | 5 |
| Ringborg, U | 3 |
| Skog, S | 5 |
| Tribukait, B | 3 |
| Harada, S | 1 |
| Ping, L | 1 |
| Obara, T | 1 |
| Oikawa, H | 1 |
| Miyata, M | 1 |
| Matsuo, M | 1 |
| Takahashi, T | 1 |
| Yanagisawa, T | 1 |
| Oku, N | 2 |
| Yamashita, S | 1 |
| Sakuragi, N | 1 |
| Doi, K | 2 |
| Okada, S | 2 |
| Shimidzu, K | 1 |
| Sumi, M | 1 |
| Nadai, T | 1 |
| Kusumoto, S | 1 |
| Suda, Y | 1 |
| Itoh, H | 2 |
| Ito, H | 1 |
| Amano, H | 1 |
| Noda, H | 1 |
| Toyota, T | 1 |
| Shuto, S | 1 |
| Sakai, A | 1 |
| Ueda, H | 1 |
| Manda, T | 1 |
| Matsumoto, S | 1 |
| Mukumoto, S | 1 |
| Nishigaki, F | 1 |
| Kawamura, I | 1 |
| Shimomura, K | 1 |
| Wasserlauf, S | 1 |
| Warshawsky, A | 1 |
| Arad-Yelin, R | 1 |
| Mazur, Y | 1 |
| Salama, R | 1 |
| Dekel, S | 1 |
| Nylén, U | 2 |
| Shimamato, Y | 1 |
| Ohshimo, H | 1 |
| Yamaguchi, M | 1 |
| Kato, T | 2 |
| Yonekura, K | 1 |
| Fukushima, M | 1 |
| Fujii, Y | 2 |
| Itoyanagi, H | 1 |
| Hirose, I | 1 |
| Hasumi, K | 2 |
| Eriguchi, M | 2 |
| McSheehy, PM | 1 |
| Robinson, SP | 1 |
| Ojugo, AS | 1 |
| Cannell, MB | 1 |
| Leach, MO | 1 |
| Judson, IR | 1 |
| Griffiths, JR | 1 |
| He, Q | 1 |
| Welander, I | 1 |
| Iwasa, H | 1 |
| Hirai, J | 1 |
| Kimura, Y | 1 |
| Okuda, H | 1 |
| Tunggal, JK | 1 |
| Melo, T | 1 |
| Ballinger, JR | 1 |
| Schumann, J | 1 |
| Ehring, F | 1 |
| Gohde, W | 1 |
| Sviridenko, OP | 1 |
| Lelieveld, P | 1 |
| Pantarotto, C | 1 |
| Salmona, M | 1 |
| Spreafico, F | 1 |
| Jones, PA | 1 |
| Benedict, WF | 1 |
| Baker, MS | 1 |
| Mondal, S | 1 |
| Rapp, U | 1 |
| Heidelberger, C | 1 |
| Shani, J | 1 |
| Wolf, W | 1 |
| Schlesinger, T | 1 |
| Atkins, HL | 1 |
| Bradley-Moore, PR | 1 |
| Casella, V | 1 |
| Fowler, JS | 1 |
| Greenberg, D | 1 |
| Ido, T | 1 |
| Lambrecht, RM | 1 |
| MacGregor, R | 1 |
| Mantescu, C | 1 |
| Neirinckx, R | 1 |
| Som, P | 1 |
| Wolf, AP | 1 |
| Wodinsky, I | 1 |
| Meaney, K | 1 |
| Osswald, H | 1 |
| Youssef, M | 1 |
| Yakushiji, M | 1 |
| Ide, K | 1 |
| Nishimura, H | 1 |
| Nishida, T | 1 |
| Iigo, M | 2 |
| Hoshi, A | 3 |
| Nakamura, A | 2 |
| Kuretani, K | 3 |
| Yoshida, M | 1 |
| Beltz, RE | 1 |
| Poland, LL | 1 |
| Ning, SC | 1 |
| Hahn, GM | 3 |
| Akamatsu, K | 1 |
| Endo, K | 1 |
| Tsunenari, T | 1 |
| Matsumoto, T | 1 |
| Kaiho, S | 1 |
| Morikawa, K | 1 |
| Koizumi, M | 1 |
| Mitsui, H | 1 |
| Koizumi, K | 1 |
| Krosnick, JA | 1 |
| Mulé, JJ | 1 |
| McIntosh, JK | 1 |
| Rosenberg, SA | 1 |
| Fukushima, K | 1 |
| Takimoto, CH | 1 |
| Cadman, EC | 1 |
| Armstrong, RD | 1 |
| Taguchi, T | 1 |
| Todorov, DK | 1 |
| Silyanovska, KK | 1 |
| Maneva, KM | 1 |
| Ilarionova, MV | 1 |
| Gantchev, GT | 1 |
| Getov, CM | 1 |
| Komiyama, K | 1 |
| Hirokawa, Y | 1 |
| Zhibo, Y | 1 |
| Umezawa, I | 1 |
| Hata, T | 1 |
| Tsumura, M | 1 |
| Yoshiga, K | 1 |
| Takada, K | 1 |
