fluorouracil has been researched along with Dysmyelopoietic Syndromes in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Interestingly, rare balanced chromosomal abnormalities were observed in the present cases, thus providing new insights into the leukemogenesis of therapy-related leukemia." | 1.36 | Therapy-related leukemia following chemoradiotherapy for esophageal cancer. ( Ise, M; Kumagai, K; Mimura, N; Nagata, M; Sakai, C; Takagi, T; Tsujimura, H, 2010) |
| "Cytogenetic abnormalities were not found in the stem cell harvests of these patients by metaphase analysis or by fluorescence in situ hybridization (FISH)." | 1.31 | Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for breast cancer. ( de Castro, K; Griffin, M; Hesdorffer, C; Lin, N; Murty, VV; Nichols, G; Oratzi, A; Troxel, A; Vahdat, L; Wei, LX, 2002) |
| "Early changes in karyotype detected in breast cancer patients following ASCT are transient and do not correlate with or predict development of MDS/AML." | 1.31 | Chromosomal abnormalities in women with breast cancer after autologous stem cell transplantation are infrequent and may not predict development of therapy-related leukemia or myelodysplastic syndrome. ( Arbona, C; Benet, I; Comes, AM; García Clavel, B; García-Conde, J; Lluch, A; Martínez-Climent, JA; Marugán, I; Prósper, F; Solano, C; Vizcarra, E, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mimura, N | 1 |
| Tsujimura, H | 1 |
| Ise, M | 1 |
| Sakai, C | 1 |
| Takagi, T | 1 |
| Nagata, M | 1 |
| Kumagai, K | 1 |
| Nichols, G | 1 |
| de Castro, K | 1 |
| Wei, LX | 1 |
| Griffin, M | 1 |
| Lin, N | 1 |
| Oratzi, A | 1 |
| Murty, VV | 1 |
| Troxel, A | 1 |
| Vahdat, L | 1 |
| Hesdorffer, C | 1 |
| Weldon, CB | 1 |
| Jaffe, BM | 1 |
| Kahn, MJ | 1 |
| Martínez-Climent, JA | 1 |
| Comes, AM | 1 |
| Vizcarra, E | 1 |
| Benet, I | 1 |
| Arbona, C | 1 |
| Prósper, F | 1 |
| Solano, C | 1 |
| García Clavel, B | 1 |
| Marugán, I | 1 |
| Lluch, A | 1 |
| García-Conde, J | 1 |
| Pitini, V | 1 |
| Arrigo, C | 1 |
| Aloi, G | 1 |
| Righi, M | 1 |
| Falduto, M | 1 |
| Teti, D | 1 |
5 other studies available for fluorouracil and Dysmyelopoietic Syndromes
| Article | Year |
|---|---|
Therapy-related leukemia following chemoradiotherapy for esophageal cancer.
Topics: Aged; Antineoplastic Agents; Chromosome Aberrations; Chromosomes, Human, Pair 5; Combined Modality T | 2010 |
Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for breast cancer.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, D | 2002 |
Therapy-induced leukemias and myelodysplastic syndromes after breast cancer treatment: an underemphasized clinical problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Carci | 2002 |
Chromosomal abnormalities in women with breast cancer after autologous stem cell transplantation are infrequent and may not predict development of therapy-related leukemia or myelodysplastic syndrome.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Chemotherapy, | 2000 |
Myelodysplastic syndrome/acute myelogenous leukaemia after adjuvant chemotherapy with pyrimidine anti-metabolites in three patients.
Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Le | 2001 |