fluorouracil has been researched along with Dyskeratosis Congenita in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Dyskeratosis Congenita: A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres." | 1.33 | Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. ( Armanios, M; Feldser, DM; Greider, CW; Hao, LY; Huso, D; Karim, B; Strong, MA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, LY | 1 |
| Armanios, M | 1 |
| Strong, MA | 1 |
| Karim, B | 1 |
| Feldser, DM | 1 |
| Huso, D | 1 |
| Greider, CW | 1 |
1 other study available for fluorouracil and Dyskeratosis Congenita
| Article | Year |
|---|---|
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
Topics: Animals; Anticipation, Genetic; Blood Cell Count; Bone Marrow Transplantation; Crosses, Genetic; Dys | 2005 |