| Tonda, K | 2 |
| Kamata, S | 1 |
| Hirata, M | 2 |
| Tseng, A | 1 |
| Brooks, M | 1 |
| Cadman, E | 1 |
| Regenass, U | 1 |
| Müller, M | 1 |
| Curschellas, E | 1 |
| Matter, A | 1 |
| Kasai, H | 1 |
| Furue, H | 1 |
| Kreuter, J | 1 |
| Ray, GR | 1 |
| Gordon, LF | 2 |
| Kallman, RF | 1 |
| Ikawa, Y | 1 |
| Brescia, T | 1 |
| Johnson, RK | 1 |
| Goldin, A | 1 |
| Veselỳ, J | 1 |
| Cihák, A | 1 |
| Kurkjian, SD | 1 |
| Seidel, HJ | 1 |
| Wegner, LA | 1 |
| Bulbuk, GA | 1 |
| Duprez, A | 1 |
| Robert, J | 1 |
| Kissel, P | 1 |
| Stenram, U | 1 |
| Berg, R | 1 |
| Nilsson, E | 1 |
| Belousova, AK | 1 |
| Moskalik, KG | 1 |
| Kozlov, AP | 1 |
| Akimov, AA | 1 |
| Yron, I | 1 |
| Weiss, DW | 1 |
| Robinson, E | 1 |
| Cohen, D | 1 |
| Adelberg, MG | 1 |
| Mekori, T | 1 |
| Haber, M | 1 |
| Hellmann, K | 1 |
| Murkin, GE | 1 |
| Muratova, GP | 1 |
| Mal'tseva, LF | 1 |
| Rudzit, EA | 1 |
| Anada, H | 1 |
| Nakamura, N | 1 |
| Marumo, H | 1 |
| Merkulov, MF | 1 |
| Leskova, SG | 1 |
| Kumagai, K | 1 |
| Kanzawa, F | 1 |
| Eiselein, J | 1 |
| Biggs, MW | 1 |
| Mashburn, LT | 1 |
| Schmähl, D | 1 |
| Syrkin, AB | 1 |
| Unemi, N | 1 |
| Harima, K | 1 |
| Daidai, Y | 1 |
| Fujihara, H | 1 |
| Grant, JP | 1 |
| Harper PV FERGUSON, DJ | 1 |
| Kreye, VA | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors[NCT00001579] | Phase 1 | 50 participants | Interventional | 1997-06-30 | Completed | ||
| Phase I Trial of Romidepsin Given on Days One, Three, and Five in Patients With Thyroid and Other Advanced Cancers[NCT00048334] | Phase 1 | 28 participants (Actual) | Interventional | 2002-10-26 | Completed | ||
| Phase I Study of Topical Romidepsin (Depsipeptide) in Early Stage Cutaneous T-Cell Lymphoma[NCT01445340] | Phase 1 | 6 participants (Actual) | Interventional | 2007-04-21 | Terminated | ||
| Phase II Trial of Gemcitabine and S-1 for Patients With Advanced Biliary Tract Cancer[NCT02146703] | Phase 2 | 38 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449] | Phase 3 | 338 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluorouracil and EHS Tumor
| Article | Year |
|---|---|
Resistance of mammalian tumour cells toward pyrimidine analogues. A review.
Topics: Animals; Antimetabolites; Azacitidine; Azauridine; Bromouracil; Carcinoma, Ehrlich Tumor; Cell Line; | 1973 |
[Molecular basis of the relation between the cytotoxic effect of antineoplastic compounds and the cell cycle phase].
Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Alkylating Agents; Androgens; Animals; Antibiotics, Ant | 1972 |
[Use of optical quantum generators (lasers) in oncology].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bronchial Neoplasms; Carcinoma, Basal Cell; Carcinom | 1972 |
[Side-effects of cytostatic therapy with special reference to potential carcinogenic effects].
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Bus | 1971 |
1 trial available for fluorouracil and EHS Tumor
| Article | Year |
|---|---|
Metabolism of a novel nucleoside analogue, OGT 719, in the isolated perfused rat liver model, in rats, in tumour models and in patients.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Biotransformation; Fetuins; Fluorine Radioisotopes | 2003 |
90 other studies available for fluorouracil and EHS Tumor
| Article | Year |
|---|---|
Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione.
Topics: Animals; Antineoplastic Agents; Aziridines; Breast Neoplasms; Cell Division; Cell Line; Drug Screeni | 1991 |
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Topics: Animals; Arabinonucleosides; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Female; F | 1989 |
Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model.
Topics: Animals; Aspirin; Fluorouracil; Lymphangiogenesis; Lymphatic Vessels; Male; Mice; Neovascularization | 2013 |
Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice.
Topics: Absorbable Implants; Animals; Drug Delivery Systems; Fluorouracil; Lactic Acid; Male; Mice; Mice, In | 2012 |
EFFECT OF CORTICOSTEROIDS ON RIBONUCLEASE AND NUCLEIC ACID CONTENT IN LYMPHOSARCOMA P1798.
Topics: Adrenal Cortex Hormones; Animals; Edetic Acid; Fluorouracil; Glucocorticoids; Lymphoma; Lymphoma, No | 1963 |
STUDIES ON TUMOR RESISTANCE TO 5-FLUOROURACIL.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Fluorouracil; Genetics; Lymphoma; Lymphoma, Non-Hodgkin; M | 1963 |
IN VITRO CULTURE OF YOSHIDA SARCOMA CELLS: METHODS FOR DETERMINING ACQUIRED RESISTANCE TO DRUGS.
Topics: Animals; Antineoplastic Agents; Azaguanine; Culture Media; Cyclophosphamide; Dactinomycin; Drug Tole | 1964 |
COMPARISON OF THE EFFECTS OF CHEMOTHERAPY AND LOCAL IRRADIATION ON THE VASCULARITY OF A TRANSPLANTED MOUSE MAMMARY ADENOCARCINOMA AND A PLEOMORPHIC SARCOMA.
Topics: Adenocarcinoma; Angiography; Animals; Blood Vessels; Fluorouracil; Mammary Neoplasms, Animal; Mammar | 1965 |
In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope.
Topics: Animals; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; Deoxyadenosines; Enzyme Inhibitors; | 2003 |
Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells.
Topics: Animals; Cell Division; Cells, Cultured; Deoxyribonucleotides; Deoxyuridine; DNA; Dose-Response Rela | 1980 |
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei; | 1984 |
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Enzyme Activation; Female; Floxuridine; | 1984 |
[Development of fluoropyrimidine derivatives].
Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides; | 1984 |
[Studies on the mechanism of cytotoxicity of 5-fluorouracil--through impairment of metabolism].
Topics: Animals; Fluorouracil; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Ribonucleoti | 1983 |
[Chemical modification of anticancer agents from viewpoints of their pharmacokinetics].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Doxorubicin; Fibrosarcoma; | 1984 |
Protective effect of vitamin E against immunosuppression induced by adriamycin, mitomycin C and 5-fluorouracil in mice.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Fibrosarcoma; Fluorouracil; Immunity, Cellular; I | 1983 |
Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil.
Topics: Animals; Carcinoma; Cell Line; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; | 1984 |
[Effect of combined exposure to an interferon inducer, irradiation and 5-fluorouracil on sarcoma 37 in mice].
Topics: Animals; Cell Cycle; Combined Modality Therapy; Fluorouracil; Interferon Inducers; Liposomes; Mice; | 1984 |
Effect of normal allogeneic lymphoid cell transfer in combination with chemotherapy on a transplantable tumor in rats.
Topics: Animals; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Immunotherapy; Lym | 1980 |
Sequential methotrexate and 5-fluorouracil: mechanisms of synergy.
Topics: Animals; Biotransformation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergi | 1983 |
Concepts for controlling drug-resistant tumor cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Burden; Cisplatin; Cyclophosphamide; Dactinomyc | 1980 |
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemi | 1981 |
Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.
Topics: Animals; Carcinoma; Cell Line; Deoxyribonucleosides; Deoxyribose; Deoxyuridine; Drug Synergism; Fluo | 1981 |
Cell injury by antineoplastic agents and influence of coenzyme Q10 on cellular potassium activity and potential difference across the membrane in rat liver cells.
Topics: Animals; Antineoplastic Agents; Energy Metabolism; Fluorouracil; Liver; Membrane Potentials; Mitomyc | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte | 1980 |
Utilization of purine and pyrimidine in human gastric cancer cells (KATO III): effect of a nucleotide and nucleosides mixture (OG-VI) solution on proliferation with coadministration of 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Fluorouracil; Humans; Kinetics; Male; Purines; Pyrimidines; Rats; | 1994 |
The effect of 5-fluorouracil on cisplatin induced DNA interstrand cross-linking in a mouse ascites tumor growing in vivo.
Topics: Animals; Ascites; Cell Survival; Cell Transplantation; Cisplatin; Cross-Linking Reagents; DNA Damage | 1995 |
The antitumor effect of hyperthermia combined with fluorouracil and its analogues.
Topics: Animals; Combined Modality Therapy; Fluorouracil; Hyperthermia, Induced; Male; Mice; Mice, Inbred BA | 1995 |
Therapeutic efficacy of 5-fluorouracil prodrugs using endogenous serum proteins as drug carriers: a new strategy in drug delivery system.
Topics: Animals; Blood Proteins; Drug Carriers; Drug Delivery Systems; Fluorouracil; Mice; Mice, Inbred BALB | 1995 |
Inhibitory action of a (1-->6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Meth A fibrosarcoma-bearing mice and its antitumor mechanism.
Topics: Agaricus; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Synergism; Erythrocytes; Fema | 1994 |
Therapeutic effect of reticuloendothelial system (RES)-avoiding liposomes containing a phospholipid analogue of 5-fluorouracil, dipalmitoylphosphatidylfluorouridine, in Meth A sarcoma-bearing mice.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Antineoplastic Agents; Cell Division; Drug Carriers; Dr | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chromobacterium; Colonic Neoplasms; Dep | 1994 |
The release of cytotoxic drugs from acrylic bone cement.
Topics: Animals; Antineoplastic Agents; Bone Cements; Buffers; Cisplatin; Diffusion; Fibrosarcoma; Fluoroura | 1993 |
Absence of misincorporation of pyrimidines in DNA after treatment with a combination of cisplatin (CIS-diammine-dichloro-platinum) amd 5-fluorouracil of mouse sarcoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cisplatin; DNA, Neoplasm; Fluoroura | 1996 |
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Sy | 1996 |
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Sy | 1996 |
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Sy | 1996 |
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Sy | 1996 |
[Characterization of spontaneous liver metastatic model of BALB/c retroperitoneal sarcoma (LMFS) injected in footpad and antitumor effects of HCFU].
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Fluorouracil; Liver; Liver Neoplasms; Mic | 1997 |
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
Topics: Animals; Biological Transport; Carbon Dioxide; Fibrosarcoma; Fluorouracil; Hydrogen-Ion Concentratio | 1998 |
Cisplatin-induced inhibition of p34cdc2 is abolished by 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; CDC2 Protein Kinase; cdc25 Phosphat | 1998 |
[Effects of HCFU and TNP 470 on liver metastasis of BALB/c retroperitoneal sarcoma (LMFS)].
Topics: Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cyclohexanes; | 1999 |
Prevention by carp extract of myelotoxicity and gastrointestinal toxicity induced by 5-fluorouracil without loss of antitumor activity in mice.
Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Bone Marrow Diseases; Carps; Chemical and Dru | 1999 |
The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 2000 |
Cell synchronization in solid tumors.
Topics: Animals; Bleomycin; Carcinoma, Ehrlich Tumor; Cell Division; Cricetinae; DNA, Neoplasm; Fluorouracil | 1975 |
[Uridine kinase, its structure, properties and biological function].
Topics: Animals; Azacitidine; Brain; Carcinoma, Ehrlich Tumor; Chick Embryo; Drug Resistance; Fluorouracil; | 1978 |
Ftorafur: a self-limiting source of 5-fluorouracil?
Topics: Animals; Biotransformation; Fluorouracil; Hematopoietic Stem Cells; Lethal Dose 50; Leukemia L1210; | 1979 |
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Neoplast | 1976 |
Distribution of 18F-5-fluorouracil in tumor-bearing mice and rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Fluo | 1978 |
Potentiation of the chemotherapeutic action of 5-fluorouracil by combination with cytidine or guanosine on HRS-sarcoma.
Topics: Animals; Cytidine; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Guanosine; Lymph | 1979 |
Transplantation of experimental ovarian tumors and their sensitivity to carcinostatics.
Topics: Adenocarcinoma; Animals; Female; Fluorouracil; Granulosa Cell Tumor; Humans; Male; Mitomycins; Neopl | 1979 |
Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fluorouracil; Leukemia, Ex | 1978 |
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.
Topics: Adenocarcinoma; Administration, Oral; Animals; Ascites; Carcinoma, Ehrlich Tumor; Female; Fluorourac | 1976 |
Inhibition of 5-fluorouracil activation by oxipurinol in preparations of normal rat tissues and Jensen sarcoma: tumor-selective stimulation by inosine.
Topics: Animals; Biotransformation; Bone Marrow; Fluorouracil; In Vitro Techniques; Inosine; Intestine, Smal | 1991 |
Combination therapy: lonidamine, hyperthermia, and chemotherapy against the RIF-1 tumor in vivo.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Combined Modality Therapy; Fibrosarcoma; Fluo | 1991 |
[Combination therapy of a new platinum complex, DWA2114R with various antitumor agents against mouse tumors in vivo].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Doxorubicin; | 1992 |
Cell death in relation to cell cycle in a mouse ascites tumor growing in vivo after combined treatment with cisplatin and 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell | 1990 |
Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Evaluat | 1989 |
[Antitumor effects of 5-fluorouracil-bound organic silicon compound].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Ethyla | 1989 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Ex | 1986 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil | 1987 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou | 1987 |
Chemo- and immunotherapy of an adenovirus-induced transplantable sarcoma in hamsters.
Topics: Adenoviridae Infections; Alkylating Agents; Animals; Antimetabolites; Cricetinae; Cyclophosphamide; | 1987 |
[Potentiation of chemotherapeutic activity by a Chinese herb medicine juzen-taiho-toh].
Topics: Animals; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Synergism; Drugs, Chinese Herbal; Female; Fi | 1988 |
Enhancement of antitumor effects of 1-hexylcarbamoyl-5-fluorouracil combined with hyperthermia on Ehrlich ascites tumor in vivo and Nakahara-Fukuoka sarcoma cell in vitro.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Combined Modality Therapy; Fluorouracil | 1988 |
Effect of 5-fluorouracil on the cell growth and cell cycle kinetics of a mouse ascites tumor growing in vivo.
Topics: Animals; Cell Division; DNA, Neoplasm; Flow Cytometry; Fluorouracil; Interphase; Male; Mice; Mitotic | 1987 |
Metabolism of 1-phthalidyl 5-fluorouracil in rat liver and enzyme induction by phenobarbital.
Topics: Aldehyde Oxidoreductases; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug | 1987 |
Modulation of fluoropyrimidine metabolism by chlorpromazine.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cell Survival; Chlorpromazine; Deoxyuracil Nucleotides; Fl | 1986 |
Anti-tumor effects of tumor necrosis factor in combination with chemotherapeutic agents.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationshi | 1987 |
Toxicity of 5-fluorouracil for aerobic and hypoxic cells in two murine tumours.
Topics: Aerobiosis; Animals; Combined Modality Therapy; Fluorouracil; Lung Neoplasms; Mammary Neoplasms, Exp | 1987 |
Potentiation of antitumor activity of 1-phthalidyl 5-fluorouracil by acetazolamide.
Topics: Acetazolamide; Animals; Antineoplastic Agents; Drug Synergism; Female; Fluorouracil; Neoplasm Transp | 1986 |
[590-S].
Topics: Administration, Oral; Adult; Animals; Anorexia; Antineoplastic Agents; Drug Administration Schedule; | 1985 |
Poly(alkyl acrylate) nanoparticles.
Topics: Acrylic Resins; Animals; Antibody Formation; Antigens; Chemical Phenomena; Chemistry; Colloids; Dact | 1985 |
Response of solid tumor cells exposed to chemotherapeutic agents in vivo: cell survival after 2- and 24-hour exposure.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Survival; Cyclophosphamide; Female; Fluorourac | 1973 |
Chemotherapeutic response of epithelial tumors produced by primary implantation of a nonproducer line of murine sarcoma virus-transformed BALB 3T3 cells.
Topics: Animals; Bleomycin; Cyclophosphamide; Female; Fluorouracil; Male; Methotrexate; Mice; Neoplasm Trans | 1973 |
Responses of cycling and noncycling cells to 1,3-bis(2-chloroethyl)-1-nitrosourea and to bleomycin.
Topics: Animals; Bleomycin; Carmustine; Cell Division; Cell Survival; Cells, Cultured; Cricetinae; Culture T | 1974 |
[Estimation of tumor sensitivity in vitro. I. Comparative studies with the Jensen sarcoma in vivo and in vitro after 1-hour-incubation].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Autoradiography; Cycloparaffins; Dactin | 1969 |
[The effect of extirpation of the adrenals on changes in the perimural hydrolysis of carbohydrates in animals with sarcoma 45 and receiving thiophosphamide and 5-fluorouracil].
Topics: Adrenal Glands; Adrenalectomy; Amylases; Animals; Diet; Female; Fluorouracil; Intestinal Mucosa; Int | 1973 |
[Action of 5-fluoro-uracil on the synthesis of DNA by a methylcholanthrene-induced rhabdomyosarcoma in the C57-Br mouse].
Topics: Animals; DNA, Neoplasm; Fluorouracil; Methylcholanthrene; Mice; Rhabdomyosarcoma; Sarcoma, Experimen | 1966 |
Effects of some cancer-chemotherapeutic agents, especially cyclophosphamide, on an SV40 sarcoma in rat.
Topics: Animals; Azathioprine; Cyclophosphamide; Fluorouracil; Hydrocortisone; Neoplasm Transplantation; Rat | 1969 |
Immunotherapeutic studies in mice with the methanol-extraction residue (mer) fraction of BCG: solid tumors.
Topics: Animals; Antigens, Bacterial; BCG Vaccine; Benzopyrenes; Cyclophosphamide; Female; Fibrosarcoma; Flu | 1973 |
Synergism of ICRF 159 and radiotherapy in treatment of experimental tumors.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Dose-Response Re | 1974 |
[Combined action of serotonin, prednisolone and 5-fluorouracil on sarcoma 45 and M-1].
Topics: Administration, Oral; Animals; Body Weight; Drug Interactions; Drug Synergism; Fluorouracil; Injecti | 1974 |
[Studies on the metabolic fate of 5-fluorouracil in the oral administration].
Topics: Administration, Oral; Animals; Fluorouracil; Injections, Intravenous; Male; Rats; Sarcoma, Experimen | 1974 |
[Use of transplantability indices of tumor cells for evaluation of the cytotoxic effect of antineoplastic agents in vitro].
Topics: Animals; Cell Line; Cells, Cultured; Culture Media; Fluorouracil; Leukemia, Experimental; Male; Melp | 1972 |
Sensitivity of Nakahara-Fukuoka sarcoma to antitumor agents, especially to purine analogs.
Topics: Animals; Antineoplastic Agents; Busulfan; Cyclophosphamide; Female; Fluorouracil; Hydrocortisone; Me | 1969 |
Observations with a variant of lymphocytic choriomeningitis virus in mouse tumors.
Topics: Animals; Antigens; Carcinoma, Ehrlich Tumor; Female; Fluorouracil; Immunotherapy; Lymphocytic Chorio | 1970 |
Combination chemotherapy with L-asparaginase (EC-2) using P1798 lymphosarcoma.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cyclophosphami | 1971 |
[Time factor in evaluating antineoplastic agents].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Dactinomycin; Fluorouracil; M | 1972 |
[Experimental studies on antineoplastic action of N 1 -(2'-tetrahydrofuryl)-5-fluorouracil (FT-207)--effect on experimental tumors].
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Fluorouracil; Furans; Mice; Neoplasms, Experimental; | 1971 |
Effect of chemotherapy on uptake of alkali metals by experimental tumors.
Topics: Animals; Azaserine; Carcinoma; Cesium; Cyclophosphamide; Fluorouracil; In Vitro Techniques; Mammary | 1968 |
[Comparative quantitative studies of dye incorporation by Yoshida- and DS- carcinosarcoma-ascitic tumor cells as a contribution to the problem of natural resistance to cytostatic substances].
Topics: Animals; Antineoplastic Agents; Carcinosarcoma; Cell Membrane Permeability; Coloring Agents; Fluorou | 1968 |
[Basic differences in the effect of cellular parameters on the incorporation of strongly and weakly incorporated pharmaco].
Topics: Adsorption; Animals; Antineoplastic Agents; Binding Sites; Carcinosarcoma; Cell Membrane Permeabilit | 1968 |